|Institutional Source||Beutler Lab|
|Gene Name||transducer of ErbB-2.1|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||RF054 (G1)|
|Chromosomal Location||94211454-94215495 bp(+) (GRCm38)|
|Type of Mutation||small insertion (1 aa in frame mutation)|
|DNA Base Change (assembly)||GCA to GCACCA at 94214461 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000036039 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000041589]|
|Predicted Effect||probably benign
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
PHENOTYPE: Homozygous null mice are viable and exhibit increased bone mass due to increased osteoblast proliferation and differentiation. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Tob1||
(F):5'- ACTTCTCCGATCAACCTGGG -3'
(R):5'- AAGACTTCTCGTTGAGGCCTC -3'
(F):5'- TCAACCTGGGCCTGACTGTAAATG -3'
(R):5'- TCTCGTTGAGGCCTCCGTAG -3'