Mutagenetix > Incidental Mutation

Incidental Mutation 'RF004:Or51q1'

602692

Institutional Source

Beutler Lab

Gene Symbol

Or51q1

Ensembl Gene

ENSMUSG00000094520

Gene Name

olfactory receptor family 51 subfamily Q member 1

Synonyms

Olfr635, GA_x6K02T2PBJ9-6713641-6714588, MOR5-2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.116) question?

Stock #

RF004 (G1)

Quality Score

217.468

Status

Not validated

Chromosome

Chromosomal Location

103628383-103629348 bp(+) (GRCm39)

Type of Mutation

frame shift

DNA Base Change (assembly)

TCC to TCCC at 103629110 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000148103 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098185] [ENSMUST00000209473]

AlphaFold

K7N6B1

Predicted Effect

probably null
Transcript: ENSMUST00000098185

SMART Domains

Protein: ENSMUSP00000095788
Gene: ENSMUSG00000094520

Domain	Start	End	E-Value	Type
Pfam:7tm_4	39	318	1.2e-119	PFAM
Pfam:7TM_GPCR_Srsx	43	182	1.3e-9	PFAM
Pfam:7tm_1	49	300	1.9e-18	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000121874

Predicted Effect

probably null
Transcript: ENSMUST00000209473

Coding Region Coverage

1x: 99.8%
3x: 99.6%
10x: 99.1%
20x: 97.6%

Validation Efficiency

100% (34/34)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110059E24Rik	T	A	19: 21,575,645 (GRCm39)	H126L	probably benign	Het
4930407I10Rik	A	T	15: 81,943,550 (GRCm39)	Q54L	possibly damaging	Het
4930433I11Rik	AACC	A	7: 40,642,479 (GRCm39)		probably benign	Het
Adora2a	A	T	10: 75,168,988 (GRCm39)	T151S	probably benign	Het
Ankhd1	GCGGCG	GCGGCGTCGGCG	18: 36,693,963 (GRCm39)		probably benign	Het
Ankrd36	A	G	11: 5,612,411 (GRCm39)	K1248E	possibly damaging	Het
Anks1b	G	A	10: 89,869,087 (GRCm39)	G49D	probably damaging	Het
Arl11	T	C	14: 61,548,304 (GRCm39)	V38A	probably damaging	Het
Atp2c2	A	T	8: 120,479,561 (GRCm39)	N726Y	probably damaging	Het
Bcat1	T	C	6: 144,953,349 (GRCm39)	K413R	probably benign	Het
Cd244a	C	G	1: 171,405,490 (GRCm39)	Q292E	probably benign	Het
Chp1	T	A	2: 119,411,195 (GRCm39)	D123E	probably damaging	Het
Cpeb4	ACTCT	ACTCTCT	11: 31,877,634 (GRCm39)		probably benign	Het
Ddx6	A	G	9: 44,535,789 (GRCm39)	T173A	possibly damaging	Het
Dlg2	T	A	7: 90,501,885 (GRCm39)	C66S	probably benign	Het
Dnah2	T	A	11: 69,328,013 (GRCm39)	Q3370L	probably benign	Het
Dnmt1	GCACAGTTCCTACCTCGTT	GCACAGTTCCTACCTCGTTTTGGGGGCGGAACACAGTTCCTACCTCGTT	9: 20,821,423 (GRCm39)		probably null	Het
Dop1a	T	C	9: 86,436,244 (GRCm39)	V2420A	probably benign	Het
Gm8369	GTGTGT	GTGTGTATGTGT	19: 11,489,118 (GRCm39)		probably benign	Het
Igkv6-25	TTGACGGA	T	6: 70,192,647 (GRCm39)		probably null	Het
Iqgap1	G	A	7: 80,370,623 (GRCm39)	A1582V	probably benign	Het
Lmnb1	T	C	18: 56,864,046 (GRCm39)	I217T	possibly damaging	Het
Mamld1	CAG	CAGTAG	X: 70,162,437 (GRCm39)		probably null	Het
Map2k2	A	T	10: 80,951,002 (GRCm39)	H149L	probably benign	Het
Med12l	CAG	CAGAAG	3: 59,183,390 (GRCm39)		probably benign	Het
Mmp1a	TG	TGG	9: 7,465,083 (GRCm38)		probably null	Het
Nxph2	G	A	2: 23,290,080 (GRCm39)	R144Q	probably damaging	Het
Or2t48	CA	C	11: 58,419,983 (GRCm39)		probably null	Het
Or51f1e	T	TTAG	7: 102,747,516 (GRCm39)		probably null	Het
Or51f1e	GTTAT	GTTATTAT	7: 102,747,512 (GRCm39)			Het
Or51f1e	AT	ATTCT	7: 102,747,515 (GRCm39)		probably benign	Het
Or52n20	A	G	7: 104,320,248 (GRCm39)	E113G	probably damaging	Het
Or8d2	T	C	9: 38,760,114 (GRCm39)	F235L	probably benign	Het
Padi4	A	T	4: 140,487,269 (GRCm39)	V211E	probably damaging	Het
Prdm10	A	C	9: 31,270,422 (GRCm39)	D902A	probably damaging	Het
Prps1l1	A	G	12: 35,035,398 (GRCm39)	D171G	probably damaging	Het
Rasal3	A	T	17: 32,610,081 (GRCm39)	N1035K	probably damaging	Het
Rassf6	GGTCCTGTAGAGCAATGGGGATTC	GGTCCTGTAGAGCAATGGGGATTCTGCATCACTCATTGTCCTGTAGAGCAATGGGGATTC	5: 90,756,778 (GRCm39)		probably benign	Het
Rbm26	A	G	14: 105,388,931 (GRCm39)	V320A	probably damaging	Het
S1pr1	A	T	3: 115,506,536 (GRCm39)	Y19*	probably null	Het
Slc22a16	A	C	10: 40,479,642 (GRCm39)	L571F	possibly damaging	Het
Smarca2	CAGC	CAGCCCAAGC	19: 26,608,420 (GRCm39)		probably benign	Het
Ssx2ip	A	T	3: 146,132,195 (GRCm39)	K219*	probably null	Het
Trav15-2-dv6-2	AAG	AAGCAG	14: 53,887,212 (GRCm39)		probably benign	Het
Trav15-2-dv6-2	GGGAG	GGGAGGAG	14: 53,887,207 (GRCm39)		probably benign	Het
Trav15-2-dv6-2	GAA	GAATAA	14: 53,887,211 (GRCm39)		probably null	Het
Tsen15	A	G	1: 152,259,470 (GRCm39)	V63A	probably damaging	Het
Ttc21a	A	G	9: 119,795,838 (GRCm39)	Y1224C	probably damaging	Het
Usp54	T	A	14: 20,611,368 (GRCm39)	E1149D	possibly damaging	Het
Vmn2r37	A	T	7: 9,220,686 (GRCm39)	S392R	probably damaging	Het
Wdr97	GAGGAGGA	G	15: 76,247,373 (GRCm39)		probably null	Het
Zfp663	G	T	2: 165,200,363 (GRCm39)	H72Q	probably benign	Het
Zfp683	TGTGG	TGTGGTGG	4: 133,786,185 (GRCm39)		probably benign	Het

Other mutations in Or51q1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01064:Or51q1	APN	7	103,628,999 (GRCm39)	missense	probably benign	0.09
IGL01330:Or51q1	APN	7	103,629,349 (GRCm39)	utr 3 prime	probably benign
IGL01433:Or51q1	APN	7	103,628,539 (GRCm39)	missense	probably damaging	1.00
FR4304:Or51q1	UTSW	7	103,629,110 (GRCm39)	frame shift	probably null
FR4340:Or51q1	UTSW	7	103,629,110 (GRCm39)	frame shift	probably null
FR4342:Or51q1	UTSW	7	103,629,110 (GRCm39)	frame shift	probably null
R0271:Or51q1	UTSW	7	103,628,837 (GRCm39)	missense	possibly damaging	0.83
R1909:Or51q1	UTSW	7	103,628,997 (GRCm39)	nonsense	probably null
R2212:Or51q1	UTSW	7	103,628,609 (GRCm39)	missense	probably damaging	0.98
R2484:Or51q1	UTSW	7	103,628,545 (GRCm39)	missense	probably benign
R3412:Or51q1	UTSW	7	103,628,609 (GRCm39)	missense	probably damaging	0.98
R4513:Or51q1	UTSW	7	103,628,648 (GRCm39)	missense	probably benign	0.03
R4559:Or51q1	UTSW	7	103,628,767 (GRCm39)	missense	probably damaging	1.00
R5032:Or51q1	UTSW	7	103,628,581 (GRCm39)	missense	probably damaging	0.98
R5436:Or51q1	UTSW	7	103,628,473 (GRCm39)	missense	probably benign
R5591:Or51q1	UTSW	7	103,629,320 (GRCm39)	missense	probably benign	0.00
R5617:Or51q1	UTSW	7	103,628,921 (GRCm39)	missense	possibly damaging	0.91
R5911:Or51q1	UTSW	7	103,628,915 (GRCm39)	missense	probably benign
R6249:Or51q1	UTSW	7	103,628,818 (GRCm39)	missense	possibly damaging	0.85
R6275:Or51q1	UTSW	7	103,629,181 (GRCm39)	missense	probably damaging	1.00
R6806:Or51q1	UTSW	7	103,628,771 (GRCm39)	missense	possibly damaging	0.72
R7589:Or51q1	UTSW	7	103,628,998 (GRCm39)	missense	probably damaging	1.00
R8188:Or51q1	UTSW	7	103,628,743 (GRCm39)	missense	probably damaging	1.00
R8337:Or51q1	UTSW	7	103,628,581 (GRCm39)	missense	probably damaging	0.98
R9106:Or51q1	UTSW	7	103,628,581 (GRCm39)	missense	probably damaging	0.98
R9507:Or51q1	UTSW	7	103,629,198 (GRCm39)	missense	probably damaging	1.00
R9592:Or51q1	UTSW	7	103,629,179 (GRCm39)	missense	possibly damaging	0.54
RF005:Or51q1	UTSW	7	103,628,768 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGGGTTGGCCATCATTTGCC -3'
(R):5'- TCCTTGACGGATCTGCTTTG -3'

Sequencing Primer
(F):5'- GGCCATCATTTGCCGCTGTG -3'
(R):5'- CTTTACACTGTAAATGATGGGGTTC -3'

Posted On

2019-12-04