Mutagenetix > Incidental Mutation

Incidental Mutation 'RF020:Vps13b'

603836

Institutional Source

Beutler Lab

Gene Symbol

Vps13b

Ensembl Gene

ENSMUSG00000037646

Gene Name

vacuolar protein sorting 13B

Synonyms

2310042E16Rik, 1810042B05Rik, Coh1, C330002D13Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

RF020 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

35371160-35931229 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 35925406 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Leucine at position 3829 (W3829L)

Ref Sequence

ENSEMBL: ENSMUSP00000045490 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000048646]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000048646
AA Change: W3829L

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000045490
Gene: ENSMUSG00000037646
AA Change: W3829L

Domain	Start	End	E-Value	Type
Pfam:Chorein_N	2	120	1e-29	PFAM
low complexity region	128	137	N/A	INTRINSIC
low complexity region	143	160	N/A	INTRINSIC
low complexity region	975	984	N/A	INTRINSIC
low complexity region	1007	1018	N/A	INTRINSIC
low complexity region	1876	1883	N/A	INTRINSIC
low complexity region	2042	2054	N/A	INTRINSIC
low complexity region	2414	2423	N/A	INTRINSIC
Pfam:SHR-BD	2601	2700	8.4e-10	PFAM
low complexity region	2954	2964	N/A	INTRINSIC
Pfam:VPS13_C	3539	3706	2.6e-30	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000155638

Coding Region Coverage

1x: 99.8%
3x: 99.7%
10x: 99.3%
20x: 98.5%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a potential transmembrane protein that may function in vesicle-mediated transport and sorting of proteins within the cell. This protein may play a role in the development and the function of the eye, hematological system, and central nervous system. Mutations in this gene have been associated with Cohen syndrome. Multiple splice variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 90 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca16	A	G	7: 120,533,657 (GRCm38)	K1270E	possibly damaging	Het
Adgrb2	T	C	4: 130,010,084 (GRCm38)	S668P	probably damaging	Het
Ahdc1	T	G	4: 133,064,277 (GRCm38)	L943R	possibly damaging	Het
Ank2	T	C	3: 126,945,476 (GRCm38)	K2253R	unknown	Het
Arhgap23	T	C	11: 97,463,561 (GRCm38)	S767P	probably damaging	Het
Arhgef12	A	G	9: 42,989,989 (GRCm38)	I839T	possibly damaging	Het
Begain	CGCCGC	CGCCGCGGCCGC	12: 109,033,424 (GRCm38)		probably benign	Het
Btbd19	A	T	4: 117,122,275 (GRCm38)	C116S	probably damaging	Het
Cbr1	C	T	16: 93,610,179 (GRCm38)	A261V	probably benign	Het
Ccdc137	A	G	11: 120,458,196 (GRCm38)	R18G	probably benign	Het
Cdsn	AG	AGACAGGAAGTAGTAGCTCTCAG	17: 35,554,979 (GRCm38)		probably benign	Het
Celsr3	C	T	9: 108,849,057 (GRCm38)	R3162C	probably benign	Het
Cep350	A	T	1: 155,915,478 (GRCm38)	V1300E	probably benign	Het
Cluh	G	GCCAGAT	11: 74,669,538 (GRCm38)		probably benign	Het
Cmya5	G	T	13: 93,069,291 (GRCm38)	Q3357K	possibly damaging	Het
Col6a2	T	G	10: 76,606,209 (GRCm38)		probably null	Het
Cyp2j9	T	A	4: 96,577,652 (GRCm38)	T315S	probably damaging	Het
Cyp3a13	CATTATT	CATT	5: 137,894,263 (GRCm38)		probably null	Het
Dnah6	T	A	6: 73,118,057 (GRCm38)	Y2181F	probably benign	Het
Dnah7b	A	G	1: 46,373,261 (GRCm38)	D4010G	possibly damaging	Het
E4f1	CCG	CCGACG	17: 24,455,195 (GRCm38)		probably benign	Het
Ep300	A	T	15: 81,586,571 (GRCm38)		probably benign	Het
Fam234a	A	G	17: 26,218,751 (GRCm38)	V90A	probably benign	Het
Fam71e1	GGA	GGAAGGGTGGATCCTGGATACCTGGGTCTGAGGGAAGA	7: 44,500,535 (GRCm38)		probably null	Het
Gab3	TCT	TCTGCT	X: 75,000,017 (GRCm38)		probably benign	Het
Gal3st1	A	G	11: 3,998,153 (GRCm38)	Y120C	possibly damaging	Het
Gm5475	GTGGAAGGAAAGGT	G	15: 100,427,149 (GRCm38)		probably null	Het
Gm6665	T	TC	18: 31,820,377 (GRCm38)		probably null	Het
Hdlbp	T	C	1: 93,440,734 (GRCm38)	T8A	probably benign	Het
Hnrnpa2b1	T	A	6: 51,466,694 (GRCm38)	K92N	probably damaging	Het
Hsdl2	GGAGCAGCCACAGCTGCAGGAGAAGCCACAGCTGCAGGAGCAGCCACAGC	GGAGCAGCCACAGCTGCAGGAGCAGCCACAGCTGCAGGAGAAGCCACAGCTGCAGGAGCAGCCACAGC	4: 59,610,640 (GRCm38)		probably benign	Het
Klhl10	C	G	11: 100,442,070 (GRCm38)	Q14E	probably benign	Het
Klra2	GAAAGAAATCCA	GAAAGAAATCCAAAGAAATCCA	6: 131,221,838 (GRCm38)		probably null	Het
Kmt2b	CC	CCTCCTGC	7: 30,586,382 (GRCm38)		probably benign	Het
Krt2	A	G	15: 101,817,968 (GRCm38)	I45T	unknown	Het
Ksr2	T	C	5: 117,555,218 (GRCm38)	S244P	probably benign	Het
Lama5	A	T	2: 180,196,178 (GRCm38)	M915K	probably benign	Het
Lrp1b	A	C	2: 41,770,846 (GRCm38)	H197Q		Het
Lrrc1	T	C	9: 77,452,631 (GRCm38)	E293G	probably damaging	Het
Med12l	AACA	AACAACA	3: 59,275,958 (GRCm38)		probably benign	Het
Mgam	T	A	6: 40,685,309 (GRCm38)	Y1179N	probably damaging	Het
Mgat4c	A	G	10: 102,389,067 (GRCm38)	I381V	probably benign	Het
Mrgprx1	A	AGAC	7: 48,021,511 (GRCm38)		probably benign	Het
Myc	A	T	15: 61,985,823 (GRCm38)		probably benign	Het
Nipbl	A	G	15: 8,358,934 (GRCm38)	S401P	probably damaging	Het
Nlrp9c	A	T	7: 26,385,224 (GRCm38)	I310N	probably benign	Het
Nwd2	C	A	5: 63,805,723 (GRCm38)	Y883*	probably null	Het
Oas1e	T	A	5: 120,794,318 (GRCm38)	T87S	possibly damaging	Het
Olfr586	A	T	7: 103,121,891 (GRCm38)	C294S	probably benign	Het
Olfr653	A	G	7: 104,580,290 (GRCm38)	M215V	probably benign	Het
Olfr885	G	A	9: 38,061,324 (GRCm38)	M1I	probably null	Het
Olfr964-ps1	GA	GATACA	9: 39,686,753 (GRCm38)		probably null	Het
Pappa	T	G	4: 65,205,045 (GRCm38)	S872R	possibly damaging	Het
Parp4	T	C	14: 56,647,349 (GRCm38)	L1295P	unknown	Het
Pcdh15	A	T	10: 74,185,410 (GRCm38)	Y152F	probably damaging	Het
Pdk1	A	T	2: 71,883,896 (GRCm38)	I217L	possibly damaging	Het
Phldb1	A	C	9: 44,697,946 (GRCm38)	C450W	probably damaging	Het
Pnmal1	C	CCATGATGCACCTGCTTCAACATCA	7: 16,961,451 (GRCm38)		probably benign	Het
Prl2c5	G	A	13: 13,185,912 (GRCm38)	G55S	probably benign	Het
Psme2b	A	T	11: 48,945,570 (GRCm38)	H183Q	probably damaging	Het
Ptms	CCTCCTC	CCTCCTCCTC	6: 124,914,449 (GRCm38)		probably benign	Het
Rln3	T	C	8: 84,043,302 (GRCm38)	T73A	probably benign	Het
Rprd1a	T	A	18: 24,530,005 (GRCm38)	Q21L	probably damaging	Het
Sept3	A	T	15: 82,284,461 (GRCm38)	D155V	probably damaging	Het
Sh3rf3	T	A	10: 58,813,768 (GRCm38)	V65E	probably damaging	Het
Shank3	A	G	15: 89,500,390 (GRCm38)	N155S	probably benign	Het
Shox2	G	T	3: 66,973,813 (GRCm38)	P278Q	probably damaging	Het
Slc1a1	T	C	19: 28,879,155 (GRCm38)		probably null	Het
Slc39a10	A	T	1: 46,810,015 (GRCm38)	F814I	probably damaging	Het
Slc5a1	T	C	5: 33,133,429 (GRCm38)	I119T	probably damaging	Het
Slc6a13	T	C	6: 121,324,351 (GRCm38)		probably null	Het
Spta1	A	G	1: 174,213,444 (GRCm38)	D1270G	probably benign	Het
Spta1	T	A	1: 174,217,903 (GRCm38)	F1542L	probably damaging	Het
Tacc3	T	A	5: 33,661,224 (GRCm38)	M1K	probably null	Het
Tax1bp1	T	C	6: 52,721,354 (GRCm38)	V17A	probably damaging	Het
Thegl	CAGCGATCCTCCCCAGTCCCGCAAGGC	CAGCGATCCTCCCCAGTCCCGCAAGGCGAGCGATCCTCCCCAGTCCCGCAAGGC	5: 77,016,400 (GRCm38)		probably benign	Het
Tmem156	T	A	5: 65,091,547 (GRCm38)	E3D	probably benign	Het
Tmem209	T	A	6: 30,487,418 (GRCm38)	M530L	probably benign	Het
Trpc2	A	G	7: 102,096,226 (GRCm38)	D883G	unknown	Het
Tsen34	GGAGCCAAAAT	G	7: 3,695,796 (GRCm38)		probably null	Het
Uhrf2	T	C	19: 30,086,391 (GRCm38)	Y585H	probably damaging	Het
Vmn1r26	T	A	6: 58,008,720 (GRCm38)	K161N	probably benign	Het
Vmn1r29	A	G	6: 58,307,543 (GRCm38)	S83G	probably benign	Het
Vwce	G	A	19: 10,653,085 (GRCm38)	G503R	probably damaging	Het
Zc3h11a	T	C	1: 133,626,997 (GRCm38)	E415G	possibly damaging	Het
Zc3h14	T	A	12: 98,780,282 (GRCm38)		probably null	Het
Zfp119b	A	T	17: 55,939,499 (GRCm38)	M229K	probably benign	Het
Zfp384	GGCCCAGGC	GGCCCAGGCCCACGCCCAGGC	6: 125,036,488 (GRCm38)		probably benign	Het
Zfp384	CCAAGCTCAAGC	CCAAGC	6: 125,036,455 (GRCm38)		probably benign	Het
Zyx	T	A	6: 42,357,396 (GRCm38)	L518Q	probably damaging	Het

Other mutations in Vps13b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00402:Vps13b	APN	15	35,926,226 (GRCm38)	missense	possibly damaging	0.52
IGL00513:Vps13b	APN	15	35,793,884 (GRCm38)	missense	probably damaging	1.00
IGL00516:Vps13b	APN	15	35,640,557 (GRCm38)	missense	probably damaging	1.00
IGL00640:Vps13b	APN	15	35,417,577 (GRCm38)	missense	probably benign
IGL00753:Vps13b	APN	15	35,372,031 (GRCm38)	missense	probably damaging	0.99
IGL00784:Vps13b	APN	15	35,846,900 (GRCm38)	missense	probably damaging	1.00
IGL01138:Vps13b	APN	15	35,446,770 (GRCm38)	splice site	probably benign
IGL01349:Vps13b	APN	15	35,793,945 (GRCm38)	missense	probably benign	0.00
IGL01403:Vps13b	APN	15	35,709,479 (GRCm38)	missense	probably benign	0.00
IGL01535:Vps13b	APN	15	35,454,957 (GRCm38)	missense	possibly damaging	0.67
IGL01571:Vps13b	APN	15	35,877,489 (GRCm38)	splice site	probably benign
IGL01642:Vps13b	APN	15	35,792,072 (GRCm38)	missense	probably benign	0.43
IGL01658:Vps13b	APN	15	35,671,333 (GRCm38)	missense	probably damaging	0.99
IGL01759:Vps13b	APN	15	35,878,789 (GRCm38)	missense	probably damaging	1.00
IGL01763:Vps13b	APN	15	35,709,799 (GRCm38)	missense	possibly damaging	0.72
IGL01906:Vps13b	APN	15	35,639,847 (GRCm38)	splice site	probably benign
IGL01982:Vps13b	APN	15	35,438,904 (GRCm38)	nonsense	probably null
IGL01997:Vps13b	APN	15	35,709,224 (GRCm38)	missense	probably damaging	1.00
IGL02041:Vps13b	APN	15	35,423,245 (GRCm38)	missense	probably damaging	0.98
IGL02073:Vps13b	APN	15	35,875,586 (GRCm38)	missense	possibly damaging	0.52
IGL02077:Vps13b	APN	15	35,910,613 (GRCm38)	missense	possibly damaging	0.68
IGL02141:Vps13b	APN	15	35,572,081 (GRCm38)	missense	probably benign	0.09
IGL02146:Vps13b	APN	15	35,646,333 (GRCm38)	missense	probably benign	0.36
IGL02197:Vps13b	APN	15	35,930,056 (GRCm38)	missense	probably benign	0.02
IGL02311:Vps13b	APN	15	35,709,514 (GRCm38)	missense	probably benign	0.08
IGL02466:Vps13b	APN	15	35,770,741 (GRCm38)	missense	possibly damaging	0.86
IGL02506:Vps13b	APN	15	35,917,162 (GRCm38)	missense	probably damaging	1.00
IGL02550:Vps13b	APN	15	35,572,096 (GRCm38)	missense	probably benign
IGL02553:Vps13b	APN	15	35,646,301 (GRCm38)	missense	probably benign	0.00
IGL02674:Vps13b	APN	15	35,639,958 (GRCm38)	missense	probably benign	0.41
IGL02690:Vps13b	APN	15	35,917,142 (GRCm38)	missense	probably damaging	1.00
IGL02731:Vps13b	APN	15	35,917,128 (GRCm38)	missense	probably benign	0.00
IGL02739:Vps13b	APN	15	35,879,900 (GRCm38)	missense	probably damaging	1.00
IGL02868:Vps13b	APN	15	35,884,519 (GRCm38)	missense	probably benign	0.03
IGL03081:Vps13b	APN	15	35,875,820 (GRCm38)	missense	probably damaging	0.97
IGL03178:Vps13b	APN	15	35,869,300 (GRCm38)	missense	probably damaging	1.00
IGL03343:Vps13b	APN	15	35,917,170 (GRCm38)	missense	possibly damaging	0.76
IGL03407:Vps13b	APN	15	35,639,866 (GRCm38)	missense	possibly damaging	0.95
IGL03410:Vps13b	APN	15	35,910,340 (GRCm38)	missense	probably benign
omlette	UTSW	15	35,671,400 (GRCm38)	missense	probably benign	0.13
swiss	UTSW	15	35,709,673 (GRCm38)	missense	possibly damaging	0.80
FR4449:Vps13b	UTSW	15	35,846,957 (GRCm38)	missense	probably damaging	1.00
FR4548:Vps13b	UTSW	15	35,846,957 (GRCm38)	missense	probably damaging	1.00
FR4737:Vps13b	UTSW	15	35,846,957 (GRCm38)	missense	probably damaging	1.00
FR4976:Vps13b	UTSW	15	35,846,957 (GRCm38)	missense	probably damaging	1.00
LCD18:Vps13b	UTSW	15	35,846,957 (GRCm38)	missense	probably damaging	1.00
PIT4531001:Vps13b	UTSW	15	35,878,825 (GRCm38)	missense	probably damaging	1.00
PIT4581001:Vps13b	UTSW	15	35,534,263 (GRCm38)	missense	probably damaging	1.00
PIT4618001:Vps13b	UTSW	15	35,709,240 (GRCm38)	missense	probably damaging	1.00
R0026:Vps13b	UTSW	15	35,923,301 (GRCm38)	missense	possibly damaging	0.62
R0026:Vps13b	UTSW	15	35,923,301 (GRCm38)	missense	possibly damaging	0.62
R0108:Vps13b	UTSW	15	35,572,119 (GRCm38)	missense	probably benign	0.20
R0109:Vps13b	UTSW	15	35,572,119 (GRCm38)	missense	probably benign	0.20
R0109:Vps13b	UTSW	15	35,572,119 (GRCm38)	missense	probably benign	0.20
R0116:Vps13b	UTSW	15	35,423,155 (GRCm38)	missense	probably damaging	0.99
R0123:Vps13b	UTSW	15	35,887,261 (GRCm38)	missense	probably benign	0.01
R0124:Vps13b	UTSW	15	35,576,528 (GRCm38)	critical splice donor site	probably null
R0134:Vps13b	UTSW	15	35,887,261 (GRCm38)	missense	probably benign	0.01
R0137:Vps13b	UTSW	15	35,926,219 (GRCm38)	missense	probably benign	0.06
R0195:Vps13b	UTSW	15	35,471,899 (GRCm38)	missense	probably benign	0.00
R0225:Vps13b	UTSW	15	35,887,261 (GRCm38)	missense	probably benign	0.01
R0320:Vps13b	UTSW	15	35,674,828 (GRCm38)	missense	probably damaging	0.98
R0333:Vps13b	UTSW	15	35,879,803 (GRCm38)	missense	probably damaging	1.00
R0336:Vps13b	UTSW	15	35,455,133 (GRCm38)	nonsense	probably null
R0463:Vps13b	UTSW	15	35,597,409 (GRCm38)	missense	probably damaging	0.98
R0466:Vps13b	UTSW	15	35,445,602 (GRCm38)	nonsense	probably null
R0472:Vps13b	UTSW	15	35,417,633 (GRCm38)	critical splice donor site	probably null
R0523:Vps13b	UTSW	15	35,472,050 (GRCm38)	missense	probably benign	0.20
R0602:Vps13b	UTSW	15	35,422,368 (GRCm38)	missense	probably damaging	1.00
R0612:Vps13b	UTSW	15	35,623,657 (GRCm38)	missense	probably benign	0.12
R0627:Vps13b	UTSW	15	35,371,999 (GRCm38)	nonsense	probably null
R0679:Vps13b	UTSW	15	35,709,703 (GRCm38)	missense	possibly damaging	0.73
R0742:Vps13b	UTSW	15	35,794,361 (GRCm38)	missense	probably benign	0.22
R1053:Vps13b	UTSW	15	35,652,363 (GRCm38)	missense	probably damaging	1.00
R1355:Vps13b	UTSW	15	35,422,454 (GRCm38)	missense	probably damaging	1.00
R1386:Vps13b	UTSW	15	35,923,312 (GRCm38)	missense	probably damaging	0.99
R1403:Vps13b	UTSW	15	35,709,122 (GRCm38)	splice site	probably benign
R1453:Vps13b	UTSW	15	35,422,444 (GRCm38)	missense	probably damaging	0.97
R1464:Vps13b	UTSW	15	35,709,484 (GRCm38)	missense	probably benign	0.14
R1464:Vps13b	UTSW	15	35,709,484 (GRCm38)	missense	probably benign	0.14
R1511:Vps13b	UTSW	15	35,841,573 (GRCm38)	missense	probably benign	0.00
R1511:Vps13b	UTSW	15	35,839,975 (GRCm38)	missense	probably damaging	0.99
R1513:Vps13b	UTSW	15	35,438,730 (GRCm38)	nonsense	probably null
R1536:Vps13b	UTSW	15	35,875,566 (GRCm38)	missense	probably damaging	0.98
R1537:Vps13b	UTSW	15	35,792,181 (GRCm38)	missense	possibly damaging	0.62
R1558:Vps13b	UTSW	15	35,534,319 (GRCm38)	missense	probably damaging	1.00
R1601:Vps13b	UTSW	15	35,642,436 (GRCm38)	missense	probably benign	0.11
R1653:Vps13b	UTSW	15	35,607,272 (GRCm38)	nonsense	probably null
R1695:Vps13b	UTSW	15	35,576,521 (GRCm38)	missense	probably benign	0.05
R1760:Vps13b	UTSW	15	35,884,619 (GRCm38)	missense	possibly damaging	0.54
R1785:Vps13b	UTSW	15	35,879,791 (GRCm38)	missense	probably damaging	1.00
R1786:Vps13b	UTSW	15	35,879,791 (GRCm38)	missense	probably damaging	1.00
R1803:Vps13b	UTSW	15	35,430,205 (GRCm38)	nonsense	probably null
R1804:Vps13b	UTSW	15	35,917,137 (GRCm38)	missense	probably damaging	1.00
R1808:Vps13b	UTSW	15	35,792,059 (GRCm38)	missense	probably benign	0.00
R1817:Vps13b	UTSW	15	35,910,642 (GRCm38)	missense	possibly damaging	0.86
R1818:Vps13b	UTSW	15	35,877,577 (GRCm38)	missense	probably benign	0.00
R1836:Vps13b	UTSW	15	35,910,232 (GRCm38)	missense	probably damaging	0.99
R1850:Vps13b	UTSW	15	35,674,959 (GRCm38)	splice site	probably benign
R1884:Vps13b	UTSW	15	35,430,291 (GRCm38)	splice site	probably benign
R1938:Vps13b	UTSW	15	35,709,507 (GRCm38)	missense	probably damaging	1.00
R1955:Vps13b	UTSW	15	35,925,408 (GRCm38)	critical splice donor site	probably null
R1956:Vps13b	UTSW	15	35,869,407 (GRCm38)	missense	probably damaging	1.00
R1958:Vps13b	UTSW	15	35,878,689 (GRCm38)	missense	probably damaging	0.99
R2013:Vps13b	UTSW	15	35,607,142 (GRCm38)	missense	probably damaging	0.99
R2014:Vps13b	UTSW	15	35,607,142 (GRCm38)	missense	probably damaging	0.99
R2015:Vps13b	UTSW	15	35,607,142 (GRCm38)	missense	probably damaging	0.99
R2038:Vps13b	UTSW	15	35,884,741 (GRCm38)	missense	probably damaging	1.00
R2058:Vps13b	UTSW	15	35,841,447 (GRCm38)	missense	probably damaging	1.00
R2082:Vps13b	UTSW	15	35,910,746 (GRCm38)	missense	possibly damaging	0.70
R2087:Vps13b	UTSW	15	35,597,493 (GRCm38)	missense	probably damaging	0.99
R2124:Vps13b	UTSW	15	35,646,080 (GRCm38)	missense	probably benign	0.08
R2130:Vps13b	UTSW	15	35,671,400 (GRCm38)	missense	probably benign	0.13
R2168:Vps13b	UTSW	15	35,792,188 (GRCm38)	missense	probably damaging	1.00
R2168:Vps13b	UTSW	15	35,792,189 (GRCm38)	missense	probably damaging	1.00
R2171:Vps13b	UTSW	15	35,887,197 (GRCm38)	missense	probably benign	0.44
R2221:Vps13b	UTSW	15	35,884,597 (GRCm38)	missense	probably benign
R2263:Vps13b	UTSW	15	35,646,181 (GRCm38)	missense	probably benign	0.02
R2289:Vps13b	UTSW	15	35,572,105 (GRCm38)	missense	probably damaging	1.00
R2316:Vps13b	UTSW	15	35,674,899 (GRCm38)	nonsense	probably null
R2351:Vps13b	UTSW	15	35,869,311 (GRCm38)	missense	probably damaging	1.00
R2512:Vps13b	UTSW	15	35,884,555 (GRCm38)	missense	probably benign	0.35
R3054:Vps13b	UTSW	15	35,646,361 (GRCm38)	missense	probably damaging	0.99
R3055:Vps13b	UTSW	15	35,646,361 (GRCm38)	missense	probably damaging	0.99
R3196:Vps13b	UTSW	15	35,869,395 (GRCm38)	missense	probably damaging	1.00
R3236:Vps13b	UTSW	15	35,910,304 (GRCm38)	missense	probably benign	0.40
R3404:Vps13b	UTSW	15	35,926,054 (GRCm38)	missense	probably damaging	1.00
R3722:Vps13b	UTSW	15	35,671,382 (GRCm38)	missense	probably damaging	0.99
R4077:Vps13b	UTSW	15	35,455,128 (GRCm38)	missense	probably damaging	0.99
R4153:Vps13b	UTSW	15	35,792,027 (GRCm38)	splice site	probably null
R4224:Vps13b	UTSW	15	35,876,419 (GRCm38)	missense	probably damaging	0.99
R4408:Vps13b	UTSW	15	35,709,294 (GRCm38)	missense	probably damaging	0.98
R4431:Vps13b	UTSW	15	35,770,753 (GRCm38)	missense	probably damaging	1.00
R4449:Vps13b	UTSW	15	35,876,793 (GRCm38)	missense	possibly damaging	0.86
R4508:Vps13b	UTSW	15	35,709,673 (GRCm38)	missense	possibly damaging	0.80
R4631:Vps13b	UTSW	15	35,646,132 (GRCm38)	missense	possibly damaging	0.95
R4655:Vps13b	UTSW	15	35,770,689 (GRCm38)	missense	probably benign
R4666:Vps13b	UTSW	15	35,640,544 (GRCm38)	missense	probably benign	0.13
R4684:Vps13b	UTSW	15	35,879,821 (GRCm38)	missense	probably benign
R4684:Vps13b	UTSW	15	35,841,341 (GRCm38)	missense	probably benign
R4684:Vps13b	UTSW	15	35,646,178 (GRCm38)	missense	probably damaging	0.98
R4721:Vps13b	UTSW	15	35,910,718 (GRCm38)	nonsense	probably null
R4771:Vps13b	UTSW	15	35,910,800 (GRCm38)	missense	probably damaging	1.00
R4830:Vps13b	UTSW	15	35,452,224 (GRCm38)	missense	possibly damaging	0.94
R4835:Vps13b	UTSW	15	35,910,293 (GRCm38)	missense	probably benign
R4835:Vps13b	UTSW	15	35,869,372 (GRCm38)	missense	probably damaging	1.00
R4857:Vps13b	UTSW	15	35,456,654 (GRCm38)	missense	probably benign	0.01
R4891:Vps13b	UTSW	15	35,640,515 (GRCm38)	splice site	probably null
R5095:Vps13b	UTSW	15	35,923,202 (GRCm38)	missense	probably damaging	1.00
R5110:Vps13b	UTSW	15	35,770,809 (GRCm38)	missense	probably damaging	0.99
R5147:Vps13b	UTSW	15	35,456,678 (GRCm38)	missense	probably benign	0.32
R5153:Vps13b	UTSW	15	35,422,453 (GRCm38)	missense	probably damaging	0.99
R5257:Vps13b	UTSW	15	35,794,421 (GRCm38)	missense	possibly damaging	0.75
R5258:Vps13b	UTSW	15	35,794,421 (GRCm38)	missense	possibly damaging	0.75
R5296:Vps13b	UTSW	15	35,876,413 (GRCm38)	missense	probably damaging	1.00
R5386:Vps13b	UTSW	15	35,640,528 (GRCm38)	critical splice acceptor site	probably null
R5396:Vps13b	UTSW	15	35,886,948 (GRCm38)	missense	probably damaging	0.99
R5412:Vps13b	UTSW	15	35,533,385 (GRCm38)	missense	probably damaging	1.00
R5488:Vps13b	UTSW	15	35,770,542 (GRCm38)	missense	probably benign
R5489:Vps13b	UTSW	15	35,770,542 (GRCm38)	missense	probably benign
R5503:Vps13b	UTSW	15	35,452,166 (GRCm38)	missense	probably damaging	0.97
R5575:Vps13b	UTSW	15	35,929,919 (GRCm38)	missense	probably damaging	1.00
R5781:Vps13b	UTSW	15	35,794,035 (GRCm38)	missense	probably damaging	0.97
R5872:Vps13b	UTSW	15	35,869,351 (GRCm38)	missense	possibly damaging	0.56
R5876:Vps13b	UTSW	15	35,917,061 (GRCm38)	missense	probably damaging	0.99
R5994:Vps13b	UTSW	15	35,875,772 (GRCm38)	missense	probably damaging	1.00
R6031:Vps13b	UTSW	15	35,471,968 (GRCm38)	missense	probably damaging	1.00
R6031:Vps13b	UTSW	15	35,471,968 (GRCm38)	missense	probably damaging	1.00
R6045:Vps13b	UTSW	15	35,671,316 (GRCm38)	missense	probably damaging	0.99
R6143:Vps13b	UTSW	15	35,668,738 (GRCm38)	missense	probably damaging	0.99
R6147:Vps13b	UTSW	15	35,930,031 (GRCm38)	missense	probably benign	0.16
R6218:Vps13b	UTSW	15	35,770,464 (GRCm38)	missense	probably benign	0.00
R6447:Vps13b	UTSW	15	35,572,126 (GRCm38)	missense	probably benign	0.02
R6555:Vps13b	UTSW	15	35,846,847 (GRCm38)	missense	probably damaging	1.00
R6578:Vps13b	UTSW	15	35,446,101 (GRCm38)	missense	probably damaging	0.99
R6640:Vps13b	UTSW	15	35,617,696 (GRCm38)	missense	possibly damaging	0.93
R6645:Vps13b	UTSW	15	35,910,305 (GRCm38)	missense	probably benign	0.25
R6711:Vps13b	UTSW	15	35,887,249 (GRCm38)	missense	probably damaging	1.00
R6727:Vps13b	UTSW	15	35,770,683 (GRCm38)	missense	probably benign	0.19
R6737:Vps13b	UTSW	15	35,910,611 (GRCm38)	missense	probably damaging	1.00
R6844:Vps13b	UTSW	15	35,877,590 (GRCm38)	missense	probably benign	0.06
R6849:Vps13b	UTSW	15	35,905,309 (GRCm38)	missense	probably damaging	1.00
R6861:Vps13b	UTSW	15	35,576,395 (GRCm38)	missense	probably damaging	0.99
R6938:Vps13b	UTSW	15	35,423,198 (GRCm38)	missense	probably damaging	0.99
R6943:Vps13b	UTSW	15	35,448,689 (GRCm38)	missense	possibly damaging	0.95
R6989:Vps13b	UTSW	15	35,448,581 (GRCm38)	missense	probably benign	0.02
R7092:Vps13b	UTSW	15	35,640,634 (GRCm38)	missense	probably damaging	1.00
R7232:Vps13b	UTSW	15	35,877,557 (GRCm38)	missense	probably damaging	1.00
R7307:Vps13b	UTSW	15	35,841,545 (GRCm38)	missense	probably benign
R7400:Vps13b	UTSW	15	35,378,900 (GRCm38)	missense	probably damaging	1.00
R7414:Vps13b	UTSW	15	35,910,827 (GRCm38)	missense	probably damaging	1.00
R7497:Vps13b	UTSW	15	35,876,697 (GRCm38)	missense	probably benign	0.38
R7500:Vps13b	UTSW	15	35,910,524 (GRCm38)	missense	possibly damaging	0.74
R7603:Vps13b	UTSW	15	35,576,439 (GRCm38)	missense	probably damaging	0.98
R7605:Vps13b	UTSW	15	35,770,646 (GRCm38)	missense	probably damaging	0.97
R7849:Vps13b	UTSW	15	35,423,232 (GRCm38)	missense	probably damaging	0.99
R7984:Vps13b	UTSW	15	35,879,913 (GRCm38)	missense	probably benign
R8094:Vps13b	UTSW	15	35,668,906 (GRCm38)	critical splice donor site	probably null
R8097:Vps13b	UTSW	15	35,709,346 (GRCm38)	missense	probably benign	0.38
R8131:Vps13b	UTSW	15	35,372,109 (GRCm38)	critical splice donor site	probably null
R8139:Vps13b	UTSW	15	35,607,272 (GRCm38)	nonsense	probably null
R8174:Vps13b	UTSW	15	35,709,310 (GRCm38)	nonsense	probably null
R8225:Vps13b	UTSW	15	35,794,382 (GRCm38)	missense	probably damaging	0.99
R8239:Vps13b	UTSW	15	35,597,404 (GRCm38)	missense	probably damaging	1.00
R8244:Vps13b	UTSW	15	35,917,203 (GRCm38)	missense	probably damaging	1.00
R8303:Vps13b	UTSW	15	35,639,917 (GRCm38)	missense	probably damaging	1.00
R8311:Vps13b	UTSW	15	35,886,954 (GRCm38)	missense	probably benign	0.37
R8443:Vps13b	UTSW	15	35,455,100 (GRCm38)	missense	probably benign
R8494:Vps13b	UTSW	15	35,422,448 (GRCm38)	missense	probably damaging	0.99
R8499:Vps13b	UTSW	15	35,841,320 (GRCm38)	missense	probably damaging	1.00
R8506:Vps13b	UTSW	15	35,446,745 (GRCm38)	missense	probably benign	0.31
R8559:Vps13b	UTSW	15	35,876,642 (GRCm38)	missense	probably damaging	1.00
R8686:Vps13b	UTSW	15	35,925,389 (GRCm38)	missense	probably damaging	0.99
R8782:Vps13b	UTSW	15	35,422,337 (GRCm38)	missense	possibly damaging	0.93
R8806:Vps13b	UTSW	15	35,472,066 (GRCm38)	critical splice donor site	probably benign
R8824:Vps13b	UTSW	15	35,533,299 (GRCm38)	missense	probably damaging	0.99
R9024:Vps13b	UTSW	15	35,923,324 (GRCm38)	missense	probably damaging	0.97
R9038:Vps13b	UTSW	15	35,875,785 (GRCm38)	missense	possibly damaging	0.70
R9054:Vps13b	UTSW	15	35,422,391 (GRCm38)	missense	probably damaging	1.00
R9091:Vps13b	UTSW	15	35,770,773 (GRCm38)	missense	probably benign	0.13
R9129:Vps13b	UTSW	15	35,448,647 (GRCm38)	missense	probably damaging	1.00
R9214:Vps13b	UTSW	15	35,623,746 (GRCm38)	missense	probably damaging	0.99
R9237:Vps13b	UTSW	15	35,841,333 (GRCm38)	missense	probably damaging	1.00
R9256:Vps13b	UTSW	15	35,623,779 (GRCm38)	missense	possibly damaging	0.95
R9270:Vps13b	UTSW	15	35,770,773 (GRCm38)	missense	probably benign	0.13
R9279:Vps13b	UTSW	15	35,572,144 (GRCm38)	missense	probably damaging	0.97
R9291:Vps13b	UTSW	15	35,846,913 (GRCm38)	missense	probably damaging	1.00
R9342:Vps13b	UTSW	15	35,455,054 (GRCm38)	missense	possibly damaging	0.94
R9404:Vps13b	UTSW	15	35,876,419 (GRCm38)	missense	probably damaging	1.00
R9488:Vps13b	UTSW	15	35,447,734 (GRCm38)	missense	possibly damaging	0.77
R9509:Vps13b	UTSW	15	35,841,311 (GRCm38)	missense	possibly damaging	0.79
R9610:Vps13b	UTSW	15	35,642,409 (GRCm38)	missense	possibly damaging	0.85
R9611:Vps13b	UTSW	15	35,642,409 (GRCm38)	missense	possibly damaging	0.85
R9658:Vps13b	UTSW	15	35,623,628 (GRCm38)	missense	probably benign	0.00
R9674:Vps13b	UTSW	15	35,607,234 (GRCm38)	missense	probably damaging	0.98
R9696:Vps13b	UTSW	15	35,674,887 (GRCm38)	missense	possibly damaging	0.56
R9767:Vps13b	UTSW	15	35,910,257 (GRCm38)	missense	probably damaging	1.00
R9797:Vps13b	UTSW	15	35,674,876 (GRCm38)	missense	probably damaging	1.00
X0026:Vps13b	UTSW	15	35,910,646 (GRCm38)	missense	probably damaging	1.00
X0028:Vps13b	UTSW	15	35,709,431 (GRCm38)	missense	probably benign	0.00
Z1177:Vps13b	UTSW	15	35,668,885 (GRCm38)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- CCAAAGATTGGCCTCGTTTTG -3'
(R):5'- TGGTTCAACCATGACCAGCC -3'

Sequencing Primer
(F):5'- GCCTTATGATAGAACATGCTGTAGC -3'
(R):5'- CCACAGAGCAGAGTTCTCTATCTAGG -3'

Posted On

2019-12-04