Incidental Mutation 'RF020:Arhgef12'
| ID |
603816 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgef12
|
| Ensembl Gene |
ENSMUSG00000059495 |
| Gene Name |
Rho guanine nucleotide exchange factor 12 |
| Synonyms |
2310014B11Rik, LARG |
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.936)
|
| Stock # |
RF020 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
42875138-43017069 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 42901285 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 839
(I839T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126598
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000072767]
[ENSMUST00000165665]
|
| AlphaFold |
Q8R4H2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000072767
AA Change: I838T
PolyPhen 2
Score 0.632 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000072547
Gene: ENSMUSG00000059495
AA Change: I838T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
49 |
64 |
N/A |
INTRINSIC |
|
PDZ
|
80 |
148 |
1.64e-19 |
SMART |
|
coiled coil region
|
196 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
293 |
313 |
N/A |
INTRINSIC |
|
Pfam:RGS-like
|
368 |
558 |
8.6e-87 |
PFAM |
|
low complexity region
|
583 |
596 |
N/A |
INTRINSIC |
|
low complexity region
|
663 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
721 |
733 |
N/A |
INTRINSIC |
|
RhoGEF
|
791 |
976 |
6.35e-66 |
SMART |
|
PH
|
1020 |
1134 |
6.26e-6 |
SMART |
|
low complexity region
|
1256 |
1269 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000165665
AA Change: I839T
PolyPhen 2
Score 0.754 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000126598
Gene: ENSMUSG00000059495
AA Change: I839T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
49 |
64 |
N/A |
INTRINSIC |
|
PDZ
|
80 |
148 |
1.64e-19 |
SMART |
|
coiled coil region
|
196 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
293 |
313 |
N/A |
INTRINSIC |
|
Pfam:RGS-like
|
369 |
559 |
1.6e-88 |
PFAM |
|
low complexity region
|
584 |
597 |
N/A |
INTRINSIC |
|
low complexity region
|
664 |
677 |
N/A |
INTRINSIC |
|
low complexity region
|
722 |
734 |
N/A |
INTRINSIC |
|
RhoGEF
|
792 |
977 |
6.35e-66 |
SMART |
|
PH
|
1021 |
1135 |
6.26e-6 |
SMART |
|
low complexity region
|
1257 |
1270 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.8%
- 3x: 99.7%
- 10x: 99.3%
- 20x: 98.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased sensitivity to certain vasoconstrictors and resistance to salt-induced hypertension. Mice homozygous for a different knock-out allele exhibit partial prenatal lethality. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca16 |
A |
G |
7: 120,132,880 (GRCm39) |
K1270E |
possibly damaging |
Het |
| Adgrb2 |
T |
C |
4: 129,903,877 (GRCm39) |
S668P |
probably damaging |
Het |
| Ahdc1 |
T |
G |
4: 132,791,588 (GRCm39) |
L943R |
possibly damaging |
Het |
| Ank2 |
T |
C |
3: 126,739,125 (GRCm39) |
K2253R |
unknown |
Het |
| Arhgap23 |
T |
C |
11: 97,354,387 (GRCm39) |
S767P |
probably damaging |
Het |
| Begain |
CGCCGC |
CGCCGCGGCCGC |
12: 108,999,350 (GRCm39) |
|
probably benign |
Het |
| Btbd19 |
A |
T |
4: 116,979,472 (GRCm39) |
C116S |
probably damaging |
Het |
| Cbr1 |
C |
T |
16: 93,407,067 (GRCm39) |
A261V |
probably benign |
Het |
| Ccdc137 |
A |
G |
11: 120,349,022 (GRCm39) |
R18G |
probably benign |
Het |
| Cdsn |
AG |
AGACAGGAAGTAGTAGCTCTCAG |
17: 35,865,876 (GRCm39) |
|
probably benign |
Het |
| Celsr3 |
C |
T |
9: 108,726,256 (GRCm39) |
R3162C |
probably benign |
Het |
| Cep350 |
A |
T |
1: 155,791,224 (GRCm39) |
V1300E |
probably benign |
Het |
| Cluh |
G |
GCCAGAT |
11: 74,560,364 (GRCm39) |
|
probably benign |
Het |
| Cmya5 |
G |
T |
13: 93,205,799 (GRCm39) |
Q3357K |
possibly damaging |
Het |
| Col6a2 |
T |
G |
10: 76,442,043 (GRCm39) |
|
probably null |
Het |
| Cyp2j9 |
T |
A |
4: 96,465,889 (GRCm39) |
T315S |
probably damaging |
Het |
| Cyp3a13 |
CATTATT |
CATT |
5: 137,892,525 (GRCm39) |
|
probably null |
Het |
| Dnah6 |
T |
A |
6: 73,095,040 (GRCm39) |
Y2181F |
probably benign |
Het |
| Dnah7b |
A |
G |
1: 46,412,421 (GRCm39) |
D4010G |
possibly damaging |
Het |
| E4f1 |
CCG |
CCGACG |
17: 24,674,169 (GRCm39) |
|
probably benign |
Het |
| Ep300 |
A |
T |
15: 81,470,772 (GRCm39) |
|
probably benign |
Het |
| Fam234a |
A |
G |
17: 26,437,725 (GRCm39) |
V90A |
probably benign |
Het |
| Gab3 |
TCT |
TCTGCT |
X: 74,043,623 (GRCm39) |
|
probably benign |
Het |
| Gal3st1 |
A |
G |
11: 3,948,153 (GRCm39) |
Y120C |
possibly damaging |
Het |
| Garin5a |
GGA |
GGAAGGGTGGATCCTGGATACCTGGGTCTGAGGGAAGA |
7: 44,149,959 (GRCm39) |
|
probably null |
Het |
| Gm5475 |
GTGGAAGGAAAGGT |
G |
15: 100,325,030 (GRCm39) |
|
probably null |
Het |
| Gm6665 |
T |
TC |
18: 31,953,430 (GRCm39) |
|
probably null |
Het |
| Hdlbp |
T |
C |
1: 93,368,456 (GRCm39) |
T8A |
probably benign |
Het |
| Hnrnpa2b1 |
T |
A |
6: 51,443,674 (GRCm39) |
K92N |
probably damaging |
Het |
| Hsdl2 |
GGAGCAGCCACAGCTGCAGGAGAAGCCACAGCTGCAGGAGCAGCCACAGC |
GGAGCAGCCACAGCTGCAGGAGCAGCCACAGCTGCAGGAGAAGCCACAGCTGCAGGAGCAGCCACAGC |
4: 59,610,640 (GRCm39) |
|
probably benign |
Het |
| Klhl10 |
C |
G |
11: 100,332,896 (GRCm39) |
Q14E |
probably benign |
Het |
| Klra2 |
GAAAGAAATCCA |
GAAAGAAATCCAAAGAAATCCA |
6: 131,198,801 (GRCm39) |
|
probably null |
Het |
| Kmt2b |
CC |
CCTCCTGC |
7: 30,285,807 (GRCm39) |
|
probably benign |
Het |
| Krt1c |
A |
G |
15: 101,726,403 (GRCm39) |
I45T |
unknown |
Het |
| Ksr2 |
T |
C |
5: 117,693,283 (GRCm39) |
S244P |
probably benign |
Het |
| Lama5 |
A |
T |
2: 179,837,971 (GRCm39) |
M915K |
probably benign |
Het |
| Lrp1b |
A |
C |
2: 41,660,858 (GRCm39) |
H197Q |
|
Het |
| Lrrc1 |
T |
C |
9: 77,359,913 (GRCm39) |
E293G |
probably damaging |
Het |
| Med12l |
AACA |
AACAACA |
3: 59,183,379 (GRCm39) |
|
probably benign |
Het |
| Mgam |
T |
A |
6: 40,662,243 (GRCm39) |
Y1179N |
probably damaging |
Het |
| Mgat4c |
A |
G |
10: 102,224,928 (GRCm39) |
I381V |
probably benign |
Het |
| Mrgprx1 |
A |
AGAC |
7: 47,671,259 (GRCm39) |
|
probably benign |
Het |
| Myc |
A |
T |
15: 61,857,672 (GRCm39) |
|
probably benign |
Het |
| Nipbl |
A |
G |
15: 8,388,418 (GRCm39) |
S401P |
probably damaging |
Het |
| Nlrp9c |
A |
T |
7: 26,084,649 (GRCm39) |
I310N |
probably benign |
Het |
| Nwd2 |
C |
A |
5: 63,963,066 (GRCm39) |
Y883* |
probably null |
Het |
| Oas1e |
T |
A |
5: 120,932,383 (GRCm39) |
T87S |
possibly damaging |
Het |
| Or10n7-ps1 |
GA |
GATACA |
9: 39,598,049 (GRCm39) |
|
probably null |
Het |
| Or51a5 |
A |
T |
7: 102,771,098 (GRCm39) |
C294S |
probably benign |
Het |
| Or52d3 |
A |
G |
7: 104,229,497 (GRCm39) |
M215V |
probably benign |
Het |
| Or8b38 |
G |
A |
9: 37,972,620 (GRCm39) |
M1I |
probably null |
Het |
| Pappa |
T |
G |
4: 65,123,282 (GRCm39) |
S872R |
possibly damaging |
Het |
| Parp4 |
T |
C |
14: 56,884,806 (GRCm39) |
L1295P |
unknown |
Het |
| Pcdh15 |
A |
T |
10: 74,021,242 (GRCm39) |
Y152F |
probably damaging |
Het |
| Pdk1 |
A |
T |
2: 71,714,240 (GRCm39) |
I217L |
possibly damaging |
Het |
| Phldb1 |
A |
C |
9: 44,609,243 (GRCm39) |
C450W |
probably damaging |
Het |
| Pnma8a |
C |
CCATGATGCACCTGCTTCAACATCA |
7: 16,695,376 (GRCm39) |
|
probably benign |
Het |
| Prl2c5 |
G |
A |
13: 13,360,497 (GRCm39) |
G55S |
probably benign |
Het |
| Psme2b |
A |
T |
11: 48,836,397 (GRCm39) |
H183Q |
probably damaging |
Het |
| Ptms |
CCTCCTC |
CCTCCTCCTC |
6: 124,891,412 (GRCm39) |
|
probably benign |
Het |
| Rln3 |
T |
C |
8: 84,769,931 (GRCm39) |
T73A |
probably benign |
Het |
| Rprd1a |
T |
A |
18: 24,663,062 (GRCm39) |
Q21L |
probably damaging |
Het |
| Septin3 |
A |
T |
15: 82,168,662 (GRCm39) |
D155V |
probably damaging |
Het |
| Sh3rf3 |
T |
A |
10: 58,649,590 (GRCm39) |
V65E |
probably damaging |
Het |
| Shank3 |
A |
G |
15: 89,384,593 (GRCm39) |
N155S |
probably benign |
Het |
| Shox2 |
G |
T |
3: 66,881,146 (GRCm39) |
P278Q |
probably damaging |
Het |
| Slc1a1 |
T |
C |
19: 28,856,555 (GRCm39) |
|
probably null |
Het |
| Slc39a10 |
A |
T |
1: 46,849,175 (GRCm39) |
F814I |
probably damaging |
Het |
| Slc5a1 |
T |
C |
5: 33,290,773 (GRCm39) |
I119T |
probably damaging |
Het |
| Slc6a13 |
T |
C |
6: 121,301,310 (GRCm39) |
|
probably null |
Het |
| Spmap2l |
CAGCGATCCTCCCCAGTCCCGCAAGGC |
CAGCGATCCTCCCCAGTCCCGCAAGGCGAGCGATCCTCCCCAGTCCCGCAAGGC |
5: 77,164,247 (GRCm39) |
|
probably benign |
Het |
| Spta1 |
A |
G |
1: 174,041,010 (GRCm39) |
D1270G |
probably benign |
Het |
| Spta1 |
T |
A |
1: 174,045,469 (GRCm39) |
F1542L |
probably damaging |
Het |
| Tacc3 |
T |
A |
5: 33,818,568 (GRCm39) |
M1K |
probably null |
Het |
| Tax1bp1 |
T |
C |
6: 52,698,339 (GRCm39) |
V17A |
probably damaging |
Het |
| Tmem156 |
T |
A |
5: 65,248,890 (GRCm39) |
E3D |
probably benign |
Het |
| Tmem209 |
T |
A |
6: 30,487,417 (GRCm39) |
M530L |
probably benign |
Het |
| Trpc2 |
A |
G |
7: 101,745,433 (GRCm39) |
D883G |
unknown |
Het |
| Tsen34 |
GGAGCCAAAAT |
G |
7: 3,698,795 (GRCm39) |
|
probably null |
Het |
| Uhrf2 |
T |
C |
19: 30,063,791 (GRCm39) |
Y585H |
probably damaging |
Het |
| Vmn1r26 |
T |
A |
6: 57,985,705 (GRCm39) |
K161N |
probably benign |
Het |
| Vmn1r29 |
A |
G |
6: 58,284,528 (GRCm39) |
S83G |
probably benign |
Het |
| Vps13b |
G |
T |
15: 35,925,552 (GRCm39) |
W3829L |
probably null |
Het |
| Vwce |
G |
A |
19: 10,630,449 (GRCm39) |
G503R |
probably damaging |
Het |
| Zc3h11a |
T |
C |
1: 133,554,735 (GRCm39) |
E415G |
possibly damaging |
Het |
| Zc3h14 |
T |
A |
12: 98,746,541 (GRCm39) |
|
probably null |
Het |
| Zfp119b |
A |
T |
17: 56,246,499 (GRCm39) |
M229K |
probably benign |
Het |
| Zfp384 |
CCAAGCTCAAGC |
CCAAGC |
6: 125,013,418 (GRCm39) |
|
probably benign |
Het |
| Zfp384 |
GGCCCAGGC |
GGCCCAGGCCCACGCCCAGGC |
6: 125,013,451 (GRCm39) |
|
probably benign |
Het |
| Zyx |
T |
A |
6: 42,334,330 (GRCm39) |
L518Q |
probably damaging |
Het |
|
| Other mutations in Arhgef12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00923:Arhgef12
|
APN |
9 |
42,931,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00942:Arhgef12
|
APN |
9 |
42,893,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01529:Arhgef12
|
APN |
9 |
42,901,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01845:Arhgef12
|
APN |
9 |
42,934,137 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL02039:Arhgef12
|
APN |
9 |
42,883,563 (GRCm39) |
missense |
probably benign |
|
|
IGL02135:Arhgef12
|
APN |
9 |
42,883,461 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02272:Arhgef12
|
APN |
9 |
42,912,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02498:Arhgef12
|
APN |
9 |
42,893,339 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02507:Arhgef12
|
APN |
9 |
42,903,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02574:Arhgef12
|
APN |
9 |
42,916,919 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02586:Arhgef12
|
APN |
9 |
42,917,200 (GRCm39) |
nonsense |
probably null |
|
|
IGL02803:Arhgef12
|
APN |
9 |
42,883,324 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02892:Arhgef12
|
APN |
9 |
42,912,268 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02937:Arhgef12
|
APN |
9 |
42,927,216 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02992:Arhgef12
|
APN |
9 |
42,910,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03028:Arhgef12
|
APN |
9 |
42,937,524 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL03146:Arhgef12
|
APN |
9 |
42,885,866 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03193:Arhgef12
|
APN |
9 |
42,903,829 (GRCm39) |
splice site |
probably benign |
|
|
IGL03398:Arhgef12
|
APN |
9 |
42,889,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0019:Arhgef12
|
UTSW |
9 |
42,889,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0143:Arhgef12
|
UTSW |
9 |
42,916,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0211:Arhgef12
|
UTSW |
9 |
42,883,300 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0330:Arhgef12
|
UTSW |
9 |
42,931,982 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0364:Arhgef12
|
UTSW |
9 |
42,929,697 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0426:Arhgef12
|
UTSW |
9 |
42,882,286 (GRCm39) |
splice site |
probably null |
|
|
R0658:Arhgef12
|
UTSW |
9 |
42,893,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0686:Arhgef12
|
UTSW |
9 |
42,904,324 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0693:Arhgef12
|
UTSW |
9 |
42,929,697 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0990:Arhgef12
|
UTSW |
9 |
42,883,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1147:Arhgef12
|
UTSW |
9 |
42,955,552 (GRCm39) |
unclassified |
probably benign |
|
|
R1395:Arhgef12
|
UTSW |
9 |
42,917,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1419:Arhgef12
|
UTSW |
9 |
42,938,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1451:Arhgef12
|
UTSW |
9 |
42,903,874 (GRCm39) |
splice site |
probably benign |
|
|
R1458:Arhgef12
|
UTSW |
9 |
42,900,294 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1654:Arhgef12
|
UTSW |
9 |
42,908,956 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1722:Arhgef12
|
UTSW |
9 |
42,932,013 (GRCm39) |
makesense |
probably null |
|
|
R1773:Arhgef12
|
UTSW |
9 |
42,916,838 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1895:Arhgef12
|
UTSW |
9 |
42,917,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2109:Arhgef12
|
UTSW |
9 |
42,890,768 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R2215:Arhgef12
|
UTSW |
9 |
42,917,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2421:Arhgef12
|
UTSW |
9 |
42,912,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3967:Arhgef12
|
UTSW |
9 |
42,916,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3968:Arhgef12
|
UTSW |
9 |
42,916,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3969:Arhgef12
|
UTSW |
9 |
42,916,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4077:Arhgef12
|
UTSW |
9 |
42,886,588 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4079:Arhgef12
|
UTSW |
9 |
42,886,588 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4111:Arhgef12
|
UTSW |
9 |
42,883,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Arhgef12
|
UTSW |
9 |
42,929,645 (GRCm39) |
nonsense |
probably null |
|
|
R4327:Arhgef12
|
UTSW |
9 |
42,886,525 (GRCm39) |
nonsense |
probably null |
|
|
R4462:Arhgef12
|
UTSW |
9 |
42,893,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4583:Arhgef12
|
UTSW |
9 |
42,888,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4603:Arhgef12
|
UTSW |
9 |
42,921,489 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4650:Arhgef12
|
UTSW |
9 |
42,893,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4741:Arhgef12
|
UTSW |
9 |
42,883,449 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R4823:Arhgef12
|
UTSW |
9 |
42,931,992 (GRCm39) |
missense |
probably benign |
|
|
R4840:Arhgef12
|
UTSW |
9 |
42,886,364 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4912:Arhgef12
|
UTSW |
9 |
42,904,361 (GRCm39) |
nonsense |
probably null |
|
|
R5176:Arhgef12
|
UTSW |
9 |
42,931,982 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5426:Arhgef12
|
UTSW |
9 |
42,897,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5579:Arhgef12
|
UTSW |
9 |
42,921,489 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5838:Arhgef12
|
UTSW |
9 |
42,916,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6230:Arhgef12
|
UTSW |
9 |
42,900,261 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6741:Arhgef12
|
UTSW |
9 |
42,883,503 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6959:Arhgef12
|
UTSW |
9 |
42,927,249 (GRCm39) |
missense |
probably benign |
|
|
R7252:Arhgef12
|
UTSW |
9 |
42,927,205 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7470:Arhgef12
|
UTSW |
9 |
42,951,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7658:Arhgef12
|
UTSW |
9 |
42,903,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7724:Arhgef12
|
UTSW |
9 |
42,938,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7980:Arhgef12
|
UTSW |
9 |
42,882,595 (GRCm39) |
nonsense |
probably null |
|
|
R8074:Arhgef12
|
UTSW |
9 |
42,882,399 (GRCm39) |
nonsense |
probably null |
|
|
R8155:Arhgef12
|
UTSW |
9 |
42,953,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8270:Arhgef12
|
UTSW |
9 |
42,882,354 (GRCm39) |
missense |
probably benign |
|
|
R8407:Arhgef12
|
UTSW |
9 |
42,937,475 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8527:Arhgef12
|
UTSW |
9 |
42,908,944 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9116:Arhgef12
|
UTSW |
9 |
42,893,241 (GRCm39) |
splice site |
probably benign |
|
|
R9127:Arhgef12
|
UTSW |
9 |
42,885,870 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9602:Arhgef12
|
UTSW |
9 |
42,895,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9665:Arhgef12
|
UTSW |
9 |
42,929,650 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9733:Arhgef12
|
UTSW |
9 |
42,901,294 (GRCm39) |
nonsense |
probably null |
|
|
R9735:Arhgef12
|
UTSW |
9 |
42,882,399 (GRCm39) |
nonsense |
probably null |
|
|
R9760:Arhgef12
|
UTSW |
9 |
42,903,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Arhgef12
|
UTSW |
9 |
42,882,368 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1186:Arhgef12
|
UTSW |
9 |
42,911,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCCATATGTATATAAAAGGCCAC -3'
(R):5'- GGTCCCATGGAATGAGTCTAAATAAAG -3'
Sequencing Primer
(F):5'- GGCCACTTGTATACAAAAAGTAAGAC -3'
(R):5'- AAAGCAACATTCTGTACCTCCTTTTC -3'
|
| Posted On |
2019-12-04 |
Incidental Mutation