Incidental Mutation 'RF006:Strn'
ID 602853
Institutional Source Beutler Lab
Gene Symbol Strn
Ensembl Gene ENSMUSG00000024077
Gene Name striatin, calmodulin binding protein
Synonyms
Accession Numbers
Essential gene? Possibly essential (E-score: 0.565) question?
Stock # RF006 (G1)
Quality Score 217.511
Status Not validated
Chromosome 17
Chromosomal Location 78957327-79043990 bp(-) (GRCm39)
Type of Mutation frame shift
DNA Base Change (assembly) TGCTCCCTTACCCCAGTC to TGCTCCCTTACCCCAGTCCGTGCTCCCTTACCCCAGTCCGAGCTCCCTTACCCCAGTC at 78984700 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000120830 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024881] [ENSMUST00000145910]
AlphaFold O55106
Predicted Effect probably null
Transcript: ENSMUST00000024881
SMART Domains Protein: ENSMUSP00000024881
Gene: ENSMUSG00000024077

DomainStartEndE-ValueType
low complexity region 85 101 N/A INTRINSIC
low complexity region 178 195 N/A INTRINSIC
low complexity region 223 231 N/A INTRINSIC
low complexity region 259 276 N/A INTRINSIC
WD40 299 338 6.04e-8 SMART
WD40 352 391 2.42e-7 SMART
WD40 405 444 1.21e-7 SMART
WD40 493 539 1.28e1 SMART
WD40 542 581 4.4e-10 SMART
WD40 584 627 2.48e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000145480
SMART Domains Protein: ENSMUSP00000117663
Gene: ENSMUSG00000024077

DomainStartEndE-ValueType
low complexity region 60 76 N/A INTRINSIC
low complexity region 153 171 N/A INTRINSIC
low complexity region 227 235 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000145910
SMART Domains Protein: ENSMUSP00000120830
Gene: ENSMUSG00000024077

DomainStartEndE-ValueType
low complexity region 17 45 N/A INTRINSIC
Pfam:Striatin 48 177 4.2e-50 PFAM
low complexity region 238 254 N/A INTRINSIC
low complexity region 331 348 N/A INTRINSIC
low complexity region 376 384 N/A INTRINSIC
low complexity region 412 429 N/A INTRINSIC
WD40 452 491 6.04e-8 SMART
WD40 505 544 2.42e-7 SMART
WD40 558 597 1.21e-7 SMART
WD40 646 692 1.28e1 SMART
WD40 695 734 4.4e-10 SMART
WD40 737 780 2.48e-4 SMART
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.7%
  • 10x: 99.3%
  • 20x: 98.5%
Validation Efficiency 97% (36/37)
MGI Phenotype PHENOTYPE: Mice heterozygous for a knock-out allele exhibit increased blood pressure and circulating aldosterone when fed a liberal salt diet. No mice could be generated that were homozygous for the allele. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acbd7 GTT GT 2: 3,341,736 (GRCm39) probably null Het
Acp7 A T 7: 28,314,204 (GRCm39) N330K possibly damaging Het
Adam25 A T 8: 41,208,834 (GRCm39) H700L probably benign Het
Alg9 GGGTGG GGGTGGTGG 9: 50,686,717 (GRCm39) probably benign Het
Atp8b3 A T 10: 80,362,070 (GRCm39) V689E probably benign Het
Atxn2l A G 7: 126,095,063 (GRCm39) V533A probably benign Het
Catsperb G A 12: 101,542,238 (GRCm39) probably null Het
Ccdc121 C T 5: 31,644,894 (GRCm39) Q216* probably null Het
Ccdc13 T C 9: 121,643,273 (GRCm39) K376R probably damaging Het
Ccdc170 C CCAA 10: 4,511,030 (GRCm39) probably benign Het
Cdh9 G C 15: 16,855,916 (GRCm39) R652P probably damaging Het
Cenpf A C 1: 189,389,583 (GRCm39) C1416W probably damaging Het
Chga GCA GCATCA 12: 102,527,671 (GRCm39) probably benign Het
Cyb5r4 TGTGACAGACACACTGCCCAGGGAAG TGTGACAGACACACTGCCCAGGGAAGTGACAGACACACTGCCCAGGGAAG 9: 86,922,478 (GRCm39) probably benign Het
Cyb5r4 CCCAGGGA CCCAGGGATGTGAGAGACACGCTGGCCAGGGA 9: 86,922,494 (GRCm39) probably benign Het
Dennd3 T C 15: 73,419,441 (GRCm39) I744T probably damaging Het
Dnah1 C T 14: 31,029,832 (GRCm39) R491Q probably benign Het
Eif4a2 A T 16: 22,929,028 (GRCm39) M188L possibly damaging Het
Esf1 CTCCTCTTC CTC 2: 140,006,294 (GRCm39) probably benign Het
Fat3 T C 9: 15,909,913 (GRCm39) I2030V probably benign Het
Gab3 CTT CTTTTT X: 74,043,633 (GRCm39) probably benign Het
Gins4 A T 8: 23,717,183 (GRCm39) V195E possibly damaging Het
Gm17402 TCCTCCTCC TCCTCCTCCCCCTCCTCC 3: 67,272,892 (GRCm39) probably benign Het
Gm17604 CTCTCTTTC CTC X: 163,786,814 (GRCm39) probably null Het
Gm8369 GTGTGT GTGTGTTTGTGT 19: 11,489,128 (GRCm39) probably benign Het
Gnpnat1 T A 14: 45,620,900 (GRCm39) probably null Het
Inpp4a A C 1: 37,427,908 (GRCm39) N651T possibly damaging Het
Ireb2 T C 9: 54,788,768 (GRCm39) F81L possibly damaging Het
Kcnh3 T A 15: 99,137,809 (GRCm39) probably null Het
Kmt2b CTCCTC CTCCTCATCCTC 7: 30,285,802 (GRCm39) probably benign Het
Kmt2c TG TGCTGTGG 5: 25,520,770 (GRCm39) probably benign Het
Myt1 T C 2: 181,439,566 (GRCm39) S405P probably damaging Het
Net1 T C 13: 3,937,406 (GRCm39) T245A probably benign Het
Nkx2-1 T C 12: 56,580,332 (GRCm39) T203A probably damaging Het
Oas3 T C 5: 120,912,165 (GRCm39) E75G probably damaging Het
Pappa T A 4: 65,242,110 (GRCm39) D1491E probably benign Het
Pkhd1l1 C A 15: 44,366,634 (GRCm39) T704K probably benign Het
Pkhd1l1 TT TTTTTTTTTGT 15: 44,421,903 (GRCm39) probably benign Het
Plscr1l1 A T 9: 92,234,702 (GRCm39) I146F possibly damaging Het
Ppp1r8 TCTCTCAC TC 4: 132,557,928 (GRCm39) probably benign Het
Ppp2r3c T A 12: 55,340,600 (GRCm39) I157F probably benign Het
Pramel34 A T 5: 93,784,562 (GRCm39) C301S probably benign Het
Rspo4 C T 2: 151,709,797 (GRCm39) probably null Het
Rtn4 T C 11: 29,656,919 (GRCm39) S358P possibly damaging Het
Siglecg T A 7: 43,058,288 (GRCm39) Y58* probably null Het
Slc4a1 C T 11: 102,247,542 (GRCm39) probably null Het
Slc9b1 CGAAGGAACCAGAAAGGAAGGAACCAGAAAGGAAGGAACCAGAAAGGAAGGAACCAGAAAGGAAGGAACCAGAAAGGAAGG CGAAGGAACCAGAAAGGAAGGAACCAGAAAGGAAGGAACCAGAAAGGAAGG 3: 135,063,303 (GRCm39) probably benign Het
Smc2 T A 4: 52,442,276 (GRCm39) D64E probably benign Het
Spaca1 CTCGC CTCGCTATCGC 4: 34,049,853 (GRCm39) probably benign Het
Srrm2 A G 17: 24,031,562 (GRCm39) S236G unknown Het
Sry GCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTG GCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTG Y: 2,662,638 (GRCm39) probably benign Het
Tfeb CAG CAGGAG 17: 48,097,038 (GRCm39) probably benign Het
Tktl2 A T 8: 66,965,504 (GRCm39) E354V probably benign Het
Tpte A G 8: 22,796,959 (GRCm39) T94A probably benign Het
Usp40 A C 1: 87,894,917 (GRCm39) S868A possibly damaging Het
Vmn2r24 G A 6: 123,783,378 (GRCm39) C526Y probably damaging Het
Vmn2r58 CAAAATGATGTAGCACTT C 7: 41,486,383 (GRCm39) probably null Het
Other mutations in Strn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00722:Strn APN 17 78,999,849 (GRCm39) missense possibly damaging 0.89
IGL02165:Strn APN 17 78,995,049 (GRCm39) missense probably damaging 1.00
IGL02424:Strn APN 17 78,991,780 (GRCm39) missense probably damaging 1.00
IGL02473:Strn APN 17 78,991,722 (GRCm39) missense possibly damaging 0.71
IGL03306:Strn APN 17 78,974,652 (GRCm39) missense probably damaging 0.98
R0053:Strn UTSW 17 78,964,363 (GRCm39) missense possibly damaging 0.92
R0053:Strn UTSW 17 78,964,363 (GRCm39) missense possibly damaging 0.92
R0165:Strn UTSW 17 78,984,803 (GRCm39) missense possibly damaging 0.89
R1156:Strn UTSW 17 78,964,360 (GRCm39) missense probably damaging 0.99
R1191:Strn UTSW 17 78,999,855 (GRCm39) missense possibly damaging 0.82
R1256:Strn UTSW 17 78,972,046 (GRCm39) critical splice donor site probably null
R1700:Strn UTSW 17 78,999,831 (GRCm39) missense probably damaging 1.00
R1878:Strn UTSW 17 78,984,755 (GRCm39) missense possibly damaging 0.81
R1897:Strn UTSW 17 78,990,271 (GRCm39) missense probably benign 0.01
R1912:Strn UTSW 17 78,991,824 (GRCm39) missense probably damaging 1.00
R1975:Strn UTSW 17 78,999,928 (GRCm39) splice site probably null
R2357:Strn UTSW 17 78,963,028 (GRCm39) missense probably damaging 1.00
R3054:Strn UTSW 17 78,990,321 (GRCm39) missense probably damaging 0.99
R3693:Strn UTSW 17 78,964,421 (GRCm39) missense probably damaging 1.00
R3694:Strn UTSW 17 78,964,421 (GRCm39) missense probably damaging 1.00
R3695:Strn UTSW 17 78,964,421 (GRCm39) missense probably damaging 1.00
R3941:Strn UTSW 17 78,965,369 (GRCm39) missense probably damaging 0.99
R4431:Strn UTSW 17 79,043,891 (GRCm39) missense probably damaging 1.00
R4570:Strn UTSW 17 78,984,801 (GRCm39) missense possibly damaging 0.95
R4678:Strn UTSW 17 78,984,780 (GRCm39) missense probably damaging 1.00
R4729:Strn UTSW 17 78,965,390 (GRCm39) missense probably damaging 0.98
R4947:Strn UTSW 17 78,969,208 (GRCm39) missense probably damaging 0.98
R5470:Strn UTSW 17 78,964,374 (GRCm39) missense probably benign 0.01
R5710:Strn UTSW 17 78,995,028 (GRCm39) missense probably damaging 1.00
R5943:Strn UTSW 17 78,977,276 (GRCm39) missense probably damaging 0.96
R6173:Strn UTSW 17 79,008,298 (GRCm39) missense probably damaging 1.00
R6800:Strn UTSW 17 78,977,787 (GRCm39) intron probably benign
R6846:Strn UTSW 17 79,043,886 (GRCm39) missense probably damaging 0.97
R7716:Strn UTSW 17 78,963,204 (GRCm39) missense probably damaging 0.99
R7746:Strn UTSW 17 78,984,801 (GRCm39) missense probably benign 0.11
R7950:Strn UTSW 17 78,977,852 (GRCm39) missense
R7997:Strn UTSW 17 78,991,672 (GRCm39) missense probably benign 0.01
R8344:Strn UTSW 17 78,980,076 (GRCm39) missense probably damaging 1.00
R9074:Strn UTSW 17 79,043,790 (GRCm39) missense probably benign 0.00
R9523:Strn UTSW 17 78,967,575 (GRCm39) missense probably benign 0.17
R9538:Strn UTSW 17 78,972,219 (GRCm39) missense possibly damaging 0.68
RF008:Strn UTSW 17 78,984,716 (GRCm39) frame shift probably null
RF017:Strn UTSW 17 78,984,717 (GRCm39) frame shift probably null
RF018:Strn UTSW 17 78,984,712 (GRCm39) frame shift probably null
RF031:Strn UTSW 17 78,984,706 (GRCm39) frame shift probably null
RF035:Strn UTSW 17 78,984,714 (GRCm39) frame shift probably null
RF036:Strn UTSW 17 78,984,706 (GRCm39) frame shift probably null
RF038:Strn UTSW 17 78,984,711 (GRCm39) frame shift probably null
RF039:Strn UTSW 17 78,984,707 (GRCm39) frame shift probably null
RF044:Strn UTSW 17 78,984,717 (GRCm39) frame shift probably null
RF045:Strn UTSW 17 78,984,711 (GRCm39) frame shift probably null
RF047:Strn UTSW 17 78,984,703 (GRCm39) frame shift probably null
RF047:Strn UTSW 17 78,984,699 (GRCm39) frame shift probably null
RF048:Strn UTSW 17 78,984,716 (GRCm39) frame shift probably null
X0022:Strn UTSW 17 79,008,378 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCTTACACATTAGAGGAGGAGGC -3'
(R):5'- ACACAATGTGTCTGGCTGAG -3'

Sequencing Primer
(F):5'- GGAGGCAGCAGCTACAC -3'
(R):5'- ACACAATGTGTCTGGCTGAGTTAGG -3'
Posted On 2019-12-04