Incidental Mutation 'RF013:Mpdz'
| ID |
603320 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mpdz
|
| Ensembl Gene |
ENSMUSG00000028402 |
| Gene Name |
multiple PDZ domain protein |
| Synonyms |
B930003D11Rik, MUPP1 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
RF013 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
81278500-81442815 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 81293592 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Valine
at position 1566
(A1566V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000102879
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000102830]
[ENSMUST00000107258]
[ENSMUST00000107262]
[ENSMUST00000131547]
[ENSMUST00000134726]
[ENSMUST00000220807]
|
| AlphaFold |
Q8VBX6 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000102830
AA Change: A1599V
PolyPhen 2
Score 0.672 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000099894
Gene: ENSMUSG00000028402
AA Change: A1599V
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
6 |
66 |
9.04e-3 |
SMART |
|
PDZ
|
147 |
225 |
3.03e-23 |
SMART |
|
PDZ
|
266 |
338 |
8.92e-21 |
SMART |
|
low complexity region
|
345 |
360 |
N/A |
INTRINSIC |
|
PDZ
|
386 |
464 |
6.07e-23 |
SMART |
|
PDZ
|
556 |
627 |
7.31e-17 |
SMART |
|
PDZ
|
701 |
780 |
9.94e-19 |
SMART |
|
PDZ
|
1004 |
1080 |
3.44e-13 |
SMART |
|
low complexity region
|
1111 |
1126 |
N/A |
INTRINSIC |
|
PDZ
|
1148 |
1231 |
2.43e-22 |
SMART |
|
low complexity region
|
1233 |
1251 |
N/A |
INTRINSIC |
|
PDZ
|
1346 |
1421 |
3.41e-17 |
SMART |
|
low complexity region
|
1434 |
1445 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1468 |
N/A |
INTRINSIC |
|
PDZ
|
1479 |
1552 |
2.69e-15 |
SMART |
|
PDZ
|
1622 |
1697 |
3.2e-22 |
SMART |
|
PDZ
|
1719 |
1792 |
3.62e-21 |
SMART |
|
low complexity region
|
1798 |
1815 |
N/A |
INTRINSIC |
|
PDZ
|
1856 |
1933 |
9.79e-18 |
SMART |
|
PDZ
|
1980 |
2055 |
2.39e-21 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000107258
AA Change: A1566V
PolyPhen 2
Score 0.603 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000102879
Gene: ENSMUSG00000028402
AA Change: A1566V
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
1 |
73 |
3.42e-8 |
SMART |
|
low complexity region
|
104 |
119 |
N/A |
INTRINSIC |
|
PDZ
|
141 |
224 |
2.43e-22 |
SMART |
|
PDZ
|
306 |
381 |
3.41e-17 |
SMART |
|
low complexity region
|
394 |
405 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
PDZ
|
439 |
512 |
2.69e-15 |
SMART |
|
PDZ
|
582 |
657 |
3.2e-22 |
SMART |
|
PDZ
|
679 |
752 |
3.62e-21 |
SMART |
|
low complexity region
|
758 |
775 |
N/A |
INTRINSIC |
|
PDZ
|
816 |
893 |
9.79e-18 |
SMART |
|
PDZ
|
940 |
1015 |
2.39e-21 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107262
AA Change: A1600V
PolyPhen 2
Score 0.080 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000102883
Gene: ENSMUSG00000028402
AA Change: A1600V
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
6 |
66 |
9.04e-3 |
SMART |
|
PDZ
|
147 |
225 |
3.03e-23 |
SMART |
|
PDZ
|
266 |
338 |
8.92e-21 |
SMART |
|
low complexity region
|
345 |
360 |
N/A |
INTRINSIC |
|
PDZ
|
386 |
464 |
6.07e-23 |
SMART |
|
PDZ
|
556 |
627 |
7.31e-17 |
SMART |
|
PDZ
|
701 |
780 |
9.94e-19 |
SMART |
|
PDZ
|
1004 |
1080 |
3.44e-13 |
SMART |
|
low complexity region
|
1112 |
1127 |
N/A |
INTRINSIC |
|
PDZ
|
1149 |
1232 |
2.43e-22 |
SMART |
|
low complexity region
|
1234 |
1252 |
N/A |
INTRINSIC |
|
PDZ
|
1347 |
1422 |
3.41e-17 |
SMART |
|
low complexity region
|
1435 |
1446 |
N/A |
INTRINSIC |
|
low complexity region
|
1455 |
1469 |
N/A |
INTRINSIC |
|
PDZ
|
1480 |
1553 |
2.69e-15 |
SMART |
|
PDZ
|
1623 |
1698 |
3.2e-22 |
SMART |
|
PDZ
|
1720 |
1793 |
3.62e-21 |
SMART |
|
low complexity region
|
1799 |
1816 |
N/A |
INTRINSIC |
|
PDZ
|
1857 |
1934 |
9.79e-18 |
SMART |
|
PDZ
|
1981 |
2056 |
2.39e-21 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131547
|
| SMART Domains |
Protein: ENSMUSP00000116767
Gene: ENSMUSG00000028402
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:PDZ
|
1 |
33 |
8e-15 |
BLAST |
|
PDB:2OPG|B
|
1 |
37 |
1e-19 |
PDB |
|
PDZ
|
55 |
128 |
3.62e-21 |
SMART |
|
low complexity region
|
134 |
151 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
167 |
209 |
1e-11 |
BLAST |
|
PDB:2IWP|B
|
173 |
209 |
3e-6 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000134726
AA Change: A67V
PolyPhen 2
Score 0.216 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000116830
Gene: ENSMUSG00000028402
AA Change: A67V
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
90 |
137 |
7.6e0 |
SMART |
|
PDZ
|
159 |
232 |
3.62e-21 |
SMART |
|
low complexity region
|
238 |
255 |
N/A |
INTRINSIC |
|
PDZ
|
296 |
373 |
9.79e-18 |
SMART |
|
PDZ
|
420 |
495 |
2.39e-21 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000220807
AA Change: A1613V
PolyPhen 2
Score 0.879 (Sensitivity: 0.82; Specificity: 0.94)
|
| Coding Region Coverage |
- 1x: 99.8%
- 3x: 99.7%
- 10x: 99.4%
- 20x: 98.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene has multiple PDZ domains, which are hallmarks of protein-protein interactions. The encoded protein is known to interact with the HTR2C receptor and may cause it to clump at the cell surface. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
PHENOTYPE: Mutant heterozygous mice are more sensitive to ethanol withdrawal effects and consume less alcohol than controls. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 73 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700019N19Rik |
A |
G |
19: 58,789,294 (GRCm38) |
F28S |
probably damaging |
Het |
| 4930435E12Rik |
T |
C |
16: 38,828,001 (GRCm38) |
T249A |
probably benign |
Het |
| 4932438A13Rik |
TTAT |
TTATTATTATTATTAGTAT |
3: 37,050,757 (GRCm38) |
|
probably benign |
Het |
| Acap3 |
CCTGGGCTGCTG |
CCTGGGCTGCTGCATACTGGGCTGCTG |
4: 155,905,096 (GRCm38) |
|
probably benign |
Het |
| Adamts9 |
A |
G |
6: 92,943,145 (GRCm38) |
V4A |
possibly damaging |
Het |
| AI837181 |
GGC |
GGCTGC |
19: 5,425,232 (GRCm38) |
|
probably benign |
Het |
| Alk |
A |
G |
17: 71,895,936 (GRCm38) |
Y1135H |
probably damaging |
Het |
| Ankhd1 |
CGGCGG |
CGGCGGAGGCGG |
18: 36,560,926 (GRCm38) |
|
probably benign |
Het |
| Ano3 |
A |
C |
2: 110,697,036 (GRCm38) |
L609R |
probably benign |
Het |
| Bicc1 |
A |
G |
10: 70,935,830 (GRCm38) |
|
probably null |
Het |
| Card6 |
T |
C |
15: 5,100,142 (GRCm38) |
I591V |
probably benign |
Het |
| Ccdc18 |
A |
G |
5: 108,220,716 (GRCm38) |
N1235D |
probably benign |
Het |
| Cd109 |
TTAT |
TTATTTATTTATCTAT |
9: 78,712,531 (GRCm38) |
|
probably benign |
Het |
| Cnpy3 |
CCT |
CCTGCT |
17: 46,736,744 (GRCm38) |
|
probably benign |
Het |
| Col6a5 |
GCAGTC |
GCAGTCTCCAGTC |
9: 105,878,597 (GRCm38) |
|
probably null |
Het |
| Cyb5r4 |
GACACACTGCCCAGGGA |
GACACACTGCCCAGGGATGTGACACACACACTGCCCAGGGA |
9: 87,040,432 (GRCm38) |
|
probably benign |
Het |
| Cyp8b1 |
A |
T |
9: 121,915,495 (GRCm38) |
M257K |
possibly damaging |
Het |
| Dbf4 |
A |
T |
5: 8,397,985 (GRCm38) |
H408Q |
possibly damaging |
Het |
| Defb22 |
TTGCGGCA |
TTGCGGCAGAGCTGGCCTGTGCGGCA |
2: 152,485,831 (GRCm38) |
|
probably benign |
Het |
| Ercc6l2 |
A |
T |
13: 63,853,017 (GRCm38) |
T417S |
probably benign |
Het |
| Exd2 |
AGCCACAG |
A |
12: 80,475,932 (GRCm38) |
|
probably null |
Het |
| Fam171b |
GC |
GCAGCATC |
2: 83,812,895 (GRCm38) |
|
probably benign |
Het |
| Fam71e1 |
CCTGGGTCTGAGGGAGGA |
CCTGGGTCTGAGGGAGGACGGCTGGATCCTGGATCACTGGGTCTGAGGGAGGA |
7: 44,500,520 (GRCm38) |
|
probably null |
Het |
| Flvcr2 |
T |
A |
12: 85,747,186 (GRCm38) |
L112Q |
probably damaging |
Het |
| Flywch1 |
GTG |
GTGGGGGGAGGCTACGTACTCACCCACTCCTTTTG |
17: 23,762,175 (GRCm38) |
|
probably null |
Het |
| Gabre |
TCAGGCTCAGGCT |
TCAGGCTCAGGCTCAGGCT |
X: 72,270,416 (GRCm38) |
|
probably benign |
Het |
| Gm4884 |
C |
A |
7: 41,040,809 (GRCm38) |
P43Q |
probably damaging |
Het |
| Gm6588 |
T |
A |
5: 112,450,071 (GRCm38) |
N161K |
probably benign |
Het |
| Grm8 |
A |
G |
6: 27,363,780 (GRCm38) |
W579R |
probably damaging |
Het |
| Hsdl2 |
AG |
AGCAGCAGCCACAGCTGCCG |
4: 59,610,657 (GRCm38) |
|
probably benign |
Het |
| Ivl |
CTGCTGCTGCTGCTGT |
C |
3: 92,572,343 (GRCm38) |
|
probably benign |
Het |
| Kif18b |
T |
C |
11: 102,912,366 (GRCm38) |
D506G |
probably benign |
Het |
| Krtap28-10 |
AGCCAC |
AGCCACGGCCAC |
1: 83,042,135 (GRCm38) |
|
probably benign |
Het |
| Krtap28-10 |
GCCACAGCCACCACA |
GCCACAGCCACCACATCCACAGCCACCACA |
1: 83,042,274 (GRCm38) |
|
probably benign |
Het |
| Lama1 |
C |
A |
17: 67,781,062 (GRCm38) |
S1558R |
|
Het |
| Lcmt1 |
C |
CCGCGGGGCTT |
7: 123,369,836 (GRCm38) |
|
probably null |
Het |
| Lmna |
A |
G |
3: 88,484,054 (GRCm38) |
V494A |
probably benign |
Het |
| Mapk6 |
CCAC |
CCACCTCAC |
9: 75,388,260 (GRCm38) |
|
probably null |
Het |
| Mboat7 |
T |
A |
7: 3,691,857 (GRCm38) |
H52L |
probably damaging |
Het |
| Med12l |
CAG |
CAGAAG |
3: 59,275,966 (GRCm38) |
|
probably benign |
Het |
| Morc2a |
T |
A |
11: 3,676,191 (GRCm38) |
M225K |
probably benign |
Het |
| Mpi |
T |
C |
9: 57,548,641 (GRCm38) |
D186G |
probably benign |
Het |
| Mtmr12 |
C |
A |
15: 12,261,898 (GRCm38) |
N386K |
probably damaging |
Het |
| Myh3 |
ATTAC |
ATTACTTAC |
11: 67,086,356 (GRCm38) |
|
probably null |
Het |
| Myo10 |
T |
A |
15: 25,799,479 (GRCm38) |
M1376K |
probably damaging |
Het |
| Nbas |
C |
T |
12: 13,279,408 (GRCm38) |
T118I |
possibly damaging |
Het |
| Nedd4l |
C |
T |
18: 65,209,680 (GRCm38) |
R755C |
probably damaging |
Het |
| Nefh |
GACTTGGCCTCACCTGGG |
GACTTGGCCTCACCTGGGTACTTGGCCTCACCTGGG |
11: 4,941,032 (GRCm38) |
|
probably benign |
Het |
| Numa1 |
T |
C |
7: 101,999,780 (GRCm38) |
L906P |
probably damaging |
Het |
| Olfr750 |
G |
A |
14: 51,071,012 (GRCm38) |
A127V |
probably damaging |
Het |
| Olfr871 |
T |
C |
9: 20,212,894 (GRCm38) |
S182P |
probably benign |
Het |
| Otop2 |
G |
T |
11: 115,323,666 (GRCm38) |
R83L |
probably benign |
Het |
| Pmm1 |
T |
A |
15: 81,957,813 (GRCm38) |
Q62L |
probably damaging |
Het |
| Pramef25 |
C |
G |
4: 143,948,908 (GRCm38) |
Q449H |
probably damaging |
Het |
| Ptprj |
A |
T |
2: 90,471,170 (GRCm38) |
L206* |
probably null |
Het |
| Rassf6 |
TC |
TCTGCCTCACTCATGGTCCTGTAGAGCATTGGGGATCC |
5: 90,608,941 (GRCm38) |
|
probably benign |
Het |
| Rps19 |
A |
AGAAAAT |
7: 24,889,180 (GRCm38) |
|
probably benign |
Het |
| Rsrp1 |
T |
A |
4: 134,923,955 (GRCm38) |
V10E |
unknown |
Het |
| Sh2d6 |
C |
T |
6: 72,516,388 (GRCm38) |
|
probably null |
Het |
| Six4 |
TG |
T |
12: 73,103,582 (GRCm38) |
|
probably null |
Het |
| Slc6a15 |
T |
A |
10: 103,400,216 (GRCm38) |
V264D |
probably damaging |
Het |
| Snapc5 |
ATGGAAGAAGAGG |
A |
9: 64,182,211 (GRCm38) |
|
probably benign |
Het |
| Sost |
A |
T |
11: 101,964,132 (GRCm38) |
I117N |
probably damaging |
Het |
| Tbc1d22a |
AGGTGTGTG |
A |
15: 86,299,774 (GRCm38) |
|
probably null |
Het |
| Tcaf1 |
C |
T |
6: 42,679,173 (GRCm38) |
V290I |
probably benign |
Het |
| Tcof1 |
GCA |
GCACCA |
18: 60,835,743 (GRCm38) |
|
probably benign |
Het |
| Tgfbr1 |
A |
G |
4: 47,353,354 (GRCm38) |
I15V |
unknown |
Het |
| Tmem241 |
A |
T |
18: 11,983,561 (GRCm38) |
L288Q |
probably damaging |
Het |
| Tnfrsf13b |
T |
G |
11: 61,141,444 (GRCm38) |
V100G |
probably benign |
Het |
| Trim66 |
A |
G |
7: 109,460,753 (GRCm38) |
S809P |
probably damaging |
Het |
| Tubb4a |
C |
G |
17: 57,087,464 (GRCm38) |
G17A |
possibly damaging |
Het |
| Txndc16 |
A |
G |
14: 45,169,338 (GRCm38) |
V220A |
probably benign |
Het |
| Zan |
T |
A |
5: 137,391,720 (GRCm38) |
Q4830L |
unknown |
Het |
|
| Other mutations in Mpdz |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00229:Mpdz
|
APN |
4 |
81,310,224 (GRCm38) |
nonsense |
probably null |
|
|
IGL00325:Mpdz
|
APN |
4 |
81,317,631 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00497:Mpdz
|
APN |
4 |
81,335,742 (GRCm38) |
missense |
probably benign |
0.30 |
|
IGL00502:Mpdz
|
APN |
4 |
81,369,723 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00539:Mpdz
|
APN |
4 |
81,361,351 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
IGL00938:Mpdz
|
APN |
4 |
81,292,512 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00990:Mpdz
|
APN |
4 |
81,303,584 (GRCm38) |
splice site |
probably benign |
|
|
IGL01394:Mpdz
|
APN |
4 |
81,292,491 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL01537:Mpdz
|
APN |
4 |
81,369,658 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01558:Mpdz
|
APN |
4 |
81,295,530 (GRCm38) |
nonsense |
probably null |
|
|
IGL01561:Mpdz
|
APN |
4 |
81,284,614 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01649:Mpdz
|
APN |
4 |
81,303,633 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01743:Mpdz
|
APN |
4 |
81,317,682 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01941:Mpdz
|
APN |
4 |
81,286,387 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
IGL01969:Mpdz
|
APN |
4 |
81,358,724 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL02023:Mpdz
|
APN |
4 |
81,329,529 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02081:Mpdz
|
APN |
4 |
81,335,869 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02304:Mpdz
|
APN |
4 |
81,297,559 (GRCm38) |
splice site |
probably benign |
|
|
IGL02304:Mpdz
|
APN |
4 |
81,310,157 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
IGL02410:Mpdz
|
APN |
4 |
81,297,493 (GRCm38) |
missense |
probably benign |
0.13 |
|
IGL02449:Mpdz
|
APN |
4 |
81,329,422 (GRCm38) |
splice site |
probably null |
|
|
IGL02671:Mpdz
|
APN |
4 |
81,290,273 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02708:Mpdz
|
APN |
4 |
81,284,571 (GRCm38) |
splice site |
probably null |
|
|
IGL02718:Mpdz
|
APN |
4 |
81,385,202 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03065:Mpdz
|
APN |
4 |
81,292,565 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL03378:Mpdz
|
APN |
4 |
81,419,048 (GRCm38) |
splice site |
probably benign |
|
|
PIT4458001:Mpdz
|
UTSW |
4 |
81,419,026 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0108:Mpdz
|
UTSW |
4 |
81,381,805 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0108:Mpdz
|
UTSW |
4 |
81,381,805 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0119:Mpdz
|
UTSW |
4 |
81,292,531 (GRCm38) |
missense |
probably benign |
0.44 |
|
R0402:Mpdz
|
UTSW |
4 |
81,361,440 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
R0499:Mpdz
|
UTSW |
4 |
81,292,531 (GRCm38) |
missense |
probably benign |
0.44 |
|
R0718:Mpdz
|
UTSW |
4 |
81,292,473 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R0844:Mpdz
|
UTSW |
4 |
81,421,194 (GRCm38) |
start gained |
probably benign |
|
|
R0883:Mpdz
|
UTSW |
4 |
81,359,991 (GRCm38) |
splice site |
probably benign |
|
|
R0885:Mpdz
|
UTSW |
4 |
81,369,592 (GRCm38) |
missense |
probably benign |
0.04 |
|
R1344:Mpdz
|
UTSW |
4 |
81,308,319 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1432:Mpdz
|
UTSW |
4 |
81,292,551 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1488:Mpdz
|
UTSW |
4 |
81,348,708 (GRCm38) |
nonsense |
probably null |
|
|
R1589:Mpdz
|
UTSW |
4 |
81,421,176 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1756:Mpdz
|
UTSW |
4 |
81,306,877 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R1940:Mpdz
|
UTSW |
4 |
81,361,443 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2068:Mpdz
|
UTSW |
4 |
81,335,830 (GRCm38) |
missense |
probably null |
1.00 |
|
R2182:Mpdz
|
UTSW |
4 |
81,348,722 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2213:Mpdz
|
UTSW |
4 |
81,310,172 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2265:Mpdz
|
UTSW |
4 |
81,383,391 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2268:Mpdz
|
UTSW |
4 |
81,383,391 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2269:Mpdz
|
UTSW |
4 |
81,383,391 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3082:Mpdz
|
UTSW |
4 |
81,285,458 (GRCm38) |
splice site |
probably benign |
|
|
R3746:Mpdz
|
UTSW |
4 |
81,363,147 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3902:Mpdz
|
UTSW |
4 |
81,307,116 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4095:Mpdz
|
UTSW |
4 |
81,383,823 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R4097:Mpdz
|
UTSW |
4 |
81,335,700 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4206:Mpdz
|
UTSW |
4 |
81,381,762 (GRCm38) |
missense |
probably benign |
0.13 |
|
R4675:Mpdz
|
UTSW |
4 |
81,383,812 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4884:Mpdz
|
UTSW |
4 |
81,361,476 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R5044:Mpdz
|
UTSW |
4 |
81,381,697 (GRCm38) |
missense |
probably benign |
0.16 |
|
R5050:Mpdz
|
UTSW |
4 |
81,295,448 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5243:Mpdz
|
UTSW |
4 |
81,306,879 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5332:Mpdz
|
UTSW |
4 |
81,292,580 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5435:Mpdz
|
UTSW |
4 |
81,283,487 (GRCm38) |
intron |
probably benign |
|
|
R5720:Mpdz
|
UTSW |
4 |
81,287,694 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5743:Mpdz
|
UTSW |
4 |
81,421,188 (GRCm38) |
start codon destroyed |
probably null |
0.30 |
|
R5764:Mpdz
|
UTSW |
4 |
81,356,446 (GRCm38) |
missense |
probably benign |
0.13 |
|
R5876:Mpdz
|
UTSW |
4 |
81,285,474 (GRCm38) |
nonsense |
probably null |
|
|
R5938:Mpdz
|
UTSW |
4 |
81,284,614 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5988:Mpdz
|
UTSW |
4 |
81,284,575 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6125:Mpdz
|
UTSW |
4 |
81,297,527 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6178:Mpdz
|
UTSW |
4 |
81,308,365 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6235:Mpdz
|
UTSW |
4 |
81,385,281 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6293:Mpdz
|
UTSW |
4 |
81,360,056 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6387:Mpdz
|
UTSW |
4 |
81,381,709 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R6488:Mpdz
|
UTSW |
4 |
81,287,733 (GRCm38) |
missense |
probably benign |
0.11 |
|
R6536:Mpdz
|
UTSW |
4 |
81,383,417 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6673:Mpdz
|
UTSW |
4 |
81,356,430 (GRCm38) |
missense |
probably benign |
0.11 |
|
R6879:Mpdz
|
UTSW |
4 |
81,348,656 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R7180:Mpdz
|
UTSW |
4 |
81,335,751 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7199:Mpdz
|
UTSW |
4 |
81,297,333 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7209:Mpdz
|
UTSW |
4 |
81,306,877 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R7309:Mpdz
|
UTSW |
4 |
81,381,958 (GRCm38) |
splice site |
probably null |
|
|
R7359:Mpdz
|
UTSW |
4 |
81,356,395 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7561:Mpdz
|
UTSW |
4 |
81,307,151 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7565:Mpdz
|
UTSW |
4 |
81,303,654 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7738:Mpdz
|
UTSW |
4 |
81,335,749 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7941:Mpdz
|
UTSW |
4 |
81,282,750 (GRCm38) |
missense |
probably benign |
0.04 |
|
R8074:Mpdz
|
UTSW |
4 |
81,349,087 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8957:Mpdz
|
UTSW |
4 |
81,332,979 (GRCm38) |
nonsense |
probably null |
|
|
R8998:Mpdz
|
UTSW |
4 |
81,284,645 (GRCm38) |
nonsense |
probably null |
|
|
R8999:Mpdz
|
UTSW |
4 |
81,284,645 (GRCm38) |
nonsense |
probably null |
|
|
R9001:Mpdz
|
UTSW |
4 |
81,381,762 (GRCm38) |
missense |
probably benign |
|
|
R9223:Mpdz
|
UTSW |
4 |
81,284,630 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9415:Mpdz
|
UTSW |
4 |
81,317,668 (GRCm38) |
nonsense |
probably null |
|
|
R9486:Mpdz
|
UTSW |
4 |
81,335,806 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9520:Mpdz
|
UTSW |
4 |
81,386,318 (GRCm38) |
missense |
probably benign |
|
|
R9526:Mpdz
|
UTSW |
4 |
81,356,416 (GRCm38) |
missense |
probably benign |
|
|
R9556:Mpdz
|
UTSW |
4 |
81,360,026 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9722:Mpdz
|
UTSW |
4 |
81,386,267 (GRCm38) |
missense |
probably damaging |
0.97 |
|
X0011:Mpdz
|
UTSW |
4 |
81,292,759 (GRCm38) |
critical splice donor site |
probably null |
|
|
Z1177:Mpdz
|
UTSW |
4 |
81,320,490 (GRCm38) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCAAATCTCCTCCTCATGG -3'
(R):5'- TAGCCCCTAGTTTAATGATGGAG -3'
Sequencing Primer
(F):5'- CTCATGGTCTCTTGGGGCAC -3'
(R):5'- CCCCTAGTTTAATGATGGAGAAGTAG -3'
|
| Posted On |
2019-12-04 |
Incidental Mutation