Incidental Mutation 'RF003:Inpp4b'
| ID |
602633 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Inpp4b
|
| Ensembl Gene |
ENSMUSG00000037940 |
| Gene Name |
inositol polyphosphate-4-phosphatase, type II |
| Synonyms |
E130107I17Rik |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.262)
|
| Stock # |
RF003 (G1)
|
| Quality Score |
109.008 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
81342556-82127914 bp(+) (GRCm38) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 81969521 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 361
(Y361*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150520
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042529]
[ENSMUST00000109851]
[ENSMUST00000109852]
[ENSMUST00000169116]
[ENSMUST00000169387]
[ENSMUST00000170160]
[ENSMUST00000172031]
[ENSMUST00000213285]
[ENSMUST00000215332]
[ENSMUST00000217122]
|
| AlphaFold |
Q6P1Y8 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000042529
AA Change: Y344*
|
| SMART Domains |
Protein: ENSMUSP00000044466
Gene: ENSMUSG00000037940
AA Change: Y344*
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
40 |
147 |
1.72e0 |
SMART |
|
low complexity region
|
302 |
319 |
N/A |
INTRINSIC |
|
low complexity region
|
425 |
434 |
N/A |
INTRINSIC |
|
transmembrane domain
|
898 |
920 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109851
AA Change: Y229*
|
| SMART Domains |
Protein: ENSMUSP00000105477
Gene: ENSMUSG00000037940
AA Change: Y229*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
22 |
35 |
N/A |
INTRINSIC |
|
low complexity region
|
187 |
204 |
N/A |
INTRINSIC |
|
low complexity region
|
310 |
319 |
N/A |
INTRINSIC |
|
transmembrane domain
|
783 |
805 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109852
AA Change: Y361*
|
| SMART Domains |
Protein: ENSMUSP00000105478
Gene: ENSMUSG00000037940
AA Change: Y361*
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
40 |
164 |
5.29e0 |
SMART |
|
low complexity region
|
319 |
336 |
N/A |
INTRINSIC |
|
low complexity region
|
442 |
451 |
N/A |
INTRINSIC |
|
transmembrane domain
|
915 |
937 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000169116
AA Change: Y361*
|
| SMART Domains |
Protein: ENSMUSP00000131947
Gene: ENSMUSG00000037940
AA Change: Y361*
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
40 |
164 |
5.29e0 |
SMART |
|
low complexity region
|
319 |
336 |
N/A |
INTRINSIC |
|
low complexity region
|
442 |
451 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169387
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000170160
AA Change: Y176*
|
| SMART Domains |
Protein: ENSMUSP00000132156
Gene: ENSMUSG00000037940
AA Change: Y176*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
257 |
266 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000172031
AA Change: Y361*
|
| SMART Domains |
Protein: ENSMUSP00000131324
Gene: ENSMUSG00000037940
AA Change: Y361*
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
40 |
164 |
5.29e0 |
SMART |
|
low complexity region
|
319 |
336 |
N/A |
INTRINSIC |
|
low complexity region
|
442 |
451 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000213285
AA Change: Y361*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000215332
AA Change: Y361*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000217122
AA Change: Y361*
|
| Coding Region Coverage |
- 1x: 99.8%
- 3x: 99.7%
- 10x: 99.2%
- 20x: 98.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit osteoporosis, reduced long bone length, increased osteoclast numbers and size, increased osteoblast numbers, and increased bone resorption and resorption. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930433I11Rik |
AACC |
A |
7: 40,993,055 (GRCm38) |
|
probably benign |
Het |
| A630073D07Rik |
A |
C |
6: 132,627,443 (GRCm38) |
L13R |
unknown |
Het |
| Alg9 |
GGC |
GGCCGC |
9: 50,775,427 (GRCm38) |
|
probably benign |
Het |
| Arc |
G |
C |
15: 74,672,131 (GRCm38) |
T81S |
probably benign |
Het |
| Atad5 |
A |
T |
11: 80,111,560 (GRCm38) |
K1059N |
probably damaging |
Het |
| Bdp1 |
C |
A |
13: 100,060,449 (GRCm38) |
V1143F |
probably benign |
Het |
| Bdp1 |
C |
A |
13: 100,060,450 (GRCm38) |
Q1142H |
probably benign |
Het |
| Ccdc33 |
T |
C |
9: 58,058,291 (GRCm38) |
S583G |
probably benign |
Het |
| Cd109 |
TTAT |
TTATTTATTTATATAT |
9: 78,712,531 (GRCm38) |
|
probably benign |
Het |
| Cep192 |
A |
T |
18: 67,837,956 (GRCm38) |
R1009S |
probably benign |
Het |
| Clvs2 |
T |
A |
10: 33,622,925 (GRCm38) |
H3L |
probably damaging |
Het |
| Cnot6 |
T |
C |
11: 49,702,613 (GRCm38) |
M14V |
probably benign |
Het |
| Colec10 |
A |
G |
15: 54,462,391 (GRCm38) |
R206G |
possibly damaging |
Het |
| Dennd6a |
T |
C |
14: 26,629,534 (GRCm38) |
I598T |
probably damaging |
Het |
| Dmrt2 |
T |
C |
19: 25,678,134 (GRCm38) |
S366P |
probably damaging |
Het |
| Dnmt1 |
AGTTCCTACCTCGTT |
AGTTCCTACCTCGTTTTGGGGGCGGAGCACCGTTCCTACCTCGTT |
9: 20,910,131 (GRCm38) |
|
probably null |
Het |
| Efhb |
T |
C |
17: 53,400,891 (GRCm38) |
D748G |
probably damaging |
Het |
| Etl4 |
C |
T |
2: 20,519,918 (GRCm38) |
Q21* |
probably null |
Het |
| Fam172a |
A |
T |
13: 77,834,675 (GRCm38) |
I135L |
possibly damaging |
Het |
| Fam71e1 |
C |
CGGAGGGAGGAAGGCTGGATCCTGGATACCTGGGTA |
7: 44,500,527 (GRCm38) |
|
probably null |
Het |
| Flywch1 |
CCACTCCTGGTGT |
CCACTCCTGGTGTGGGGAGGCTACGTACTCACACACTCCTGGTGT |
17: 23,762,166 (GRCm38) |
|
probably null |
Het |
| Fmn1 |
ACCTCC |
ACCTCCCCCTCC |
2: 113,525,786 (GRCm38) |
|
probably benign |
Het |
| Fsip2 |
T |
A |
2: 82,991,521 (GRCm38) |
M5866K |
probably benign |
Het |
| Gab3 |
CTT |
CTTATT |
X: 75,000,006 (GRCm38) |
|
probably null |
Het |
| Gnl2 |
T |
A |
4: 125,043,725 (GRCm38) |
|
probably null |
Het |
| Grip2 |
C |
T |
6: 91,783,593 (GRCm38) |
R341Q |
probably benign |
Het |
| Hmcn1 |
T |
A |
1: 150,624,561 (GRCm38) |
H3960L |
probably damaging |
Het |
| Igkv6-25 |
T |
A |
6: 70,215,778 (GRCm38) |
Y56* |
probably null |
Het |
| Il12a |
A |
T |
3: 68,695,229 (GRCm38) |
T102S |
probably benign |
Het |
| Il1a |
T |
A |
2: 129,302,932 (GRCm38) |
I189F |
possibly damaging |
Het |
| Iqcf4 |
CTTTTCCTTTTCCTTTT |
CTTTTCCTTTTCCTTTTCCTTTTCCTTTTCCTTTTCATTTTCCTTTTCCTTTT |
9: 106,570,607 (GRCm38) |
|
probably benign |
Het |
| Krt1 |
AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC |
AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC |
15: 101,850,378 (GRCm38) |
|
probably benign |
Het |
| Las1l |
AGTGG |
AGTGGTGG |
X: 95,940,816 (GRCm38) |
|
probably benign |
Het |
| Lrmp |
AGCACATTG |
AGCACATTGTGCACATTG |
6: 145,173,783 (GRCm38) |
|
probably benign |
Het |
| Lrrc8d |
T |
C |
5: 105,812,641 (GRCm38) |
Y306H |
probably damaging |
Het |
| Mamld1 |
AGC |
AGCCGC |
X: 71,118,820 (GRCm38) |
|
probably benign |
Het |
| Map1a |
CTCCAGCTCCAGCTCCAGCTCCA |
CTCCAGCTCCAGCTCCAGCTCCAGCTCCAGATCCAGCTCCAGCTCCAGCTCCA |
2: 121,306,296 (GRCm38) |
|
probably benign |
Het |
| Map1b |
G |
T |
13: 99,430,750 (GRCm38) |
A1821E |
unknown |
Het |
| Maz |
A |
G |
7: 127,025,497 (GRCm38) |
C284R |
probably damaging |
Het |
| Med23 |
A |
G |
10: 24,903,785 (GRCm38) |
H920R |
probably damaging |
Het |
| Megf10 |
CCAGCAGCAGCAGCAGCAGCAG |
CCAGCAGCAGCAGCAGCAG |
18: 57,294,027 (GRCm38) |
|
probably benign |
Het |
| Mmp14 |
C |
T |
14: 54,439,014 (GRCm38) |
R339* |
probably null |
Het |
| Mroh9 |
T |
G |
1: 163,058,061 (GRCm38) |
K334T |
probably damaging |
Het |
| Nab1 |
A |
T |
1: 52,479,282 (GRCm38) |
C320S |
probably damaging |
Het |
| Noto |
T |
C |
6: 85,424,210 (GRCm38) |
S74P |
probably benign |
Het |
| Nudt4 |
T |
C |
10: 95,549,374 (GRCm38) |
N152D |
possibly damaging |
Het |
| Nup155 |
T |
TTTTG |
15: 8,119,176 (GRCm38) |
|
probably benign |
Het |
| Nusap1 |
AGCTGAGA |
AGCTGAGATACACGTTAGCAGTGAGGAGCAGGCTGAGA |
2: 119,627,603 (GRCm38) |
|
probably benign |
Het |
| Olfr118 |
A |
C |
17: 37,672,858 (GRCm38) |
K278N |
probably damaging |
Het |
| Olfr330 |
CA |
C |
11: 58,529,157 (GRCm38) |
|
probably null |
Het |
| Olfr461 |
T |
C |
6: 40,544,362 (GRCm38) |
I206V |
probably benign |
Het |
| Olfr585 |
TTA |
TTAGTA |
7: 103,098,306 (GRCm38) |
|
probably null |
Het |
| Olfr585 |
GTTAT |
GTTATTAT |
7: 103,098,305 (GRCm38) |
|
|
Het |
| Olfr710 |
T |
A |
7: 106,944,648 (GRCm38) |
M118L |
probably damaging |
Het |
| Olfr828 |
T |
C |
9: 18,815,482 (GRCm38) |
T271A |
probably benign |
Het |
| Plxnc1 |
T |
C |
10: 94,794,444 (GRCm38) |
Y1531C |
probably damaging |
Het |
| Pnmal2 |
TGA |
TGAAGA |
7: 16,946,016 (GRCm38) |
|
probably benign |
Het |
| Rp1 |
A |
G |
1: 4,344,694 (GRCm38) |
V2065A |
probably damaging |
Het |
| Sbp |
AAGATGCTGACAACA |
AAGATGCTGACAACAGAGATGCTGACAACA |
17: 23,945,369 (GRCm38) |
|
probably benign |
Het |
| Sepsecs |
G |
A |
5: 52,647,191 (GRCm38) |
T379M |
probably benign |
Het |
| Sfswap |
GGCC |
GGCCCACTCTGCC |
5: 129,569,764 (GRCm38) |
|
probably benign |
Het |
| Six3 |
GCG |
GCGTCG |
17: 85,621,370 (GRCm38) |
|
probably benign |
Het |
| Tfeb |
C |
T |
17: 47,788,078 (GRCm38) |
T259I |
possibly damaging |
Het |
| Tgoln1 |
A |
AAACTCAG |
6: 72,616,352 (GRCm38) |
|
probably null |
Het |
| Tmem94 |
G |
A |
11: 115,796,132 (GRCm38) |
V1108M |
probably damaging |
Het |
| Usp35 |
T |
C |
7: 97,322,096 (GRCm38) |
K297E |
possibly damaging |
Het |
| Vcpkmt |
T |
A |
12: 69,582,824 (GRCm38) |
T55S |
possibly damaging |
Het |
| Zfp384 |
GCCCAGGCCCAG |
GCCCAGGCCCAGTCCCAGGCCCAG |
6: 125,036,483 (GRCm38) |
|
probably benign |
Het |
| Zfp384 |
GGCCC |
GGCCCTGGCCCAAGCCC |
6: 125,036,476 (GRCm38) |
|
probably benign |
Het |
| Zfp384 |
GCCCAGGCCCAGGCCCAGGCCCAG |
GCCCAGGCCCAGTCCCAGGCCCAGGCCCAGGCCCAG |
6: 125,036,471 (GRCm38) |
|
probably benign |
Het |
| Zfp407 |
A |
T |
18: 84,209,563 (GRCm38) |
S1974T |
probably benign |
Het |
| Zfp677 |
T |
C |
17: 21,397,442 (GRCm38) |
S254P |
probably damaging |
Het |
|
| Other mutations in Inpp4b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00850:Inpp4b
|
APN |
8 |
81,856,750 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01481:Inpp4b
|
APN |
8 |
81,997,380 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01509:Inpp4b
|
APN |
8 |
81,890,703 (GRCm38) |
splice site |
probably benign |
|
|
IGL01515:Inpp4b
|
APN |
8 |
81,952,711 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
IGL01607:Inpp4b
|
APN |
8 |
82,010,663 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL01643:Inpp4b
|
APN |
8 |
82,071,771 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL01736:Inpp4b
|
APN |
8 |
81,997,339 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02154:Inpp4b
|
APN |
8 |
81,969,501 (GRCm38) |
splice site |
probably benign |
|
|
IGL02327:Inpp4b
|
APN |
8 |
82,041,962 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02413:Inpp4b
|
APN |
8 |
82,033,171 (GRCm38) |
missense |
probably benign |
|
|
IGL02652:Inpp4b
|
APN |
8 |
81,770,800 (GRCm38) |
splice site |
probably benign |
|
|
IGL02678:Inpp4b
|
APN |
8 |
81,856,744 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03146:Inpp4b
|
APN |
8 |
81,743,781 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
LCD18:Inpp4b
|
UTSW |
8 |
81,693,010 (GRCm38) |
intron |
probably benign |
|
|
PIT4280001:Inpp4b
|
UTSW |
8 |
82,034,417 (GRCm38) |
missense |
probably benign |
0.00 |
|
PIT4480001:Inpp4b
|
UTSW |
8 |
82,046,267 (GRCm38) |
missense |
probably damaging |
1.00 |
|
PIT4504001:Inpp4b
|
UTSW |
8 |
82,041,935 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0083:Inpp4b
|
UTSW |
8 |
81,741,462 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R0212:Inpp4b
|
UTSW |
8 |
81,770,917 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0285:Inpp4b
|
UTSW |
8 |
82,034,516 (GRCm38) |
splice site |
probably benign |
|
|
R0363:Inpp4b
|
UTSW |
8 |
81,884,257 (GRCm38) |
splice site |
probably benign |
|
|
R0364:Inpp4b
|
UTSW |
8 |
81,997,314 (GRCm38) |
missense |
probably benign |
0.09 |
|
R0471:Inpp4b
|
UTSW |
8 |
82,041,899 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R0550:Inpp4b
|
UTSW |
8 |
81,997,337 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0562:Inpp4b
|
UTSW |
8 |
81,768,151 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R0661:Inpp4b
|
UTSW |
8 |
81,741,462 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R0693:Inpp4b
|
UTSW |
8 |
81,997,314 (GRCm38) |
missense |
probably benign |
0.09 |
|
R1081:Inpp4b
|
UTSW |
8 |
82,069,024 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1251:Inpp4b
|
UTSW |
8 |
81,890,753 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1374:Inpp4b
|
UTSW |
8 |
81,743,816 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1445:Inpp4b
|
UTSW |
8 |
81,952,834 (GRCm38) |
splice site |
probably null |
|
|
R1465:Inpp4b
|
UTSW |
8 |
81,768,157 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1465:Inpp4b
|
UTSW |
8 |
81,768,157 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1647:Inpp4b
|
UTSW |
8 |
81,856,774 (GRCm38) |
splice site |
probably benign |
|
|
R1754:Inpp4b
|
UTSW |
8 |
81,770,811 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1759:Inpp4b
|
UTSW |
8 |
81,768,103 (GRCm38) |
missense |
probably benign |
0.06 |
|
R2085:Inpp4b
|
UTSW |
8 |
81,952,274 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2156:Inpp4b
|
UTSW |
8 |
82,048,489 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2160:Inpp4b
|
UTSW |
8 |
82,121,375 (GRCm38) |
nonsense |
probably null |
|
|
R2175:Inpp4b
|
UTSW |
8 |
81,856,699 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2191:Inpp4b
|
UTSW |
8 |
81,997,302 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2401:Inpp4b
|
UTSW |
8 |
81,997,339 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2475:Inpp4b
|
UTSW |
8 |
82,041,978 (GRCm38) |
missense |
probably benign |
0.09 |
|
R2512:Inpp4b
|
UTSW |
8 |
82,010,550 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2919:Inpp4b
|
UTSW |
8 |
81,985,329 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R3021:Inpp4b
|
UTSW |
8 |
81,902,838 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R3423:Inpp4b
|
UTSW |
8 |
81,952,261 (GRCm38) |
missense |
possibly damaging |
0.63 |
|
R3777:Inpp4b
|
UTSW |
8 |
82,041,992 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R3778:Inpp4b
|
UTSW |
8 |
82,041,992 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R3794:Inpp4b
|
UTSW |
8 |
82,033,216 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3795:Inpp4b
|
UTSW |
8 |
82,033,216 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4590:Inpp4b
|
UTSW |
8 |
81,741,411 (GRCm38) |
start codon destroyed |
probably null |
1.00 |
|
R4602:Inpp4b
|
UTSW |
8 |
81,969,535 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4691:Inpp4b
|
UTSW |
8 |
82,122,653 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4924:Inpp4b
|
UTSW |
8 |
82,122,624 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4992:Inpp4b
|
UTSW |
8 |
82,033,208 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5219:Inpp4b
|
UTSW |
8 |
81,884,156 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5228:Inpp4b
|
UTSW |
8 |
81,768,115 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5557:Inpp4b
|
UTSW |
8 |
81,952,259 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5627:Inpp4b
|
UTSW |
8 |
81,743,816 (GRCm38) |
critical splice donor site |
probably benign |
|
|
R5691:Inpp4b
|
UTSW |
8 |
81,890,694 (GRCm38) |
intron |
probably benign |
|
|
R6186:Inpp4b
|
UTSW |
8 |
82,046,234 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6213:Inpp4b
|
UTSW |
8 |
81,997,390 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6232:Inpp4b
|
UTSW |
8 |
81,952,184 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6283:Inpp4b
|
UTSW |
8 |
81,770,833 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6302:Inpp4b
|
UTSW |
8 |
81,768,177 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6309:Inpp4b
|
UTSW |
8 |
82,041,917 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6360:Inpp4b
|
UTSW |
8 |
81,902,852 (GRCm38) |
missense |
probably benign |
0.20 |
|
R6477:Inpp4b
|
UTSW |
8 |
81,844,714 (GRCm38) |
splice site |
probably null |
|
|
R6773:Inpp4b
|
UTSW |
8 |
81,856,620 (GRCm38) |
intron |
probably benign |
|
|
R6968:Inpp4b
|
UTSW |
8 |
81,844,457 (GRCm38) |
missense |
probably benign |
0.18 |
|
R7147:Inpp4b
|
UTSW |
8 |
81,902,771 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7318:Inpp4b
|
UTSW |
8 |
82,071,745 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7409:Inpp4b
|
UTSW |
8 |
81,952,685 (GRCm38) |
splice site |
probably null |
|
|
R7455:Inpp4b
|
UTSW |
8 |
82,071,703 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7632:Inpp4b
|
UTSW |
8 |
82,046,339 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7844:Inpp4b
|
UTSW |
8 |
81,741,320 (GRCm38) |
start gained |
probably benign |
|
|
R7958:Inpp4b
|
UTSW |
8 |
81,969,589 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8440:Inpp4b
|
UTSW |
8 |
82,041,895 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9160:Inpp4b
|
UTSW |
8 |
81,884,153 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
R9303:Inpp4b
|
UTSW |
8 |
82,033,129 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9390:Inpp4b
|
UTSW |
8 |
81,770,893 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9583:Inpp4b
|
UTSW |
8 |
81,770,926 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9705:Inpp4b
|
UTSW |
8 |
82,046,261 (GRCm38) |
missense |
probably benign |
0.14 |
|
R9778:Inpp4b
|
UTSW |
8 |
82,048,531 (GRCm38) |
missense |
probably benign |
|
|
Z1088:Inpp4b
|
UTSW |
8 |
82,068,931 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
Z1176:Inpp4b
|
UTSW |
8 |
82,069,001 (GRCm38) |
missense |
possibly damaging |
0.60 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCACAGGTGGCTTTTAGAAAGATTG -3'
(R):5'- ATTCATTGGGATAGACTGGTCTCC -3'
Sequencing Primer
(F):5'- AAAGATTGATTAGTTCTTCTTGCCCC -3'
(R):5'- GATAGACTGGTCTCCAAAGTATTAAC -3'
|
| Posted On |
2019-12-04 |
Incidental Mutation