Incidental Mutation 'RF006:Vmn2r58'
ID 602821
Institutional Source Beutler Lab
Gene Symbol Vmn2r58
Ensembl Gene ENSMUSG00000090383
Gene Name vomeronasal 2, receptor 58
Synonyms EG628422
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.377) question?
Stock # RF006 (G1)
Quality Score 214.458
Status Not validated
Chromosome 7
Chromosomal Location 41486305-41522094 bp(-) (GRCm39)
Type of Mutation frame shift
DNA Base Change (assembly) CAAAATGATGTAGCACTT to C at 41486383 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000126966 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171671]
AlphaFold K7N6V2
Predicted Effect probably null
Transcript: ENSMUST00000171671
SMART Domains Protein: ENSMUSP00000126966
Gene: ENSMUSG00000090383

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 471 8e-43 PFAM
Pfam:NCD3G 514 567 1.8e-23 PFAM
Pfam:7tm_3 597 835 2.9e-52 PFAM
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.7%
  • 10x: 99.3%
  • 20x: 98.5%
Validation Efficiency 97% (36/37)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acbd7 GTT GT 2: 3,341,736 (GRCm39) probably null Het
Acp7 A T 7: 28,314,204 (GRCm39) N330K possibly damaging Het
Adam25 A T 8: 41,208,834 (GRCm39) H700L probably benign Het
Alg9 GGGTGG GGGTGGTGG 9: 50,686,717 (GRCm39) probably benign Het
Atp8b3 A T 10: 80,362,070 (GRCm39) V689E probably benign Het
Atxn2l A G 7: 126,095,063 (GRCm39) V533A probably benign Het
Catsperb G A 12: 101,542,238 (GRCm39) probably null Het
Ccdc121 C T 5: 31,644,894 (GRCm39) Q216* probably null Het
Ccdc13 T C 9: 121,643,273 (GRCm39) K376R probably damaging Het
Ccdc170 C CCAA 10: 4,511,030 (GRCm39) probably benign Het
Cdh9 G C 15: 16,855,916 (GRCm39) R652P probably damaging Het
Cenpf A C 1: 189,389,583 (GRCm39) C1416W probably damaging Het
Chga GCA GCATCA 12: 102,527,671 (GRCm39) probably benign Het
Cyb5r4 TGTGACAGACACACTGCCCAGGGAAG TGTGACAGACACACTGCCCAGGGAAGTGACAGACACACTGCCCAGGGAAG 9: 86,922,478 (GRCm39) probably benign Het
Cyb5r4 CCCAGGGA CCCAGGGATGTGAGAGACACGCTGGCCAGGGA 9: 86,922,494 (GRCm39) probably benign Het
Dennd3 T C 15: 73,419,441 (GRCm39) I744T probably damaging Het
Dnah1 C T 14: 31,029,832 (GRCm39) R491Q probably benign Het
Eif4a2 A T 16: 22,929,028 (GRCm39) M188L possibly damaging Het
Esf1 CTCCTCTTC CTC 2: 140,006,294 (GRCm39) probably benign Het
Fat3 T C 9: 15,909,913 (GRCm39) I2030V probably benign Het
Gab3 CTT CTTTTT X: 74,043,633 (GRCm39) probably benign Het
Gins4 A T 8: 23,717,183 (GRCm39) V195E possibly damaging Het
Gm17402 TCCTCCTCC TCCTCCTCCCCCTCCTCC 3: 67,272,892 (GRCm39) probably benign Het
Gm17604 CTCTCTTTC CTC X: 163,786,814 (GRCm39) probably null Het
Gm8369 GTGTGT GTGTGTTTGTGT 19: 11,489,128 (GRCm39) probably benign Het
Gnpnat1 T A 14: 45,620,900 (GRCm39) probably null Het
Inpp4a A C 1: 37,427,908 (GRCm39) N651T possibly damaging Het
Ireb2 T C 9: 54,788,768 (GRCm39) F81L possibly damaging Het
Kcnh3 T A 15: 99,137,809 (GRCm39) probably null Het
Kmt2b CTCCTC CTCCTCATCCTC 7: 30,285,802 (GRCm39) probably benign Het
Kmt2c TG TGCTGTGG 5: 25,520,770 (GRCm39) probably benign Het
Myt1 T C 2: 181,439,566 (GRCm39) S405P probably damaging Het
Net1 T C 13: 3,937,406 (GRCm39) T245A probably benign Het
Nkx2-1 T C 12: 56,580,332 (GRCm39) T203A probably damaging Het
Oas3 T C 5: 120,912,165 (GRCm39) E75G probably damaging Het
Pappa T A 4: 65,242,110 (GRCm39) D1491E probably benign Het
Pkhd1l1 C A 15: 44,366,634 (GRCm39) T704K probably benign Het
Pkhd1l1 TT TTTTTTTTTGT 15: 44,421,903 (GRCm39) probably benign Het
Plscr1l1 A T 9: 92,234,702 (GRCm39) I146F possibly damaging Het
Ppp1r8 TCTCTCAC TC 4: 132,557,928 (GRCm39) probably benign Het
Ppp2r3c T A 12: 55,340,600 (GRCm39) I157F probably benign Het
Pramel34 A T 5: 93,784,562 (GRCm39) C301S probably benign Het
Rspo4 C T 2: 151,709,797 (GRCm39) probably null Het
Rtn4 T C 11: 29,656,919 (GRCm39) S358P possibly damaging Het
Siglecg T A 7: 43,058,288 (GRCm39) Y58* probably null Het
Slc4a1 C T 11: 102,247,542 (GRCm39) probably null Het
Slc9b1 CGAAGGAACCAGAAAGGAAGGAACCAGAAAGGAAGGAACCAGAAAGGAAGGAACCAGAAAGGAAGGAACCAGAAAGGAAGG CGAAGGAACCAGAAAGGAAGGAACCAGAAAGGAAGGAACCAGAAAGGAAGG 3: 135,063,303 (GRCm39) probably benign Het
Smc2 T A 4: 52,442,276 (GRCm39) D64E probably benign Het
Spaca1 CTCGC CTCGCTATCGC 4: 34,049,853 (GRCm39) probably benign Het
Srrm2 A G 17: 24,031,562 (GRCm39) S236G unknown Het
Sry GCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTG GCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTG Y: 2,662,638 (GRCm39) probably benign Het
Strn TGCTCCCTTACCCCAGTC TGCTCCCTTACCCCAGTCCGTGCTCCCTTACCCCAGTCCGAGCTCCCTTACCCCAGTC 17: 78,984,700 (GRCm39) probably null Het
Tfeb CAG CAGGAG 17: 48,097,038 (GRCm39) probably benign Het
Tktl2 A T 8: 66,965,504 (GRCm39) E354V probably benign Het
Tpte A G 8: 22,796,959 (GRCm39) T94A probably benign Het
Usp40 A C 1: 87,894,917 (GRCm39) S868A possibly damaging Het
Vmn2r24 G A 6: 123,783,378 (GRCm39) C526Y probably damaging Het
Other mutations in Vmn2r58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Vmn2r58 APN 7 41,513,854 (GRCm39) missense possibly damaging 0.53
IGL00924:Vmn2r58 APN 7 41,486,891 (GRCm39) missense probably damaging 1.00
IGL01291:Vmn2r58 APN 7 41,513,935 (GRCm39) missense probably benign 0.02
IGL01480:Vmn2r58 APN 7 41,514,116 (GRCm39) missense probably benign 0.01
IGL01551:Vmn2r58 APN 7 41,514,703 (GRCm39) missense probably damaging 0.97
IGL01591:Vmn2r58 APN 7 41,514,753 (GRCm39) missense probably benign 0.03
IGL01940:Vmn2r58 APN 7 41,487,071 (GRCm39) missense probably benign 0.00
IGL01994:Vmn2r58 APN 7 41,486,394 (GRCm39) missense probably damaging 0.98
IGL02041:Vmn2r58 APN 7 41,514,703 (GRCm39) missense probably damaging 0.97
IGL02222:Vmn2r58 APN 7 41,513,449 (GRCm39) missense possibly damaging 0.81
IGL02317:Vmn2r58 APN 7 41,486,765 (GRCm39) missense possibly damaging 0.89
IGL02614:Vmn2r58 APN 7 41,486,553 (GRCm39) missense probably damaging 1.00
IGL02673:Vmn2r58 APN 7 41,514,082 (GRCm39) missense possibly damaging 0.90
IGL03323:Vmn2r58 APN 7 41,511,295 (GRCm39) missense probably benign 0.06
IGL03337:Vmn2r58 APN 7 41,513,810 (GRCm39) missense possibly damaging 0.93
IGL03380:Vmn2r58 APN 7 41,513,874 (GRCm39) missense probably benign 0.00
ANU05:Vmn2r58 UTSW 7 41,513,935 (GRCm39) missense probably benign 0.02
R0138:Vmn2r58 UTSW 7 41,487,048 (GRCm39) missense probably damaging 1.00
R0141:Vmn2r58 UTSW 7 41,511,309 (GRCm39) missense probably benign 0.11
R0421:Vmn2r58 UTSW 7 41,514,628 (GRCm39) missense probably benign 0.02
R0604:Vmn2r58 UTSW 7 41,510,000 (GRCm39) missense possibly damaging 0.78
R0854:Vmn2r58 UTSW 7 41,486,562 (GRCm39) missense probably damaging 1.00
R1413:Vmn2r58 UTSW 7 41,513,387 (GRCm39) missense probably benign 0.01
R1441:Vmn2r58 UTSW 7 41,486,864 (GRCm39) missense probably damaging 1.00
R1678:Vmn2r58 UTSW 7 41,513,480 (GRCm39) missense probably benign 0.40
R1691:Vmn2r58 UTSW 7 41,486,913 (GRCm39) missense possibly damaging 0.95
R1699:Vmn2r58 UTSW 7 41,509,951 (GRCm39) missense probably benign
R1865:Vmn2r58 UTSW 7 41,486,682 (GRCm39) missense possibly damaging 0.95
R2008:Vmn2r58 UTSW 7 41,509,924 (GRCm39) missense probably damaging 1.00
R2036:Vmn2r58 UTSW 7 41,513,417 (GRCm39) missense probably benign
R2202:Vmn2r58 UTSW 7 41,513,594 (GRCm39) missense probably benign 0.07
R3787:Vmn2r58 UTSW 7 41,513,498 (GRCm39) missense probably benign 0.01
R3883:Vmn2r58 UTSW 7 41,513,914 (GRCm39) nonsense probably null
R3944:Vmn2r58 UTSW 7 41,513,885 (GRCm39) missense probably benign 0.03
R3949:Vmn2r58 UTSW 7 41,513,348 (GRCm39) missense probably benign 0.08
R4232:Vmn2r58 UTSW 7 41,487,011 (GRCm39) missense possibly damaging 0.91
R4409:Vmn2r58 UTSW 7 41,522,051 (GRCm39) missense possibly damaging 0.69
R4411:Vmn2r58 UTSW 7 41,511,360 (GRCm39) missense possibly damaging 0.85
R4413:Vmn2r58 UTSW 7 41,511,360 (GRCm39) missense possibly damaging 0.85
R4600:Vmn2r58 UTSW 7 41,522,046 (GRCm39) missense probably benign 0.03
R4610:Vmn2r58 UTSW 7 41,487,117 (GRCm39) missense probably benign
R4646:Vmn2r58 UTSW 7 41,509,935 (GRCm39) missense probably damaging 0.96
R4793:Vmn2r58 UTSW 7 41,514,495 (GRCm39) missense probably damaging 0.99
R4870:Vmn2r58 UTSW 7 41,486,639 (GRCm39) missense possibly damaging 0.76
R4981:Vmn2r58 UTSW 7 41,486,885 (GRCm39) missense probably damaging 1.00
R4993:Vmn2r58 UTSW 7 41,487,176 (GRCm39) missense probably benign 0.00
R5024:Vmn2r58 UTSW 7 41,513,746 (GRCm39) missense probably damaging 0.99
R5064:Vmn2r58 UTSW 7 41,486,534 (GRCm39) missense probably damaging 0.99
R5330:Vmn2r58 UTSW 7 41,513,384 (GRCm39) nonsense probably null
R5526:Vmn2r58 UTSW 7 41,522,069 (GRCm39) missense probably benign 0.01
R5980:Vmn2r58 UTSW 7 41,514,480 (GRCm39) missense possibly damaging 0.81
R6163:Vmn2r58 UTSW 7 41,486,825 (GRCm39) missense probably benign 0.31
R6365:Vmn2r58 UTSW 7 41,513,607 (GRCm39) missense probably benign 0.42
R6567:Vmn2r58 UTSW 7 41,514,673 (GRCm39) missense probably benign 0.34
R6594:Vmn2r58 UTSW 7 41,486,535 (GRCm39) missense possibly damaging 0.69
R6980:Vmn2r58 UTSW 7 41,513,662 (GRCm39) missense possibly damaging 0.64
R7373:Vmn2r58 UTSW 7 41,487,212 (GRCm39) missense probably damaging 1.00
R7458:Vmn2r58 UTSW 7 41,487,123 (GRCm39) missense probably benign 0.06
R7630:Vmn2r58 UTSW 7 41,513,611 (GRCm39) missense probably damaging 0.99
R7807:Vmn2r58 UTSW 7 41,521,910 (GRCm39) missense probably benign 0.05
R8114:Vmn2r58 UTSW 7 41,511,392 (GRCm39) missense probably damaging 1.00
R8232:Vmn2r58 UTSW 7 41,514,076 (GRCm39) missense probably damaging 0.97
R8313:Vmn2r58 UTSW 7 41,521,952 (GRCm39) missense probably benign 0.01
R8412:Vmn2r58 UTSW 7 41,513,722 (GRCm39) missense probably benign 0.01
R8530:Vmn2r58 UTSW 7 41,513,576 (GRCm39) missense probably damaging 1.00
R8851:Vmn2r58 UTSW 7 41,487,219 (GRCm39) missense probably benign
R8881:Vmn2r58 UTSW 7 41,486,609 (GRCm39) missense probably benign 0.05
R8936:Vmn2r58 UTSW 7 41,513,981 (GRCm39) missense
R9045:Vmn2r58 UTSW 7 41,487,087 (GRCm39) missense probably benign 0.00
R9166:Vmn2r58 UTSW 7 41,513,431 (GRCm39) missense probably damaging 1.00
R9706:Vmn2r58 UTSW 7 41,510,000 (GRCm39) missense probably damaging 0.99
RF027:Vmn2r58 UTSW 7 41,486,383 (GRCm39) frame shift probably null
Z1176:Vmn2r58 UTSW 7 41,513,789 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CCCATCAGGTTATGCCACAC -3'
(R):5'- GTTCCTGTCATTCAGCATGCAG -3'

Sequencing Primer
(F):5'- TATGCCACACTAATATAATCACGGG -3'
(R):5'- GTCATTCAGCATGCAGGTATTC -3'
Posted On 2019-12-04