|Institutional Source||Beutler Lab|
|Gene Name||cytochrome c oxidase subunit VIIa polypeptide 2-like|
|Synonyms||SIG81, COX7RP, COX7AR, SIG-81, EB1|
|Is this an essential gene?||Probably non essential (E-score: 0.170)|
|Stock #||RF034 (G1)|
|Chromosomal Location||83501919-83514333 bp(-) (GRCm38)|
|Type of Mutation||small insertion (2 aa in frame mutation)|
|DNA Base Change (assembly)||GGA to GGATGGGGA at 83502722 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000131584 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000025095] [ENSMUST00000167741]|
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cox7a2l||
(F):5'- GGATTCAAAGGGTTTGTGCC -3'
(R):5'- CCCAGTTGCCCGCTATATTGTG -3'
(F):5'- TTTGTGCCACAAAGTGAACCAGTC -3'
(R):5'- AGTACACTGTAGCTGTCTTCAGAC -3'