Incidental Mutation 'RF054:Prp2'
ID 605202
Institutional Source Beutler Lab
Gene Symbol Prp2
Ensembl Gene ENSMUSG00000058295
Gene Name proline rich protein 2
Synonyms MP14
Accession Numbers
Essential gene? Not available question?
Stock # RF054 (G1)
Quality Score 181.468
Status Not validated
Chromosome 6
Chromosomal Location 132595913-132601236 bp(+) (GRCm38)
Type of Mutation frame shift
DNA Base Change (assembly) CTCAAGGCCCACCACCACCAGGTGGCCCACAGCCGAGACCCCCT to C at 132600521 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000135942 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076061] [ENSMUST00000178961]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000076061
SMART Domains Protein: ENSMUSP00000075435
Gene: ENSMUSG00000058295

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
low complexity region 24 44 N/A INTRINSIC
low complexity region 49 299 N/A INTRINSIC
low complexity region 302 316 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000178961
SMART Domains Protein: ENSMUSP00000135942
Gene: ENSMUSG00000058295

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
low complexity region 24 44 N/A INTRINSIC
low complexity region 49 299 N/A INTRINSIC
low complexity region 302 316 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.7%
  • 10x: 99.3%
  • 20x: 98.6%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The expression of this gene is dramatically induced in the parotid and submandibular glands of mice by beta-adrenergic stimulation. The encoded protein serves an important dental function by protecting mice against toxic dietary polyphenols such as tannins and influence the visco-elastic properties of the mucus. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 6. [provided by RefSeq, Nov 2015]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankhd1 CGGC CGGCGGAGGC 18: 36,560,929 probably benign Het
Bean1 CT C 8: 104,182,032 probably null Het
Cep131 CTGTTGTT CTGTTGTTGTT 11: 120,072,968 probably benign Het
Chga AGC AGCTGC 12: 102,561,423 probably benign Het
Dmkn GAAGTGGTGGAAGTGGTGG GAAGTGGTGGAAGTGGTGGAAGTGGTGTAAGTGGTGGAAGTGGTGG 7: 30,767,188 probably benign Het
Dnmt1 CCTCGTT CCTCGTTTTGGGGGCGGAGCACAGTTCCTAGCTCGTT 9: 20,910,139 probably null Het
Epha8 CCTGGGC CC 4: 136,933,037 probably benign Het
F830016B08Rik AAAAAA AAAAAAAAA 18: 60,299,938 probably benign Het
Gabre TCAGGCTCAGGCT TCAGGCTCAGGCTCAGGCT X: 72,270,416 probably benign Het
Gm8369 GTGT GTGTCTGT 19: 11,511,764 probably null Het
Lce1m CAC CACCGCTGCGGCGAC 3: 93,018,298 probably benign Het
Lrmp ATTG ATTGAGCACTTTG 6: 145,173,788 probably benign Het
Lypd8 TC TCGCCTCTGTTACCCCACAAATCACCAACACCTCCCCC 11: 58,390,251 probably benign Het
Nefh GGGACT GGGACTGGGCCTCACCTGCGGACT 11: 4,941,048 probably benign Het
Rassf6 TCACTCATGGTCCTGTAGAGCAATGGGGATTC TCACTCATGGTCCTGTAGAGCAATGGGGATTCTGCCCCACTCATGGTCCTGTAGAGCAATGGGGATTC 5: 90,608,911 probably benign Het
Rassf6 TGTAGAGCAATGGGGATTC TGTAGAGCAATGGGGATTCTGCCTCACTCATGGTCCAGTAGAGCAATGGGGATTC 5: 90,608,924 probably benign Het
Rassf6 CAATGGGGATTC CAATGGGGATTCTGCCTCACTCATGGTCCTGTAGAGAAATGGGGATTC 5: 90,608,931 probably benign Het
Sbp GATGCTGACAACAAA GATGCTGACAACAAATATGCTGACAACAAA 17: 23,945,371 probably benign Het
Six3 GCG GCGCCG 17: 85,621,355 probably benign Het
Tfeb CAG CAGTAG 17: 47,786,098 probably null Het
Thbs1 TGACCTTAG TG 2: 118,122,865 probably benign Het
Tob1 GCA GCACCA 11: 94,214,461 probably benign Het
Ubqln3 AACAC A 7: 104,141,178 probably null Het
Zfhx3 AACAGCAGC AACAGCAGCCACAGCAGC 8: 108,956,096 probably benign Het
Other mutations in Prp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01383:Prp2 APN 6 132599878 missense unknown
IGL02951:Prp2 APN 6 132599825 missense unknown
PIT4458001:Prp2 UTSW 6 132600547 missense unknown
R2034:Prp2 UTSW 6 132595984 splice site probably null
R2432:Prp2 UTSW 6 132599911 missense unknown
R5283:Prp2 UTSW 6 132600643 missense unknown
R7761:Prp2 UTSW 6 132600343 nonsense probably null
R7877:Prp2 UTSW 6 132595965 missense unknown
R8033:Prp2 UTSW 6 132600428 missense unknown
R8062:Prp2 UTSW 6 132600688 missense unknown
R8695:Prp2 UTSW 6 132599969 missense unknown
R8696:Prp2 UTSW 6 132600359 missense unknown
R8938:Prp2 UTSW 6 132600618 missense unknown
RF005:Prp2 UTSW 6 132600501 small deletion probably benign
RF016:Prp2 UTSW 6 132600512 small deletion probably benign
RF039:Prp2 UTSW 6 132600501 small deletion probably benign
RF052:Prp2 UTSW 6 132600512 small deletion probably benign
RF057:Prp2 UTSW 6 132600530 frame shift probably null
X0053:Prp2 UTSW 6 132600596 missense unknown
Z1176:Prp2 UTSW 6 132600237 missense unknown
Z1177:Prp2 UTSW 6 132595970 missense unknown
Predicted Primers PCR Primer
(F):5'- AGCAGCGATACCCTCAAAGC -3'
(R):5'- AAGGGGATAACAATGAGTCATACCT -3'

Sequencing Primer
(F):5'- GCCCACCACCACCAGGAG -3'
(R):5'- AATGAGTCATACCTGTCACGG -3'
Posted On 2019-12-04