Mutagenetix > Incidental Mutations

Incidental Mutation 'RF020:Celsr3'

603819

Institutional Source

Beutler Lab

Gene Symbol

Celsr3

Ensembl Gene

ENSMUSG00000023473

Gene Name

cadherin, EGF LAG seven-pass G-type receptor 3

Synonyms

Fmi1, flamingo

Accession Numbers

Genbank: NM_080437; MGI: 1858236

Is this an essential gene?

Essential (E-score: 1.000) question?

Stock #

RF020 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

108826320-108852969 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 108849057 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Cysteine at position 3162 (R3162C)

Ref Sequence

ENSEMBL: ENSMUSP00000150759 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000024238] [ENSMUST00000098376] [ENSMUST00000192507] [ENSMUST00000192559] [ENSMUST00000193291] [ENSMUST00000194079] [ENSMUST00000213524]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000024238
AA Change: R3154C

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000024238
Gene: ENSMUSG00000023473
AA Change: R3154C

Domain	Start	End	E-Value	Type
signal peptide	1	31	N/A	INTRINSIC
low complexity region	264	293	N/A	INTRINSIC
CA	338	422	2.25e-27	SMART
CA	446	534	5.05e-30	SMART
CA	558	640	7.6e-25	SMART
CA	664	745	7.36e-32	SMART
CA	769	847	5.95e-18	SMART
CA	871	950	5.25e-28	SMART
CA	974	1056	2.67e-29	SMART
CA	1080	1158	1.18e-21	SMART
CA	1186	1262	3.2e-1	SMART
low complexity region	1328	1335	N/A	INTRINSIC
low complexity region	1350	1360	N/A	INTRINSIC
EGF	1369	1424	1.02e-2	SMART
EGF	1429	1464	3.23e0	SMART
EGF	1467	1503	8.78e-2	SMART
LamG	1524	1691	2.27e-35	SMART
EGF	1714	1747	4.22e-4	SMART
LamG	1774	1913	9.02e-21	SMART
EGF	1938	1971	2.43e-4	SMART
EGF	1973	2009	1.3e-4	SMART
EGF_Lam	2066	2111	5.08e-7	SMART
HormR	2114	2176	3.42e-21	SMART
Pfam:GAIN	2188	2441	1.1e-57	PFAM
GPS	2467	2520	7.92e-20	SMART
Pfam:7tm_2	2527	2758	1.5e-56	PFAM
low complexity region	2813	2829	N/A	INTRINSIC
low complexity region	2882	2906	N/A	INTRINSIC
low complexity region	3058	3072	N/A	INTRINSIC
low complexity region	3149	3189	N/A	INTRINSIC
low complexity region	3239	3261	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000098376

SMART Domains

Protein: ENSMUSP00000095979
Gene: ENSMUSG00000023259

Domain	Start	End	E-Value	Type
Pfam:Sulfate_transp	69	458	4.4e-113	PFAM
low complexity region	471	484	N/A	INTRINSIC
PDB:3LLO\|A	489	546	2e-16	PDB
low complexity region	554	593	N/A	INTRINSIC
low complexity region	638	650	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000192507

SMART Domains

Protein: ENSMUSP00000141336
Gene: ENSMUSG00000023259

Domain	Start	End	E-Value	Type
Pfam:Sulfate_tra_GLY	54	137	4.1e-33	PFAM
Pfam:Sulfate_transp	176	454	1.9e-67	PFAM
low complexity region	471	484	N/A	INTRINSIC
PDB:3LLO\|A	489	546	6e-16	PDB
low complexity region	554	593	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000192559

SMART Domains

Protein: ENSMUSP00000141632
Gene: ENSMUSG00000023259

Domain	Start	End	E-Value	Type
Pfam:Sulfate_tra_GLY	54	137	7.7e-34	PFAM
Pfam:Sulfate_transp	176	225	1.8e-5	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000193291

SMART Domains

Protein: ENSMUSP00000142250
Gene: ENSMUSG00000023259

Domain	Start	End	E-Value	Type
Pfam:Sulfate_tra_GLY	54	137	4.1e-33	PFAM
Pfam:Sulfate_transp	176	454	1.9e-67	PFAM
low complexity region	471	484	N/A	INTRINSIC
PDB:3LLO\|A	489	546	6e-16	PDB
low complexity region	554	593	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000194079

SMART Domains

Protein: ENSMUSP00000141789
Gene: ENSMUSG00000023473

Domain	Start	End	E-Value	Type
Pfam:7tm_2	1	185	6.9e-45	PFAM
low complexity region	240	256	N/A	INTRINSIC
low complexity region	309	333	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000213524
AA Change: R3162C

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Coding Region Coverage

1x: 99.8%
3x: 99.7%
10x: 99.3%
20x: 98.5%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality, abnormal neurvous system development, and abnormal respiratory system development. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted, knock-out(2) Targeted, other(2)

Other mutations in this stock

Total: 90 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca16	A	G	7: 120,533,657	K1270E	possibly damaging	Het
Adgrb2	T	C	4: 130,010,084	S668P	probably damaging	Het
Ahdc1	T	G	4: 133,064,277	L943R	possibly damaging	Het
Ank2	T	C	3: 126,945,476	K2253R	unknown	Het
Arhgap23	T	C	11: 97,463,561	S767P	probably damaging	Het
Arhgef12	A	G	9: 42,989,989	I839T	possibly damaging	Het
Begain	CGCCGC	CGCCGCGGCCGC	12: 109,033,424		probably benign	Het
Btbd19	A	T	4: 117,122,275	C116S	probably damaging	Het
Cbr1	C	T	16: 93,610,179	A261V	probably benign	Het
Ccdc137	A	G	11: 120,458,196	R18G	probably benign	Het
Cdsn	AG	AGACAGGAAGTAGTAGCTCTCAG	17: 35,554,979		probably benign	Het
Cep350	A	T	1: 155,915,478	V1300E	probably benign	Het
Cluh	G	GCCAGAT	11: 74,669,538		probably benign	Het
Cmya5	G	T	13: 93,069,291	Q3357K	possibly damaging	Het
Col6a2	T	G	10: 76,606,209		probably null	Het
Cyp2j9	T	A	4: 96,577,652	T315S	probably damaging	Het
Cyp3a13	CATTATT	CATT	5: 137,894,263		probably null	Het
Dnah6	T	A	6: 73,118,057	Y2181F	probably benign	Het
Dnah7b	A	G	1: 46,373,261	D4010G	possibly damaging	Het
E4f1	CCG	CCGACG	17: 24,455,195		probably benign	Het
Ep300	A	T	15: 81,586,571		probably benign	Het
Fam234a	A	G	17: 26,218,751	V90A	probably benign	Het
Fam71e1	GGA	GGAAGGGTGGATCCTGGATACCTGGGTCTGAGGGAAGA	7: 44,500,535		probably null	Het
Gab3	TCT	TCTGCT	X: 75,000,017		probably benign	Het
Gal3st1	A	G	11: 3,998,153	Y120C	possibly damaging	Het
Gm5475	GTGGAAGGAAAGGT	G	15: 100,427,149		probably null	Het
Gm6665	T	TC	18: 31,820,377		probably null	Het
Hdlbp	T	C	1: 93,440,734	T8A	probably benign	Het
Hnrnpa2b1	T	A	6: 51,466,694	K92N	probably damaging	Het
Hsdl2	GGAGCAGCCACAGCTGCAGGAGAAGCCACAGCTGCAGGAGCAGCCACAGC	GGAGCAGCCACAGCTGCAGGAGCAGCCACAGCTGCAGGAGAAGCCACAGCTGCAGGAGCAGCCACAGC	4: 59,610,640		probably benign	Het
Klhl10	C	G	11: 100,442,070	Q14E	probably benign	Het
Klra2	GAAAGAAATCCA	GAAAGAAATCCAAAGAAATCCA	6: 131,221,838		probably null	Het
Kmt2b	CC	CCTCCTGC	7: 30,586,382		probably benign	Het
Krt2	A	G	15: 101,817,968	I45T	unknown	Het
Ksr2	T	C	5: 117,555,218	S244P	probably benign	Het
Lama5	A	T	2: 180,196,178	M915K	probably benign	Het
Lrp1b	A	C	2: 41,770,846	H197Q		Het
Lrrc1	T	C	9: 77,452,631	E293G	probably damaging	Het
Med12l	AACA	AACAACA	3: 59,275,958		probably benign	Het
Mgam	T	A	6: 40,685,309	Y1179N	probably damaging	Het
Mgat4c	A	G	10: 102,389,067	I381V	probably benign	Het
Mrgprx1	A	AGAC	7: 48,021,511		probably benign	Het
Myc	A	T	15: 61,985,823		probably benign	Het
Nipbl	A	G	15: 8,358,934	S401P	probably damaging	Het
Nlrp9c	A	T	7: 26,385,224	I310N	probably benign	Het
Nwd2	C	A	5: 63,805,723	Y883*	probably null	Het
Oas1e	T	A	5: 120,794,318	T87S	possibly damaging	Het
Olfr586	A	T	7: 103,121,891	C294S	probably benign	Het
Olfr653	A	G	7: 104,580,290	M215V	probably benign	Het
Olfr885	G	A	9: 38,061,324	M1I	probably null	Het
Olfr964-ps1	GA	GATACA	9: 39,686,753		probably null	Het
Pappa	T	G	4: 65,205,045	S872R	possibly damaging	Het
Parp4	T	C	14: 56,647,349	L1295P	unknown	Het
Pcdh15	A	T	10: 74,185,410	Y152F	probably damaging	Het
Pdk1	A	T	2: 71,883,896	I217L	possibly damaging	Het
Phldb1	A	C	9: 44,697,946	C450W	probably damaging	Het
Pnmal1	C	CCATGATGCACCTGCTTCAACATCA	7: 16,961,451		probably benign	Het
Prl2c5	G	A	13: 13,185,912	G55S	probably benign	Het
Psme2b	A	T	11: 48,945,570	H183Q	probably damaging	Het
Ptms	CCTCCTC	CCTCCTCCTC	6: 124,914,449		probably benign	Het
Rln3	T	C	8: 84,043,302	T73A	probably benign	Het
Rprd1a	T	A	18: 24,530,005	Q21L	probably damaging	Het
Sept3	A	T	15: 82,284,461	D155V	probably damaging	Het
Sh3rf3	T	A	10: 58,813,768	V65E	probably damaging	Het
Shank3	A	G	15: 89,500,390	N155S	probably benign	Het
Shox2	G	T	3: 66,973,813	P278Q	probably damaging	Het
Slc1a1	T	C	19: 28,879,155		probably null	Het
Slc39a10	A	T	1: 46,810,015	F814I	probably damaging	Het
Slc5a1	T	C	5: 33,133,429	I119T	probably damaging	Het
Slc6a13	T	C	6: 121,324,351		probably null	Het
Spta1	A	G	1: 174,213,444	D1270G	probably benign	Het
Spta1	T	A	1: 174,217,903	F1542L	probably damaging	Het
Tacc3	T	A	5: 33,661,224	M1K	probably null	Het
Tax1bp1	T	C	6: 52,721,354	V17A	probably damaging	Het
Thegl	CAGCGATCCTCCCCAGTCCCGCAAGGC	CAGCGATCCTCCCCAGTCCCGCAAGGCGAGCGATCCTCCCCAGTCCCGCAAGGC	5: 77,016,400		probably benign	Het
Tmem156	T	A	5: 65,091,547	E3D	probably benign	Het
Tmem209	T	A	6: 30,487,418	M530L	probably benign	Het
Trpc2	A	G	7: 102,096,226	D883G	unknown	Het
Tsen34	GGAGCCAAAAT	G	7: 3,695,796		probably null	Het
Uhrf2	T	C	19: 30,086,391	Y585H	probably damaging	Het
Vmn1r26	T	A	6: 58,008,720	K161N	probably benign	Het
Vmn1r29	A	G	6: 58,307,543	S83G	probably benign	Het
Vps13b	G	T	15: 35,925,406	W3829L	probably null	Het
Vwce	G	A	19: 10,653,085	G503R	probably damaging	Het
Zc3h11a	T	C	1: 133,626,997	E415G	possibly damaging	Het
Zc3h14	T	A	12: 98,780,282		probably null	Het
Zfp119b	A	T	17: 55,939,499	M229K	probably benign	Het
Zfp384	CCAAGCTCAAGC	CCAAGC	6: 125,036,455		probably benign	Het
Zfp384	GGCCCAGGC	GGCCCAGGCCCACGCCCAGGC	6: 125,036,488		probably benign	Het
Zyx	T	A	6: 42,357,396	L518Q	probably damaging	Het

Other mutations in Celsr3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00233:Celsr3	APN	9	108848925	missense	probably damaging	1.00
IGL00536:Celsr3	APN	9	108829192	missense	probably benign	0.33
IGL00552:Celsr3	APN	9	108841263	missense	possibly damaging	0.88
IGL00801:Celsr3	APN	9	108842576	missense	probably benign
IGL01420:Celsr3	APN	9	108841190	critical splice acceptor site	probably null
IGL01541:Celsr3	APN	9	108831708	missense	probably damaging	1.00
IGL01619:Celsr3	APN	9	108834557	missense	probably damaging	1.00
IGL01619:Celsr3	APN	9	108837404	missense	probably benign	0.00
IGL01631:Celsr3	APN	9	108837404	missense	probably benign	0.00
IGL01777:Celsr3	APN	9	108835942	missense	probably benign	0.08
IGL01938:Celsr3	APN	9	108828415	missense	probably benign	0.34
IGL02135:Celsr3	APN	9	108827556	missense	probably benign	0.11
IGL02231:Celsr3	APN	9	108842510	missense	probably damaging	1.00
IGL02234:Celsr3	APN	9	108829960	missense	probably benign
IGL02392:Celsr3	APN	9	108834721	splice site	probably benign
IGL02416:Celsr3	APN	9	108832119	missense	probably damaging	1.00
IGL02421:Celsr3	APN	9	108840463	missense	probably damaging	1.00
IGL02455:Celsr3	APN	9	108842893	missense	probably benign	0.15
IGL02798:Celsr3	APN	9	108843575	missense	probably damaging	1.00
IGL02939:Celsr3	APN	9	108849453	missense	probably damaging	1.00
IGL02947:Celsr3	APN	9	108845935	missense	probably benign	0.12
IGL02986:Celsr3	APN	9	108841255	splice site	probably null
IGL03089:Celsr3	APN	9	108826607	missense	probably benign	0.04
IGL03162:Celsr3	APN	9	108842558	missense	probably damaging	1.00
IGL03267:Celsr3	APN	9	108836525	splice site	probably benign
Diminishment	UTSW	9	108842708	intron	probably benign
little_d	UTSW	9	108827692	missense	probably damaging	0.98
nogal	UTSW	9	108835838	missense	probably benign
F6893:Celsr3	UTSW	9	108835067	missense	probably benign	0.00
PIT4243001:Celsr3	UTSW	9	108832308	missense	probably benign	0.13
PIT4810001:Celsr3	UTSW	9	108845733	missense	probably damaging	1.00
R0110:Celsr3	UTSW	9	108827005	missense	possibly damaging	0.62
R0243:Celsr3	UTSW	9	108843724	splice site	probably benign
R0382:Celsr3	UTSW	9	108829218	missense	probably damaging	1.00
R0482:Celsr3	UTSW	9	108829073	nonsense	probably null
R0510:Celsr3	UTSW	9	108827005	missense	possibly damaging	0.62
R0630:Celsr3	UTSW	9	108827692	missense	probably damaging	0.98
R0656:Celsr3	UTSW	9	108834655	missense	possibly damaging	0.89
R0764:Celsr3	UTSW	9	108827818	missense	probably damaging	1.00
R0883:Celsr3	UTSW	9	108842633	missense	probably damaging	1.00
R0924:Celsr3	UTSW	9	108846025	missense	possibly damaging	0.78
R1015:Celsr3	UTSW	9	108833176	missense	probably benign	0.17
R1321:Celsr3	UTSW	9	108835870	missense	probably damaging	1.00
R1423:Celsr3	UTSW	9	108826905	missense	probably benign	0.00
R1497:Celsr3	UTSW	9	108848865	missense	probably benign	0.14
R1520:Celsr3	UTSW	9	108848658	missense	probably damaging	1.00
R1534:Celsr3	UTSW	9	108848884	missense	probably damaging	0.99
R1569:Celsr3	UTSW	9	108829068	missense	probably damaging	1.00
R1657:Celsr3	UTSW	9	108842952	nonsense	probably null
R1753:Celsr3	UTSW	9	108831857	missense	probably damaging	0.99
R1764:Celsr3	UTSW	9	108828958	missense	probably damaging	1.00
R1801:Celsr3	UTSW	9	108834626	missense	possibly damaging	0.88
R1838:Celsr3	UTSW	9	108829906	missense	probably benign
R1839:Celsr3	UTSW	9	108829906	missense	probably benign
R1874:Celsr3	UTSW	9	108835838	missense	probably benign
R1875:Celsr3	UTSW	9	108835838	missense	probably benign
R1953:Celsr3	UTSW	9	108843182	missense	probably benign	0.19
R1960:Celsr3	UTSW	9	108845817	missense	probably benign
R2113:Celsr3	UTSW	9	108838470	missense	probably damaging	1.00
R2290:Celsr3	UTSW	9	108843224	missense	probably damaging	1.00
R2369:Celsr3	UTSW	9	108842552	missense	probably benign
R2373:Celsr3	UTSW	9	108842552	missense	probably benign
R2374:Celsr3	UTSW	9	108842552	missense	probably benign
R2375:Celsr3	UTSW	9	108842552	missense	probably benign
R2844:Celsr3	UTSW	9	108829308	missense	probably damaging	1.00
R2968:Celsr3	UTSW	9	108832191	missense	probably damaging	1.00
R3103:Celsr3	UTSW	9	108837139	missense	probably benign	0.31
R3159:Celsr3	UTSW	9	108827710	missense	possibly damaging	0.94
R3791:Celsr3	UTSW	9	108842552	missense	probably benign
R4194:Celsr3	UTSW	9	108843302	critical splice donor site	probably null
R4329:Celsr3	UTSW	9	108846049	missense	probably benign	0.00
R4365:Celsr3	UTSW	9	108829847	missense	possibly damaging	0.47
R4419:Celsr3	UTSW	9	108843244	missense	possibly damaging	0.84
R4484:Celsr3	UTSW	9	108846063	critical splice donor site	probably null
R4582:Celsr3	UTSW	9	108845723	missense	probably damaging	1.00
R4681:Celsr3	UTSW	9	108827754	missense	possibly damaging	0.58
R4729:Celsr3	UTSW	9	108847652	missense	probably benign	0.05
R4881:Celsr3	UTSW	9	108843941	missense	probably damaging	1.00
R4893:Celsr3	UTSW	9	108849421	missense	probably damaging	1.00
R5183:Celsr3	UTSW	9	108837560	missense	probably damaging	0.99
R5207:Celsr3	UTSW	9	108832759	missense	probably benign	0.01
R5290:Celsr3	UTSW	9	108843158	missense	probably benign	0.01
R5327:Celsr3	UTSW	9	108842708	intron	probably benign
R5345:Celsr3	UTSW	9	108832124	missense	probably damaging	1.00
R5358:Celsr3	UTSW	9	108832025	missense	possibly damaging	0.96
R5396:Celsr3	UTSW	9	108828582	missense	probably damaging	1.00
R5414:Celsr3	UTSW	9	108840042	missense	possibly damaging	0.88
R5452:Celsr3	UTSW	9	108844034	missense	possibly damaging	0.68
R5467:Celsr3	UTSW	9	108828637	missense	probably damaging	1.00
R5479:Celsr3	UTSW	9	108844544	critical splice donor site	probably null
R5629:Celsr3	UTSW	9	108849067	missense	probably benign	0.41
R5637:Celsr3	UTSW	9	108837133	missense	probably damaging	1.00
R5652:Celsr3	UTSW	9	108838472	missense	probably benign	0.03
R5739:Celsr3	UTSW	9	108827158	missense	probably benign
R5785:Celsr3	UTSW	9	108827797	missense	probably damaging	1.00
R5877:Celsr3	UTSW	9	108845727	missense	probably damaging	0.98
R5961:Celsr3	UTSW	9	108831794	missense	probably damaging	1.00
R6046:Celsr3	UTSW	9	108837151	missense	probably benign	0.01
R6176:Celsr3	UTSW	9	108828355	missense	probably damaging	1.00
R6291:Celsr3	UTSW	9	108828842	missense	probably damaging	1.00
R6468:Celsr3	UTSW	9	108835790	missense	probably benign	0.08
R6481:Celsr3	UTSW	9	108837084	missense	possibly damaging	0.92
R6547:Celsr3	UTSW	9	108829128	missense	probably damaging	1.00
R6763:Celsr3	UTSW	9	108827350	missense	probably damaging	1.00
R6870:Celsr3	UTSW	9	108829191	missense	probably benign	0.02
R6977:Celsr3	UTSW	9	108827715	missense	probably benign
R7061:Celsr3	UTSW	9	108847594	nonsense	probably null
R7122:Celsr3	UTSW	9	108828567	missense	possibly damaging	0.90
R7156:Celsr3	UTSW	9	108838004	missense	possibly damaging	0.95
R7166:Celsr3	UTSW	9	108842951	missense	probably damaging	1.00
R7176:Celsr3	UTSW	9	108845762	missense	probably benign
R7213:Celsr3	UTSW	9	108849040	missense	probably damaging	0.98
R7314:Celsr3	UTSW	9	108829144	missense	probably damaging	1.00
R7478:Celsr3	UTSW	9	108843578	missense	probably benign	0.37
R7508:Celsr3	UTSW	9	108836622	missense	probably benign
R7554:Celsr3	UTSW	9	108841209	missense	probably benign
R7615:Celsr3	UTSW	9	108837652	missense	possibly damaging	0.75
R7653:Celsr3	UTSW	9	108835070	nonsense	probably null
R7747:Celsr3	UTSW	9	108829978	missense	possibly damaging	0.61
R7881:Celsr3	UTSW	9	108828072	missense	probably benign	0.28
R7935:Celsr3	UTSW	9	108829641	missense	probably benign	0.01
R7995:Celsr3	UTSW	9	108845083	missense	probably damaging	0.99
R8006:Celsr3	UTSW	9	108829107	missense	probably damaging	1.00
R8077:Celsr3	UTSW	9	108828331	missense	probably benign	0.15
R8284:Celsr3	UTSW	9	108846413	missense	probably damaging	0.99
R8291:Celsr3	UTSW	9	108837970	missense	probably damaging	1.00
R8322:Celsr3	UTSW	9	108848794	missense	probably damaging	1.00
R8334:Celsr3	UTSW	9	108841272	frame shift	probably null
R8337:Celsr3	UTSW	9	108841272	frame shift	probably null
R8338:Celsr3	UTSW	9	108827340	nonsense	probably null
R8353:Celsr3	UTSW	9	108826535	missense	probably benign	0.00
R8407:Celsr3	UTSW	9	108829057	missense	probably damaging	1.00
R8408:Celsr3	UTSW	9	108831789	missense	probably damaging	1.00
R8459:Celsr3	UTSW	9	108829630	missense	probably damaging	1.00
R8510:Celsr3	UTSW	9	108838120	missense	possibly damaging	0.93
R8713:Celsr3	UTSW	9	108829863	missense	probably benign
R8728:Celsr3	UTSW	9	108846741	missense	probably benign	0.24
R8829:Celsr3	UTSW	9	108840383	missense	probably benign
R8877:Celsr3	UTSW	9	108829678	missense	probably damaging	1.00
R8905:Celsr3	UTSW	9	108841302	missense	probably damaging	1.00
R9008:Celsr3	UTSW	9	108828952	missense	possibly damaging	0.94
R9072:Celsr3	UTSW	9	108827094	missense	probably benign
R9157:Celsr3	UTSW	9	108829986	missense	probably damaging	1.00
R9183:Celsr3	UTSW	9	108829396	missense	probably damaging	1.00
R9275:Celsr3	UTSW	9	108838490	missense	probably benign	0.27
R9361:Celsr3	UTSW	9	108849322	missense	probably damaging	1.00
R9382:Celsr3	UTSW	9	108829762	missense	possibly damaging	0.60
R9407:Celsr3	UTSW	9	108846397	missense	not run
R9432:Celsr3	UTSW	9	108848833	missense	not run
X0018:Celsr3	UTSW	9	108827778	missense	possibly damaging	0.65
X0018:Celsr3	UTSW	9	108840412	missense	probably benign	0.01
X0026:Celsr3	UTSW	9	108828930	missense	probably damaging	0.99
Z1177:Celsr3	UTSW	9	108826477	missense	probably benign	0.34

Predicted Primers

PCR Primer
(F):5'- AGAAGAGGTCCCAGTTCCTG -3'
(R):5'- AATGTCCAGTTGCTCTGTGGAG -3'

Sequencing Primer
(F):5'- GGTCCCAGTTCCTGCACCTG -3'
(R):5'- TCCTCCCTGGCTCTGAGAAG -3'

Posted On

2019-12-04