Incidental Mutation 'RF005:Prp2'
ID 602748
Institutional Source Beutler Lab
Gene Symbol Prp2
Ensembl Gene ENSMUSG00000058295
Gene Name proline rich protein 2
Synonyms MP14
Accession Numbers
Essential gene? Not available question?
Stock # RF005 (G1)
Quality Score 217.468
Status Not validated
Chromosome 6
Chromosomal Location 132572874-132577665 bp(+) (GRCm39)
Type of Mutation small deletion (14 aa in frame mutation)
DNA Base Change (assembly) AGGCCCACAGCAGCGACCCCCTCAAGGCCCACCACCACCAGGTGGCCCACAGCCGAGACCCCCTCAAGGCCCACCACC to AGGCCCACAGCCGAGACCCCCTCAAGGCCCACCACC at 132577464 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000135942 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076061] [ENSMUST00000178961]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000076061
SMART Domains Protein: ENSMUSP00000075435
Gene: ENSMUSG00000058295

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
low complexity region 24 44 N/A INTRINSIC
low complexity region 49 299 N/A INTRINSIC
low complexity region 302 316 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000178961
SMART Domains Protein: ENSMUSP00000135942
Gene: ENSMUSG00000058295

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
low complexity region 24 44 N/A INTRINSIC
low complexity region 49 299 N/A INTRINSIC
low complexity region 302 316 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.7%
  • 10x: 99.4%
  • 20x: 98.6%
Validation Efficiency 94% (65/69)
MGI Phenotype FUNCTION: This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The expression of this gene is dramatically induced in the parotid and submandibular glands of mice by beta-adrenergic stimulation. The encoded protein serves an important dental function by protecting mice against toxic dietary polyphenols such as tannins and influence the visco-elastic properties of the mucus. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 6. [provided by RefSeq, Nov 2015]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5430401F13Rik AGAAAGGAAAAGGTGGCCAG AGAAAGGAAAAGGTGGCCAGCAAAAACAGAAAGGAAAAGGTGGCCAG 6: 131,529,847 (GRCm39) probably benign Het
A030005L19Rik CTGCTG CTGCTGTGGATGCTG 1: 82,891,306 (GRCm39) probably benign Het
Abca1 G T 4: 53,049,125 (GRCm39) T1651N probably damaging Het
Adamtsl3 A G 7: 82,261,603 (GRCm39) T40A Het
Adgra3 A T 5: 50,170,729 (GRCm39) probably null Het
Apcs A T 1: 172,721,809 (GRCm39) M179K probably damaging Het
Baiap2 G A 11: 119,887,355 (GRCm39) E217K possibly damaging Het
Bltp3a A T 17: 28,104,505 (GRCm39) D517V probably damaging Het
Ccdc69 A G 11: 54,951,349 (GRCm39) L24P probably damaging Het
Cdh16 T G 8: 105,343,684 (GRCm39) N604T probably damaging Het
Cfb C T 17: 35,077,022 (GRCm39) V538I possibly damaging Het
Col6a3 A G 1: 90,738,984 (GRCm39) S1022P probably benign Het
Cpeb1 A G 7: 81,011,554 (GRCm39) L129S possibly damaging Het
Crybg1 A G 10: 43,880,741 (GRCm39) V149A probably benign Het
Cyp4f16 C A 17: 32,764,169 (GRCm39) probably null Het
Dlg5 G A 14: 24,208,561 (GRCm39) Q882* probably null Het
Fsip2 T A 2: 82,822,876 (GRCm39) I6203K probably benign Het
Gabre CCGGCT CCGGCTACGGCT X: 71,313,651 (GRCm39) probably null Het
Gprc5d A T 6: 135,093,517 (GRCm39) L130Q probably damaging Het
H13 G A 2: 152,511,589 (GRCm39) E30K probably damaging Het
Hmcn1 T A 1: 150,510,897 (GRCm39) K3609* probably null Het
Hsdl2 GCTGCAG GCTGCAGCAGCAGCCACATCTGCAG 4: 59,610,652 (GRCm39) probably benign Het
Kl A C 5: 150,876,885 (GRCm39) Y235S probably benign Het
Map6d1 G A 16: 20,059,750 (GRCm39) T105I probably benign Het
Mast4 GGTGGTGGTGG GGTGGTGGTGGTGGTGG 13: 102,872,815 (GRCm39) probably benign Het
Mbd1 TGTCTGCATCTGCGTCTTCGTCTGCATCTGCATCTGCGTCTTCGTCTGCATCTGCATCTGC TATCTGCATCTGCGTCTTCGTCTGCATCTGCATCTGC 18: 74,406,644 (GRCm39) probably benign Het
Mms22l A G 4: 24,517,207 (GRCm39) I363V probably benign Het
Myo7a T C 7: 97,742,824 (GRCm39) I391V probably benign Het
Nab2 A T 10: 127,500,233 (GRCm39) D286E probably benign Het
Nrxn1 G A 17: 90,670,304 (GRCm39) R1144C probably damaging Het
Or51q1 A G 7: 103,628,768 (GRCm39) D123G probably damaging Het
Or52j3 T C 7: 102,835,898 (GRCm39) I30T possibly damaging Het
Or5al5 T C 2: 85,961,414 (GRCm39) M198V probably benign Het
Pan2 G A 10: 128,151,404 (GRCm39) E842K probably benign Het
Pate11 T C 9: 36,386,970 (GRCm39) S13P possibly damaging Het
Polr1has CACCACCACCACCACCACCAC CACCACCACCACCACCACCACAACCACCACCACCACCACCAC 17: 37,275,940 (GRCm39) probably benign Het
Prex2 A C 1: 11,255,390 (GRCm39) D1145A possibly damaging Het
Prop1 A C 11: 50,841,957 (GRCm39) Y150D possibly damaging Het
Psip1 T C 4: 83,378,735 (GRCm39) I353M probably damaging Het
Rapgef1 C A 2: 29,597,207 (GRCm39) probably null Het
Rgl1 G A 1: 152,397,114 (GRCm39) S684L probably benign Het
Sbf2 T A 7: 109,916,215 (GRCm39) D1552V probably damaging Het
Scpppq1 A C 5: 104,222,725 (GRCm39) probably null Het
Serpinh1 C T 7: 98,995,410 (GRCm39) V391M probably damaging Het
Slc35e4 A T 11: 3,857,960 (GRCm39) L215Q possibly damaging Het
Tbl3 TCTT TCTTCTT 17: 24,921,515 (GRCm39) probably benign Het
Tex15 T A 8: 34,066,705 (GRCm39) M2045K probably benign Het
Tmprss15 T C 16: 78,750,689 (GRCm39) *1070W probably null Het
Trav15-2-dv6-2 GAA GAACAA 14: 53,887,211 (GRCm39) probably benign Het
Trav15-2-dv6-2 GGGAG GGGAGGAG 14: 53,887,207 (GRCm39) probably benign Het
Trav15-2-dv6-2 GGAG GGAGGAG 14: 53,887,208 (GRCm39) probably benign Het
Trim33 GCCCCGGCCCCCG GCCCCG 3: 103,187,528 (GRCm39) probably null Het
Triobp GACAA GACAACCCCAGGACTCCCTGTGCCCAACGGAACAA 15: 78,851,261 (GRCm39) probably benign Het
Tub C A 7: 108,621,846 (GRCm39) Q95K probably benign Het
Usp9y T A Y: 1,435,046 (GRCm39) Q261L probably benign Het
Utp20 A T 10: 88,661,319 (GRCm39) D29E probably damaging Het
Vill G A 9: 118,889,507 (GRCm39) V148M probably damaging Het
Vmn2r120 C T 17: 57,828,991 (GRCm39) E535K possibly damaging Het
Zfp451 A T 1: 33,815,873 (GRCm39) Y692* probably null Het
Zfp599 A C 9: 22,165,180 (GRCm39) V65G probably benign Het
Zfp808 T C 13: 62,319,113 (GRCm39) V114A probably benign Het
Other mutations in Prp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01383:Prp2 APN 6 132,576,841 (GRCm39) missense unknown
IGL02951:Prp2 APN 6 132,576,788 (GRCm39) missense unknown
PIT4458001:Prp2 UTSW 6 132,577,510 (GRCm39) missense unknown
R2034:Prp2 UTSW 6 132,572,947 (GRCm39) splice site probably null
R2432:Prp2 UTSW 6 132,576,874 (GRCm39) missense unknown
R5283:Prp2 UTSW 6 132,577,606 (GRCm39) missense unknown
R7761:Prp2 UTSW 6 132,577,306 (GRCm39) nonsense probably null
R7877:Prp2 UTSW 6 132,572,928 (GRCm39) missense unknown
R8033:Prp2 UTSW 6 132,577,391 (GRCm39) missense unknown
R8062:Prp2 UTSW 6 132,577,651 (GRCm39) missense unknown
R8695:Prp2 UTSW 6 132,576,932 (GRCm39) missense unknown
R8696:Prp2 UTSW 6 132,577,322 (GRCm39) missense unknown
R8938:Prp2 UTSW 6 132,577,581 (GRCm39) missense unknown
RF016:Prp2 UTSW 6 132,577,475 (GRCm39) small deletion probably benign
RF039:Prp2 UTSW 6 132,577,464 (GRCm39) small deletion probably benign
RF052:Prp2 UTSW 6 132,577,475 (GRCm39) small deletion probably benign
RF054:Prp2 UTSW 6 132,577,484 (GRCm39) frame shift probably null
RF057:Prp2 UTSW 6 132,577,493 (GRCm39) frame shift probably null
X0053:Prp2 UTSW 6 132,577,559 (GRCm39) missense unknown
Z1176:Prp2 UTSW 6 132,577,200 (GRCm39) missense unknown
Z1177:Prp2 UTSW 6 132,572,933 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CGCCTGTTAATGGGAGCCAG -3'
(R):5'- GCCTTGTGGGTTTCCAGCC -3'

Sequencing Primer
(F):5'- AGGTCCACAGCCGAGAC -3'
(R):5'- TTTCCAGCCAGAGGAGGTG -3'
Posted On 2019-12-04