Mutagenetix > Incidental Mutation

Incidental Mutation 'RF021:Kmt2b'

603881

Institutional Source

Beutler Lab

Gene Symbol

Kmt2b

Ensembl Gene

ENSMUSG00000006307

Gene Name

lysine (K)-specific methyltransferase 2B

Synonyms

2610014H22Rik, Wbp7, Mll2

Accession Numbers

Genbank: NM_029274; MGI: 109565

Essential gene?

Essential (E-score: 1.000) question?

Stock #

RF021 (G1)

Quality Score

217.468

Status

Not validated

Chromosome

Chromosomal Location

30568858-30588726 bp(-) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

TTCTCCT to TTCTCCTTCTCCT at 30586357 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000006470] [ENSMUST00000108150] [ENSMUST00000108151] [ENSMUST00000108154]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000006470

SMART Domains

Protein: ENSMUSP00000006470
Gene: ENSMUSG00000006307

Domain	Start	End	E-Value	Type
AT_hook	18	30	2.82e2	SMART
low complexity region	66	106	N/A	INTRINSIC
low complexity region	110	122	N/A	INTRINSIC
AT_hook	149	159	2.4e2	SMART
AT_hook	218	230	1.95e2	SMART
low complexity region	249	263	N/A	INTRINSIC
low complexity region	272	302	N/A	INTRINSIC
coiled coil region	353	413	N/A	INTRINSIC
AT_hook	476	488	5.47e-1	SMART
low complexity region	501	517	N/A	INTRINSIC
low complexity region	578	606	N/A	INTRINSIC
low complexity region	621	657	N/A	INTRINSIC
low complexity region	673	700	N/A	INTRINSIC
low complexity region	715	728	N/A	INTRINSIC
low complexity region	738	777	N/A	INTRINSIC
low complexity region	910	922	N/A	INTRINSIC
Pfam:zf-CXXC	963	1010	7.2e-15	PFAM
low complexity region	1039	1061	N/A	INTRINSIC
low complexity region	1103	1115	N/A	INTRINSIC
PHD	1209	1256	1.25e-5	SMART
PHD	1257	1307	5.4e-10	SMART
PHD	1343	1400	1.27e-6	SMART
low complexity region	1415	1427	N/A	INTRINSIC
PHD	1646	1692	3.82e-1	SMART
FYRN	1745	1788	3.25e-19	SMART
low complexity region	1881	1899	N/A	INTRINSIC
low complexity region	1912	1942	N/A	INTRINSIC
low complexity region	1961	1978	N/A	INTRINSIC
low complexity region	1991	2003	N/A	INTRINSIC
low complexity region	2013	2026	N/A	INTRINSIC
low complexity region	2048	2061	N/A	INTRINSIC
low complexity region	2087	2105	N/A	INTRINSIC
low complexity region	2127	2138	N/A	INTRINSIC
low complexity region	2215	2235	N/A	INTRINSIC
low complexity region	2239	2270	N/A	INTRINSIC
low complexity region	2396	2406	N/A	INTRINSIC
FYRC	2419	2504	4.83e-36	SMART
SET	2581	2703	1.67e-42	SMART
PostSET	2705	2721	4.65e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000108150

SMART Domains

Protein: ENSMUSP00000103785
Gene: ENSMUSG00000006310

Domain	Start	End	E-Value	Type
ZnF_C2H2	14	36	1.67e-2	SMART
ZnF_C2H2	41	63	2.4e-3	SMART
low complexity region	81	101	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108151

SMART Domains

Protein: ENSMUSP00000103786
Gene: ENSMUSG00000006310

Domain	Start	End	E-Value	Type
BTB	29	117	1.67e-8	SMART
low complexity region	207	222	N/A	INTRINSIC
ZnF_C2H2	350	372	1.28e-3	SMART
ZnF_C2H2	378	400	1.67e-2	SMART
ZnF_C2H2	405	427	2.4e-3	SMART
low complexity region	445	465	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108154

SMART Domains

Protein: ENSMUSP00000103789
Gene: ENSMUSG00000006307

Domain	Start	End	E-Value	Type
AT_hook	18	30	2.82e2	SMART
low complexity region	66	106	N/A	INTRINSIC
low complexity region	110	122	N/A	INTRINSIC
AT_hook	149	159	2.4e2	SMART
AT_hook	218	230	1.95e2	SMART
low complexity region	249	263	N/A	INTRINSIC
low complexity region	272	302	N/A	INTRINSIC
coiled coil region	353	413	N/A	INTRINSIC
AT_hook	476	488	5.47e-1	SMART
low complexity region	501	517	N/A	INTRINSIC
low complexity region	578	606	N/A	INTRINSIC
low complexity region	621	657	N/A	INTRINSIC
low complexity region	673	700	N/A	INTRINSIC
low complexity region	715	728	N/A	INTRINSIC
low complexity region	738	777	N/A	INTRINSIC
low complexity region	910	922	N/A	INTRINSIC
Pfam:zf-CXXC	963	1010	1e-14	PFAM
low complexity region	1039	1061	N/A	INTRINSIC
low complexity region	1103	1115	N/A	INTRINSIC
PHD	1209	1256	1.25e-5	SMART
PHD	1257	1307	5.4e-10	SMART
PHD	1343	1400	1.27e-6	SMART
low complexity region	1415	1427	N/A	INTRINSIC
PHD	1646	1692	3.82e-1	SMART
FYRN	1745	1788	3.25e-19	SMART
low complexity region	1872	1890	N/A	INTRINSIC
low complexity region	1903	1933	N/A	INTRINSIC
low complexity region	1952	1969	N/A	INTRINSIC
low complexity region	1982	1994	N/A	INTRINSIC
low complexity region	2004	2017	N/A	INTRINSIC
low complexity region	2039	2052	N/A	INTRINSIC
low complexity region	2078	2096	N/A	INTRINSIC
low complexity region	2118	2129	N/A	INTRINSIC
low complexity region	2206	2226	N/A	INTRINSIC
low complexity region	2230	2261	N/A	INTRINSIC
low complexity region	2383	2398	N/A	INTRINSIC
FYRC	2411	2496	4.83e-36	SMART
SET	2573	2695	1.67e-42	SMART
PostSET	2697	2713	4.65e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000131002

SMART Domains

Protein: ENSMUSP00000118486
Gene: ENSMUSG00000006307

Domain	Start	End	E-Value	Type
low complexity region	7	20	N/A	INTRINSIC
low complexity region	30	69	N/A	INTRINSIC
low complexity region	202	214	N/A	INTRINSIC
Pfam:zf-CXXC	255	302	5.2e-15	PFAM
low complexity region	331	353	N/A	INTRINSIC
low complexity region	395	407	N/A	INTRINSIC
PHD	501	548	1.25e-5	SMART
PHD	549	599	5.4e-10	SMART
PHD	635	692	1.27e-6	SMART
low complexity region	707	719	N/A	INTRINSIC
PHD	938	984	3.82e-1	SMART
FYRN	1037	1080	3.25e-19	SMART
low complexity region	1173	1191	N/A	INTRINSIC
low complexity region	1204	1234	N/A	INTRINSIC
low complexity region	1253	1270	N/A	INTRINSIC
low complexity region	1283	1295	N/A	INTRINSIC
low complexity region	1305	1318	N/A	INTRINSIC
low complexity region	1340	1353	N/A	INTRINSIC
low complexity region	1379	1397	N/A	INTRINSIC
low complexity region	1419	1430	N/A	INTRINSIC
low complexity region	1507	1527	N/A	INTRINSIC
low complexity region	1531	1562	N/A	INTRINSIC
low complexity region	1684	1699	N/A	INTRINSIC
FYRC	1712	1797	4.83e-36	SMART
SET	1874	1996	1.67e-42	SMART
PostSET	1998	2014	4.65e-4	SMART

Coding Region Coverage

1x: 99.8%
3x: 99.7%
10x: 99.3%
20x: 98.3%

Validation Efficiency

91% (50/55)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous disruption of this gene leads to embryonic growth retardation, abnormal somite development, neural tube defects, increased apoptosis, and complete embryonic lethality. Homozygotes for a hypomorphic allele show embryonic growth arrest, altered DNA methylation, and reduced female fertility. [provided by MGI curators]

Allele List at MGI

All alleles(8) : Targeted, knock-out(2) Targeted, other(2) Gene trapped(4)

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	TTATTATTATTAT	TTATTATTATTATTAATATTATTATTAT	3: 37,050,748 (GRCm38)		probably benign	Het
A030005L19Rik	GTGGTGGCTG	GTGGTGGCTGTGGTGGCTG	1: 82,913,569 (GRCm38)		probably benign	Het
AI837181	CGG	CGGTGG	19: 5,425,234 (GRCm38)		probably benign	Het
Ankrd44	T	C	1: 54,778,312 (GRCm38)	H79R	probably damaging	Het
Atg9a	T	A	1: 75,182,629 (GRCm38)	E826V	probably damaging	Het
Atrnl1	T	C	19: 57,642,473 (GRCm38)	V224A	probably benign	Het
Cpn2	G	A	16: 30,259,338 (GRCm38)	A515V	probably benign	Het
Cyp2a12	T	C	7: 27,035,360 (GRCm38)	F402S	possibly damaging	Het
Defb22	TGCGGCA	TGCGGCAGAGCTGGGCGTTGCGGCA	2: 152,485,832 (GRCm38)		probably benign	Het
Diexf	A	G	1: 193,120,666 (GRCm38)	F248L	probably benign	Het
Dnah10	G	T	5: 124,777,907 (GRCm38)	V2016F	probably damaging	Het
Dock10	T	C	1: 80,564,573 (GRCm38)		probably null	Het
Efhd2	GCC	GCCGCCCCC	4: 141,874,773 (GRCm38)		probably benign	Het
Fam131a	A	C	16: 20,694,940 (GRCm38)		probably benign	Het
Gm6614	A	T	6: 142,008,714 (GRCm38)	V31E	probably damaging	Het
Gm7247	AGACCAGACC	A	14: 51,364,324 (GRCm38)		probably benign	Het
Gna13	T	C	11: 109,392,392 (GRCm38)	V186A	probably benign	Het
Grk3	T	A	5: 112,941,688 (GRCm38)	I333L	probably benign	Het
Gstp1	A	T	19: 4,035,507 (GRCm38)	V200E	probably benign	Het
Gtf2h1	T	G	7: 46,803,865 (GRCm38)	V74G	possibly damaging	Het
Kcnh8	G	A	17: 52,978,239 (GRCm38)	R1079H	probably benign	Het
Kiz	A	G	2: 146,870,830 (GRCm38)	D138G	possibly damaging	Het
Lats1	A	G	10: 7,710,608 (GRCm38)	T912A	probably damaging	Het
Lce1m	GCTGCCACC	GCTGCCACCACTTCTGCCACC	3: 93,018,269 (GRCm38)		probably benign	Het
Lce1m	TGCC	TGCCGCCGCTGCCGCC	3: 93,018,295 (GRCm38)		probably benign	Het
Lrrc2	TTGATTCGGTTCACC	T	9: 110,981,676 (GRCm38)		probably null	Het
Med12l	T	C	3: 59,073,290 (GRCm38)	F359S	probably benign	Het
Mut	A	G	17: 40,951,758 (GRCm38)	I444V	probably benign	Het
Ncoa2	CTTAAAA	C	1: 13,149,109 (GRCm38)		probably benign	Het
Ngp	A	G	9: 110,421,756 (GRCm38)	T114A	possibly damaging	Het
Nlrc5	A	T	8: 94,476,888 (GRCm38)	T539S	probably benign	Het
Nxf1	A	G	19: 8,772,309 (GRCm38)	D190G	probably damaging	Het
Olfr229	A	T	9: 39,910,045 (GRCm38)	M81L	probably benign	Het
Olfr769	A	T	10: 129,112,342 (GRCm38)	F28I	probably damaging	Het
Pramef25	C	G	4: 143,948,908 (GRCm38)	Q449H	probably damaging	Het
Prdm15	G	A	16: 97,808,756 (GRCm38)	H563Y	probably damaging	Het
Rbm12	CAGG	CAGGGATTGCGGGACCTGGTATTGCGGGACCAGG	2: 156,096,106 (GRCm38)		probably benign	Het
Sema3g	C	T	14: 31,227,841 (GRCm38)	H660Y	probably damaging	Het
Smarca2	AGCAGCAGCAGCAGCAGCAGCA	AGCAGCAGCAGCAGCAGCAGCAGCAGCA	19: 26,630,997 (GRCm38)		probably benign	Het
Stpg2	A	T	3: 139,212,250 (GRCm38)		probably null	Het
Taar7f	C	T	10: 24,050,423 (GRCm38)	T305M	possibly damaging	Het
Tbcb	C	T	7: 30,224,346 (GRCm38)	V208M	probably damaging	Het
Tenm2	T	A	11: 36,024,203 (GRCm38)	Q2169L	possibly damaging	Het
Tln1	A	G	4: 43,555,890 (GRCm38)	V108A	probably damaging	Het
Tmc8	T	C	11: 117,783,234 (GRCm38)	M42T	probably benign	Het
Trdc	T	C	14: 54,144,203 (GRCm38)	V115A		Het
Ttbk2	A	G	2: 120,748,634 (GRCm38)	V669A	probably benign	Het
Tusc1	GCC	GCCACCACC	4: 93,335,316 (GRCm38)		probably benign	Het
Vps16	A	G	2: 130,438,209 (GRCm38)	H118R	probably benign	Het
Wdpcp	T	A	11: 21,711,587 (GRCm38)	C286*	probably null	Het
Zbed4	C	A	15: 88,781,236 (GRCm38)	Y502*	probably null	Het
Zdbf2	T	A	1: 63,302,652 (GRCm38)	N63K	possibly damaging	Het

Other mutations in Kmt2b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00580:Kmt2b	APN	7	30,586,513 (GRCm38)	unclassified	probably benign
IGL00821:Kmt2b	APN	7	30,570,613 (GRCm38)	missense	probably damaging	1.00
IGL00985:Kmt2b	APN	7	30,579,927 (GRCm38)	missense	probably damaging	1.00
IGL01092:Kmt2b	APN	7	30,580,507 (GRCm38)	missense	probably damaging	1.00
IGL01933:Kmt2b	APN	7	30,569,514 (GRCm38)	critical splice donor site	probably null
IGL01949:Kmt2b	APN	7	30,577,161 (GRCm38)	splice site	probably null
IGL02253:Kmt2b	APN	7	30,581,727 (GRCm38)	missense	probably damaging	1.00
IGL02455:Kmt2b	APN	7	30,578,878 (GRCm38)	critical splice donor site	probably null
IGL02493:Kmt2b	APN	7	30,569,511 (GRCm38)	unclassified	probably benign
IGL02504:Kmt2b	APN	7	30,586,543 (GRCm38)	unclassified	probably benign
IGL02532:Kmt2b	APN	7	30,586,889 (GRCm38)	unclassified	probably benign
IGL02698:Kmt2b	APN	7	30,578,693 (GRCm38)	splice site	probably benign
IGL02717:Kmt2b	APN	7	30,583,444 (GRCm38)	missense	probably damaging	1.00
IGL02826:Kmt2b	APN	7	30,577,144 (GRCm38)	missense	probably damaging	1.00
IGL02966:Kmt2b	APN	7	30,575,462 (GRCm38)	missense	probably benign	0.02
IGL03386:Kmt2b	APN	7	30,573,971 (GRCm38)	missense	possibly damaging	0.94
Dean	UTSW	7	30,569,410 (GRCm38)	missense	possibly damaging	0.83
provost	UTSW	7	30,582,208 (GRCm38)	missense	probably damaging	1.00
tenure	UTSW	7	30,569,175 (GRCm38)	missense	probably damaging	1.00
3-1:Kmt2b	UTSW	7	30,569,615 (GRCm38)	nonsense	probably null
FR4304:Kmt2b	UTSW	7	30,586,363 (GRCm38)	unclassified	probably benign
FR4340:Kmt2b	UTSW	7	30,586,375 (GRCm38)	unclassified	probably benign
FR4340:Kmt2b	UTSW	7	30,586,369 (GRCm38)	unclassified	probably benign
FR4340:Kmt2b	UTSW	7	30,586,363 (GRCm38)	unclassified	probably benign
FR4342:Kmt2b	UTSW	7	30,586,375 (GRCm38)	unclassified	probably benign
FR4449:Kmt2b	UTSW	7	30,586,369 (GRCm38)	unclassified	probably benign
FR4449:Kmt2b	UTSW	7	30,586,366 (GRCm38)	unclassified	probably benign
FR4449:Kmt2b	UTSW	7	30,586,361 (GRCm38)	unclassified	probably benign
FR4548:Kmt2b	UTSW	7	30,586,380 (GRCm38)	unclassified	probably benign
FR4589:Kmt2b	UTSW	7	30,586,381 (GRCm38)	unclassified	probably benign
FR4589:Kmt2b	UTSW	7	30,586,364 (GRCm38)	nonsense	probably null
FR4589:Kmt2b	UTSW	7	30,586,361 (GRCm38)	unclassified	probably benign
FR4737:Kmt2b	UTSW	7	30,586,370 (GRCm38)	unclassified	probably benign
FR4737:Kmt2b	UTSW	7	30,586,367 (GRCm38)	unclassified	probably benign
FR4737:Kmt2b	UTSW	7	30,586,366 (GRCm38)	unclassified	probably benign
FR4737:Kmt2b	UTSW	7	30,586,378 (GRCm38)	unclassified	probably benign
FR4976:Kmt2b	UTSW	7	30,586,362 (GRCm38)	unclassified	probably benign
FR4976:Kmt2b	UTSW	7	30,586,360 (GRCm38)	unclassified	probably benign
FR4976:Kmt2b	UTSW	7	30,586,373 (GRCm38)	unclassified	probably benign
FR4976:Kmt2b	UTSW	7	30,586,366 (GRCm38)	unclassified	probably benign
FR4976:Kmt2b	UTSW	7	30,586,364 (GRCm38)	nonsense	probably null
PIT4403001:Kmt2b	UTSW	7	30,585,689 (GRCm38)	missense	probably damaging	1.00
PIT4802001:Kmt2b	UTSW	7	30,579,571 (GRCm38)	missense	probably damaging	0.99
R0057:Kmt2b	UTSW	7	30,576,792 (GRCm38)	splice site	probably benign
R0131:Kmt2b	UTSW	7	30,583,921 (GRCm38)	missense	probably damaging	0.99
R0241:Kmt2b	UTSW	7	30,577,069 (GRCm38)	missense	probably damaging	1.00
R0241:Kmt2b	UTSW	7	30,577,069 (GRCm38)	missense	probably damaging	1.00
R0377:Kmt2b	UTSW	7	30,574,193 (GRCm38)	missense	probably damaging	1.00
R0396:Kmt2b	UTSW	7	30,576,755 (GRCm38)	missense	probably damaging	1.00
R1241:Kmt2b	UTSW	7	30,574,940 (GRCm38)	missense	probably damaging	0.98
R1252:Kmt2b	UTSW	7	30,580,487 (GRCm38)	missense	probably damaging	0.99
R1418:Kmt2b	UTSW	7	30,576,960 (GRCm38)	splice site	probably benign
R1599:Kmt2b	UTSW	7	30,570,575 (GRCm38)	missense	probably damaging	1.00
R1632:Kmt2b	UTSW	7	30,583,962 (GRCm38)	missense	probably damaging	1.00
R1745:Kmt2b	UTSW	7	30,585,850 (GRCm38)	missense	possibly damaging	0.90
R1867:Kmt2b	UTSW	7	30,574,658 (GRCm38)	missense	possibly damaging	0.71
R1955:Kmt2b	UTSW	7	30,575,351 (GRCm38)	missense	possibly damaging	0.90
R2040:Kmt2b	UTSW	7	30,569,420 (GRCm38)	missense	probably damaging	1.00
R2113:Kmt2b	UTSW	7	30,583,387 (GRCm38)	missense	probably damaging	1.00
R2216:Kmt2b	UTSW	7	30,574,065 (GRCm38)	missense	probably benign	0.25
R2401:Kmt2b	UTSW	7	30,576,708 (GRCm38)	missense	probably damaging	1.00
R2518:Kmt2b	UTSW	7	30,576,068 (GRCm38)	missense	probably benign	0.10
R3436:Kmt2b	UTSW	7	30,576,692 (GRCm38)	missense	probably damaging	1.00
R4248:Kmt2b	UTSW	7	30,574,064 (GRCm38)	missense	probably benign	0.25
R4259:Kmt2b	UTSW	7	30,581,081 (GRCm38)	missense	probably damaging	0.99
R4290:Kmt2b	UTSW	7	30,581,836 (GRCm38)	critical splice donor site	probably null
R4388:Kmt2b	UTSW	7	30,588,590 (GRCm38)	unclassified	probably benign
R4542:Kmt2b	UTSW	7	30,580,259 (GRCm38)	missense	probably damaging	0.99
R4649:Kmt2b	UTSW	7	30,586,358 (GRCm38)	unclassified	probably benign
R4722:Kmt2b	UTSW	7	30,583,202 (GRCm38)	missense	probably damaging	1.00
R4891:Kmt2b	UTSW	7	30,576,761 (GRCm38)	nonsense	probably null
R4916:Kmt2b	UTSW	7	30,578,517 (GRCm38)	missense	probably damaging	0.99
R5104:Kmt2b	UTSW	7	30,569,840 (GRCm38)	missense	probably damaging	1.00
R5254:Kmt2b	UTSW	7	30,569,175 (GRCm38)	missense	probably damaging	1.00
R5262:Kmt2b	UTSW	7	30,569,794 (GRCm38)	missense	probably damaging	1.00
R5307:Kmt2b	UTSW	7	30,581,673 (GRCm38)	missense	possibly damaging	0.91
R5526:Kmt2b	UTSW	7	30,580,444 (GRCm38)	missense	probably damaging	1.00
R5609:Kmt2b	UTSW	7	30,577,145 (GRCm38)	missense	probably damaging	0.99
R6150:Kmt2b	UTSW	7	30,588,477 (GRCm38)	unclassified	probably benign
R6727:Kmt2b	UTSW	7	30,584,559 (GRCm38)	missense	probably damaging	0.98
R6824:Kmt2b	UTSW	7	30,586,276 (GRCm38)	unclassified	probably benign
R7048:Kmt2b	UTSW	7	30,569,306 (GRCm38)	missense	probably damaging	0.99
R7155:Kmt2b	UTSW	7	30,579,963 (GRCm38)	missense	probably damaging	0.99
R7307:Kmt2b	UTSW	7	30,580,471 (GRCm38)	missense	probably damaging	0.99
R7388:Kmt2b	UTSW	7	30,581,960 (GRCm38)	missense	probably damaging	1.00
R7555:Kmt2b	UTSW	7	30,569,410 (GRCm38)	missense	possibly damaging	0.83
R7569:Kmt2b	UTSW	7	30,569,553 (GRCm38)	missense	possibly damaging	0.54
R7616:Kmt2b	UTSW	7	30,582,208 (GRCm38)	missense	probably damaging	1.00
R7669:Kmt2b	UTSW	7	30,583,231 (GRCm38)	missense	possibly damaging	0.84
R7881:Kmt2b	UTSW	7	30,579,783 (GRCm38)	missense	probably damaging	1.00
R7999:Kmt2b	UTSW	7	30,576,774 (GRCm38)	missense	probably damaging	1.00
R8003:Kmt2b	UTSW	7	30,569,377 (GRCm38)	missense	probably damaging	0.98
R8189:Kmt2b	UTSW	7	30,569,331 (GRCm38)	missense	probably damaging	0.98
R8291:Kmt2b	UTSW	7	30,585,469 (GRCm38)	missense	probably damaging	1.00
R8314:Kmt2b	UTSW	7	30,578,922 (GRCm38)	missense	probably damaging	0.99
R8802:Kmt2b	UTSW	7	30,584,071 (GRCm38)	missense	probably damaging	1.00
R8954:Kmt2b	UTSW	7	30,574,215 (GRCm38)	missense	probably damaging	1.00
R9046:Kmt2b	UTSW	7	30,586,054 (GRCm38)	missense	probably benign	0.00
R9225:Kmt2b	UTSW	7	30,586,747 (GRCm38)	missense	unknown
R9258:Kmt2b	UTSW	7	30,582,468 (GRCm38)	missense	probably null	0.99
R9414:Kmt2b	UTSW	7	30,582,882 (GRCm38)	missense	probably damaging	0.99
R9468:Kmt2b	UTSW	7	30,585,088 (GRCm38)	missense	probably damaging	0.98
R9508:Kmt2b	UTSW	7	30,569,834 (GRCm38)	missense	probably damaging	0.99
R9642:Kmt2b	UTSW	7	30,583,915 (GRCm38)	critical splice donor site	probably null
R9667:Kmt2b	UTSW	7	30,588,359 (GRCm38)	missense	unknown
R9709:Kmt2b	UTSW	7	30,579,803 (GRCm38)	missense	probably damaging	0.98
RF001:Kmt2b	UTSW	7	30,586,382 (GRCm38)	unclassified	probably benign
RF006:Kmt2b	UTSW	7	30,586,377 (GRCm38)	unclassified	probably benign
RF020:Kmt2b	UTSW	7	30,586,382 (GRCm38)	unclassified	probably benign
RF030:Kmt2b	UTSW	7	30,586,377 (GRCm38)	unclassified	probably benign
RF035:Kmt2b	UTSW	7	30,586,357 (GRCm38)	unclassified	probably benign
X0067:Kmt2b	UTSW	7	30,579,573 (GRCm38)	missense	probably damaging	0.99
Z1088:Kmt2b	UTSW	7	30,585,251 (GRCm38)	missense	probably benign	0.28
Z1176:Kmt2b	UTSW	7	30,577,370 (GRCm38)	missense	probably damaging	1.00
Z1177:Kmt2b	UTSW	7	30,586,416 (GRCm38)	missense	unknown
Z1177:Kmt2b	UTSW	7	30,584,163 (GRCm38)	missense	probably damaging	0.98
Z1177:Kmt2b	UTSW	7	30,575,024 (GRCm38)	missense	probably benign	0.08
Z1186:Kmt2b	UTSW	7	30,585,307 (GRCm38)	missense	probably benign
Z1186:Kmt2b	UTSW	7	30,574,979 (GRCm38)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- CCCTCTTCCTAGAGCATGTAGC -3'
(R):5'- TGTTTCCAAGGCCAAGAAAGTG -3'

Sequencing Primer
(F):5'- AGGAGACTCTTCCTGCTTCTCTG -3'
(R):5'- TTTCCAAGGCCAAGAAAGTGAAGATG -3'

Posted On

2019-12-04