Incidental Mutation 'RF010:Vmn2r26'
ID |
603126 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r26
|
Ensembl Gene |
ENSMUSG00000096630 |
Gene Name |
vomeronasal 2, receptor 26 |
Synonyms |
V2r1b |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.094)
|
Stock # |
RF010 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
6 |
Chromosomal Location |
124001717-124038994 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to T
at 124016448 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Isoleucine
at position 304
(T304I)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000032238
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032238]
|
AlphaFold |
Q6TAC4 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000032238
AA Change: T304I
PolyPhen 2
Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000032238 Gene: ENSMUSG00000096630 AA Change: T304I
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
82 |
471 |
1.5e-31 |
PFAM |
Pfam:NCD3G
|
519 |
572 |
4.6e-25 |
PFAM |
Pfam:7tm_3
|
603 |
840 |
1.5e-55 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.8%
- 3x: 99.7%
- 10x: 99.4%
- 20x: 98.8%
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 70 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2300002M23Rik |
GGGTTATGGTCAGTACCCCCCAGTAGGGACCTGGGGCGGTTATGGTCAGTACCCCCCAGTAGGGCCCTGGGGCGGTTATGGTCAGTACCCCCCAGTAGGGACCTGGGG |
GGGTTATGGTCAGTACCCCCCAGTAGGGCCCTGGGGCGGTTATGGTCAGTACCCCCCAGTAGGGACCTGGGG |
17: 35,879,473 (GRCm39) |
|
probably benign |
Het |
Acap3 |
CCTGGGCTGCTG |
CCTGGGCTGCTGCATACTGGGCTGCTG |
4: 155,989,553 (GRCm39) |
|
probably benign |
Het |
Ankrd28 |
A |
G |
14: 31,500,943 (GRCm39) |
I16T |
probably damaging |
Het |
AY761185 |
GCACTGTGGGC |
G |
8: 21,433,927 (GRCm39) |
|
probably null |
Het |
Bend3 |
T |
A |
10: 43,386,180 (GRCm39) |
F191Y |
possibly damaging |
Het |
Calhm1 |
GTGGC |
GTGGCTGTGGCTATGGC |
19: 47,129,712 (GRCm39) |
|
probably benign |
Het |
Camkv |
CGCTGCTGC |
CGC |
9: 107,825,059 (GRCm39) |
|
probably benign |
Het |
Cfap251 |
TCTCA |
T |
5: 123,412,224 (GRCm39) |
|
probably benign |
Het |
Chga |
GCA |
GCATCA |
12: 102,527,662 (GRCm39) |
|
probably benign |
Het |
Cngb1 |
CTCTGGCTCTGGCTCTGGCTCTG |
C |
8: 96,030,278 (GRCm39) |
|
probably null |
Het |
Cnot3 |
T |
C |
7: 3,659,068 (GRCm39) |
V438A |
probably benign |
Het |
Cntnap5c |
T |
A |
17: 58,593,790 (GRCm39) |
W710R |
probably damaging |
Het |
Dyrk1a |
A |
G |
16: 94,478,422 (GRCm39) |
S404G |
probably benign |
Het |
Efhd2 |
GCCGCC |
GCCGCCTCCGCC |
4: 141,602,075 (GRCm39) |
|
probably benign |
Het |
Flywch1 |
GTGT |
GTGTGGGGAGGCTACGTACTCACCCACACCTGTTGT |
17: 23,981,149 (GRCm39) |
|
probably null |
Het |
Fmn2 |
T |
A |
1: 174,409,581 (GRCm39) |
S605T |
unknown |
Het |
Gab3 |
TCT |
TCTGCT |
X: 74,043,617 (GRCm39) |
|
probably benign |
Het |
Gabre |
GCTC |
GCTCCGTCTC |
X: 71,313,666 (GRCm39) |
|
probably benign |
Het |
Gli3 |
A |
G |
13: 15,900,954 (GRCm39) |
Y1447C |
probably damaging |
Het |
Hibch |
T |
C |
1: 52,952,891 (GRCm39) |
V297A |
probably benign |
Het |
Ifi213 |
C |
G |
1: 173,409,719 (GRCm39) |
D462H |
probably damaging |
Het |
Kcnh8 |
G |
A |
17: 53,285,267 (GRCm39) |
R1079H |
probably benign |
Het |
Lce1m |
GCTGCTGCC |
GCTGCTGCCCCCACTGCTGCC |
3: 92,925,597 (GRCm39) |
|
probably benign |
Het |
Lpo |
A |
G |
11: 87,711,928 (GRCm39) |
V43A |
probably benign |
Het |
Map1a |
A |
AGCTCCAGCTCCAGCCCCACCTCCAGCTCCC |
2: 121,136,799 (GRCm39) |
|
probably benign |
Het |
Mapk9 |
A |
G |
11: 49,745,083 (GRCm39) |
|
probably benign |
Het |
Mep1a |
G |
A |
17: 43,797,126 (GRCm39) |
H314Y |
probably damaging |
Het |
Myh3 |
ATTAC |
ATTACTTAC |
11: 66,977,182 (GRCm39) |
|
probably null |
Het |
Myh3 |
AC |
ACTTCC |
11: 66,977,185 (GRCm39) |
|
probably null |
Het |
Nusap1 |
ACGTTAGCAGTGAGGAGCAA |
ACGTTAGCAGTGAGGAGCAAACTGAGATACTCGTTAGCAGTGAGGAGCAA |
2: 119,458,065 (GRCm39) |
|
probably benign |
Het |
Or10ag56 |
T |
A |
2: 87,139,184 (GRCm39) |
V37E |
possibly damaging |
Het |
Or14a259 |
T |
C |
7: 86,012,594 (GRCm39) |
Q317R |
probably benign |
Het |
Pdcd11 |
AGGAGG |
A |
19: 47,101,890 (GRCm39) |
|
probably null |
Het |
Pfkm |
T |
A |
15: 98,027,674 (GRCm39) |
I651N |
possibly damaging |
Het |
Phldb3 |
CCCCCGCCCC |
CCCCC |
7: 24,325,920 (GRCm39) |
|
probably null |
Het |
Polr1has |
CACCACCAC |
CACCACCACCACCACCACCACTACCACCAC |
17: 37,275,955 (GRCm39) |
|
probably benign |
Het |
Prkce |
T |
C |
17: 86,795,627 (GRCm39) |
V288A |
probably damaging |
Het |
Pxmp4 |
A |
G |
2: 154,434,183 (GRCm39) |
S93P |
probably damaging |
Het |
Rfc4 |
T |
C |
16: 22,946,232 (GRCm39) |
T17A |
probably benign |
Het |
Rfx4 |
CTCTCTCT |
CTCTCTCTCTCTCTCTATCTCTCT |
10: 84,694,351 (GRCm39) |
|
probably benign |
Het |
Ryr3 |
G |
T |
2: 112,606,015 (GRCm39) |
A2415E |
probably damaging |
Het |
Sbp |
ACAAAGATGCTGACAACAAAGATGCTGACA |
ACAAAGATGCTGACACCAAAGATGCTGACAACAAAGATGCTGACA |
17: 24,164,325 (GRCm39) |
|
probably benign |
Het |
Sec24c |
T |
A |
14: 20,738,783 (GRCm39) |
|
probably null |
Het |
Sec63 |
C |
A |
10: 42,682,620 (GRCm39) |
A437E |
probably benign |
Het |
Six3 |
GCG |
GCGTCG |
17: 85,928,783 (GRCm39) |
|
probably benign |
Het |
Slco5a1 |
G |
A |
1: 12,942,171 (GRCm39) |
T825I |
probably damaging |
Het |
Spmap2l |
CAG |
CAGCGATCCTCCCCAGTCCCGCAAGGCGAG |
5: 77,164,274 (GRCm39) |
|
probably benign |
Het |
Stard8 |
GGA |
GGAAGA |
X: 98,110,123 (GRCm39) |
|
probably benign |
Het |
Stxbp1 |
A |
G |
2: 32,711,927 (GRCm39) |
V30A |
probably benign |
Het |
Supt20 |
AGCAGC |
AGCAGCGGCAGC |
3: 54,635,083 (GRCm39) |
|
probably benign |
Het |
Syne1 |
T |
A |
10: 5,196,386 (GRCm39) |
D3882V |
possibly damaging |
Het |
T |
A |
G |
17: 8,660,540 (GRCm39) |
T384A |
probably benign |
Het |
Tbc1d12 |
CGGGGCGG |
CG |
19: 38,825,384 (GRCm39) |
|
probably benign |
Het |
Tcof1 |
CAG |
CAGAAG |
18: 60,968,816 (GRCm39) |
|
probably benign |
Het |
Tcstv5 |
A |
T |
13: 120,411,582 (GRCm39) |
V8E |
probably benign |
Het |
Tfeb |
GCA |
GCAACA |
17: 48,097,019 (GRCm39) |
|
probably benign |
Het |
Tfeb |
CAG |
CAGAAG |
17: 48,097,032 (GRCm39) |
|
probably benign |
Het |
Thumpd3 |
C |
T |
6: 113,033,006 (GRCm39) |
A248V |
probably damaging |
Het |
Tlcd4 |
T |
A |
3: 121,022,533 (GRCm39) |
I103L |
probably benign |
Het |
Tmem181a |
T |
C |
17: 6,330,978 (GRCm39) |
|
probably null |
Het |
Trim41 |
A |
T |
11: 48,698,165 (GRCm39) |
H600Q |
probably damaging |
Het |
Ttbk2 |
A |
T |
2: 120,620,820 (GRCm39) |
C147* |
probably null |
Het |
Ttll2 |
C |
T |
17: 7,618,737 (GRCm39) |
A397T |
probably benign |
Het |
Unc79 |
T |
A |
12: 103,079,046 (GRCm39) |
L1737Q |
probably benign |
Het |
Usp47 |
T |
A |
7: 111,692,145 (GRCm39) |
V869E |
probably damaging |
Het |
Vmn1r231 |
T |
A |
17: 21,110,255 (GRCm39) |
Q220L |
probably damaging |
Het |
Wrn |
T |
C |
8: 33,778,793 (GRCm39) |
N839S |
probably benign |
Het |
Zfp384 |
GCCCAGGCCCAGGCCCAGGCCCAG |
GCCCAGGCCCAGTCCCAGGCCCAGGCCCAGGCCCAG |
6: 125,013,434 (GRCm39) |
|
probably benign |
Het |
Zfp384 |
GGCCCAGG |
GGCCCAGGAGCACGCCCAGG |
6: 125,013,451 (GRCm39) |
|
probably benign |
Het |
Zfyve26 |
C |
T |
12: 79,302,112 (GRCm39) |
C1828Y |
probably damaging |
Het |
|
Other mutations in Vmn2r26 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01070:Vmn2r26
|
APN |
6 |
124,038,566 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01370:Vmn2r26
|
APN |
6 |
124,038,715 (GRCm39) |
missense |
probably benign |
0.08 |
IGL01603:Vmn2r26
|
APN |
6 |
124,030,833 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01651:Vmn2r26
|
APN |
6 |
124,027,632 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02282:Vmn2r26
|
APN |
6 |
124,038,584 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02425:Vmn2r26
|
APN |
6 |
124,038,777 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02551:Vmn2r26
|
APN |
6 |
124,003,100 (GRCm39) |
missense |
probably benign |
0.11 |
IGL02690:Vmn2r26
|
APN |
6 |
124,003,091 (GRCm39) |
missense |
probably benign |
0.14 |
IGL03002:Vmn2r26
|
APN |
6 |
124,016,754 (GRCm39) |
missense |
possibly damaging |
0.78 |
IGL03270:Vmn2r26
|
APN |
6 |
124,027,778 (GRCm39) |
missense |
probably benign |
0.16 |
R0032:Vmn2r26
|
UTSW |
6 |
124,016,858 (GRCm39) |
missense |
possibly damaging |
0.72 |
R0052:Vmn2r26
|
UTSW |
6 |
124,038,992 (GRCm39) |
makesense |
probably null |
|
R0083:Vmn2r26
|
UTSW |
6 |
124,030,940 (GRCm39) |
splice site |
probably null |
|
R0682:Vmn2r26
|
UTSW |
6 |
124,038,129 (GRCm39) |
missense |
probably damaging |
0.97 |
R1061:Vmn2r26
|
UTSW |
6 |
124,038,603 (GRCm39) |
missense |
probably benign |
0.12 |
R1077:Vmn2r26
|
UTSW |
6 |
124,030,872 (GRCm39) |
missense |
probably benign |
0.00 |
R1263:Vmn2r26
|
UTSW |
6 |
124,027,667 (GRCm39) |
missense |
probably benign |
|
R1579:Vmn2r26
|
UTSW |
6 |
124,016,706 (GRCm39) |
missense |
probably benign |
0.00 |
R1741:Vmn2r26
|
UTSW |
6 |
124,038,431 (GRCm39) |
missense |
probably damaging |
1.00 |
R1834:Vmn2r26
|
UTSW |
6 |
124,038,369 (GRCm39) |
missense |
possibly damaging |
0.54 |
R1838:Vmn2r26
|
UTSW |
6 |
124,001,730 (GRCm39) |
missense |
probably benign |
|
R1956:Vmn2r26
|
UTSW |
6 |
124,030,846 (GRCm39) |
missense |
probably damaging |
1.00 |
R1996:Vmn2r26
|
UTSW |
6 |
124,038,144 (GRCm39) |
missense |
probably damaging |
1.00 |
R2140:Vmn2r26
|
UTSW |
6 |
124,038,196 (GRCm39) |
missense |
probably benign |
0.01 |
R2327:Vmn2r26
|
UTSW |
6 |
124,016,708 (GRCm39) |
missense |
probably benign |
0.07 |
R2417:Vmn2r26
|
UTSW |
6 |
124,038,309 (GRCm39) |
missense |
probably damaging |
1.00 |
R3930:Vmn2r26
|
UTSW |
6 |
124,002,938 (GRCm39) |
missense |
probably benign |
|
R4490:Vmn2r26
|
UTSW |
6 |
124,027,697 (GRCm39) |
missense |
possibly damaging |
0.47 |
R4629:Vmn2r26
|
UTSW |
6 |
124,038,150 (GRCm39) |
missense |
possibly damaging |
0.50 |
R4655:Vmn2r26
|
UTSW |
6 |
124,038,375 (GRCm39) |
missense |
probably damaging |
1.00 |
R4709:Vmn2r26
|
UTSW |
6 |
124,030,924 (GRCm39) |
missense |
probably damaging |
1.00 |
R4992:Vmn2r26
|
UTSW |
6 |
124,003,070 (GRCm39) |
missense |
probably benign |
0.00 |
R5297:Vmn2r26
|
UTSW |
6 |
124,038,832 (GRCm39) |
missense |
probably damaging |
1.00 |
R5482:Vmn2r26
|
UTSW |
6 |
124,038,285 (GRCm39) |
missense |
possibly damaging |
0.88 |
R5517:Vmn2r26
|
UTSW |
6 |
124,027,676 (GRCm39) |
missense |
probably damaging |
1.00 |
R5737:Vmn2r26
|
UTSW |
6 |
124,016,408 (GRCm39) |
missense |
probably benign |
0.00 |
R5739:Vmn2r26
|
UTSW |
6 |
124,002,925 (GRCm39) |
missense |
probably benign |
0.00 |
R5873:Vmn2r26
|
UTSW |
6 |
124,038,633 (GRCm39) |
missense |
probably benign |
0.01 |
R5907:Vmn2r26
|
UTSW |
6 |
124,016,830 (GRCm39) |
missense |
probably benign |
0.00 |
R6086:Vmn2r26
|
UTSW |
6 |
124,016,519 (GRCm39) |
missense |
possibly damaging |
0.48 |
R6134:Vmn2r26
|
UTSW |
6 |
124,038,444 (GRCm39) |
missense |
probably damaging |
0.97 |
R6391:Vmn2r26
|
UTSW |
6 |
124,038,348 (GRCm39) |
missense |
probably damaging |
1.00 |
R6428:Vmn2r26
|
UTSW |
6 |
124,003,039 (GRCm39) |
missense |
probably benign |
0.17 |
R6637:Vmn2r26
|
UTSW |
6 |
124,038,650 (GRCm39) |
missense |
probably damaging |
1.00 |
R6927:Vmn2r26
|
UTSW |
6 |
124,016,057 (GRCm39) |
missense |
possibly damaging |
0.93 |
R6953:Vmn2r26
|
UTSW |
6 |
124,016,741 (GRCm39) |
missense |
probably benign |
0.00 |
R7173:Vmn2r26
|
UTSW |
6 |
124,038,255 (GRCm39) |
missense |
probably benign |
0.16 |
R7206:Vmn2r26
|
UTSW |
6 |
124,016,727 (GRCm39) |
missense |
probably benign |
0.17 |
R7208:Vmn2r26
|
UTSW |
6 |
124,038,948 (GRCm39) |
missense |
probably damaging |
1.00 |
R7283:Vmn2r26
|
UTSW |
6 |
124,002,914 (GRCm39) |
missense |
probably damaging |
0.97 |
R7506:Vmn2r26
|
UTSW |
6 |
124,016,700 (GRCm39) |
missense |
probably benign |
0.00 |
R7672:Vmn2r26
|
UTSW |
6 |
124,016,606 (GRCm39) |
missense |
probably benign |
0.25 |
R7674:Vmn2r26
|
UTSW |
6 |
124,016,321 (GRCm39) |
missense |
probably benign |
|
R7696:Vmn2r26
|
UTSW |
6 |
124,038,494 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7716:Vmn2r26
|
UTSW |
6 |
124,038,704 (GRCm39) |
missense |
probably damaging |
1.00 |
R7831:Vmn2r26
|
UTSW |
6 |
124,016,758 (GRCm39) |
nonsense |
probably null |
|
R8063:Vmn2r26
|
UTSW |
6 |
124,001,914 (GRCm39) |
missense |
probably benign |
0.00 |
R8331:Vmn2r26
|
UTSW |
6 |
124,038,887 (GRCm39) |
missense |
probably benign |
0.22 |
R8352:Vmn2r26
|
UTSW |
6 |
124,016,577 (GRCm39) |
missense |
probably benign |
0.09 |
R8445:Vmn2r26
|
UTSW |
6 |
124,002,995 (GRCm39) |
missense |
probably damaging |
0.97 |
R8452:Vmn2r26
|
UTSW |
6 |
124,016,577 (GRCm39) |
missense |
probably benign |
0.09 |
R8681:Vmn2r26
|
UTSW |
6 |
124,001,877 (GRCm39) |
missense |
probably benign |
0.00 |
R8914:Vmn2r26
|
UTSW |
6 |
124,038,983 (GRCm39) |
missense |
probably benign |
|
R9333:Vmn2r26
|
UTSW |
6 |
124,003,009 (GRCm39) |
missense |
probably benign |
0.13 |
R9351:Vmn2r26
|
UTSW |
6 |
124,016,333 (GRCm39) |
missense |
probably benign |
|
R9436:Vmn2r26
|
UTSW |
6 |
124,002,826 (GRCm39) |
missense |
probably damaging |
1.00 |
R9515:Vmn2r26
|
UTSW |
6 |
124,038,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- CCAAGGAGATGATCAGCCATG -3'
(R):5'- GGACATCCAAATAAGCTTGACC -3'
Sequencing Primer
(F):5'- ATCAGCCATGGAATTTGTTTTGC -3'
(R):5'- TAAGCTTGACCATACATGCCGG -3'
|
Posted On |
2019-12-04 |