Incidental Mutation 'RF043:Rgs22'
ID 604934
Institutional Source Beutler Lab
Gene Symbol Rgs22
Ensembl Gene ENSMUSG00000037627
Gene Name regulator of G-protein signalling 22
Synonyms
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # RF043 (G1)
Quality Score 217.468
Status Not validated
Chromosome 15
Chromosomal Location 36009625-36140546 bp(-) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) CTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA to CAAAAAAAAAAAA at 36010982 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000134259 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172831]
AlphaFold G3UYX5
Predicted Effect probably benign
Transcript: ENSMUST00000172831
SMART Domains Protein: ENSMUSP00000134259
Gene: ENSMUSG00000037627

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
low complexity region 62 76 N/A INTRINSIC
low complexity region 173 179 N/A INTRINSIC
low complexity region 376 391 N/A INTRINSIC
RGS 845 973 3.15e-2 SMART
RGS 1014 1134 1.56e-15 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000173018
SMART Domains Protein: ENSMUSP00000133703
Gene: ENSMUSG00000037627

DomainStartEndE-ValueType
RGS 4 124 1.56e-15 SMART
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.7%
  • 10x: 99.4%
  • 20x: 98.7%
Validation Efficiency
Allele List at MGI

All alleles(2) : Targeted, other(2)

Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anapc2 GCGGCGGCGGCGAC GC 2: 25,162,573 (GRCm39) probably benign Het
Ankhd1 CGGCGG CGGCGGTGGCGG 18: 36,693,970 (GRCm39) probably benign Het
Btnl10 CAAA CAAAAAA 11: 58,814,752 (GRCm39) probably benign Het
Cpne1 TCCAC TC 2: 155,915,430 (GRCm39) probably benign Het
Cyb5r4 ACACTGCCCAGGGATGTGACAGACACACTGCCCAGGGA ACACTGCCCAGGGATGTGACAGACGCACTGCCCAGGGATGTGACAGACACACTGCCCAGGGA 9: 86,922,464 (GRCm39) probably benign Het
Cyb5r4 AGACACACTGCCCAGGGA AGACACACTGCCCAGGGATGTGACCGACACACTGCCCAGGGA 9: 86,922,484 (GRCm39) probably benign Het
Dbr1 GAGGAG GAGGAGCAGGAG 9: 99,465,750 (GRCm39) probably benign Het
Defb22 GCGGCA GCGGCAGAGCTGGCCTTTGCGGCA 2: 152,327,753 (GRCm39) probably benign Het
Emid1 G T 11: 5,094,322 (GRCm39) P63Q probably damaging Het
Gabre GCTCCG GCTCCGACTCCG X: 71,313,654 (GRCm39) probably benign Het
Gar1 AACTGCC A 3: 129,624,337 (GRCm39) probably benign Het
Gm10181 GAGAGAGAGAGAGA G 9: 25,000,755 (GRCm39) probably null Het
Hic1 GGGA G 11: 75,060,281 (GRCm39) probably benign Het
Il2 GG GGGCTTGAAGTGTG 3: 37,179,991 (GRCm39) probably benign Het
Iqcf4 CTTTTCCTTTT CTTTTCCTTTTCCTTTTCCTTTTCCTTTTCCTTTTCGTTTTCCTTTT 9: 106,447,812 (GRCm39) probably benign Het
Irag2 TG TGAGCACATGG 6: 145,119,516 (GRCm39) probably benign Het
Krtap4-2 AGGGGCGGCAGC A 11: 99,525,547 (GRCm39) probably null Het
Lmx1b CATCTTGATGCCGTCCAA CA 2: 33,530,521 (GRCm39) probably null Het
Lrch1 TGGTGGTG T 14: 75,185,015 (GRCm39) probably null Het
Lypd8 CA CAGTTCCCTCGCCTCTGTTACCCCACAAATCACCAAGA 11: 58,281,069 (GRCm39) probably benign Het
Mamld1 AGC AGCTGC X: 70,162,441 (GRCm39) probably benign Het
Mrgprx1 GAAC GAACAAC 7: 47,671,257 (GRCm39) probably benign Het
Nefh CTTGGCCTCACCTGGGGACTTGGCCTCACCTGGGGA CTTGGCCTCACCTGGGGAATTGGCCTCACCTGGGGACTTGGCCTCACCTGGGGA 11: 4,891,016 (GRCm39) probably benign Het
Nusap1 AGTGAGGAGCAAGCTGAGA AGTGAGGAGCAAGCTGAGATACACGTTAGCCGTGAGGAGCAAGCTGAGA 2: 119,458,073 (GRCm39) probably benign Het
P4ha2 GGTGTTG GG 11: 54,001,076 (GRCm39) probably null Het
Padi3 TCTCAC TC 4: 140,520,283 (GRCm39) probably benign Het
Plekhs1 TCCAGAC TCCAGACCTCCCCCCAGAC 19: 56,468,290 (GRCm39) probably benign Het
Ptms TCCTCCTC TCCTCCTCCTC 6: 124,891,411 (GRCm39) probably benign Het
Rassf6 AATGGGGATTC AATGGGGATTCTGCCTCACTCATGGTCCTGTAGAGCCATGGGGATTC 5: 90,756,791 (GRCm39) probably benign Het
Rassf6 ATTC ATTCTGCCTCACTCAGGGTCCTGTAGAGCAATGGGGCTTC 5: 90,756,798 (GRCm39) probably benign Het
Rnf144a TCTC TCTCTCTCTCTCTCGCTC 12: 26,364,013 (GRCm39) probably benign Het
Rpgrip1 GAG GAGAAG 14: 52,386,852 (GRCm39) probably benign Het
Sgpp1 ACACAC A 12: 75,769,399 (GRCm39) probably null Het
Slc39a4 GTC GTCATCATGATCACCATGGTCACCATGATCGCTGTGTTC 15: 76,499,070 (GRCm39) probably benign Het
Spaca1 TCTCGC TCTCGCGCTCGC 4: 34,049,846 (GRCm39) probably benign Het
Stard8 GGA GGATGA X: 98,110,126 (GRCm39) probably benign Het
Stard8 GA GAGCA X: 98,110,133 (GRCm39) probably benign Het
Tcof1 AGATCCCCTTGGC AGATCCCCTTGGCTGCTGAGAAGGGCACTTTCCCAGGGATCCCCTTGGC 18: 60,966,644 (GRCm39) probably benign Het
Tgoln1 TGGGCTTG TGGGCTTGTCAGAATCACCTCCTGCGGGCTTG 6: 72,593,019 (GRCm39) probably benign Het
Tgoln1 GCTTGCCAGAAT GCTTGCCAGAATCACCGCCCGTGGTCTTGCCAGAAT 6: 72,593,046 (GRCm39) probably benign Het
Tmed6 AGC AGCTCGC 8: 107,788,228 (GRCm39) probably null Het
Trappc9 GCTGCTGCTGCTGCTGCTGCTGCTGCT GCTGCTGCTGCTGCTACTGCTGCTGCTGCTGCTGCTGCTGCT 15: 72,673,154 (GRCm39) probably benign Het
Zfp933 TT TTTGCCT 4: 147,910,188 (GRCm39) probably null Het
Other mutations in Rgs22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00164:Rgs22 APN 15 36,100,077 (GRCm39) missense possibly damaging 0.93
IGL00594:Rgs22 APN 15 36,083,777 (GRCm39) missense probably benign 0.00
IGL01464:Rgs22 APN 15 36,083,787 (GRCm39) missense possibly damaging 0.90
IGL01686:Rgs22 APN 15 36,103,981 (GRCm39) missense probably benign 0.00
IGL01761:Rgs22 APN 15 36,103,897 (GRCm39) missense probably damaging 0.99
IGL02045:Rgs22 APN 15 36,013,300 (GRCm39) missense probably benign 0.33
IGL02378:Rgs22 APN 15 36,103,951 (GRCm39) missense probably benign 0.00
IGL02490:Rgs22 APN 15 36,054,993 (GRCm39) missense probably damaging 1.00
IGL03219:Rgs22 APN 15 36,107,194 (GRCm39) missense probably damaging 1.00
IGL03229:Rgs22 APN 15 36,015,925 (GRCm39) splice site probably benign
IGL03328:Rgs22 APN 15 36,043,350 (GRCm39) critical splice donor site probably null
3-1:Rgs22 UTSW 15 36,100,182 (GRCm39) missense possibly damaging 0.48
R0254:Rgs22 UTSW 15 36,104,698 (GRCm39) missense probably damaging 0.99
R0463:Rgs22 UTSW 15 36,093,084 (GRCm39) missense probably damaging 1.00
R0467:Rgs22 UTSW 15 36,099,941 (GRCm39) nonsense probably null
R0486:Rgs22 UTSW 15 36,093,028 (GRCm39) missense probably damaging 0.98
R0554:Rgs22 UTSW 15 36,054,855 (GRCm39) missense probably benign 0.10
R0602:Rgs22 UTSW 15 36,140,018 (GRCm39) splice site probably benign
R0906:Rgs22 UTSW 15 36,104,048 (GRCm39) intron probably benign
R1159:Rgs22 UTSW 15 36,040,839 (GRCm39) missense probably damaging 1.00
R1300:Rgs22 UTSW 15 36,101,908 (GRCm39) missense probably benign 0.43
R1439:Rgs22 UTSW 15 36,025,939 (GRCm39) splice site probably benign
R1491:Rgs22 UTSW 15 36,093,047 (GRCm39) missense probably damaging 0.98
R1502:Rgs22 UTSW 15 36,080,997 (GRCm39) missense probably damaging 1.00
R1514:Rgs22 UTSW 15 36,013,246 (GRCm39) missense probably benign 0.00
R1538:Rgs22 UTSW 15 36,048,922 (GRCm39) missense probably damaging 1.00
R1784:Rgs22 UTSW 15 36,087,582 (GRCm39) missense probably damaging 1.00
R1938:Rgs22 UTSW 15 36,101,950 (GRCm39) missense probably benign 0.00
R1972:Rgs22 UTSW 15 36,103,982 (GRCm39) missense probably benign 0.01
R2109:Rgs22 UTSW 15 36,099,880 (GRCm39) nonsense probably null
R2208:Rgs22 UTSW 15 36,050,378 (GRCm39) missense probably benign 0.01
R3696:Rgs22 UTSW 15 36,100,038 (GRCm39) missense probably benign 0.00
R3697:Rgs22 UTSW 15 36,100,038 (GRCm39) missense probably benign 0.00
R3698:Rgs22 UTSW 15 36,100,038 (GRCm39) missense probably benign 0.00
R3879:Rgs22 UTSW 15 36,107,051 (GRCm39) missense possibly damaging 0.52
R4080:Rgs22 UTSW 15 36,107,222 (GRCm39) missense probably damaging 1.00
R4363:Rgs22 UTSW 15 36,104,020 (GRCm39) missense probably damaging 0.99
R4591:Rgs22 UTSW 15 36,100,282 (GRCm39) missense probably benign 0.01
R4673:Rgs22 UTSW 15 36,100,079 (GRCm39) missense probably benign 0.04
R4829:Rgs22 UTSW 15 36,104,034 (GRCm39) missense probably damaging 1.00
R4831:Rgs22 UTSW 15 36,050,294 (GRCm39) missense probably benign 0.00
R4865:Rgs22 UTSW 15 36,100,358 (GRCm39) missense probably damaging 1.00
R4907:Rgs22 UTSW 15 36,087,570 (GRCm39) missense possibly damaging 0.61
R4944:Rgs22 UTSW 15 36,026,088 (GRCm39) missense possibly damaging 0.83
R4975:Rgs22 UTSW 15 36,055,022 (GRCm39) nonsense probably null
R5056:Rgs22 UTSW 15 36,050,391 (GRCm39) splice site probably null
R5126:Rgs22 UTSW 15 36,040,790 (GRCm39) missense probably damaging 0.96
R5138:Rgs22 UTSW 15 36,099,934 (GRCm39) missense probably benign 0.04
R5444:Rgs22 UTSW 15 36,015,773 (GRCm39) missense possibly damaging 0.83
R5507:Rgs22 UTSW 15 36,099,798 (GRCm39) missense probably damaging 0.99
R5640:Rgs22 UTSW 15 36,107,101 (GRCm39) missense probably benign 0.00
R5969:Rgs22 UTSW 15 36,015,782 (GRCm39) missense probably benign 0.00
R6005:Rgs22 UTSW 15 36,010,713 (GRCm39) missense probably benign 0.39
R6053:Rgs22 UTSW 15 36,100,153 (GRCm39) missense probably benign 0.04
R6134:Rgs22 UTSW 15 36,107,194 (GRCm39) missense probably damaging 1.00
R6230:Rgs22 UTSW 15 36,100,176 (GRCm39) missense probably benign 0.02
R6295:Rgs22 UTSW 15 36,087,520 (GRCm39) missense probably benign 0.00
R6352:Rgs22 UTSW 15 36,093,067 (GRCm39) missense probably damaging 1.00
R6809:Rgs22 UTSW 15 36,048,910 (GRCm39) missense probably damaging 1.00
R6900:Rgs22 UTSW 15 36,010,893 (GRCm39) missense possibly damaging 0.61
R6947:Rgs22 UTSW 15 36,104,036 (GRCm39) critical splice acceptor site probably null
R7102:Rgs22 UTSW 15 36,122,459 (GRCm39) missense probably damaging 1.00
R7126:Rgs22 UTSW 15 36,103,954 (GRCm39) missense probably damaging 0.97
R7263:Rgs22 UTSW 15 36,015,789 (GRCm39) missense possibly damaging 0.86
R7623:Rgs22 UTSW 15 36,040,856 (GRCm39) missense probably benign 0.08
R7732:Rgs22 UTSW 15 36,026,127 (GRCm39) missense probably damaging 1.00
R7748:Rgs22 UTSW 15 36,122,415 (GRCm39) critical splice donor site probably null
R7771:Rgs22 UTSW 15 36,050,224 (GRCm39) missense possibly damaging 0.94
R7835:Rgs22 UTSW 15 36,082,057 (GRCm39) critical splice donor site probably null
R7849:Rgs22 UTSW 15 36,099,858 (GRCm39) missense probably damaging 1.00
R7954:Rgs22 UTSW 15 36,082,148 (GRCm39) missense possibly damaging 0.75
R8384:Rgs22 UTSW 15 36,046,158 (GRCm39) critical splice donor site probably null
R8516:Rgs22 UTSW 15 36,010,481 (GRCm39) makesense probably null
R8904:Rgs22 UTSW 15 36,026,127 (GRCm39) missense probably damaging 1.00
R8923:Rgs22 UTSW 15 36,093,106 (GRCm39) missense probably damaging 1.00
R9287:Rgs22 UTSW 15 36,098,409 (GRCm39) missense probably damaging 1.00
R9324:Rgs22 UTSW 15 36,087,544 (GRCm39) missense probably benign
R9660:Rgs22 UTSW 15 36,040,856 (GRCm39) missense probably benign 0.08
R9679:Rgs22 UTSW 15 36,087,587 (GRCm39) missense probably benign 0.00
R9728:Rgs22 UTSW 15 36,040,856 (GRCm39) missense probably benign 0.08
RF035:Rgs22 UTSW 15 36,010,981 (GRCm39) critical splice acceptor site probably benign
Predicted Primers PCR Primer
(F):5'- GCTCGTTGCAGACACCTTAC -3'
(R):5'- CACAGTTAGAAAGATCGAGATGTGTAC -3'

Sequencing Primer
(F):5'- TACCTTACTGTGCGGTAGACAGC -3'
(R):5'- GCCCAGGTTAGCCTAAAAGTTATGC -3'
Posted On 2019-12-04