Incidental Mutation 'RF038:Dennd10'
ID 604692
Institutional Source Beutler Lab
Gene Symbol Dennd10
Ensembl Gene ENSMUSG00000024993
Gene Name DENN domain containing 10
Synonyms 1810055E12Rik, Fam45a
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # RF038 (G1)
Quality Score 214.458
Status Not validated
Chromosome 19
Chromosomal Location 60800023-60824665 bp(+) (GRCm39)
Type of Mutation small insertion (1 aa in frame mutation)
DNA Base Change (assembly) ACTC to ACTCCTC at 60803056 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000121853 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025957] [ENSMUST00000119633] [ENSMUST00000128357] [ENSMUST00000148577]
AlphaFold Q9D8N2
Predicted Effect probably benign
Transcript: ENSMUST00000025957
SMART Domains Protein: ENSMUSP00000025957
Gene: ENSMUSG00000024993

DomainStartEndE-ValueType
Pfam:Avl9 118 207 1.7e-9 PFAM
Pfam:SPA 157 264 2.2e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000119633
SMART Domains Protein: ENSMUSP00000112839
Gene: ENSMUSG00000024993

DomainStartEndE-ValueType
Pfam:Avl9 5 88 1.4e-9 PFAM
Pfam:SPA 36 143 4.7e-11 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000121724
Predicted Effect probably benign
Transcript: ENSMUST00000128357
SMART Domains Protein: ENSMUSP00000118461
Gene: ENSMUSG00000024993

DomainStartEndE-ValueType
Pfam:Avl9 4 88 4e-10 PFAM
Pfam:SPA 35 136 1.2e-10 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136146
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147049
Predicted Effect probably benign
Transcript: ENSMUST00000148577
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.7%
  • 10x: 99.3%
  • 20x: 98.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A030005L19Rik TGT TGTAGCTGCGGT 1: 82,891,301 (GRCm39) probably benign Het
Abcf1 CTCTTC CTC 17: 36,274,093 (GRCm39) probably benign Het
Acap3 GCATCCTGGGCTGCT GCATCCTGGGCTGCTTCATCCTGGGCTGCT 4: 155,989,549 (GRCm39) probably benign Het
AI837181 GGC GGCAGC 19: 5,475,254 (GRCm39) probably benign Het
AI837181 GCG GCGACG 19: 5,475,264 (GRCm39) probably benign Het
Cdx1 CTGCTG CTGCTGGTGCTG 18: 61,152,942 (GRCm39) probably benign Het
Cyb5r4 CCAGGGA CCAGGGATGTGACACACACACTGCGCAGGGA 9: 86,922,495 (GRCm39) probably benign Het
Dbr1 GAGGAG GAGGAGAAGGAG 9: 99,465,750 (GRCm39) probably benign Het
Dmkn GTGGAAGTGGTGG GTGGAAGTGGTGGAAGTGGTGGAAGTGTTGGAAGTGGTGG 7: 30,466,619 (GRCm39) probably benign Het
Dnaaf9 CTC CTCATC 2: 130,612,664 (GRCm39) probably null Het
Enah TGGCGGCGG TGG 1: 181,749,500 (GRCm39) probably benign Het
Flywch1 ACCCACTCCTGGTGT ACCCACTCCTGGTGTGGGGAGGCTACGTACTCCCCCACTCCTGGTGT 17: 23,981,138 (GRCm39) probably null Het
Foxd3 GGACCCTACGGCCG GG 4: 99,545,633 (GRCm39) probably benign Het
Fscb CTTCTACAGGGGCCTCCTCAGTTGCTGGAGGTAGAACTTCTACAGGGGCCTCCTCAGTTGCTGGAGGT CTTCTACAGGGGCCTCCTCAGTTGCTGGAGGTAGAAATTCTACAGGGGCCTCCTCAGTTGCTGGAGGTAGAACTTCTACAGGGGCCTCCTCAGTTGCTGGAGGT 12: 64,519,343 (GRCm39) probably benign Het
Fsip2 TAGATGTGAAACCCTTAGAGGTAAGATGTGAAACTCTTAGAGGTAAGA TAGATGTGAAACTCTTAGAGGTAAGA 2: 82,824,352 (GRCm39) probably null Het
Garin5a TGGGTCTGAGGGAGGA TGGGTCTGAGGGAGGAAGGCTGGATCCTGGATACCGGGGTCTGAGGGAGGA 7: 44,149,946 (GRCm39) probably null Het
Gas1 CGAGGA CGAGGAGGA 13: 60,324,342 (GRCm39) probably benign Het
Gas1 AG AGATG 13: 60,324,344 (GRCm39) probably benign Het
Gm15155 CAAAAA CAAAAACAAAAAA X: 155,128,636 (GRCm39) probably null Het
Habp4 TGAGG TG 13: 64,309,976 (GRCm39) probably benign Het
Hsdl2 CACAGCTGCAG CACAGCTGCAGCAGCAGCGACAGCTGCAG 4: 59,610,648 (GRCm39) probably benign Het
Il2 CTT CTTCAAGTGGGGATT 3: 37,179,970 (GRCm39) probably null Het
Irag2 TG TGAGCACATCG 6: 145,119,516 (GRCm39) probably benign Het
Ivl CTTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTG CCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTG 3: 92,479,607 (GRCm39) probably benign Het
Krtap28-10 CA CAACCAAA 1: 83,019,849 (GRCm39) probably benign Het
Krtap28-10 CAGCCACAGCCACCACAGCCACAGCCACCA CAGCCACAGCCACCAAAGCCACAGCCACCACAGCCACAGCCACCA 1: 83,019,978 (GRCm39) probably benign Het
Lmx1b CATCTTGATGCCGTCCAA C 2: 33,530,521 (GRCm39) probably null Het
Mamld1 CAG CAGGAG X: 70,162,452 (GRCm39) probably benign Het
Nefh CTGGGGACTTGGCCTCACCTGGGGACTTGGCCTC CTGGGGACTTGGCCTCACCTGGGGACTTGGCCTCACCTGGGGACTTGGCCTC 11: 4,891,027 (GRCm39) probably benign Het
Nefh GGGGACTTGGCCTCACCTGGGGACTTGGCCTC GGGGACTTGGCCTCACCTGGGGACTTGGCCTCACCTGGGGACTTGGCCTC 11: 4,891,029 (GRCm39) probably benign Het
Nefh CTCACCTGGGGACTTGGC CTCACCTGGGGACTTGGCATCACCTGGGGACTTGGC 11: 4,891,040 (GRCm39) probably benign Het
Nefh GGGACTTGGCCTCACCTGGGGACTTGGCCTCACCTGGGGACTTGGCCTC GGGACTTGGCCTCACCTGGGGACTTGGCCTCACCTGGGGACTTGGCCTCACCTGGGGACTTGGCCTC 11: 4,891,012 (GRCm39) probably benign Het
Nefh TGGCCTCACCTGGGGACTTGGCCTCACCTGGGGACTTGGCCTC TGGCCTCACCTGGGGACTTGGCCTCACCTGGGGACTTGGCCTCACCTGGGGACTTGGCCTC 11: 4,891,018 (GRCm39) probably benign Het
Nefh GGCCTCACCTGGGGACTTGGCCTCACCTGGGGACTTGGCCTC GGCCTCACCTGGGGACTTGGCCTCACCTGGGGACTTGGCCTCACCTGGGGACTTGGCCTC 11: 4,891,019 (GRCm39) probably benign Het
Pabpc6 AGCTGC AGC 17: 9,887,044 (GRCm39) probably benign Het
Pkhd1l1 TTTTTT TTTTTTTTGTTTTT 15: 44,421,899 (GRCm39) probably benign Het
Rassf6 TGTAGAGCAATGGGGATTC TGTAGAGCAATGGGGATTCTGCCTCACTCATGGTCCAGTAGAGCAATGGGGATTC 5: 90,756,783 (GRCm39) probably benign Het
Rassf6 GCAATGGGGATTC GCAATGGGGATTCTGCCTCACTCATGGTCCTGTAGATCAATGGGGATTC 5: 90,756,789 (GRCm39) probably benign Het
Rbm12 CAGGTATTGCGGGACC CAGGTATTGCGGGACCTGGTATTGCGGGACCAGGTATTGCGGGACC 2: 155,938,026 (GRCm39) probably benign Het
Sbp AAGATG AAGATGCTGACAACACAGATG 17: 24,164,358 (GRCm39) probably benign Het
Strn CCCAGTC CCCAGTCCGTGCTCCCTTACCCCAGTCCGTGCTCCCTTACGCCAGTC 17: 78,984,711 (GRCm39) probably null Het
Supt20 TTCAGCA TTCAGCATCAGCA 3: 54,635,068 (GRCm39) probably benign Het
Tcof1 TCCCAGAGATCCCC TCCCAGAGATCCCCCTGGCTGCTGAGATGGGCACTTCCCCAGAGATCCCC 18: 60,966,638 (GRCm39) probably benign Het
Tfeb AGC AGCGGC 17: 48,097,030 (GRCm39) probably benign Het
Tfeb GCA GCACCA 17: 48,097,037 (GRCm39) probably benign Het
Trappc9 GCTGCTGCT GCTGCTGCTGCTGCTCCTGCTGCT 15: 72,673,172 (GRCm39) probably benign Het
Zfhx3 CAGCA CAGCACCAGAAGCA 8: 109,682,733 (GRCm39) probably benign Het
Other mutations in Dennd10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01680:Dennd10 APN 19 60,805,972 (GRCm39) missense possibly damaging 0.81
IGL02644:Dennd10 APN 19 60,810,741 (GRCm39) missense possibly damaging 0.71
FR4340:Dennd10 UTSW 19 60,803,059 (GRCm39) small insertion probably benign
FR4976:Dennd10 UTSW 19 60,803,060 (GRCm39) small insertion probably benign
FR4976:Dennd10 UTSW 19 60,803,056 (GRCm39) small insertion probably benign
IGL02796:Dennd10 UTSW 19 60,806,081 (GRCm39) intron probably benign
R1613:Dennd10 UTSW 19 60,810,763 (GRCm39) missense possibly damaging 0.90
R1710:Dennd10 UTSW 19 60,806,021 (GRCm39) missense probably damaging 1.00
R2860:Dennd10 UTSW 19 60,803,232 (GRCm39) missense probably benign 0.01
R2861:Dennd10 UTSW 19 60,803,232 (GRCm39) missense probably benign 0.01
R3698:Dennd10 UTSW 19 60,821,054 (GRCm39) splice site probably null
R4729:Dennd10 UTSW 19 60,823,309 (GRCm39) missense probably benign 0.03
R4844:Dennd10 UTSW 19 60,823,435 (GRCm39) makesense probably null
R4871:Dennd10 UTSW 19 60,819,252 (GRCm39) missense probably damaging 0.99
R5361:Dennd10 UTSW 19 60,814,324 (GRCm39) missense probably benign
R5396:Dennd10 UTSW 19 60,823,274 (GRCm39) missense probably benign 0.01
R7102:Dennd10 UTSW 19 60,821,034 (GRCm39) missense probably damaging 1.00
R7842:Dennd10 UTSW 19 60,819,317 (GRCm39) missense not run
R8903:Dennd10 UTSW 19 60,823,423 (GRCm39) nonsense probably null
RF033:Dennd10 UTSW 19 60,803,056 (GRCm39) small insertion probably benign
Predicted Primers PCR Primer
(F):5'- AGATCACCTTTGACCATATCATGTG -3'
(R):5'- AATCTGGAACTTCAACTGTCGTG -3'

Sequencing Primer
(F):5'- TGACCATATCATGTGACTGGC -3'
(R):5'- CTGTCGTGACATAAAACCATGTTC -3'
Posted On 2019-12-04