Incidental Mutation 'RF011:Triml2'
ID 603208
Institutional Source Beutler Lab
Gene Symbol Triml2
Ensembl Gene ENSMUSG00000091490
Gene Name tripartite motif family-like 2
Synonyms EG622117
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # RF011 (G1)
Quality Score 193.009
Status Not validated
Chromosome 8
Chromosomal Location 43633578-43646918 bp(+) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) G to T at 43636201 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000148196 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163869] [ENSMUST00000209200] [ENSMUST00000209872] [ENSMUST00000210136]
AlphaFold E9PW10
Predicted Effect probably benign
Transcript: ENSMUST00000163869
SMART Domains Protein: ENSMUSP00000132971
Gene: ENSMUSG00000091490

DomainStartEndE-ValueType
Pfam:zf-B_box 13 51 7e-7 PFAM
PRY 242 294 2.86e-14 SMART
Pfam:SPRY 297 414 2.2e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209200
Predicted Effect probably benign
Transcript: ENSMUST00000209872
Predicted Effect probably benign
Transcript: ENSMUST00000210136
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.7%
  • 10x: 99.5%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tri-partite motif (TRIM) family of proteins. This protein may be regulated by the tumor suppressor p53 and may regulate p53 through the enhancement of p53 SUMOylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A030005L19Rik GTGGTGGCTG GTGGTGGCTGTGGTGGCTG 1: 82,891,290 (GRCm39) probably benign Het
A030005L19Rik TGCTG TGCTGTGGCGGCTG 1: 82,891,307 (GRCm39) probably benign Het
A030005L19Rik TGGCTGCTG TGGCTGCTGGGGCTGCTG 1: 82,891,294 (GRCm39) probably benign Het
AI837181 GCG GCGTCG 19: 5,475,264 (GRCm39) probably benign Het
Ankrd24 C CGGAGGCAGAGGA 10: 81,479,405 (GRCm39) probably benign Het
Aqp2 T C 15: 99,481,753 (GRCm39) S216P probably damaging Het
Brd10 T C 19: 29,721,009 (GRCm39) K672R possibly damaging Het
Cacna1f GGA GGAAGA X: 7,486,295 (GRCm39) probably benign Het
Ccdc170 CCA CCAGCA 10: 4,511,018 (GRCm39) probably benign Het
Cd109 TATTTAT TATTTATTTATTCATTTAT 9: 78,619,810 (GRCm39) probably benign Het
Cela2a T C 4: 141,549,026 (GRCm39) N117D probably benign Het
Cul9 CTTC CTTCTTC 17: 46,811,774 (GRCm39) probably benign Het
Cyb5r2 A T 7: 107,350,375 (GRCm39) S235R probably benign Het
Dnmt1 CACAGTTCCTACCTCGTT CACAGTTCCTACCTCGTTTTGGGGGCGGAGAACAGTTCCTACCTCGTT 9: 20,821,424 (GRCm39) probably null Het
Dnmt1 TT TTTTGGGGGCGGAGCACAGTTCCTACCTCGAT 9: 20,821,440 (GRCm39) probably null Het
E4f1 CCG CCGTCG 17: 24,674,160 (GRCm39) probably benign Het
Fam171b TCCAGCA TCCAGCACCAGCA 2: 83,643,217 (GRCm39) probably benign Het
Fam171b GC GCAGCATC 2: 83,643,239 (GRCm39) probably benign Het
Fam81b CTGTT CTGTTGTT 13: 76,419,435 (GRCm39) probably benign Het
Fkbp1a GCCGCCGCCA G 2: 151,384,619 (GRCm39) probably null Het
Flii G A 11: 60,607,069 (GRCm39) A969V probably benign Het
Fscb AGTGGAACTTCTGCAGGCCCCTCTTCAGTTAGTGTAGGTGGAACTTCTGCAGGCCCCTCTTCAGTTAGTGGAGGTGGAACTTCTGCAGG AGTGGAACTTCTGCAGGCCCCTCTTCAGTTAGTGGAGGTGGAACTTCTGCAGG 12: 64,519,768 (GRCm39) probably benign Het
Gas1 G GAAA 13: 60,324,345 (GRCm39) probably benign Het
Grip1 A G 10: 119,767,220 (GRCm39) D115G probably null Het
Guca2b G T 4: 119,514,044 (GRCm39) T89N possibly damaging Het
Hcn4 T A 9: 58,767,198 (GRCm39) S920T unknown Het
Heatr1 A G 13: 12,422,425 (GRCm39) M484V probably benign Het
Iba57 G T 11: 59,054,438 (GRCm39) A27E probably benign Het
Ifi207 G C 1: 173,556,687 (GRCm39) L684V not run Het
Ints13 T C 6: 146,457,738 (GRCm39) H380R probably damaging Het
Jmjd1c C T 10: 67,055,978 (GRCm39) T466I possibly damaging Het
Kcnh8 G A 17: 53,285,267 (GRCm39) R1079H probably benign Het
Kif12 C CCTCCACCCGGCGGGG 4: 63,089,664 (GRCm39) probably benign Het
Kmt2c A T 5: 25,543,457 (GRCm39) D1399E probably damaging Het
Macf1 A T 4: 123,367,648 (GRCm39) L2371Q probably damaging Het
Mbd1 GTCTTCGTCTGCATCTGCATCTGCATCT GTCT 18: 74,406,681 (GRCm39) probably benign Het
Med12l GCA GCATCA 3: 59,183,401 (GRCm39) probably benign Het
Mgam C A 6: 40,734,370 (GRCm39) Q1472K probably damaging Het
Mup21 TATACTT TATACTTTTTAGATACTT 4: 62,067,582 (GRCm39) probably benign Het
Nalf2 CGCCGC CGCCGCAGCCGC X: 98,864,967 (GRCm39) probably benign Het
Nipal1 A G 5: 72,824,156 (GRCm39) N167D probably damaging Het
Or4d10c C T 19: 12,065,611 (GRCm39) V182I probably benign Het
Or5be3 T A 2: 86,864,385 (GRCm39) Y60F probably damaging Het
Osbpl3 CCTGCA C 6: 50,325,118 (GRCm39) probably benign Het
Phf20 CCCCCCCCC CCCCCCCCCCCCCCCC 2: 156,146,540 (GRCm39) probably benign Het
Phf20 CCCCCCCC CCCCCCCCCCCCCCC 2: 156,146,541 (GRCm39) probably benign Het
Pramel16 C G 4: 143,675,478 (GRCm39) Q449H probably damaging Het
Rassf6 TCCTGTAGAGCAATGGGGATTC TCCTGTAGAGCAATGGGGATTCTGCCTCACTCATGGGCCTGTAGAGCAATGGGGATTC 5: 90,756,780 (GRCm39) probably benign Het
Rbm33 CCAGCCGCAGC CCAGC 5: 28,599,179 (GRCm39) probably benign Het
Rubcnl T C 14: 75,281,878 (GRCm39) F445S probably damaging Het
S100a10 TTTTTTTA T 3: 93,471,541 (GRCm39) probably benign Het
Sbp AA AAAATGCTGACAACGGA 17: 24,164,328 (GRCm39) probably benign Het
Sec14l3 A C 11: 4,017,963 (GRCm39) Q81P possibly damaging Het
Setd1a TGGTGGTGG TGGTGGTGGGGGTGGTGG 7: 127,384,515 (GRCm39) probably benign Het
Six3 CGG CGGGGG 17: 85,928,796 (GRCm39) probably benign Het
Snapc5 ATGGAAGAAGAGG A 9: 64,089,493 (GRCm39) probably benign Het
Tbc1d12 CGGAGGAGG CGG 19: 38,825,401 (GRCm39) probably benign Het
Tcof1 AGC AGCCGC 18: 60,968,811 (GRCm39) probably benign Het
Tox2 A G 2: 163,067,484 (GRCm39) I68V probably benign Het
Tspan33 A G 6: 29,716,729 (GRCm39) Y162C probably damaging Het
Zfp384 GGCCCAGGCCCA GGCCCAGGCCCAAGCCCAGGCCCA 6: 125,013,439 (GRCm39) probably benign Het
Zfp948 T C 17: 21,808,574 (GRCm39) Y589H probably damaging Het
Zic1 T C 9: 91,246,383 (GRCm39) I230V probably benign Het
Other mutations in Triml2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01534:Triml2 APN 8 43,640,660 (GRCm39) missense probably benign 0.00
IGL01919:Triml2 APN 8 43,643,349 (GRCm39) missense probably damaging 1.00
IGL03382:Triml2 APN 8 43,646,776 (GRCm39) missense probably benign 0.00
R0025:Triml2 UTSW 8 43,638,469 (GRCm39) missense probably benign 0.00
R0058:Triml2 UTSW 8 43,638,306 (GRCm39) splice site probably benign
R0058:Triml2 UTSW 8 43,638,306 (GRCm39) splice site probably benign
R0180:Triml2 UTSW 8 43,643,346 (GRCm39) missense probably benign 0.14
R1671:Triml2 UTSW 8 43,636,780 (GRCm39) missense possibly damaging 0.88
R2143:Triml2 UTSW 8 43,646,548 (GRCm39) missense probably damaging 1.00
R2210:Triml2 UTSW 8 43,636,397 (GRCm39) missense probably damaging 1.00
R3156:Triml2 UTSW 8 43,640,716 (GRCm39) missense probably benign 0.10
R3902:Triml2 UTSW 8 43,643,397 (GRCm39) missense probably benign 0.03
R4981:Triml2 UTSW 8 43,640,717 (GRCm39) missense probably benign 0.10
R6125:Triml2 UTSW 8 43,640,659 (GRCm39) missense probably benign 0.02
R6478:Triml2 UTSW 8 43,638,165 (GRCm39) splice site probably null
R6994:Triml2 UTSW 8 43,643,115 (GRCm39) missense possibly damaging 0.57
R7037:Triml2 UTSW 8 43,646,573 (GRCm39) missense probably damaging 1.00
R7113:Triml2 UTSW 8 43,636,370 (GRCm39) missense probably benign 0.01
R7660:Triml2 UTSW 8 43,646,357 (GRCm39) missense probably damaging 1.00
R7683:Triml2 UTSW 8 43,638,325 (GRCm39) missense probably damaging 0.99
R7971:Triml2 UTSW 8 43,643,313 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GGCTTAATCTTGTCTGGCCG -3'
(R):5'- AGCTTCTTGGATACCGTATGC -3'

Sequencing Primer
(F):5'- AATCTTGTCTGGCCGGGGATAC -3'
(R):5'- TGGATACCGTATGCCCCATG -3'
Posted On 2019-12-04