Incidental Mutation 'RF026:Lce1m'
ID 604159
Institutional Source Beutler Lab
Gene Symbol Lce1m
Ensembl Gene ENSMUSG00000027912
Gene Name late cornified envelope 1M
Synonyms 1110059L13Rik, Sprrl10, Lce5a
Accession Numbers
Essential gene? Not available question?
Stock # RF026 (G1)
Quality Score 217.468
Status Not validated
Chromosome 3
Chromosomal Location 92925117-92926367 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) CCACTGCTGCT to CCACTGCTGCTTTCACTGCTGCT at 92925445 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000141488 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029520] [ENSMUST00000029521] [ENSMUST00000107301] [ENSMUST00000193944]
AlphaFold Q9CR91
Predicted Effect probably benign
Transcript: ENSMUST00000029520
SMART Domains Protein: ENSMUSP00000029520
Gene: ENSMUSG00000027912

DomainStartEndE-ValueType
Pfam:LCE 9 96 5.4e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000029521
SMART Domains Protein: ENSMUSP00000029521
Gene: ENSMUSG00000027913

DomainStartEndE-ValueType
low complexity region 12 102 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000107301
SMART Domains Protein: ENSMUSP00000102922
Gene: ENSMUSG00000027913

DomainStartEndE-ValueType
Pfam:NICE-1 5 100 5.4e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000193944
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.7%
  • 10x: 99.3%
  • 20x: 98.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AI837181 GCG GCGTCG 19: 5,475,252 (GRCm39) probably benign Het
Ankhd1 GGCGGC GGCGGCTGCGGC 18: 36,693,965 (GRCm39) probably benign Het
Cacna1f GA GAGTA X: 7,486,314 (GRCm39) probably null Het
Cox7a2l GGA GGATGGGGA 17: 83,810,151 (GRCm39) probably benign Het
Cul9 CCT CCTACT 17: 46,811,795 (GRCm39) probably null Het
Cyb5r4 ACACACTGCC ACACACTGCCTAGGGATGTGACAGCCACACTGCC 9: 86,922,486 (GRCm39) probably benign Het
Foxd3 GGACCCTACGGCCG GG 4: 99,545,633 (GRCm39) probably benign Het
Gab3 TCT TCTGCT X: 74,043,596 (GRCm39) probably benign Het
Gab3 TCT TCTGCT X: 74,043,629 (GRCm39) probably benign Het
Hsdl2 GCAG GCAGCAGCAGCCACAGCTACAG 4: 59,610,655 (GRCm39) probably benign Het
Kmt2e TTT TTTTGTT 5: 23,683,507 (GRCm39) probably benign Het
Krtap28-10 CACAGC CACAGCAACAGC 1: 83,019,847 (GRCm39) probably benign Het
Mrgprx1 GAAC GAACAAC 7: 47,671,257 (GRCm39) probably benign Het
Nusap1 GCTG GCTGGGATACACGTTAGCAGTGAGGAGCAATCTG 2: 119,458,085 (GRCm39) probably benign Het
Nusap1 GCAGTGAGGAGCAAGCTGAGA GCAGTGAGGAGCAAGCTGAGATACACGTTATCAGTGAGGAGCAAGCTGAGA 2: 119,458,071 (GRCm39) probably benign Het
Pdik1l CCCA CCCACCA 4: 134,013,905 (GRCm39) probably benign Het
Rbm33 CCAGCCGCAGC CCAGC 5: 28,599,179 (GRCm39) probably benign Het
Supt20 CA CAGCAGTA 3: 54,635,091 (GRCm39) probably null Het
Supt20 T TACAGCA 3: 54,635,068 (GRCm39) probably benign Het
Trav15-2-dv6-2 G GAAT 14: 53,887,214 (GRCm39) probably benign Het
Yipf3 AGAGGA AGA 17: 46,559,898 (GRCm39) probably benign Het
Zfp384 CAGGC CAGGCCCATGCCAAGGC 6: 125,013,455 (GRCm39) probably benign Het
Other mutations in Lce1m
AlleleSourceChrCoordTypePredicted EffectPPH Score
FR4342:Lce1m UTSW 3 92,925,554 (GRCm39) unclassified probably benign
FR4449:Lce1m UTSW 3 92,925,459 (GRCm39) unclassified probably benign
FR4589:Lce1m UTSW 3 92,925,575 (GRCm39) unclassified probably benign
FR4976:Lce1m UTSW 3 92,925,455 (GRCm39) unclassified probably benign
R1513:Lce1m UTSW 3 92,925,932 (GRCm39) unclassified probably benign
R7621:Lce1m UTSW 3 92,925,177 (GRCm39) splice site probably null
R7753:Lce1m UTSW 3 92,925,815 (GRCm39) missense unknown
RF001:Lce1m UTSW 3 92,925,576 (GRCm39) unclassified probably benign
RF001:Lce1m UTSW 3 92,925,459 (GRCm39) unclassified probably benign
RF002:Lce1m UTSW 3 92,925,606 (GRCm39) unclassified probably benign
RF002:Lce1m UTSW 3 92,925,590 (GRCm39) unclassified probably benign
RF007:Lce1m UTSW 3 92,925,451 (GRCm39) unclassified probably benign
RF009:Lce1m UTSW 3 92,925,438 (GRCm39) unclassified probably benign
RF010:Lce1m UTSW 3 92,925,597 (GRCm39) unclassified probably benign
RF015:Lce1m UTSW 3 92,925,455 (GRCm39) unclassified probably benign
RF021:Lce1m UTSW 3 92,925,602 (GRCm39) unclassified probably benign
RF021:Lce1m UTSW 3 92,925,576 (GRCm39) unclassified probably benign
RF023:Lce1m UTSW 3 92,925,587 (GRCm39) unclassified probably benign
RF026:Lce1m UTSW 3 92,925,450 (GRCm39) unclassified probably benign
RF028:Lce1m UTSW 3 92,925,438 (GRCm39) unclassified probably benign
RF030:Lce1m UTSW 3 92,925,651 (GRCm39) unclassified probably benign
RF030:Lce1m UTSW 3 92,925,448 (GRCm39) unclassified probably benign
RF037:Lce1m UTSW 3 92,925,607 (GRCm39) unclassified probably benign
RF041:Lce1m UTSW 3 92,925,448 (GRCm39) unclassified probably benign
RF042:Lce1m UTSW 3 92,925,446 (GRCm39) unclassified probably benign
RF045:Lce1m UTSW 3 92,925,599 (GRCm39) unclassified probably benign
RF046:Lce1m UTSW 3 92,925,600 (GRCm39) unclassified probably benign
RF054:Lce1m UTSW 3 92,925,605 (GRCm39) unclassified probably benign
RF059:Lce1m UTSW 3 92,925,636 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- ACCTCGTGGTAGATGAGCTTTAGG -3'
(R):5'- ACAGCTCTGGATGCTGTAGC -3'

Sequencing Primer
(F):5'- CTTTAGGGAGATGAAGAGGACGTAC -3'
(R):5'- TGTAGCAGCGGTGGCAG -3'
Posted On 2019-12-04