Mutagenetix > Incidental Mutation

Incidental Mutation 'RF020:Celsr3'

603819

Institutional Source

Beutler Lab

Gene Symbol

Celsr3

Ensembl Gene

ENSMUSG00000023473

Gene Name

cadherin, EGF LAG seven-pass G-type receptor 3

Synonyms

Fmi1, flamingo

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

RF020 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

108826320-108852969 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 108849057 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Cysteine at position 3162 (R3162C)

Ref Sequence

ENSEMBL: ENSMUSP00000150759 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000024238] [ENSMUST00000098376] [ENSMUST00000192507] [ENSMUST00000192559] [ENSMUST00000193291] [ENSMUST00000194079] [ENSMUST00000213524]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000024238
AA Change: R3154C

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000024238
Gene: ENSMUSG00000023473
AA Change: R3154C

Domain	Start	End	E-Value	Type
signal peptide	1	31	N/A	INTRINSIC
low complexity region	264	293	N/A	INTRINSIC
CA	338	422	2.25e-27	SMART
CA	446	534	5.05e-30	SMART
CA	558	640	7.6e-25	SMART
CA	664	745	7.36e-32	SMART
CA	769	847	5.95e-18	SMART
CA	871	950	5.25e-28	SMART
CA	974	1056	2.67e-29	SMART
CA	1080	1158	1.18e-21	SMART
CA	1186	1262	3.2e-1	SMART
low complexity region	1328	1335	N/A	INTRINSIC
low complexity region	1350	1360	N/A	INTRINSIC
EGF	1369	1424	1.02e-2	SMART
EGF	1429	1464	3.23e0	SMART
EGF	1467	1503	8.78e-2	SMART
LamG	1524	1691	2.27e-35	SMART
EGF	1714	1747	4.22e-4	SMART
LamG	1774	1913	9.02e-21	SMART
EGF	1938	1971	2.43e-4	SMART
EGF	1973	2009	1.3e-4	SMART
EGF_Lam	2066	2111	5.08e-7	SMART
HormR	2114	2176	3.42e-21	SMART
Pfam:GAIN	2188	2441	1.1e-57	PFAM
GPS	2467	2520	7.92e-20	SMART
Pfam:7tm_2	2527	2758	1.5e-56	PFAM
low complexity region	2813	2829	N/A	INTRINSIC
low complexity region	2882	2906	N/A	INTRINSIC
low complexity region	3058	3072	N/A	INTRINSIC
low complexity region	3149	3189	N/A	INTRINSIC
low complexity region	3239	3261	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000098376

SMART Domains

Protein: ENSMUSP00000095979
Gene: ENSMUSG00000023259

Domain	Start	End	E-Value	Type
Pfam:Sulfate_transp	69	458	4.4e-113	PFAM
low complexity region	471	484	N/A	INTRINSIC
PDB:3LLO\|A	489	546	2e-16	PDB
low complexity region	554	593	N/A	INTRINSIC
low complexity region	638	650	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000192507

SMART Domains

Protein: ENSMUSP00000141336
Gene: ENSMUSG00000023259

Domain	Start	End	E-Value	Type
Pfam:Sulfate_tra_GLY	54	137	4.1e-33	PFAM
Pfam:Sulfate_transp	176	454	1.9e-67	PFAM
low complexity region	471	484	N/A	INTRINSIC
PDB:3LLO\|A	489	546	6e-16	PDB
low complexity region	554	593	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000192559

SMART Domains

Protein: ENSMUSP00000141632
Gene: ENSMUSG00000023259

Domain	Start	End	E-Value	Type
Pfam:Sulfate_tra_GLY	54	137	7.7e-34	PFAM
Pfam:Sulfate_transp	176	225	1.8e-5	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000193291

SMART Domains

Protein: ENSMUSP00000142250
Gene: ENSMUSG00000023259

Domain	Start	End	E-Value	Type
Pfam:Sulfate_tra_GLY	54	137	4.1e-33	PFAM
Pfam:Sulfate_transp	176	454	1.9e-67	PFAM
low complexity region	471	484	N/A	INTRINSIC
PDB:3LLO\|A	489	546	6e-16	PDB
low complexity region	554	593	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000194079

SMART Domains

Protein: ENSMUSP00000141789
Gene: ENSMUSG00000023473

Domain	Start	End	E-Value	Type
Pfam:7tm_2	1	185	6.9e-45	PFAM
low complexity region	240	256	N/A	INTRINSIC
low complexity region	309	333	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000213524
AA Change: R3162C

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Coding Region Coverage

1x: 99.8%
3x: 99.7%
10x: 99.3%
20x: 98.5%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality, abnormal neurvous system development, and abnormal respiratory system development. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted, knock-out(2) Targeted, other(2)

Other mutations in this stock

Total: 90 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca16	A	G	7: 120,533,657 (GRCm38)	K1270E	possibly damaging	Het
Adgrb2	T	C	4: 130,010,084 (GRCm38)	S668P	probably damaging	Het
Ahdc1	T	G	4: 133,064,277 (GRCm38)	L943R	possibly damaging	Het
Ank2	T	C	3: 126,945,476 (GRCm38)	K2253R	unknown	Het
Arhgap23	T	C	11: 97,463,561 (GRCm38)	S767P	probably damaging	Het
Arhgef12	A	G	9: 42,989,989 (GRCm38)	I839T	possibly damaging	Het
Begain	CGCCGC	CGCCGCGGCCGC	12: 109,033,424 (GRCm38)		probably benign	Het
Btbd19	A	T	4: 117,122,275 (GRCm38)	C116S	probably damaging	Het
Cbr1	C	T	16: 93,610,179 (GRCm38)	A261V	probably benign	Het
Ccdc137	A	G	11: 120,458,196 (GRCm38)	R18G	probably benign	Het
Cdsn	AG	AGACAGGAAGTAGTAGCTCTCAG	17: 35,554,979 (GRCm38)		probably benign	Het
Cep350	A	T	1: 155,915,478 (GRCm38)	V1300E	probably benign	Het
Cluh	G	GCCAGAT	11: 74,669,538 (GRCm38)		probably benign	Het
Cmya5	G	T	13: 93,069,291 (GRCm38)	Q3357K	possibly damaging	Het
Col6a2	T	G	10: 76,606,209 (GRCm38)		probably null	Het
Cyp2j9	T	A	4: 96,577,652 (GRCm38)	T315S	probably damaging	Het
Cyp3a13	CATTATT	CATT	5: 137,894,263 (GRCm38)		probably null	Het
Dnah6	T	A	6: 73,118,057 (GRCm38)	Y2181F	probably benign	Het
Dnah7b	A	G	1: 46,373,261 (GRCm38)	D4010G	possibly damaging	Het
E4f1	CCG	CCGACG	17: 24,455,195 (GRCm38)		probably benign	Het
Ep300	A	T	15: 81,586,571 (GRCm38)		probably benign	Het
Fam234a	A	G	17: 26,218,751 (GRCm38)	V90A	probably benign	Het
Fam71e1	GGA	GGAAGGGTGGATCCTGGATACCTGGGTCTGAGGGAAGA	7: 44,500,535 (GRCm38)		probably null	Het
Gab3	TCT	TCTGCT	X: 75,000,017 (GRCm38)		probably benign	Het
Gal3st1	A	G	11: 3,998,153 (GRCm38)	Y120C	possibly damaging	Het
Gm5475	GTGGAAGGAAAGGT	G	15: 100,427,149 (GRCm38)		probably null	Het
Gm6665	T	TC	18: 31,820,377 (GRCm38)		probably null	Het
Hdlbp	T	C	1: 93,440,734 (GRCm38)	T8A	probably benign	Het
Hnrnpa2b1	T	A	6: 51,466,694 (GRCm38)	K92N	probably damaging	Het
Hsdl2	GGAGCAGCCACAGCTGCAGGAGAAGCCACAGCTGCAGGAGCAGCCACAGC	GGAGCAGCCACAGCTGCAGGAGCAGCCACAGCTGCAGGAGAAGCCACAGCTGCAGGAGCAGCCACAGC	4: 59,610,640 (GRCm38)		probably benign	Het
Klhl10	C	G	11: 100,442,070 (GRCm38)	Q14E	probably benign	Het
Klra2	GAAAGAAATCCA	GAAAGAAATCCAAAGAAATCCA	6: 131,221,838 (GRCm38)		probably null	Het
Kmt2b	CC	CCTCCTGC	7: 30,586,382 (GRCm38)		probably benign	Het
Krt2	A	G	15: 101,817,968 (GRCm38)	I45T	unknown	Het
Ksr2	T	C	5: 117,555,218 (GRCm38)	S244P	probably benign	Het
Lama5	A	T	2: 180,196,178 (GRCm38)	M915K	probably benign	Het
Lrp1b	A	C	2: 41,770,846 (GRCm38)	H197Q		Het
Lrrc1	T	C	9: 77,452,631 (GRCm38)	E293G	probably damaging	Het
Med12l	AACA	AACAACA	3: 59,275,958 (GRCm38)		probably benign	Het
Mgam	T	A	6: 40,685,309 (GRCm38)	Y1179N	probably damaging	Het
Mgat4c	A	G	10: 102,389,067 (GRCm38)	I381V	probably benign	Het
Mrgprx1	A	AGAC	7: 48,021,511 (GRCm38)		probably benign	Het
Myc	A	T	15: 61,985,823 (GRCm38)		probably benign	Het
Nipbl	A	G	15: 8,358,934 (GRCm38)	S401P	probably damaging	Het
Nlrp9c	A	T	7: 26,385,224 (GRCm38)	I310N	probably benign	Het
Nwd2	C	A	5: 63,805,723 (GRCm38)	Y883*	probably null	Het
Oas1e	T	A	5: 120,794,318 (GRCm38)	T87S	possibly damaging	Het
Olfr586	A	T	7: 103,121,891 (GRCm38)	C294S	probably benign	Het
Olfr653	A	G	7: 104,580,290 (GRCm38)	M215V	probably benign	Het
Olfr885	G	A	9: 38,061,324 (GRCm38)	M1I	probably null	Het
Olfr964-ps1	GA	GATACA	9: 39,686,753 (GRCm38)		probably null	Het
Pappa	T	G	4: 65,205,045 (GRCm38)	S872R	possibly damaging	Het
Parp4	T	C	14: 56,647,349 (GRCm38)	L1295P	unknown	Het
Pcdh15	A	T	10: 74,185,410 (GRCm38)	Y152F	probably damaging	Het
Pdk1	A	T	2: 71,883,896 (GRCm38)	I217L	possibly damaging	Het
Phldb1	A	C	9: 44,697,946 (GRCm38)	C450W	probably damaging	Het
Pnmal1	C	CCATGATGCACCTGCTTCAACATCA	7: 16,961,451 (GRCm38)		probably benign	Het
Prl2c5	G	A	13: 13,185,912 (GRCm38)	G55S	probably benign	Het
Psme2b	A	T	11: 48,945,570 (GRCm38)	H183Q	probably damaging	Het
Ptms	CCTCCTC	CCTCCTCCTC	6: 124,914,449 (GRCm38)		probably benign	Het
Rln3	T	C	8: 84,043,302 (GRCm38)	T73A	probably benign	Het
Rprd1a	T	A	18: 24,530,005 (GRCm38)	Q21L	probably damaging	Het
Sept3	A	T	15: 82,284,461 (GRCm38)	D155V	probably damaging	Het
Sh3rf3	T	A	10: 58,813,768 (GRCm38)	V65E	probably damaging	Het
Shank3	A	G	15: 89,500,390 (GRCm38)	N155S	probably benign	Het
Shox2	G	T	3: 66,973,813 (GRCm38)	P278Q	probably damaging	Het
Slc1a1	T	C	19: 28,879,155 (GRCm38)		probably null	Het
Slc39a10	A	T	1: 46,810,015 (GRCm38)	F814I	probably damaging	Het
Slc5a1	T	C	5: 33,133,429 (GRCm38)	I119T	probably damaging	Het
Slc6a13	T	C	6: 121,324,351 (GRCm38)		probably null	Het
Spta1	A	G	1: 174,213,444 (GRCm38)	D1270G	probably benign	Het
Spta1	T	A	1: 174,217,903 (GRCm38)	F1542L	probably damaging	Het
Tacc3	T	A	5: 33,661,224 (GRCm38)	M1K	probably null	Het
Tax1bp1	T	C	6: 52,721,354 (GRCm38)	V17A	probably damaging	Het
Thegl	CAGCGATCCTCCCCAGTCCCGCAAGGC	CAGCGATCCTCCCCAGTCCCGCAAGGCGAGCGATCCTCCCCAGTCCCGCAAGGC	5: 77,016,400 (GRCm38)		probably benign	Het
Tmem156	T	A	5: 65,091,547 (GRCm38)	E3D	probably benign	Het
Tmem209	T	A	6: 30,487,418 (GRCm38)	M530L	probably benign	Het
Trpc2	A	G	7: 102,096,226 (GRCm38)	D883G	unknown	Het
Tsen34	GGAGCCAAAAT	G	7: 3,695,796 (GRCm38)		probably null	Het
Uhrf2	T	C	19: 30,086,391 (GRCm38)	Y585H	probably damaging	Het
Vmn1r26	T	A	6: 58,008,720 (GRCm38)	K161N	probably benign	Het
Vmn1r29	A	G	6: 58,307,543 (GRCm38)	S83G	probably benign	Het
Vps13b	G	T	15: 35,925,406 (GRCm38)	W3829L	probably null	Het
Vwce	G	A	19: 10,653,085 (GRCm38)	G503R	probably damaging	Het
Zc3h11a	T	C	1: 133,626,997 (GRCm38)	E415G	possibly damaging	Het
Zc3h14	T	A	12: 98,780,282 (GRCm38)		probably null	Het
Zfp119b	A	T	17: 55,939,499 (GRCm38)	M229K	probably benign	Het
Zfp384	GGCCCAGGC	GGCCCAGGCCCACGCCCAGGC	6: 125,036,488 (GRCm38)		probably benign	Het
Zfp384	CCAAGCTCAAGC	CCAAGC	6: 125,036,455 (GRCm38)		probably benign	Het
Zyx	T	A	6: 42,357,396 (GRCm38)	L518Q	probably damaging	Het

Other mutations in Celsr3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00233:Celsr3	APN	9	108,848,925 (GRCm38)	missense	probably damaging	1.00
IGL00536:Celsr3	APN	9	108,829,192 (GRCm38)	missense	probably benign	0.33
IGL00552:Celsr3	APN	9	108,841,263 (GRCm38)	missense	possibly damaging	0.88
IGL00801:Celsr3	APN	9	108,842,576 (GRCm38)	missense	probably benign
IGL01420:Celsr3	APN	9	108,841,190 (GRCm38)	critical splice acceptor site	probably null
IGL01541:Celsr3	APN	9	108,831,708 (GRCm38)	missense	probably damaging	1.00
IGL01619:Celsr3	APN	9	108,834,557 (GRCm38)	missense	probably damaging	1.00
IGL01619:Celsr3	APN	9	108,837,404 (GRCm38)	missense	probably benign	0.00
IGL01631:Celsr3	APN	9	108,837,404 (GRCm38)	missense	probably benign	0.00
IGL01777:Celsr3	APN	9	108,835,942 (GRCm38)	missense	probably benign	0.08
IGL01938:Celsr3	APN	9	108,828,415 (GRCm38)	missense	probably benign	0.34
IGL02135:Celsr3	APN	9	108,827,556 (GRCm38)	missense	probably benign	0.11
IGL02231:Celsr3	APN	9	108,842,510 (GRCm38)	missense	probably damaging	1.00
IGL02234:Celsr3	APN	9	108,829,960 (GRCm38)	missense	probably benign
IGL02392:Celsr3	APN	9	108,834,721 (GRCm38)	splice site	probably benign
IGL02416:Celsr3	APN	9	108,832,119 (GRCm38)	missense	probably damaging	1.00
IGL02421:Celsr3	APN	9	108,840,463 (GRCm38)	missense	probably damaging	1.00
IGL02455:Celsr3	APN	9	108,842,893 (GRCm38)	missense	probably benign	0.15
IGL02798:Celsr3	APN	9	108,843,575 (GRCm38)	missense	probably damaging	1.00
IGL02939:Celsr3	APN	9	108,849,453 (GRCm38)	missense	probably damaging	1.00
IGL02947:Celsr3	APN	9	108,845,935 (GRCm38)	missense	probably benign	0.12
IGL02986:Celsr3	APN	9	108,841,255 (GRCm38)	splice site	probably null
IGL03089:Celsr3	APN	9	108,826,607 (GRCm38)	missense	probably benign	0.04
IGL03162:Celsr3	APN	9	108,842,558 (GRCm38)	missense	probably damaging	1.00
IGL03267:Celsr3	APN	9	108,836,525 (GRCm38)	splice site	probably benign
Diminishment	UTSW	9	108,842,708 (GRCm38)	intron	probably benign
little_d	UTSW	9	108,827,692 (GRCm38)	missense	probably damaging	0.98
nogal	UTSW	9	108,835,838 (GRCm38)	missense	probably benign
F6893:Celsr3	UTSW	9	108,835,067 (GRCm38)	missense	probably benign	0.00
PIT4243001:Celsr3	UTSW	9	108,832,308 (GRCm38)	missense	probably benign	0.13
PIT4810001:Celsr3	UTSW	9	108,845,733 (GRCm38)	missense	probably damaging	1.00
R0110:Celsr3	UTSW	9	108,827,005 (GRCm38)	missense	possibly damaging	0.62
R0243:Celsr3	UTSW	9	108,843,724 (GRCm38)	splice site	probably benign
R0382:Celsr3	UTSW	9	108,829,218 (GRCm38)	missense	probably damaging	1.00
R0482:Celsr3	UTSW	9	108,829,073 (GRCm38)	nonsense	probably null
R0510:Celsr3	UTSW	9	108,827,005 (GRCm38)	missense	possibly damaging	0.62
R0630:Celsr3	UTSW	9	108,827,692 (GRCm38)	missense	probably damaging	0.98
R0656:Celsr3	UTSW	9	108,834,655 (GRCm38)	missense	possibly damaging	0.89
R0764:Celsr3	UTSW	9	108,827,818 (GRCm38)	missense	probably damaging	1.00
R0883:Celsr3	UTSW	9	108,842,633 (GRCm38)	missense	probably damaging	1.00
R0924:Celsr3	UTSW	9	108,846,025 (GRCm38)	missense	possibly damaging	0.78
R1015:Celsr3	UTSW	9	108,833,176 (GRCm38)	missense	probably benign	0.17
R1321:Celsr3	UTSW	9	108,835,870 (GRCm38)	missense	probably damaging	1.00
R1423:Celsr3	UTSW	9	108,826,905 (GRCm38)	missense	probably benign	0.00
R1497:Celsr3	UTSW	9	108,848,865 (GRCm38)	missense	probably benign	0.14
R1520:Celsr3	UTSW	9	108,848,658 (GRCm38)	missense	probably damaging	1.00
R1534:Celsr3	UTSW	9	108,848,884 (GRCm38)	missense	probably damaging	0.99
R1569:Celsr3	UTSW	9	108,829,068 (GRCm38)	missense	probably damaging	1.00
R1657:Celsr3	UTSW	9	108,842,952 (GRCm38)	nonsense	probably null
R1753:Celsr3	UTSW	9	108,831,857 (GRCm38)	missense	probably damaging	0.99
R1764:Celsr3	UTSW	9	108,828,958 (GRCm38)	missense	probably damaging	1.00
R1801:Celsr3	UTSW	9	108,834,626 (GRCm38)	missense	possibly damaging	0.88
R1838:Celsr3	UTSW	9	108,829,906 (GRCm38)	missense	probably benign
R1839:Celsr3	UTSW	9	108,829,906 (GRCm38)	missense	probably benign
R1874:Celsr3	UTSW	9	108,835,838 (GRCm38)	missense	probably benign
R1875:Celsr3	UTSW	9	108,835,838 (GRCm38)	missense	probably benign
R1953:Celsr3	UTSW	9	108,843,182 (GRCm38)	missense	probably benign	0.19
R1960:Celsr3	UTSW	9	108,845,817 (GRCm38)	missense	probably benign
R2113:Celsr3	UTSW	9	108,838,470 (GRCm38)	missense	probably damaging	1.00
R2290:Celsr3	UTSW	9	108,843,224 (GRCm38)	missense	probably damaging	1.00
R2369:Celsr3	UTSW	9	108,842,552 (GRCm38)	missense	probably benign
R2373:Celsr3	UTSW	9	108,842,552 (GRCm38)	missense	probably benign
R2374:Celsr3	UTSW	9	108,842,552 (GRCm38)	missense	probably benign
R2375:Celsr3	UTSW	9	108,842,552 (GRCm38)	missense	probably benign
R2844:Celsr3	UTSW	9	108,829,308 (GRCm38)	missense	probably damaging	1.00
R2968:Celsr3	UTSW	9	108,832,191 (GRCm38)	missense	probably damaging	1.00
R3103:Celsr3	UTSW	9	108,837,139 (GRCm38)	missense	probably benign	0.31
R3159:Celsr3	UTSW	9	108,827,710 (GRCm38)	missense	possibly damaging	0.94
R3791:Celsr3	UTSW	9	108,842,552 (GRCm38)	missense	probably benign
R4194:Celsr3	UTSW	9	108,843,302 (GRCm38)	critical splice donor site	probably null
R4329:Celsr3	UTSW	9	108,846,049 (GRCm38)	missense	probably benign	0.00
R4365:Celsr3	UTSW	9	108,829,847 (GRCm38)	missense	possibly damaging	0.47
R4419:Celsr3	UTSW	9	108,843,244 (GRCm38)	missense	possibly damaging	0.84
R4484:Celsr3	UTSW	9	108,846,063 (GRCm38)	critical splice donor site	probably null
R4582:Celsr3	UTSW	9	108,845,723 (GRCm38)	missense	probably damaging	1.00
R4681:Celsr3	UTSW	9	108,827,754 (GRCm38)	missense	possibly damaging	0.58
R4729:Celsr3	UTSW	9	108,847,652 (GRCm38)	missense	probably benign	0.05
R4881:Celsr3	UTSW	9	108,843,941 (GRCm38)	missense	probably damaging	1.00
R4893:Celsr3	UTSW	9	108,849,421 (GRCm38)	missense	probably damaging	1.00
R5183:Celsr3	UTSW	9	108,837,560 (GRCm38)	missense	probably damaging	0.99
R5207:Celsr3	UTSW	9	108,832,759 (GRCm38)	missense	probably benign	0.01
R5290:Celsr3	UTSW	9	108,843,158 (GRCm38)	missense	probably benign	0.01
R5327:Celsr3	UTSW	9	108,842,708 (GRCm38)	intron	probably benign
R5345:Celsr3	UTSW	9	108,832,124 (GRCm38)	missense	probably damaging	1.00
R5358:Celsr3	UTSW	9	108,832,025 (GRCm38)	missense	possibly damaging	0.96
R5396:Celsr3	UTSW	9	108,828,582 (GRCm38)	missense	probably damaging	1.00
R5414:Celsr3	UTSW	9	108,840,042 (GRCm38)	missense	possibly damaging	0.88
R5452:Celsr3	UTSW	9	108,844,034 (GRCm38)	missense	possibly damaging	0.68
R5467:Celsr3	UTSW	9	108,828,637 (GRCm38)	missense	probably damaging	1.00
R5479:Celsr3	UTSW	9	108,844,544 (GRCm38)	critical splice donor site	probably null
R5629:Celsr3	UTSW	9	108,849,067 (GRCm38)	missense	probably benign	0.41
R5637:Celsr3	UTSW	9	108,837,133 (GRCm38)	missense	probably damaging	1.00
R5652:Celsr3	UTSW	9	108,838,472 (GRCm38)	missense	probably benign	0.03
R5739:Celsr3	UTSW	9	108,827,158 (GRCm38)	missense	probably benign
R5785:Celsr3	UTSW	9	108,827,797 (GRCm38)	missense	probably damaging	1.00
R5877:Celsr3	UTSW	9	108,845,727 (GRCm38)	missense	probably damaging	0.98
R5961:Celsr3	UTSW	9	108,831,794 (GRCm38)	missense	probably damaging	1.00
R6046:Celsr3	UTSW	9	108,837,151 (GRCm38)	missense	probably benign	0.01
R6176:Celsr3	UTSW	9	108,828,355 (GRCm38)	missense	probably damaging	1.00
R6291:Celsr3	UTSW	9	108,828,842 (GRCm38)	missense	probably damaging	1.00
R6468:Celsr3	UTSW	9	108,835,790 (GRCm38)	missense	probably benign	0.08
R6481:Celsr3	UTSW	9	108,837,084 (GRCm38)	missense	possibly damaging	0.92
R6547:Celsr3	UTSW	9	108,829,128 (GRCm38)	missense	probably damaging	1.00
R6763:Celsr3	UTSW	9	108,827,350 (GRCm38)	missense	probably damaging	1.00
R6870:Celsr3	UTSW	9	108,829,191 (GRCm38)	missense	probably benign	0.02
R6977:Celsr3	UTSW	9	108,827,715 (GRCm38)	missense	probably benign
R7061:Celsr3	UTSW	9	108,847,594 (GRCm38)	nonsense	probably null
R7122:Celsr3	UTSW	9	108,828,567 (GRCm38)	missense	possibly damaging	0.90
R7156:Celsr3	UTSW	9	108,838,004 (GRCm38)	missense	possibly damaging	0.95
R7166:Celsr3	UTSW	9	108,842,951 (GRCm38)	missense	probably damaging	1.00
R7176:Celsr3	UTSW	9	108,845,762 (GRCm38)	missense	probably benign
R7213:Celsr3	UTSW	9	108,849,040 (GRCm38)	missense	probably damaging	0.98
R7314:Celsr3	UTSW	9	108,829,144 (GRCm38)	missense	probably damaging	1.00
R7478:Celsr3	UTSW	9	108,843,578 (GRCm38)	missense	probably benign	0.37
R7508:Celsr3	UTSW	9	108,836,622 (GRCm38)	missense	probably benign
R7554:Celsr3	UTSW	9	108,841,209 (GRCm38)	missense	probably benign
R7615:Celsr3	UTSW	9	108,837,652 (GRCm38)	missense	possibly damaging	0.75
R7653:Celsr3	UTSW	9	108,835,070 (GRCm38)	nonsense	probably null
R7747:Celsr3	UTSW	9	108,829,978 (GRCm38)	missense	possibly damaging	0.61
R7881:Celsr3	UTSW	9	108,828,072 (GRCm38)	missense	probably benign	0.28
R7935:Celsr3	UTSW	9	108,829,641 (GRCm38)	missense	probably benign	0.01
R7995:Celsr3	UTSW	9	108,845,083 (GRCm38)	missense	probably damaging	0.99
R8006:Celsr3	UTSW	9	108,829,107 (GRCm38)	missense	probably damaging	1.00
R8077:Celsr3	UTSW	9	108,828,331 (GRCm38)	missense	probably benign	0.15
R8284:Celsr3	UTSW	9	108,846,413 (GRCm38)	missense	probably damaging	0.99
R8291:Celsr3	UTSW	9	108,837,970 (GRCm38)	missense	probably damaging	1.00
R8322:Celsr3	UTSW	9	108,848,794 (GRCm38)	missense	probably damaging	1.00
R8334:Celsr3	UTSW	9	108,841,272 (GRCm38)	frame shift	probably null
R8337:Celsr3	UTSW	9	108,841,272 (GRCm38)	frame shift	probably null
R8338:Celsr3	UTSW	9	108,827,340 (GRCm38)	nonsense	probably null
R8353:Celsr3	UTSW	9	108,826,535 (GRCm38)	missense	probably benign	0.00
R8407:Celsr3	UTSW	9	108,829,057 (GRCm38)	missense	probably damaging	1.00
R8408:Celsr3	UTSW	9	108,831,789 (GRCm38)	missense	probably damaging	1.00
R8459:Celsr3	UTSW	9	108,829,630 (GRCm38)	missense	probably damaging	1.00
R8510:Celsr3	UTSW	9	108,838,120 (GRCm38)	missense	possibly damaging	0.93
R8713:Celsr3	UTSW	9	108,829,863 (GRCm38)	missense	probably benign
R8728:Celsr3	UTSW	9	108,846,741 (GRCm38)	missense	probably benign	0.24
R8829:Celsr3	UTSW	9	108,840,383 (GRCm38)	missense	probably benign
R8877:Celsr3	UTSW	9	108,829,678 (GRCm38)	missense	probably damaging	1.00
R8905:Celsr3	UTSW	9	108,841,302 (GRCm38)	missense	probably damaging	1.00
R9008:Celsr3	UTSW	9	108,828,952 (GRCm38)	missense	possibly damaging	0.94
R9072:Celsr3	UTSW	9	108,827,094 (GRCm38)	missense	probably benign
R9157:Celsr3	UTSW	9	108,829,986 (GRCm38)	missense	probably damaging	1.00
R9183:Celsr3	UTSW	9	108,829,396 (GRCm38)	missense	probably damaging	1.00
R9275:Celsr3	UTSW	9	108,838,490 (GRCm38)	missense	probably benign	0.27
R9361:Celsr3	UTSW	9	108,849,322 (GRCm38)	missense	probably damaging	1.00
R9382:Celsr3	UTSW	9	108,829,762 (GRCm38)	missense	possibly damaging	0.60
R9407:Celsr3	UTSW	9	108,846,397 (GRCm38)	missense	probably damaging	1.00
R9432:Celsr3	UTSW	9	108,848,833 (GRCm38)	missense	probably benign	0.00
R9607:Celsr3	UTSW	9	108,840,502 (GRCm38)	critical splice donor site	probably null
R9626:Celsr3	UTSW	9	108,849,322 (GRCm38)	missense	probably damaging	1.00
R9628:Celsr3	UTSW	9	108,826,360 (GRCm38)	nonsense	probably null
R9630:Celsr3	UTSW	9	108,827,097 (GRCm38)	missense	probably benign
R9645:Celsr3	UTSW	9	108,827,492 (GRCm38)	nonsense	probably null
R9683:Celsr3	UTSW	9	108,827,323 (GRCm38)	missense	probably damaging	1.00
R9794:Celsr3	UTSW	9	108,851,303 (GRCm38)	missense	probably benign	0.00
R9798:Celsr3	UTSW	9	108,828,595 (GRCm38)	missense	probably damaging	1.00
X0018:Celsr3	UTSW	9	108,840,412 (GRCm38)	missense	probably benign	0.01
X0018:Celsr3	UTSW	9	108,827,778 (GRCm38)	missense	possibly damaging	0.65
X0026:Celsr3	UTSW	9	108,828,930 (GRCm38)	missense	probably damaging	0.99
Z1177:Celsr3	UTSW	9	108,826,477 (GRCm38)	missense	probably benign	0.34

Predicted Primers

PCR Primer
(F):5'- AGAAGAGGTCCCAGTTCCTG -3'
(R):5'- AATGTCCAGTTGCTCTGTGGAG -3'

Sequencing Primer
(F):5'- GGTCCCAGTTCCTGCACCTG -3'
(R):5'- TCCTCCCTGGCTCTGAGAAG -3'

Posted On

2019-12-04