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|Institutional Source||Beutler Lab|
|Gene Name||sialic acid binding Ig-like lectin G|
|Is this an essential gene?||Probably non essential (E-score: 0.063)|
|Stock #||RF006 (G1)|
|Chromosomal Location||43408204-43418358 bp(+) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||T to A at 43408864 bp|
|Amino Acid Change||Tyrosine to Stop codon at position 58 (Y58*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000005592 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000005592]|
|Predicted Effect||probably null
AA Change: Y58*
AA Change: Y58*
|Coding Region Coverage||
|Validation Efficiency||97% (36/37)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]
PHENOTYPE: Mice homozygous for a null allele exhibit increased B-1 cell numbers, increased IgM levels and IgM-producing plasma cells, and produce more IgM autoantibodies. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Siglecg||
(F):5'- GATGTCACTGCTGCTGTTCC -3'
(R):5'- TTGAGTCTCCCCACTGAACATC -3'
(F):5'- CCAGAGTGGCTCAAATTGGG -3'
(R):5'- CCCACTGAACATCTTTGATTAGCAAG -3'