Incidental Mutation 'RF021:Taar7f'
ID 603891
Institutional Source Beutler Lab
Gene Symbol Taar7f
Ensembl Gene ENSMUSG00000100950
Gene Name trace amine-associated receptor 7F
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # RF021 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 23925408-23926484 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 23926321 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 305 (T305M)
Ref Sequence ENSEMBL: ENSMUSP00000071611 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071691]
AlphaFold Q5QD08
Predicted Effect possibly damaging
Transcript: ENSMUST00000071691
AA Change: T305M

PolyPhen 2 Score 0.889 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000071611
Gene: ENSMUSG00000100950
AA Change: T305M

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 56 261 1.6e-7 PFAM
Pfam:7TM_GPCR_Srsx 58 341 2e-10 PFAM
Pfam:7tm_1 64 326 6.6e-58 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000119318
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.7%
  • 10x: 99.3%
  • 20x: 98.3%
Validation Efficiency 91% (50/55)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A030005L19Rik GTGGTGGCTG GTGGTGGCTGTGGTGGCTG 1: 82,891,290 (GRCm39) probably benign Het
AI837181 CGG CGGTGG 19: 5,475,262 (GRCm39) probably benign Het
Ankrd44 T C 1: 54,817,471 (GRCm39) H79R probably damaging Het
Atg9a T A 1: 75,159,273 (GRCm39) E826V probably damaging Het
Atrnl1 T C 19: 57,630,905 (GRCm39) V224A probably benign Het
Bltp1 TTATTATTATTAT TTATTATTATTATTAATATTATTATTAT 3: 37,104,897 (GRCm39) probably benign Het
Cpn2 G A 16: 30,078,156 (GRCm39) A515V probably benign Het
Cyp2a12 T C 7: 26,734,785 (GRCm39) F402S possibly damaging Het
Defb22 TGCGGCA TGCGGCAGAGCTGGGCGTTGCGGCA 2: 152,327,752 (GRCm39) probably benign Het
Dnah10 G T 5: 124,854,971 (GRCm39) V2016F probably damaging Het
Dock10 T C 1: 80,542,290 (GRCm39) probably null Het
Efhd2 GCC GCCGCCCCC 4: 141,602,084 (GRCm39) probably benign Het
Fam131a A C 16: 20,513,690 (GRCm39) probably benign Het
Gm7247 AGACCAGACC A 14: 51,601,781 (GRCm39) probably benign Het
Gna13 T C 11: 109,283,218 (GRCm39) V186A probably benign Het
Grk3 T A 5: 113,089,554 (GRCm39) I333L probably benign Het
Gstp1 A T 19: 4,085,507 (GRCm39) V200E probably benign Het
Gtf2h1 T G 7: 46,453,289 (GRCm39) V74G possibly damaging Het
Kcnh8 G A 17: 53,285,267 (GRCm39) R1079H probably benign Het
Kiz A G 2: 146,712,750 (GRCm39) D138G possibly damaging Het
Kmt2b TTCTCCT TTCTCCTTCTCCT 7: 30,285,782 (GRCm39) probably benign Het
Lats1 A G 10: 7,586,372 (GRCm39) T912A probably damaging Het
Lce1m GCTGCCACC GCTGCCACCACTTCTGCCACC 3: 92,925,576 (GRCm39) probably benign Het
Lce1m TGCC TGCCGCCGCTGCCGCC 3: 92,925,602 (GRCm39) probably benign Het
Lrrc2 TTGATTCGGTTCACC T 9: 110,810,744 (GRCm39) probably null Het
Med12l T C 3: 58,980,711 (GRCm39) F359S probably benign Het
Mmut A G 17: 41,262,649 (GRCm39) I444V probably benign Het
Ncoa2 CTTAAAA C 1: 13,219,333 (GRCm39) probably benign Het
Ngp A G 9: 110,250,824 (GRCm39) T114A possibly damaging Het
Nlrc5 A T 8: 95,203,516 (GRCm39) T539S probably benign Het
Nxf1 A G 19: 8,749,673 (GRCm39) D190G probably damaging Het
Or6c2b A T 10: 128,948,211 (GRCm39) F28I probably damaging Het
Or8g2 A T 9: 39,821,341 (GRCm39) M81L probably benign Het
Pramel16 C G 4: 143,675,478 (GRCm39) Q449H probably damaging Het
Prdm15 G A 16: 97,609,956 (GRCm39) H563Y probably damaging Het
Rbm12 CAGG CAGGGATTGCGGGACCTGGTATTGCGGGACCAGG 2: 155,938,026 (GRCm39) probably benign Het
Sema3g C T 14: 30,949,798 (GRCm39) H660Y probably damaging Het
Slco1a8 A T 6: 141,954,440 (GRCm39) V31E probably damaging Het
Smarca2 AGCAGCAGCAGCAGCAGCAGCA AGCAGCAGCAGCAGCAGCAGCAGCAGCA 19: 26,608,397 (GRCm39) probably benign Het
Stpg2 A T 3: 138,918,011 (GRCm39) probably null Het
Tbcb C T 7: 29,923,771 (GRCm39) V208M probably damaging Het
Tenm2 T A 11: 35,915,030 (GRCm39) Q2169L possibly damaging Het
Tln1 A G 4: 43,555,890 (GRCm39) V108A probably damaging Het
Tmc8 T C 11: 117,674,060 (GRCm39) M42T probably benign Het
Trdc T C 14: 54,381,660 (GRCm39) V115A Het
Ttbk2 A G 2: 120,579,115 (GRCm39) V669A probably benign Het
Tusc1 GCC GCCACCACC 4: 93,223,553 (GRCm39) probably benign Het
Utp25 A G 1: 192,802,974 (GRCm39) F248L probably benign Het
Vps16 A G 2: 130,280,129 (GRCm39) H118R probably benign Het
Wdpcp T A 11: 21,661,587 (GRCm39) C286* probably null Het
Zbed4 C A 15: 88,665,439 (GRCm39) Y502* probably null Het
Zdbf2 T A 1: 63,341,811 (GRCm39) N63K possibly damaging Het
Other mutations in Taar7f
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00936:Taar7f APN 10 23,926,066 (GRCm39) missense probably benign
IGL01618:Taar7f APN 10 23,926,239 (GRCm39) missense possibly damaging 0.56
IGL02567:Taar7f APN 10 23,926,323 (GRCm39) missense probably damaging 0.97
R0096:Taar7f UTSW 10 23,926,152 (GRCm39) missense probably benign 0.00
R0139:Taar7f UTSW 10 23,926,312 (GRCm39) missense probably benign 0.04
R0363:Taar7f UTSW 10 23,925,839 (GRCm39) missense probably damaging 1.00
R1776:Taar7f UTSW 10 23,925,546 (GRCm39) missense probably benign 0.14
R1952:Taar7f UTSW 10 23,925,747 (GRCm39) missense probably damaging 1.00
R2049:Taar7f UTSW 10 23,926,323 (GRCm39) missense possibly damaging 0.65
R2280:Taar7f UTSW 10 23,925,417 (GRCm39) missense probably benign
R3120:Taar7f UTSW 10 23,925,478 (GRCm39) missense probably benign
R4210:Taar7f UTSW 10 23,925,921 (GRCm39) missense probably damaging 1.00
R4211:Taar7f UTSW 10 23,925,921 (GRCm39) missense probably damaging 1.00
R4587:Taar7f UTSW 10 23,926,473 (GRCm39) missense probably damaging 0.97
R5092:Taar7f UTSW 10 23,925,451 (GRCm39) missense probably benign
R5512:Taar7f UTSW 10 23,926,321 (GRCm39) missense possibly damaging 0.89
R7439:Taar7f UTSW 10 23,925,885 (GRCm39) missense possibly damaging 0.88
R7441:Taar7f UTSW 10 23,925,885 (GRCm39) missense possibly damaging 0.88
R7839:Taar7f UTSW 10 23,925,967 (GRCm39) missense possibly damaging 0.90
R8326:Taar7f UTSW 10 23,925,811 (GRCm39) missense possibly damaging 0.81
R9443:Taar7f UTSW 10 23,926,311 (GRCm39) missense probably benign 0.00
R9687:Taar7f UTSW 10 23,925,727 (GRCm39) missense probably benign 0.19
Predicted Primers PCR Primer
(F):5'- ATGAGCAAGCAGACTGCCAG -3'
(R):5'- AGAAACAGACCTGGGCACTC -3'

Sequencing Primer
(F):5'- CAGGGCATCAGACAGCTAC -3'
(R):5'- AGACCTGGGCACTCAGTCTC -3'
Posted On 2019-12-04