Incidental Mutation 'RF020:Adgrb2'
| ID |
603780 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrb2
|
| Ensembl Gene |
ENSMUSG00000028782 |
| Gene Name |
adhesion G protein-coupled receptor B2 |
| Synonyms |
Bai2 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
RF020 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
129878663-129916426 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 129903877 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 668
(S668P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112524
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030571]
[ENSMUST00000097868]
[ENSMUST00000106015]
[ENSMUST00000106017]
[ENSMUST00000106018]
[ENSMUST00000120204]
[ENSMUST00000121049]
|
| AlphaFold |
Q8CGM1 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000030571
AA Change: S723P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000030571
Gene: ENSMUSG00000028782
AA Change: S723P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:GAIN
|
600 |
842 |
1.6e-41 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1192 |
1.7e-67 |
PFAM |
|
low complexity region
|
1357 |
1371 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000097868
AA Change: S723P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000095480
Gene: ENSMUSG00000028782
AA Change: S723P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
1.2e-54 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1159 |
2.6e-69 |
PFAM |
|
low complexity region
|
1324 |
1338 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106015
AA Change: S723P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000101636
Gene: ENSMUSG00000028782
AA Change: S723P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
6.4e-55 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1192 |
4.1e-68 |
PFAM |
|
low complexity region
|
1357 |
1371 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106017
AA Change: S723P
PolyPhen 2
Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000101638
Gene: ENSMUSG00000028782
AA Change: S723P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
6.3e-55 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1180 |
4.6e-68 |
PFAM |
|
low complexity region
|
1345 |
1359 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106018
AA Change: S668P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000101639
Gene: ENSMUSG00000028782
AA Change: S668P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
1.86e-13 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
1.1e-54 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1104 |
2.4e-69 |
PFAM |
|
low complexity region
|
1269 |
1283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120204
AA Change: S668P
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000112524
Gene: ENSMUSG00000028782
AA Change: S668P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
8.2e-55 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1104 |
9.6e-70 |
PFAM |
|
low complexity region
|
1269 |
1283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000121049
AA Change: S668P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000112869
Gene: ENSMUSG00000028782
AA Change: S668P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
1.86e-13 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
6.1e-55 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1137 |
3.8e-68 |
PFAM |
|
low complexity region
|
1302 |
1316 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.8%
- 3x: 99.7%
- 10x: 99.3%
- 20x: 98.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
PHENOTYPE: Mice homozygous for disruptions in this gene show a lessening of depression like behavior. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca16 |
A |
G |
7: 120,132,880 (GRCm39) |
K1270E |
possibly damaging |
Het |
| Ahdc1 |
T |
G |
4: 132,791,588 (GRCm39) |
L943R |
possibly damaging |
Het |
| Ank2 |
T |
C |
3: 126,739,125 (GRCm39) |
K2253R |
unknown |
Het |
| Arhgap23 |
T |
C |
11: 97,354,387 (GRCm39) |
S767P |
probably damaging |
Het |
| Arhgef12 |
A |
G |
9: 42,901,285 (GRCm39) |
I839T |
possibly damaging |
Het |
| Begain |
CGCCGC |
CGCCGCGGCCGC |
12: 108,999,350 (GRCm39) |
|
probably benign |
Het |
| Btbd19 |
A |
T |
4: 116,979,472 (GRCm39) |
C116S |
probably damaging |
Het |
| Cbr1 |
C |
T |
16: 93,407,067 (GRCm39) |
A261V |
probably benign |
Het |
| Ccdc137 |
A |
G |
11: 120,349,022 (GRCm39) |
R18G |
probably benign |
Het |
| Cdsn |
AG |
AGACAGGAAGTAGTAGCTCTCAG |
17: 35,865,876 (GRCm39) |
|
probably benign |
Het |
| Celsr3 |
C |
T |
9: 108,726,256 (GRCm39) |
R3162C |
probably benign |
Het |
| Cep350 |
A |
T |
1: 155,791,224 (GRCm39) |
V1300E |
probably benign |
Het |
| Cluh |
G |
GCCAGAT |
11: 74,560,364 (GRCm39) |
|
probably benign |
Het |
| Cmya5 |
G |
T |
13: 93,205,799 (GRCm39) |
Q3357K |
possibly damaging |
Het |
| Col6a2 |
T |
G |
10: 76,442,043 (GRCm39) |
|
probably null |
Het |
| Cyp2j9 |
T |
A |
4: 96,465,889 (GRCm39) |
T315S |
probably damaging |
Het |
| Cyp3a13 |
CATTATT |
CATT |
5: 137,892,525 (GRCm39) |
|
probably null |
Het |
| Dnah6 |
T |
A |
6: 73,095,040 (GRCm39) |
Y2181F |
probably benign |
Het |
| Dnah7b |
A |
G |
1: 46,412,421 (GRCm39) |
D4010G |
possibly damaging |
Het |
| E4f1 |
CCG |
CCGACG |
17: 24,674,169 (GRCm39) |
|
probably benign |
Het |
| Ep300 |
A |
T |
15: 81,470,772 (GRCm39) |
|
probably benign |
Het |
| Fam234a |
A |
G |
17: 26,437,725 (GRCm39) |
V90A |
probably benign |
Het |
| Gab3 |
TCT |
TCTGCT |
X: 74,043,623 (GRCm39) |
|
probably benign |
Het |
| Gal3st1 |
A |
G |
11: 3,948,153 (GRCm39) |
Y120C |
possibly damaging |
Het |
| Garin5a |
GGA |
GGAAGGGTGGATCCTGGATACCTGGGTCTGAGGGAAGA |
7: 44,149,959 (GRCm39) |
|
probably null |
Het |
| Gm5475 |
GTGGAAGGAAAGGT |
G |
15: 100,325,030 (GRCm39) |
|
probably null |
Het |
| Gm6665 |
T |
TC |
18: 31,953,430 (GRCm39) |
|
probably null |
Het |
| Hdlbp |
T |
C |
1: 93,368,456 (GRCm39) |
T8A |
probably benign |
Het |
| Hnrnpa2b1 |
T |
A |
6: 51,443,674 (GRCm39) |
K92N |
probably damaging |
Het |
| Hsdl2 |
GGAGCAGCCACAGCTGCAGGAGAAGCCACAGCTGCAGGAGCAGCCACAGC |
GGAGCAGCCACAGCTGCAGGAGCAGCCACAGCTGCAGGAGAAGCCACAGCTGCAGGAGCAGCCACAGC |
4: 59,610,640 (GRCm39) |
|
probably benign |
Het |
| Klhl10 |
C |
G |
11: 100,332,896 (GRCm39) |
Q14E |
probably benign |
Het |
| Klra2 |
GAAAGAAATCCA |
GAAAGAAATCCAAAGAAATCCA |
6: 131,198,801 (GRCm39) |
|
probably null |
Het |
| Kmt2b |
CC |
CCTCCTGC |
7: 30,285,807 (GRCm39) |
|
probably benign |
Het |
| Krt1c |
A |
G |
15: 101,726,403 (GRCm39) |
I45T |
unknown |
Het |
| Ksr2 |
T |
C |
5: 117,693,283 (GRCm39) |
S244P |
probably benign |
Het |
| Lama5 |
A |
T |
2: 179,837,971 (GRCm39) |
M915K |
probably benign |
Het |
| Lrp1b |
A |
C |
2: 41,660,858 (GRCm39) |
H197Q |
|
Het |
| Lrrc1 |
T |
C |
9: 77,359,913 (GRCm39) |
E293G |
probably damaging |
Het |
| Med12l |
AACA |
AACAACA |
3: 59,183,379 (GRCm39) |
|
probably benign |
Het |
| Mgam |
T |
A |
6: 40,662,243 (GRCm39) |
Y1179N |
probably damaging |
Het |
| Mgat4c |
A |
G |
10: 102,224,928 (GRCm39) |
I381V |
probably benign |
Het |
| Mrgprx1 |
A |
AGAC |
7: 47,671,259 (GRCm39) |
|
probably benign |
Het |
| Myc |
A |
T |
15: 61,857,672 (GRCm39) |
|
probably benign |
Het |
| Nipbl |
A |
G |
15: 8,388,418 (GRCm39) |
S401P |
probably damaging |
Het |
| Nlrp9c |
A |
T |
7: 26,084,649 (GRCm39) |
I310N |
probably benign |
Het |
| Nwd2 |
C |
A |
5: 63,963,066 (GRCm39) |
Y883* |
probably null |
Het |
| Oas1e |
T |
A |
5: 120,932,383 (GRCm39) |
T87S |
possibly damaging |
Het |
| Or10n7-ps1 |
GA |
GATACA |
9: 39,598,049 (GRCm39) |
|
probably null |
Het |
| Or51a5 |
A |
T |
7: 102,771,098 (GRCm39) |
C294S |
probably benign |
Het |
| Or52d3 |
A |
G |
7: 104,229,497 (GRCm39) |
M215V |
probably benign |
Het |
| Or8b38 |
G |
A |
9: 37,972,620 (GRCm39) |
M1I |
probably null |
Het |
| Pappa |
T |
G |
4: 65,123,282 (GRCm39) |
S872R |
possibly damaging |
Het |
| Parp4 |
T |
C |
14: 56,884,806 (GRCm39) |
L1295P |
unknown |
Het |
| Pcdh15 |
A |
T |
10: 74,021,242 (GRCm39) |
Y152F |
probably damaging |
Het |
| Pdk1 |
A |
T |
2: 71,714,240 (GRCm39) |
I217L |
possibly damaging |
Het |
| Phldb1 |
A |
C |
9: 44,609,243 (GRCm39) |
C450W |
probably damaging |
Het |
| Pnma8a |
C |
CCATGATGCACCTGCTTCAACATCA |
7: 16,695,376 (GRCm39) |
|
probably benign |
Het |
| Prl2c5 |
G |
A |
13: 13,360,497 (GRCm39) |
G55S |
probably benign |
Het |
| Psme2b |
A |
T |
11: 48,836,397 (GRCm39) |
H183Q |
probably damaging |
Het |
| Ptms |
CCTCCTC |
CCTCCTCCTC |
6: 124,891,412 (GRCm39) |
|
probably benign |
Het |
| Rln3 |
T |
C |
8: 84,769,931 (GRCm39) |
T73A |
probably benign |
Het |
| Rprd1a |
T |
A |
18: 24,663,062 (GRCm39) |
Q21L |
probably damaging |
Het |
| Septin3 |
A |
T |
15: 82,168,662 (GRCm39) |
D155V |
probably damaging |
Het |
| Sh3rf3 |
T |
A |
10: 58,649,590 (GRCm39) |
V65E |
probably damaging |
Het |
| Shank3 |
A |
G |
15: 89,384,593 (GRCm39) |
N155S |
probably benign |
Het |
| Shox2 |
G |
T |
3: 66,881,146 (GRCm39) |
P278Q |
probably damaging |
Het |
| Slc1a1 |
T |
C |
19: 28,856,555 (GRCm39) |
|
probably null |
Het |
| Slc39a10 |
A |
T |
1: 46,849,175 (GRCm39) |
F814I |
probably damaging |
Het |
| Slc5a1 |
T |
C |
5: 33,290,773 (GRCm39) |
I119T |
probably damaging |
Het |
| Slc6a13 |
T |
C |
6: 121,301,310 (GRCm39) |
|
probably null |
Het |
| Spmap2l |
CAGCGATCCTCCCCAGTCCCGCAAGGC |
CAGCGATCCTCCCCAGTCCCGCAAGGCGAGCGATCCTCCCCAGTCCCGCAAGGC |
5: 77,164,247 (GRCm39) |
|
probably benign |
Het |
| Spta1 |
A |
G |
1: 174,041,010 (GRCm39) |
D1270G |
probably benign |
Het |
| Spta1 |
T |
A |
1: 174,045,469 (GRCm39) |
F1542L |
probably damaging |
Het |
| Tacc3 |
T |
A |
5: 33,818,568 (GRCm39) |
M1K |
probably null |
Het |
| Tax1bp1 |
T |
C |
6: 52,698,339 (GRCm39) |
V17A |
probably damaging |
Het |
| Tmem156 |
T |
A |
5: 65,248,890 (GRCm39) |
E3D |
probably benign |
Het |
| Tmem209 |
T |
A |
6: 30,487,417 (GRCm39) |
M530L |
probably benign |
Het |
| Trpc2 |
A |
G |
7: 101,745,433 (GRCm39) |
D883G |
unknown |
Het |
| Tsen34 |
GGAGCCAAAAT |
G |
7: 3,698,795 (GRCm39) |
|
probably null |
Het |
| Uhrf2 |
T |
C |
19: 30,063,791 (GRCm39) |
Y585H |
probably damaging |
Het |
| Vmn1r26 |
T |
A |
6: 57,985,705 (GRCm39) |
K161N |
probably benign |
Het |
| Vmn1r29 |
A |
G |
6: 58,284,528 (GRCm39) |
S83G |
probably benign |
Het |
| Vps13b |
G |
T |
15: 35,925,552 (GRCm39) |
W3829L |
probably null |
Het |
| Vwce |
G |
A |
19: 10,630,449 (GRCm39) |
G503R |
probably damaging |
Het |
| Zc3h11a |
T |
C |
1: 133,554,735 (GRCm39) |
E415G |
possibly damaging |
Het |
| Zc3h14 |
T |
A |
12: 98,746,541 (GRCm39) |
|
probably null |
Het |
| Zfp119b |
A |
T |
17: 56,246,499 (GRCm39) |
M229K |
probably benign |
Het |
| Zfp384 |
CCAAGCTCAAGC |
CCAAGC |
6: 125,013,418 (GRCm39) |
|
probably benign |
Het |
| Zfp384 |
GGCCCAGGC |
GGCCCAGGCCCACGCCCAGGC |
6: 125,013,451 (GRCm39) |
|
probably benign |
Het |
| Zyx |
T |
A |
6: 42,334,330 (GRCm39) |
L518Q |
probably damaging |
Het |
|
| Other mutations in Adgrb2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00309:Adgrb2
|
APN |
4 |
129,912,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00425:Adgrb2
|
APN |
4 |
129,912,865 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL00490:Adgrb2
|
APN |
4 |
129,905,665 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL00928:Adgrb2
|
APN |
4 |
129,886,096 (GRCm39) |
missense |
probably benign |
|
|
IGL01353:Adgrb2
|
APN |
4 |
129,906,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01521:Adgrb2
|
APN |
4 |
129,886,085 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01590:Adgrb2
|
APN |
4 |
129,907,606 (GRCm39) |
splice site |
probably benign |
|
|
IGL01813:Adgrb2
|
APN |
4 |
129,906,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01831:Adgrb2
|
APN |
4 |
129,903,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01939:Adgrb2
|
APN |
4 |
129,885,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01960:Adgrb2
|
APN |
4 |
129,906,177 (GRCm39) |
splice site |
probably benign |
|
|
IGL01993:Adgrb2
|
APN |
4 |
129,912,635 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02646:Adgrb2
|
APN |
4 |
129,913,075 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02655:Adgrb2
|
APN |
4 |
129,885,972 (GRCm39) |
nonsense |
probably null |
|
|
IGL02695:Adgrb2
|
APN |
4 |
129,912,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02998:Adgrb2
|
APN |
4 |
129,912,862 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL03372:Adgrb2
|
APN |
4 |
129,911,362 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0098:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0206:Adgrb2
|
UTSW |
4 |
129,886,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0311:Adgrb2
|
UTSW |
4 |
129,910,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0380:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0382:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0492:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0544:Adgrb2
|
UTSW |
4 |
129,911,335 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0965:Adgrb2
|
UTSW |
4 |
129,886,209 (GRCm39) |
small deletion |
probably benign |
|
|
R1458:Adgrb2
|
UTSW |
4 |
129,908,384 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1601:Adgrb2
|
UTSW |
4 |
129,886,630 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1711:Adgrb2
|
UTSW |
4 |
129,886,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1758:Adgrb2
|
UTSW |
4 |
129,905,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1783:Adgrb2
|
UTSW |
4 |
129,903,098 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1827:Adgrb2
|
UTSW |
4 |
129,906,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Adgrb2
|
UTSW |
4 |
129,904,024 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1881:Adgrb2
|
UTSW |
4 |
129,904,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1894:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2275:Adgrb2
|
UTSW |
4 |
129,900,647 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2926:Adgrb2
|
UTSW |
4 |
129,902,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4472:Adgrb2
|
UTSW |
4 |
129,902,146 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4490:Adgrb2
|
UTSW |
4 |
129,906,121 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4499:Adgrb2
|
UTSW |
4 |
129,886,454 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4758:Adgrb2
|
UTSW |
4 |
129,903,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4900:Adgrb2
|
UTSW |
4 |
129,907,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4904:Adgrb2
|
UTSW |
4 |
129,906,332 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4922:Adgrb2
|
UTSW |
4 |
129,901,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Adgrb2
|
UTSW |
4 |
129,915,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5331:Adgrb2
|
UTSW |
4 |
129,915,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5550:Adgrb2
|
UTSW |
4 |
129,908,727 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5995:Adgrb2
|
UTSW |
4 |
129,910,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6047:Adgrb2
|
UTSW |
4 |
129,912,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6534:Adgrb2
|
UTSW |
4 |
129,916,012 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6565:Adgrb2
|
UTSW |
4 |
129,913,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6813:Adgrb2
|
UTSW |
4 |
129,903,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6963:Adgrb2
|
UTSW |
4 |
129,908,155 (GRCm39) |
frame shift |
probably null |
|
|
R6966:Adgrb2
|
UTSW |
4 |
129,908,155 (GRCm39) |
frame shift |
probably null |
|
|
R7197:Adgrb2
|
UTSW |
4 |
129,903,315 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7409:Adgrb2
|
UTSW |
4 |
129,912,862 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7451:Adgrb2
|
UTSW |
4 |
129,908,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7453:Adgrb2
|
UTSW |
4 |
129,908,430 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7461:Adgrb2
|
UTSW |
4 |
129,915,006 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R7511:Adgrb2
|
UTSW |
4 |
129,915,904 (GRCm39) |
missense |
probably benign |
|
|
R7613:Adgrb2
|
UTSW |
4 |
129,915,006 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R7729:Adgrb2
|
UTSW |
4 |
129,885,917 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7818:Adgrb2
|
UTSW |
4 |
129,908,353 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7818:Adgrb2
|
UTSW |
4 |
129,908,762 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8033:Adgrb2
|
UTSW |
4 |
129,912,805 (GRCm39) |
missense |
probably benign |
|
|
R8039:Adgrb2
|
UTSW |
4 |
129,916,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8097:Adgrb2
|
UTSW |
4 |
129,901,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8256:Adgrb2
|
UTSW |
4 |
129,901,921 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8425:Adgrb2
|
UTSW |
4 |
129,898,850 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8804:Adgrb2
|
UTSW |
4 |
129,899,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9011:Adgrb2
|
UTSW |
4 |
129,916,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9018:Adgrb2
|
UTSW |
4 |
129,907,659 (GRCm39) |
missense |
probably benign |
0.34 |
|
R9102:Adgrb2
|
UTSW |
4 |
129,912,802 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9113:Adgrb2
|
UTSW |
4 |
129,910,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9120:Adgrb2
|
UTSW |
4 |
129,906,302 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R9211:Adgrb2
|
UTSW |
4 |
129,886,199 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9267:Adgrb2
|
UTSW |
4 |
129,885,901 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9328:Adgrb2
|
UTSW |
4 |
129,915,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9470:Adgrb2
|
UTSW |
4 |
129,903,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9608:Adgrb2
|
UTSW |
4 |
129,907,352 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Adgrb2
|
UTSW |
4 |
129,911,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Adgrb2
|
UTSW |
4 |
129,912,912 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Adgrb2
|
UTSW |
4 |
129,905,619 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCTGAGGGACACTTTGGG -3'
(R):5'- TAGGAGGAGGACTCTTCGGG -3'
Sequencing Primer
(F):5'- AGGGACACTTTGGGTTTGCTC -3'
(R):5'- ACTCTTCGGGGTCAGCTG -3'
|
| Posted On |
2019-12-04 |
Incidental Mutation