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|Institutional Source||Beutler Lab|
|Gene Name||protein phosphatase 2, regulatory subunit B'', gamma|
|Synonyms||4930511A21Rik, G5pr, G4-1, 5730412A08Rik|
|Is this an essential gene?||Probably essential (E-score: 0.963)|
|Stock #||RF006 (G1)|
|Chromosomal Location||55278991-55302998 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 55293815 bp|
|Amino Acid Change||Isoleucine to Phenylalanine at position 157 (I157F)|
|Ref Sequence||ENSEMBL: ENSMUSP00000021410 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000021410]|
|Predicted Effect||probably benign
AA Change: I157F
PolyPhen 2 Score 0.239 (Sensitivity: 0.91; Specificity: 0.88)
AA Change: I157F
|Coding Region Coverage||
|Validation Efficiency||97% (36/37)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ppp2r3c||
(F):5'- CACAGCTCTGTCTGGTGTCTAG -3'
(R):5'- AGCTGTGAAGAGTCTTTATAGTCTC -3'
(F):5'- AGCTCTGTCTGGTGTCTAGAAGAATC -3'
(R):5'- TGCTATCCAAAATCCCCTGTAC -3'