Incidental Mutation 'RF042:Tob1'
ID 604880
Institutional Source Beutler Lab
Gene Symbol Tob1
Ensembl Gene ENSMUSG00000037573
Gene Name transducer of ErbB-2.1
Synonyms Tob, Trob
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # RF042 (G1)
Quality Score 180.468
Status Not validated
Chromosome 11
Chromosomal Location 94102280-94106321 bp(+) (GRCm39)
Type of Mutation small insertion (1 aa in frame mutation)
DNA Base Change (assembly) CACA to CACAACA at 94105277 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000036039 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041589]
AlphaFold Q61471
Predicted Effect probably benign
Transcript: ENSMUST00000041589
SMART Domains Protein: ENSMUSP00000036039
Gene: ENSMUSG00000037573

DomainStartEndE-ValueType
btg1 1 106 2.41e-77 SMART
low complexity region 141 160 N/A INTRINSIC
low complexity region 176 187 N/A INTRINSIC
low complexity region 238 280 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.7%
  • 10x: 99.4%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
PHENOTYPE: Homozygous null mice are viable and exhibit increased bone mass due to increased osteoblast proliferation and differentiation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5430401F13Rik AAAGGAAAAGGTGGCCAG AAAGGAAAAGGTGGCCAGCAAAAACAGGAAGGAAAAGGTGGCCAG 6: 131,529,849 (GRCm39) probably benign Het
A030005L19Rik GCTGCTG GCTGCTGTGACTGCTG 1: 82,891,305 (GRCm39) probably benign Het
AI837181 GGC GGCTGC 19: 5,475,245 (GRCm39) probably benign Het
AI837181 CG CGGTG 19: 5,475,265 (GRCm39) probably benign Het
Anapc2 GCGGCGGCGGCGAC GC 2: 25,162,573 (GRCm39) probably benign Het
Cgnl1 AGCG AGCGGCG 9: 71,631,997 (GRCm39) probably benign Het
Cntnap1 TTT TTTTGTT 11: 101,071,131 (GRCm39) probably benign Het
Cul9 TTCTC TTC 17: 46,851,541 (GRCm39) probably null Het
Dnmt1 GGGGCGGAGCACAGTTCCTACCTCGTT GGGGCGGAGCACAGTTCCTACCTCGTTTTGTGGGCGGAGCACAGTTCCTACCTCGTT 9: 20,821,415 (GRCm39) probably null Het
Frem3 GATC GATCATC 8: 81,341,867 (GRCm39) probably benign Het
Gab3 TCT TCTACT X: 74,043,611 (GRCm39) probably benign Het
Gab3 TTC TTCGTC X: 74,043,628 (GRCm39) probably benign Het
Gabre GGCTCC GGCTCCTGCTCC X: 71,313,653 (GRCm39) probably benign Het
Gm8369 TGTG TGTGAGTG 19: 11,489,137 (GRCm39) probably null Het
Gm8369 GTGTGT GTGTGTTTGTGT 19: 11,489,142 (GRCm39) probably benign Het
Gykl1 G A 18: 52,827,488 (GRCm39) R232Q probably benign Het
Igkv12-89 G GCAACGCCAT 6: 68,812,270 (GRCm39) probably benign Het
Iqcf4 TCCTTTTCCTTTTCCTTTT TCCTTTTCCTTTTCCTTTTCCTTTTCCTTTTCCTTTGCCTTTTCCTTTTCCTTTT 9: 106,447,804 (GRCm39) probably benign Het
Kmt2e TTT TTTTCTT 5: 23,683,507 (GRCm39) probably benign Het
Krtap28-10 CCACAG CCACAGACACAG 1: 83,019,846 (GRCm39) probably benign Het
Las1l CTTCCT CTTCCTTTTCCT X: 94,984,226 (GRCm39) probably benign Het
Lca5l GCCCTGGCCCTGGCCCC GCCC 16: 95,960,497 (GRCm39) probably null Het
Lce1m CACTGCTGCTGC CACTGCTGCTGCAACTGCTGCTGC 3: 92,925,446 (GRCm39) probably benign Het
Lypd8 CA CAGTTCCCTCGCCTCTGTTACCCCACAAATCACCAATA 11: 58,281,069 (GRCm39) probably benign Het
Mamld1 GCAACA GCAACAACA X: 70,162,418 (GRCm39) probably benign Het
Mamld1 A AGCC X: 70,162,459 (GRCm39) probably benign Het
Map1a T TTGCTCCACCTCCAGCTCCAGCTCCAGCTCC 2: 121,136,768 (GRCm39) probably benign Het
Med12l CAG CAGAAG 3: 59,183,402 (GRCm39) probably benign Het
Med12l GC GCATC 3: 59,183,416 (GRCm39) probably benign Het
Med12l GCAACA GCAACAACA 3: 59,183,377 (GRCm39) probably benign Het
Med12l AGC AGCGGC 3: 59,183,388 (GRCm39) probably benign Het
Morn4 GCAGTGAG GCAGTGAGTCAGTCAGTGAG 19: 42,064,550 (GRCm39) probably null Het
Nusap1 GAGA GAGATACACGTTAGCAGTGAGGAGCAAGCTTAGA 2: 119,458,088 (GRCm39) probably null Het
Opa3 GCGGGC GCGGGCGGAGCTGCGGGCGGAGCTGCGGGCGGAGCTACGGGC 7: 18,989,594 (GRCm39) probably benign Het
Pdia4 CTCTTCCTCCT C 6: 47,785,240 (GRCm39) probably null Het
Reep1 CGCCA CGCCAGCCA 6: 71,684,950 (GRCm39) probably null Het
Sbp AAGA AAGACGCTGACAACAGAGA 17: 24,164,358 (GRCm39) probably benign Het
Sfswap CTCGGCCCA CTCGGCCCAGTCGGCCCA 5: 129,646,807 (GRCm39) probably benign Het
Slc39a4 TC TCATCATGATCACCATGGTCACCATGATCACTGTGGCC 15: 76,499,071 (GRCm39) probably benign Het
Srpk2 ATCCT AT 5: 23,730,573 (GRCm39) probably benign Het
Tfeb GCA GCACCA 17: 48,097,022 (GRCm39) probably benign Het
Tgoln1 T TCACCTCCCGTGGGCTTGCCAGAAG 6: 72,593,057 (GRCm39) probably benign Het
Trappc9 A AGCTGCTGCTGCTGCT 15: 72,673,132 (GRCm39) probably benign Het
Tsen2 GGA GGATGA 6: 115,537,028 (GRCm39) probably benign Het
Zfhx3 GC GCCACAGCAAC 8: 109,682,720 (GRCm39) probably benign Het
Zfhx3 CAGCAGCA CAGCAGCAAAAGCAGCA 8: 109,682,730 (GRCm39) probably benign Het
Other mutations in Tob1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01069:Tob1 APN 11 94,104,881 (GRCm39) missense probably damaging 1.00
IGL02028:Tob1 APN 11 94,105,052 (GRCm39) missense probably benign 0.43
IGL02866:Tob1 APN 11 94,104,883 (GRCm39) missense possibly damaging 0.87
FR4304:Tob1 UTSW 11 94,105,303 (GRCm39) nonsense probably null
FR4304:Tob1 UTSW 11 94,105,290 (GRCm39) small insertion probably benign
FR4340:Tob1 UTSW 11 94,105,303 (GRCm39) small insertion probably benign
FR4340:Tob1 UTSW 11 94,105,280 (GRCm39) small insertion probably benign
FR4340:Tob1 UTSW 11 94,105,286 (GRCm39) small insertion probably benign
FR4342:Tob1 UTSW 11 94,105,298 (GRCm39) small insertion probably benign
FR4449:Tob1 UTSW 11 94,105,301 (GRCm39) small insertion probably benign
FR4449:Tob1 UTSW 11 94,105,294 (GRCm39) small insertion probably benign
FR4548:Tob1 UTSW 11 94,105,295 (GRCm39) small insertion probably benign
FR4548:Tob1 UTSW 11 94,105,281 (GRCm39) small insertion probably benign
FR4589:Tob1 UTSW 11 94,105,303 (GRCm39) frame shift probably null
FR4589:Tob1 UTSW 11 94,105,277 (GRCm39) small insertion probably benign
FR4737:Tob1 UTSW 11 94,105,304 (GRCm39) small insertion probably benign
FR4737:Tob1 UTSW 11 94,105,277 (GRCm39) small insertion probably benign
FR4737:Tob1 UTSW 11 94,105,290 (GRCm39) small insertion probably benign
FR4976:Tob1 UTSW 11 94,105,298 (GRCm39) small insertion probably benign
R0142:Tob1 UTSW 11 94,105,423 (GRCm39) missense probably damaging 1.00
R1777:Tob1 UTSW 11 94,104,580 (GRCm39) missense probably damaging 1.00
R4213:Tob1 UTSW 11 94,105,018 (GRCm39) missense probably damaging 1.00
R4280:Tob1 UTSW 11 94,105,148 (GRCm39) missense probably benign
R4537:Tob1 UTSW 11 94,105,278 (GRCm39) small deletion probably benign
R4899:Tob1 UTSW 11 94,105,278 (GRCm39) small deletion probably benign
R5074:Tob1 UTSW 11 94,104,567 (GRCm39) missense possibly damaging 0.88
R5502:Tob1 UTSW 11 94,105,278 (GRCm39) small deletion probably benign
R5828:Tob1 UTSW 11 94,104,583 (GRCm39) missense probably damaging 1.00
R5828:Tob1 UTSW 11 94,104,585 (GRCm39) nonsense probably null
R7471:Tob1 UTSW 11 94,104,708 (GRCm39) missense probably benign 0.45
R7839:Tob1 UTSW 11 94,104,598 (GRCm39) missense probably damaging 1.00
R8383:Tob1 UTSW 11 94,105,203 (GRCm39) small deletion probably benign
R8491:Tob1 UTSW 11 94,105,115 (GRCm39) missense probably benign 0.11
R9131:Tob1 UTSW 11 94,105,203 (GRCm39) small deletion probably benign
R9521:Tob1 UTSW 11 94,105,205 (GRCm39) small deletion probably benign
R9542:Tob1 UTSW 11 94,105,234 (GRCm39) missense unknown
R9729:Tob1 UTSW 11 94,104,880 (GRCm39) missense probably damaging 1.00
R9744:Tob1 UTSW 11 94,105,054 (GRCm39) missense probably damaging 0.99
RF028:Tob1 UTSW 11 94,105,277 (GRCm39) small insertion probably benign
RF041:Tob1 UTSW 11 94,105,277 (GRCm39) small insertion probably benign
RF044:Tob1 UTSW 11 94,105,287 (GRCm39) small insertion probably benign
RF054:Tob1 UTSW 11 94,105,287 (GRCm39) small insertion probably benign
Z1177:Tob1 UTSW 11 94,104,818 (GRCm39) missense probably benign 0.38
Predicted Primers PCR Primer
(F):5'- ACTTCTCCGATCAACCTGGG -3'
(R):5'- AGACTTCTCGTTGAGGCCTC -3'

Sequencing Primer
(F):5'- TCAACCTGGGCCTGACTGTAAATG -3'
(R):5'- TCTCGTTGAGGCCTCCGTAG -3'
Posted On 2019-12-04