Incidental Mutation 'RF018:Anks1b'
| ID |
603688 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Anks1b
|
| Ensembl Gene |
ENSMUSG00000058589 |
| Gene Name |
ankyrin repeat and sterile alpha motif domain containing 1B |
| Synonyms |
C030032C09Rik, Gm10937, AIDA-1b, LOC380650, E530015N03Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
RF018 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
89709371-90809162 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 89869087 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Aspartic acid
at position 49
(G49D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000138539
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099368]
[ENSMUST00000182907]
[ENSMUST00000182936]
[ENSMUST00000183156]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000099368
AA Change: G49D
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000096968
Gene: ENSMUSG00000058589
AA Change: G49D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
46 |
N/A |
INTRINSIC |
|
ANK
|
58 |
87 |
1.88e-5 |
SMART |
|
ANK
|
91 |
123 |
3.13e-2 |
SMART |
|
ANK
|
127 |
156 |
6.92e-4 |
SMART |
|
ANK
|
160 |
189 |
3.08e-1 |
SMART |
|
ANK
|
193 |
222 |
1.43e-5 |
SMART |
|
ANK
|
225 |
254 |
4.75e-2 |
SMART |
|
low complexity region
|
498 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
551 |
577 |
N/A |
INTRINSIC |
|
low complexity region
|
659 |
670 |
N/A |
INTRINSIC |
|
SAM
|
806 |
875 |
2.06e-19 |
SMART |
|
SAM
|
880 |
931 |
4.44e-1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182907
|
| SMART Domains |
Protein: ENSMUSP00000138614
Gene: ENSMUSG00000058589
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
45 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000182936
AA Change: G49D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000138209
Gene: ENSMUSG00000058589
AA Change: G49D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
46 |
N/A |
INTRINSIC |
|
ANK
|
58 |
87 |
1.88e-5 |
SMART |
|
ANK
|
91 |
123 |
3.13e-2 |
SMART |
|
ANK
|
127 |
156 |
6.92e-4 |
SMART |
|
ANK
|
160 |
189 |
3.08e-1 |
SMART |
|
ANK
|
193 |
222 |
1.43e-5 |
SMART |
|
ANK
|
225 |
254 |
5.03e2 |
SMART |
|
low complexity region
|
464 |
479 |
N/A |
INTRINSIC |
|
low complexity region
|
517 |
543 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000183156
AA Change: G49D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000138539
Gene: ENSMUSG00000058589
AA Change: G49D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
46 |
N/A |
INTRINSIC |
|
ANK
|
58 |
87 |
1.88e-5 |
SMART |
|
ANK
|
91 |
123 |
3.13e-2 |
SMART |
|
ANK
|
127 |
156 |
6.92e-4 |
SMART |
|
ANK
|
160 |
189 |
3.08e-1 |
SMART |
|
ANK
|
193 |
222 |
1.43e-5 |
SMART |
|
ANK
|
225 |
254 |
4.75e-2 |
SMART |
|
low complexity region
|
498 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
551 |
577 |
N/A |
INTRINSIC |
|
low complexity region
|
659 |
670 |
N/A |
INTRINSIC |
|
SAM
|
806 |
875 |
2.06e-19 |
SMART |
|
SAM
|
880 |
948 |
5.66e-17 |
SMART |
|
low complexity region
|
968 |
983 |
N/A |
INTRINSIC |
|
PTB
|
1056 |
1194 |
2.94e-38 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.8%
- 3x: 99.7%
- 10x: 99.3%
- 20x: 98.6%
|
| Validation Efficiency |
100% (54/54) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a conditional allele activated in neurons alters hippocampal synaptic transmission. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A030005L19Rik |
GTGGCTGCT |
GTGGCTGCTTTGGCTGCT |
1: 82,891,293 (GRCm39) |
|
probably benign |
Het |
| Abca15 |
T |
A |
7: 119,993,683 (GRCm39) |
V1301E |
possibly damaging |
Het |
| Adcy10 |
T |
A |
1: 165,379,678 (GRCm39) |
V980E |
probably damaging |
Het |
| Aldh1a2 |
T |
C |
9: 71,192,552 (GRCm39) |
V469A |
probably damaging |
Het |
| Alk |
T |
A |
17: 72,256,808 (GRCm39) |
T684S |
probably benign |
Het |
| Ankhd1 |
GGCGGC |
GGCGGCAGCGGC |
18: 36,693,965 (GRCm39) |
|
probably benign |
Het |
| Blm |
CCTCCTCC |
CCTCCTCCTCCTACTCCTCC |
7: 80,162,674 (GRCm39) |
|
probably null |
Het |
| Btnl10 |
CAAA |
CAAAAAA |
11: 58,814,752 (GRCm39) |
|
probably benign |
Het |
| Ccdc81 |
C |
A |
7: 89,515,906 (GRCm39) |
|
probably null |
Het |
| Cd209g |
A |
G |
8: 4,187,398 (GRCm39) |
Y194C |
probably benign |
Het |
| Cenpc1 |
A |
T |
5: 86,193,228 (GRCm39) |
S220R |
possibly damaging |
Het |
| Ddx42 |
A |
T |
11: 106,123,630 (GRCm39) |
|
probably null |
Het |
| Dock4 |
GTGCCGGTGCCCGT |
G |
12: 40,894,398 (GRCm39) |
|
probably null |
Het |
| Eif5b |
A |
T |
1: 38,060,673 (GRCm39) |
|
probably null |
Het |
| Ell2 |
C |
A |
13: 75,911,727 (GRCm39) |
H338N |
probably damaging |
Het |
| Entpd2 |
CTT |
CTTT |
2: 25,290,907 (GRCm39) |
|
probably null |
Het |
| Flywch1 |
CCACTCCTGGTGT |
CCACTCCTGGTGTGGGGAGGCTACGTACTCACGCACTCCTGGTGT |
17: 23,981,140 (GRCm39) |
|
probably null |
Het |
| Gm8369 |
GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG |
GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG |
19: 11,489,106 (GRCm39) |
|
probably null |
Het |
| Gnat2 |
T |
C |
3: 108,003,645 (GRCm39) |
S107P |
unknown |
Het |
| Guk1 |
T |
A |
11: 59,077,234 (GRCm39) |
D70V |
probably benign |
Het |
| Itpkb |
C |
T |
1: 180,160,887 (GRCm39) |
R338W |
probably damaging |
Het |
| Krtap28-10 |
ACCACAGCCACAGCCACCACAGCCACAGCC |
ACCACAGCCACAGCCCCCACAGCCACAGCCACCACAGCCACAGCC |
1: 83,019,974 (GRCm39) |
|
probably benign |
Het |
| Lamp3 |
A |
C |
16: 19,520,000 (GRCm39) |
I61R |
probably benign |
Het |
| Lrch1 |
GCTGGTGGTGT |
G |
14: 75,184,995 (GRCm39) |
|
probably null |
Het |
| Lrp1b |
C |
T |
2: 41,000,919 (GRCm39) |
E2216K |
|
Het |
| Lrrc27 |
A |
G |
7: 138,806,016 (GRCm39) |
D227G |
probably benign |
Het |
| Lrrk1 |
C |
T |
7: 66,031,250 (GRCm39) |
G16E |
possibly damaging |
Het |
| Lrrtm1 |
T |
A |
6: 77,221,334 (GRCm39) |
S264T |
possibly damaging |
Het |
| Lypd8 |
CCAATCACCAACA |
CCAATCACCAACAGTTTCCTCGCCTCTGTTACCCCACCAATCACCAACA |
11: 58,281,058 (GRCm39) |
|
probably benign |
Het |
| Mamld1 |
CAG |
CAGAAG |
X: 70,162,455 (GRCm39) |
|
probably benign |
Het |
| Mpo |
G |
C |
11: 87,688,465 (GRCm39) |
A375P |
probably damaging |
Het |
| Myo9a |
A |
G |
9: 59,776,869 (GRCm39) |
H1089R |
probably benign |
Het |
| Nalf2 |
CGCCGC |
CGCCGCTGCCGC |
X: 98,864,967 (GRCm39) |
|
probably benign |
Het |
| Ndufc2 |
T |
C |
7: 97,056,228 (GRCm39) |
*109Q |
probably null |
Het |
| Nudt16 |
A |
T |
9: 105,008,898 (GRCm39) |
Y28N |
probably damaging |
Het |
| Nudt4 |
A |
T |
10: 95,385,675 (GRCm39) |
|
probably null |
Het |
| Nusap1 |
AGATACACGTTAGCAGTGAGGAGCAAGCTG |
AGATACACGTTAGCAGTGAGGAGCAAGCTGCGATACACGTTAGCAGTGAGGAGCAAGCTG |
2: 119,458,059 (GRCm39) |
|
probably benign |
Het |
| Or2ag15 |
T |
A |
7: 106,340,692 (GRCm39) |
I150F |
probably benign |
Het |
| P2ry12 |
T |
A |
3: 59,124,833 (GRCm39) |
T281S |
probably benign |
Het |
| P4ha2 |
TGTTGG |
T |
11: 54,001,072 (GRCm39) |
|
probably null |
Het |
| Pcnx2 |
A |
G |
8: 126,604,258 (GRCm39) |
V666A |
probably damaging |
Het |
| Pde6a |
T |
A |
18: 61,364,475 (GRCm39) |
I177N |
possibly damaging |
Het |
| Pgm1 |
A |
T |
4: 99,819,500 (GRCm39) |
|
probably null |
Het |
| Plce1 |
T |
A |
19: 38,705,651 (GRCm39) |
W1019R |
probably damaging |
Het |
| Plch1 |
C |
A |
3: 63,628,636 (GRCm39) |
K542N |
probably damaging |
Het |
| Plekhj1 |
T |
C |
10: 80,632,471 (GRCm39) |
Q113R |
not run |
Het |
| Postn |
A |
T |
3: 54,291,913 (GRCm39) |
I705F |
probably damaging |
Het |
| Ppp1r15b |
G |
T |
1: 133,059,352 (GRCm39) |
|
probably benign |
Het |
| Prkab1 |
T |
C |
5: 116,159,689 (GRCm39) |
E59G |
probably damaging |
Het |
| Qrfprl |
T |
A |
6: 65,433,174 (GRCm39) |
Y331* |
probably null |
Het |
| Raph1 |
GG |
GGGGG |
1: 60,528,426 (GRCm39) |
|
probably benign |
Het |
| Rassf6 |
AGCAATGGGGATTC |
AGCAATGGGGATTCTGCCTCACTCATGGTCCTGTAGCGCAATGGGGATTC |
5: 90,756,788 (GRCm39) |
|
probably benign |
Het |
| Rnf144a |
TCTC |
TCTCTCTCTCTCTCTCACTC |
12: 26,364,013 (GRCm39) |
|
probably benign |
Het |
| Ros1 |
T |
A |
10: 52,031,217 (GRCm39) |
M484L |
probably benign |
Het |
| Rpa1 |
GCTGCTGCC |
GC |
11: 75,209,343 (GRCm39) |
|
probably null |
Het |
| Sectm1b |
A |
G |
11: 120,945,756 (GRCm39) |
V195A |
probably benign |
Het |
| Sirpa |
TCATCAG |
T |
2: 129,451,123 (GRCm39) |
|
probably null |
Het |
| Slc28a1 |
T |
A |
7: 80,819,032 (GRCm39) |
|
probably null |
Het |
| Sphk1 |
G |
C |
11: 116,425,771 (GRCm39) |
S42T |
possibly damaging |
Het |
| Spta1 |
T |
C |
1: 174,036,885 (GRCm39) |
L1132P |
probably damaging |
Het |
| Srrt |
A |
T |
5: 137,298,262 (GRCm39) |
N303K |
probably benign |
Het |
| Ssh2 |
A |
G |
11: 77,344,880 (GRCm39) |
E955G |
probably damaging |
Het |
| Strn |
CCAGTC |
CCAGTCCGTGCTCCCTTACCCCAGTCCGTGCTCCCTTACCACAGTC |
17: 78,984,712 (GRCm39) |
|
probably null |
Het |
| Tchhl1 |
T |
C |
3: 93,377,691 (GRCm39) |
F132L |
probably benign |
Het |
| Tex14 |
A |
G |
11: 87,405,572 (GRCm39) |
E828G |
probably benign |
Het |
| Tfeb |
CAG |
CAGGAG |
17: 48,097,020 (GRCm39) |
|
probably benign |
Het |
| Tmtc1 |
T |
C |
6: 148,149,009 (GRCm39) |
Y699C |
probably damaging |
Het |
| Ubn1 |
A |
G |
16: 4,882,256 (GRCm39) |
Y239C |
probably damaging |
Het |
| Vmn2r23 |
T |
G |
6: 123,690,075 (GRCm39) |
L317R |
probably benign |
Het |
| Vmn2r78 |
C |
T |
7: 86,603,639 (GRCm39) |
R606* |
probably null |
Het |
| Vps72 |
T |
G |
3: 95,028,719 (GRCm39) |
|
probably null |
Het |
| Zc3h11a |
A |
G |
1: 133,554,853 (GRCm39) |
S376P |
possibly damaging |
Het |
| Zfp384 |
GCCCAGGC |
GCCCAGGCCCAGTCCCAGGC |
6: 125,013,452 (GRCm39) |
|
probably benign |
Het |
| Zfp598 |
CAACCAC |
CAACCACAACCAC |
17: 24,899,745 (GRCm39) |
|
probably benign |
Het |
| Zfp628 |
TACTCCTCCACCC |
T |
7: 4,923,948 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Anks1b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01669:Anks1b
|
APN |
10 |
90,733,100 (GRCm39) |
splice site |
probably benign |
|
|
IGL01890:Anks1b
|
APN |
10 |
90,480,389 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL01966:Anks1b
|
APN |
10 |
90,730,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02176:Anks1b
|
APN |
10 |
89,878,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02205:Anks1b
|
APN |
10 |
89,906,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02465:Anks1b
|
APN |
10 |
89,999,127 (GRCm39) |
nonsense |
probably null |
|
|
IGL02534:Anks1b
|
APN |
10 |
90,730,979 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL02554:Anks1b
|
APN |
10 |
90,757,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02820:Anks1b
|
APN |
10 |
89,912,921 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03164:Anks1b
|
APN |
10 |
89,878,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0096:Anks1b
|
UTSW |
10 |
89,909,924 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0096:Anks1b
|
UTSW |
10 |
89,909,924 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0482:Anks1b
|
UTSW |
10 |
90,195,057 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0542:Anks1b
|
UTSW |
10 |
89,909,829 (GRCm39) |
splice site |
probably benign |
|
|
R0848:Anks1b
|
UTSW |
10 |
89,906,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1056:Anks1b
|
UTSW |
10 |
90,757,291 (GRCm39) |
splice site |
probably null |
|
|
R1398:Anks1b
|
UTSW |
10 |
89,885,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1446:Anks1b
|
UTSW |
10 |
90,346,935 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1548:Anks1b
|
UTSW |
10 |
89,885,847 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1551:Anks1b
|
UTSW |
10 |
89,912,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1607:Anks1b
|
UTSW |
10 |
89,878,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1667:Anks1b
|
UTSW |
10 |
90,347,046 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1701:Anks1b
|
UTSW |
10 |
89,885,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1843:Anks1b
|
UTSW |
10 |
90,348,751 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1899:Anks1b
|
UTSW |
10 |
90,096,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1957:Anks1b
|
UTSW |
10 |
89,885,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2036:Anks1b
|
UTSW |
10 |
90,805,715 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2279:Anks1b
|
UTSW |
10 |
89,885,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2280:Anks1b
|
UTSW |
10 |
90,802,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2937:Anks1b
|
UTSW |
10 |
89,912,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3739:Anks1b
|
UTSW |
10 |
89,869,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4061:Anks1b
|
UTSW |
10 |
90,143,484 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4459:Anks1b
|
UTSW |
10 |
90,346,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4479:Anks1b
|
UTSW |
10 |
89,885,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4510:Anks1b
|
UTSW |
10 |
90,346,652 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4511:Anks1b
|
UTSW |
10 |
90,346,652 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4780:Anks1b
|
UTSW |
10 |
89,709,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4785:Anks1b
|
UTSW |
10 |
90,750,612 (GRCm39) |
missense |
probably null |
0.88 |
|
R4790:Anks1b
|
UTSW |
10 |
89,999,137 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5012:Anks1b
|
UTSW |
10 |
90,194,999 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5400:Anks1b
|
UTSW |
10 |
90,348,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5586:Anks1b
|
UTSW |
10 |
89,912,926 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5687:Anks1b
|
UTSW |
10 |
90,750,573 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5899:Anks1b
|
UTSW |
10 |
90,759,379 (GRCm39) |
splice site |
probably null |
|
|
R5917:Anks1b
|
UTSW |
10 |
90,412,803 (GRCm39) |
intron |
probably benign |
|
|
R5999:Anks1b
|
UTSW |
10 |
90,194,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6080:Anks1b
|
UTSW |
10 |
90,802,211 (GRCm39) |
nonsense |
probably null |
|
|
R6216:Anks1b
|
UTSW |
10 |
90,096,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6265:Anks1b
|
UTSW |
10 |
90,777,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6298:Anks1b
|
UTSW |
10 |
90,516,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6337:Anks1b
|
UTSW |
10 |
90,757,158 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6522:Anks1b
|
UTSW |
10 |
90,733,189 (GRCm39) |
intron |
probably benign |
|
|
R6843:Anks1b
|
UTSW |
10 |
90,784,460 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6852:Anks1b
|
UTSW |
10 |
90,096,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6933:Anks1b
|
UTSW |
10 |
89,905,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7114:Anks1b
|
UTSW |
10 |
90,143,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7211:Anks1b
|
UTSW |
10 |
90,346,932 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7241:Anks1b
|
UTSW |
10 |
90,348,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7264:Anks1b
|
UTSW |
10 |
90,348,732 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7325:Anks1b
|
UTSW |
10 |
90,777,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7392:Anks1b
|
UTSW |
10 |
90,516,648 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7578:Anks1b
|
UTSW |
10 |
89,885,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7604:Anks1b
|
UTSW |
10 |
90,096,708 (GRCm39) |
splice site |
probably null |
|
|
R7633:Anks1b
|
UTSW |
10 |
90,784,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7881:Anks1b
|
UTSW |
10 |
90,802,880 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7910:Anks1b
|
UTSW |
10 |
90,516,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7941:Anks1b
|
UTSW |
10 |
90,413,017 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8045:Anks1b
|
UTSW |
10 |
90,516,722 (GRCm39) |
missense |
probably benign |
|
|
R8146:Anks1b
|
UTSW |
10 |
90,143,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8176:Anks1b
|
UTSW |
10 |
89,905,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8535:Anks1b
|
UTSW |
10 |
90,784,493 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8681:Anks1b
|
UTSW |
10 |
89,885,868 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9300:Anks1b
|
UTSW |
10 |
90,412,966 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9469:Anks1b
|
UTSW |
10 |
90,733,205 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R9541:Anks1b
|
UTSW |
10 |
90,412,947 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9550:Anks1b
|
UTSW |
10 |
90,412,360 (GRCm39) |
start codon destroyed |
probably null |
|
|
R9653:Anks1b
|
UTSW |
10 |
90,346,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF004:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF008:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF017:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF023:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0064:Anks1b
|
UTSW |
10 |
90,348,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCTGAAGATGCTGACACTTGC -3'
(R):5'- TCGCTAAATTGCCTACAACCAG -3'
Sequencing Primer
(F):5'- GATGCTGACACTTGCTGTTTAATTTC -3'
(R):5'- CAGAAGGCTGGAGAGATGAG -3'
|
| Posted On |
2019-12-04 |
Incidental Mutation