Incidental Mutation 'RF007:Vmn2r104'
ID 602943
Institutional Source Beutler Lab
Gene Symbol Vmn2r104
Ensembl Gene ENSMUSG00000090315
Gene Name vomeronasal 2, receptor 104
Synonyms V2r7
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # RF007 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 20249687-20268467 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 20268302 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 56 (Y56N)
Ref Sequence ENSEMBL: ENSMUSP00000129895 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168050]
AlphaFold E9Q2J5
Predicted Effect probably benign
Transcript: ENSMUST00000168050
AA Change: Y56N

PolyPhen 2 Score 0.360 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000129895
Gene: ENSMUSG00000090315
AA Change: Y56N

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 85 457 4e-38 PFAM
Pfam:NCD3G 512 565 2.1e-20 PFAM
Pfam:7tm_3 598 833 1.7e-52 PFAM
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.7%
  • 10x: 99.2%
  • 20x: 98.2%
Validation Efficiency 97% (73/75)
Allele List at MGI
Other mutations in this stock
Total: 102 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl1 T A 8: 84,661,401 (GRCm39) S933T probably benign Het
Adgrl2 G A 3: 148,544,884 (GRCm39) T737I probably damaging Het
Adra2c T A 5: 35,438,386 (GRCm39) V386E probably damaging Het
Agbl5 C A 5: 31,060,589 (GRCm39) T761N unknown Het
Ahnak T A 19: 8,990,965 (GRCm39) M4083K possibly damaging Het
Aldh1l1 A T 6: 90,575,241 (GRCm39) I843F probably damaging Het
Ankhd1 GGCGGC GGCGGCTGCGGC 18: 36,693,962 (GRCm39) probably benign Het
Arid1b GCG GCGCCG 17: 5,045,869 (GRCm39) probably benign Het
B4galnt4 T C 7: 140,650,609 (GRCm39) probably null Het
Blm C CTCCTCCTCCTAG 7: 80,162,681 (GRCm39) probably null Het
Btg3 A G 16: 78,129,836 (GRCm39) *52W probably null Het
Cc2d1a T C 8: 84,861,298 (GRCm39) T796A probably damaging Het
Cd200r1 T C 16: 44,610,374 (GRCm39) S161P possibly damaging Het
Cenpj A G 14: 56,767,505 (GRCm39) probably null Het
Cfap251 G GGAT 5: 123,392,317 (GRCm39) probably benign Het
Chd9 A G 8: 91,760,578 (GRCm39) T2108A possibly damaging Het
Cherp TGGAGCG T 8: 73,215,903 (GRCm39) probably benign Het
Cnot11 T C 1: 39,581,575 (GRCm39) V372A probably damaging Het
Cntnap5b T C 1: 100,091,795 (GRCm39) C179R probably damaging Het
Cntrl T A 2: 35,060,512 (GRCm39) N1901K probably benign Het
Coil CTGG C 11: 88,872,656 (GRCm39) probably benign Het
Col1a1 A G 11: 94,833,866 (GRCm39) D488G probably damaging Het
Coro1a T C 7: 126,301,024 (GRCm39) H130R probably damaging Het
Crybg3 A C 16: 59,377,067 (GRCm39) S1396A possibly damaging Het
Csf2rb2 A G 15: 78,176,126 (GRCm39) I259T probably benign Het
Cyp1a2 G T 9: 57,589,253 (GRCm39) P187Q probably damaging Het
Cyp3a13 CATTATT CATT 5: 137,892,525 (GRCm39) probably null Het
Dcun1d3 T C 7: 119,458,726 (GRCm39) E103G possibly damaging Het
Dmkn T A 7: 30,469,129 (GRCm39) probably null Het
Dna2 T C 10: 62,802,474 (GRCm39) L864P probably damaging Het
Dnah14 T A 1: 181,513,374 (GRCm39) M1909K probably benign Het
Dspp TGACAGCAGTGACAGCAGCGACAGCAGCGACAGCAGTGACAGCAGCGACAGCAGCGACAGCAGTGACAGCAGCGACAGCAGCAACAGCAGTGACAGCAG TGACAGCAGTGACAGCAGCGACAGCAGCGACAGCAGTGACAGCAGCGACAGCAGCAACAGCAGTGACAGCAG 5: 104,326,227 (GRCm39) probably benign Het
Ecrg4 TTCTGTA T 1: 43,776,352 (GRCm39) probably benign Het
Efna5 T C 17: 62,920,389 (GRCm39) S163G probably benign Het
Entpd2 CTT CTTT 2: 25,290,907 (GRCm39) probably null Het
Ercc4 C T 16: 12,941,371 (GRCm39) S253L possibly damaging Het
Flywch1 ACCCA ACCCAATTCTGGTGTGGGGAGGCTACGTACTCTCCCA 17: 23,981,138 (GRCm39) probably null Het
Flywch1 CCTGGTGT CCTGGTGTGGGGAGGCTACGTACTCACCCACTTCTGGTGT 17: 23,981,145 (GRCm39) probably null Het
Folh1 T C 7: 86,424,895 (GRCm39) T25A probably benign Het
Foxi3 C A 6: 70,937,845 (GRCm39) T359K possibly damaging Het
Gab3 TTC TTCATC X: 74,043,631 (GRCm39) probably benign Het
Gab3 TCT TCTGCT X: 74,043,602 (GRCm39) probably benign Het
Gab3 TCT TCTGCT X: 74,043,617 (GRCm39) probably benign Het
Gba2 G T 4: 43,569,894 (GRCm39) L440M probably damaging Het
Gm14412 T A 2: 177,007,494 (GRCm39) N134Y possibly damaging Het
Gpr88 A G 3: 116,046,018 (GRCm39) S98P probably benign Het
Il1r1 A G 1: 40,352,438 (GRCm39) Y539C probably damaging Het
Iqcf4 TTTCCTTTTCCTTTT TTTCCTTTTCCTTTTCCTTTTCCTTTTCCTTTTCCTCTTCCTTTTCCTTTT 9: 106,447,808 (GRCm39) probably benign Het
Lce1m CTGCT CTGCTTCCACTGTTGCT 3: 92,925,451 (GRCm39) probably benign Het
Lkaaear1 T TATCTCCAGCTCC 2: 181,339,352 (GRCm39) probably benign Het
Lkaaear1 CAGCTCCAGCTCCAGCTCCAGCTC CAGCTCCAGCTCTAGCTCCAGCTCCAGCTCCAGCTC 2: 181,339,370 (GRCm39) probably benign Het
Ltb4r1 T A 14: 56,005,426 (GRCm39) L243Q possibly damaging Het
Man2a1 T A 17: 65,019,248 (GRCm39) V704D probably damaging Het
Map1a CTCCAGCTCCA CTCCAGCTCCAGCTCCAGCTCCAGCTCCAGTTCCAGCTCCA 2: 121,136,789 (GRCm39) probably benign Het
Mcu G T 10: 59,326,938 (GRCm39) A63E probably benign Het
Mrps31 A T 8: 22,909,880 (GRCm39) D182V possibly damaging Het
Mslnl T A 17: 25,962,202 (GRCm39) V200E possibly damaging Het
Naip1 A T 13: 100,562,642 (GRCm39) M841K probably benign Het
Ndufab1 T C 7: 121,695,861 (GRCm39) K88E possibly damaging Het
Nlrp5 A C 7: 23,117,586 (GRCm39) I437L probably benign Het
Nnt C T 13: 119,533,393 (GRCm39) V91M probably damaging Het
Nusap1 TACACGTTAGCAGTGAGGAGCAAGCTGAGA TACACGTTAGCAGTGAGGAGCAAGCTGAGAGACACGTTAGCAGTGAGGAGCAAGCTGAGA 2: 119,458,062 (GRCm39) probably benign Het
Nynrin T G 14: 56,103,658 (GRCm39) probably null Het
Or12k5 T G 2: 36,895,186 (GRCm39) T147P probably damaging Het
Or5ak22 C A 2: 85,230,137 (GRCm39) A247S probably damaging Het
Or6c204 T A 10: 129,022,562 (GRCm39) I243F probably damaging Het
Osbpl8 A G 10: 111,112,328 (GRCm39) K481R possibly damaging Het
Padi6 T C 4: 140,457,054 (GRCm39) D540G probably damaging Het
Pcmtd1 T C 1: 7,225,329 (GRCm39) probably benign Het
Pdik1l TTTTTGTTTT TTTTTGTTTTGGTTTTGTTTT 4: 134,006,679 (GRCm39) probably null Het
Phospho1 T C 11: 95,721,881 (GRCm39) Y184H probably damaging Het
Pi4ka T A 16: 17,115,097 (GRCm39) R1431W Het
Plxdc1 T A 11: 97,869,504 (GRCm39) H28L probably benign Het
Pnma8a ACCTCATGATGCACCTGCTTCAACA ACCTCATGATGCACCTGCTTCAACACCTCATGATGCACCTGCTTCAACA 7: 16,695,349 (GRCm39) probably benign Het
Ppp1r7 T C 1: 93,274,011 (GRCm39) probably null Het
Ppp1r9a T A 6: 4,906,657 (GRCm39) V404E probably damaging Het
Scfd1 T A 12: 51,469,756 (GRCm39) S434T probably benign Het
Six5 A G 7: 18,828,862 (GRCm39) S101G probably benign Het
Slc6a4 C A 11: 76,910,008 (GRCm39) T421K probably damaging Het
Smarcd3 C A 5: 24,801,068 (GRCm39) R113L probably damaging Het
Son T A 16: 91,456,257 (GRCm39) M1668K possibly damaging Het
Spmap2l CTCCCCAGTCCCGCAAGGCCAG CTCCCCAGTCCCGCAAGGCCAGCGATCGTCCCCAGTCCCGCAAGGCCAG 5: 77,164,255 (GRCm39) probably benign Het
Tcf25 A G 8: 124,122,369 (GRCm39) D434G probably benign Het
Tcof1 CCAGAGATCCCC CCAGAGATCCCCGTGGCTGCCGAGATGGGCACTTTCACAGAGATCCCC 18: 60,966,640 (GRCm39) probably benign Het
Tep1 A G 14: 51,098,402 (GRCm39) V463A possibly damaging Het
Trav15-2-dv6-2 GGGAG GGGAGGAG 14: 53,887,207 (GRCm39) probably benign Het
Trav15-2-dv6-2 GGAG GGAGGAG 14: 53,887,208 (GRCm39) probably benign Het
Trav15-2-dv6-2 AAG AAGCAG 14: 53,887,212 (GRCm39) probably benign Het
Trim24 A G 6: 37,930,471 (GRCm39) K642E possibly damaging Het
Trim33 GGCCCCCGC GGC 3: 103,187,533 (GRCm39) probably benign Het
Triobp CTCCCTGTGCCCAACGG CTCCCTGTGCCCAACGGAACAACCCCAGGATTCCCTGTGCCCAACGG 15: 78,851,244 (GRCm39) probably benign Het
Trmu G T 15: 85,776,770 (GRCm39) V161L possibly damaging Het
Try4 T A 6: 41,282,297 (GRCm39) C206S probably damaging Het
Usp2 TTCACTTAC TTCACTTACTCATGTGACCTGTTCGTCACTTAC 9: 44,000,418 (GRCm39) probably benign Het
Vmn1r62 A T 7: 5,678,669 (GRCm39) M117L probably benign Het
Xxylt1 C T 16: 30,869,498 (GRCm39) D201N possibly damaging Het
Zfp563 T A 17: 33,323,999 (GRCm39) I198K probably benign Het
Zfp612 T A 8: 110,816,174 (GRCm39) C460* probably null Het
Zfp691 G A 4: 119,027,932 (GRCm39) T100M probably benign Het
Zfp773 A T 7: 7,135,689 (GRCm39) C302* probably null Het
Zmat2 A G 18: 36,930,936 (GRCm39) E154G probably damaging Het
Zw10 T A 9: 48,972,220 (GRCm39) I132N possibly damaging Het
Other mutations in Vmn2r104
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00427:Vmn2r104 APN 17 20,258,501 (GRCm39) missense probably damaging 0.98
IGL01098:Vmn2r104 APN 17 20,268,358 (GRCm39) missense probably benign 0.27
IGL01333:Vmn2r104 APN 17 20,263,055 (GRCm39) missense probably benign 0.17
IGL01527:Vmn2r104 APN 17 20,263,158 (GRCm39) missense possibly damaging 0.82
IGL01773:Vmn2r104 APN 17 20,260,930 (GRCm39) missense probably benign 0.10
IGL01939:Vmn2r104 APN 17 20,250,187 (GRCm39) missense probably damaging 0.99
IGL02121:Vmn2r104 APN 17 20,262,056 (GRCm39) nonsense probably null
IGL02305:Vmn2r104 APN 17 20,263,118 (GRCm39) missense probably benign 0.09
IGL02374:Vmn2r104 APN 17 20,263,048 (GRCm39) missense probably benign 0.34
IGL03260:Vmn2r104 APN 17 20,263,083 (GRCm39) missense probably benign 0.05
IGL03366:Vmn2r104 APN 17 20,249,866 (GRCm39) missense probably damaging 1.00
R0091:Vmn2r104 UTSW 17 20,262,075 (GRCm39) missense possibly damaging 0.79
R0125:Vmn2r104 UTSW 17 20,250,069 (GRCm39) missense probably damaging 0.98
R0257:Vmn2r104 UTSW 17 20,249,889 (GRCm39) missense probably damaging 1.00
R0381:Vmn2r104 UTSW 17 20,268,264 (GRCm39) nonsense probably null
R0709:Vmn2r104 UTSW 17 20,263,166 (GRCm39) missense probably damaging 1.00
R0786:Vmn2r104 UTSW 17 20,262,987 (GRCm39) missense probably benign
R1575:Vmn2r104 UTSW 17 20,262,477 (GRCm39) missense probably damaging 1.00
R1827:Vmn2r104 UTSW 17 20,262,497 (GRCm39) missense probably damaging 0.97
R1932:Vmn2r104 UTSW 17 20,261,031 (GRCm39) missense probably damaging 1.00
R1956:Vmn2r104 UTSW 17 20,262,313 (GRCm39) missense probably damaging 0.98
R2203:Vmn2r104 UTSW 17 20,250,083 (GRCm39) missense probably benign 0.05
R2205:Vmn2r104 UTSW 17 20,250,083 (GRCm39) missense probably benign 0.05
R2859:Vmn2r104 UTSW 17 20,268,455 (GRCm39) missense possibly damaging 0.82
R3701:Vmn2r104 UTSW 17 20,249,818 (GRCm39) missense probably damaging 1.00
R3834:Vmn2r104 UTSW 17 20,250,183 (GRCm39) missense probably benign 0.02
R4151:Vmn2r104 UTSW 17 20,250,147 (GRCm39) missense probably damaging 1.00
R4470:Vmn2r104 UTSW 17 20,262,503 (GRCm39) missense probably damaging 1.00
R4625:Vmn2r104 UTSW 17 20,268,443 (GRCm39) missense probably benign 0.00
R4754:Vmn2r104 UTSW 17 20,261,030 (GRCm39) nonsense probably null
R4911:Vmn2r104 UTSW 17 20,250,288 (GRCm39) missense probably benign 0.00
R5270:Vmn2r104 UTSW 17 20,258,528 (GRCm39) missense probably damaging 1.00
R5279:Vmn2r104 UTSW 17 20,262,146 (GRCm39) missense probably benign 0.07
R5311:Vmn2r104 UTSW 17 20,250,163 (GRCm39) missense probably damaging 1.00
R5370:Vmn2r104 UTSW 17 20,250,450 (GRCm39) missense probably damaging 0.97
R5461:Vmn2r104 UTSW 17 20,250,343 (GRCm39) missense probably damaging 1.00
R5683:Vmn2r104 UTSW 17 20,260,981 (GRCm39) nonsense probably null
R5795:Vmn2r104 UTSW 17 20,250,544 (GRCm39) missense possibly damaging 0.89
R5795:Vmn2r104 UTSW 17 20,250,372 (GRCm39) missense probably benign 0.02
R5970:Vmn2r104 UTSW 17 20,249,733 (GRCm39) missense probably benign 0.01
R5983:Vmn2r104 UTSW 17 20,261,970 (GRCm39) missense probably damaging 1.00
R5992:Vmn2r104 UTSW 17 20,249,747 (GRCm39) missense probably damaging 1.00
R6066:Vmn2r104 UTSW 17 20,258,573 (GRCm39) missense possibly damaging 0.69
R6156:Vmn2r104 UTSW 17 20,261,909 (GRCm39) missense probably damaging 1.00
R6182:Vmn2r104 UTSW 17 20,250,507 (GRCm39) missense probably benign 0.16
R6245:Vmn2r104 UTSW 17 20,261,829 (GRCm39) missense possibly damaging 0.69
R6333:Vmn2r104 UTSW 17 20,249,848 (GRCm39) missense probably benign 0.30
R6573:Vmn2r104 UTSW 17 20,262,487 (GRCm39) missense probably damaging 1.00
R7101:Vmn2r104 UTSW 17 20,250,358 (GRCm39) missense possibly damaging 0.65
R7123:Vmn2r104 UTSW 17 20,261,088 (GRCm39) missense probably benign 0.12
R7485:Vmn2r104 UTSW 17 20,249,737 (GRCm39) missense probably benign 0.01
R7514:Vmn2r104 UTSW 17 20,249,791 (GRCm39) missense probably damaging 1.00
R7634:Vmn2r104 UTSW 17 20,261,971 (GRCm39) missense possibly damaging 0.48
R7958:Vmn2r104 UTSW 17 20,262,988 (GRCm39) missense probably benign
R8031:Vmn2r104 UTSW 17 20,263,048 (GRCm39) missense probably benign 0.34
R8094:Vmn2r104 UTSW 17 20,250,483 (GRCm39) missense possibly damaging 0.77
R8191:Vmn2r104 UTSW 17 20,250,465 (GRCm39) missense possibly damaging 0.89
R8308:Vmn2r104 UTSW 17 20,261,040 (GRCm39) missense possibly damaging 0.55
R8691:Vmn2r104 UTSW 17 20,262,110 (GRCm39) missense probably damaging 0.98
R8795:Vmn2r104 UTSW 17 20,262,988 (GRCm39) missense probably benign
R8900:Vmn2r104 UTSW 17 20,261,924 (GRCm39) missense probably damaging 0.99
R8913:Vmn2r104 UTSW 17 20,249,968 (GRCm39) missense probably damaging 1.00
R9180:Vmn2r104 UTSW 17 20,263,087 (GRCm39) missense probably benign 0.00
R9199:Vmn2r104 UTSW 17 20,262,097 (GRCm39) missense probably damaging 0.99
R9282:Vmn2r104 UTSW 17 20,261,098 (GRCm39) missense probably damaging 1.00
R9303:Vmn2r104 UTSW 17 20,268,439 (GRCm39) missense possibly damaging 0.90
R9305:Vmn2r104 UTSW 17 20,268,439 (GRCm39) missense possibly damaging 0.90
R9322:Vmn2r104 UTSW 17 20,263,087 (GRCm39) missense probably benign 0.00
R9325:Vmn2r104 UTSW 17 20,268,433 (GRCm39) missense possibly damaging 0.95
R9414:Vmn2r104 UTSW 17 20,250,250 (GRCm39) missense probably damaging 0.99
R9785:Vmn2r104 UTSW 17 20,268,409 (GRCm39) missense probably benign
Z1177:Vmn2r104 UTSW 17 20,250,051 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTTTCCCCAAGTGAGGAAAATAATC -3'
(R):5'- GTGATTTGCATCAAGCTGACC -3'

Sequencing Primer
(F):5'- CAAATTTTAGTGACAACACCCTA -3'
(R):5'- CAAGCTGACCCATGTATTAATAGG -3'
Posted On 2019-12-04