|Institutional Source||Beutler Lab|
|Gene Name||RAS p21 protein activator 2|
|Is this an essential gene?||Probably non essential (E-score: 0.112)|
|Stock #||RF029 (G1)|
|Chromosomal Location||96539300-96631617 bp(-) (GRCm38)|
|Type of Mutation||small insertion (1 aa in frame mutation)|
|DNA Base Change (assembly)||CGC to CGCAGC at 96631467 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000115629 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000034984] [ENSMUST00000128346]|
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Rasa2||
(F):5'- TGTAATTACCACGGGGCTCC -3'
(R):5'- CGTCCAATTCTCAGGGTTCTGG -3'
(F):5'- AGTCTCACCAGTCCCGG -3'
(R):5'- TTCTGGGGATCACAGCAGG -3'