|Institutional Source||Beutler Lab|
|Gene Name||mitogen-activated protein kinase 6|
|Synonyms||Mapk4, D130053K17Rik, ERK3, Prkm6, Mapk63, Prkm4, Erk3, 2610021I23Rik|
|Is this an essential gene?||Possibly essential (E-score: 0.533)|
|Stock #||RF013 (G1)|
|Chromosomal Location||75369062-75410005 bp(-) (GRCm38)|
|Type of Mutation||frame shift|
|DNA Base Change (assembly)||CCAC to CCACCTCAC at 75388260 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000040315 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000049355] [ENSMUST00000168937]|
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice show limited fetal growth, reduced serum IGF2 levels, pulmonary hypoplasia and early neonatal death. About 40% of newborns die of acute respiratory failure exhibiting delayed lung maturation, reduced sacculation, atelectasis, and impaired type II pneumocyte differentiation. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Mapk6||
(F):5'- AAATGTCTGCTGAGGTTTAGTTCAG -3'
(R):5'- TGGGACAGCCAGTTTGTGAG -3'
(F):5'- AGTTCAGATGTTTCAGAATGCTGC -3'
(R):5'- CCAGTTTGTGAGTGGCGG -3'