|Institutional Source||Beutler Lab|
|Gene Name||caudal type homeobox 1|
|Is this an essential gene?||Probably essential (E-score: 0.894)|
|Stock #||RF049 (G1)|
|Chromosomal Location||61018862-61036199 bp(-) (GRCm38)|
|Type of Mutation||small insertion (2 aa in frame mutation)|
|DNA Base Change (assembly)||GGGGCTG to GGGGCTGGGGCTG at 61019866 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000025521 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000025521]|
|Predicted Effect||probably benign
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene results in abnormalities of the basiocciptal bone, vertebrae, and ribs. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cdx1||
(F):5'- ACTCAGAACAGGTCCTTGGG -3'
(R):5'- GTCACAGAACACAGGAGCTC -3'
(F):5'- TCCTTGGGCCCCAGAAAAG -3'
(R):5'- CTCTGGAGAACTGGGGCCTTG -3'