Incidental Mutation 'RF057:Prp2'
ID 605301
Institutional Source Beutler Lab
Gene Symbol Prp2
Ensembl Gene ENSMUSG00000058295
Gene Name proline rich protein 2
Synonyms MP14
Accession Numbers
Essential gene? Not available question?
Stock # RF057 (G1)
Quality Score 213.49
Status Not validated
Chromosome 6
Chromosomal Location 132572874-132577665 bp(+) (GRCm39)
Type of Mutation frame shift
DNA Base Change (assembly) CACCACCACCAGGTGGCCCACAGCCGAGACCCCCTCAAGGCCCA to C at 132577493 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000135942 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076061] [ENSMUST00000178961]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000076061
SMART Domains Protein: ENSMUSP00000075435
Gene: ENSMUSG00000058295

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
low complexity region 24 44 N/A INTRINSIC
low complexity region 49 299 N/A INTRINSIC
low complexity region 302 316 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000178961
SMART Domains Protein: ENSMUSP00000135942
Gene: ENSMUSG00000058295

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
low complexity region 24 44 N/A INTRINSIC
low complexity region 49 299 N/A INTRINSIC
low complexity region 302 316 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.6%
  • 10x: 99.3%
  • 20x: 98.6%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The expression of this gene is dramatically induced in the parotid and submandibular glands of mice by beta-adrenergic stimulation. The encoded protein serves an important dental function by protecting mice against toxic dietary polyphenols such as tannins and influence the visco-elastic properties of the mucus. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 6. [provided by RefSeq, Nov 2015]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6030445D17Rik GCACATGCACACACA GCACA 4: 136,189,617 (GRCm39) probably null Het
Alpk3 AAGGCACCGAC A 7: 80,742,165 (GRCm39) probably null Het
Ankhd1 CGGC CGGCGGTGGC 18: 36,693,982 (GRCm39) probably benign Het
Calhm1 GCTGTGGC GCTGTGGCTGTGTCTGTGGC 19: 47,129,709 (GRCm39) probably benign Het
Crtam TTCTTGATCTGAA T 9: 40,895,650 (GRCm39) probably null Het
Cul9 CCT CCTACT 17: 46,811,789 (GRCm39) probably null Het
Dmkn GAAGTGGTGGAAGTGGTGG GAAGTGGTGGAAGTGGTGGAAGTGGTGTAAGTGGTGGAAGTGGTGG 7: 30,466,613 (GRCm39) probably benign Het
Efhd2 CGCCG CGCCGAAGCCG 4: 141,602,080 (GRCm39) probably benign Het
Eps8 CGCTC CGCTCGCTC 6: 137,494,062 (GRCm39) probably benign Het
Garin5a GGAGGA GGAGGAAGGCTGGATCCTGGATACCTGGGTCTGAGTGAGGA 7: 44,149,956 (GRCm39) probably null Het
Gm16519 AAGCAG AAGCAGCAG 17: 71,236,326 (GRCm39) probably benign Het
Krt10 CGCC CGCCGCC 11: 99,277,025 (GRCm39) probably benign Het
Lypd8 CCAACA CCAACAGTTCCCTCGCCTCTGTTACCCCACAAATCAACAACA 11: 58,281,065 (GRCm39) probably benign Het
Mapk6 CCCCA CCCCATCCCA 9: 75,295,540 (GRCm39) probably null Het
Med12l GCA GCATCA 3: 59,183,401 (GRCm39) probably benign Het
Morn4 GTCAGGCAGTGA GTCAGGCAGTGACTCAGGCAGTGA 19: 42,064,545 (GRCm39) probably null Het
Pdik1l TTTTTGTTTT TTTTTGTTTTGGTTTTGTTTT 4: 134,006,679 (GRCm39) probably null Het
Rtbdn GCAGCG GCAGCGACAGCG 8: 85,682,795 (GRCm39) probably benign Het
Tcof1 TTTCCCAGAGATCCCCTTGGC TTTCCCAGAGATCCCCTTGGCTGCTGAGATGGGCACCTTCCCAGAGATCCCCTTGGC 18: 60,966,636 (GRCm39) probably benign Het
Tcof1 GAGATCCCCTTGGC GAGATCCCCTTGGCTGCTGAGATGGGCACTTTCCCATAGATCCCCTTGGC 18: 60,966,643 (GRCm39) probably benign Het
Tcof1 TCCCAGAGATCCCCTTGGC TCCCAGAGATCCCCTTGGCTGCTGAGATGGGCACTTGCCCAGAGATCCCCTTGGC 18: 60,966,638 (GRCm39) probably benign Het
Tcof1 TTCCCAGAGATCCCCTTGGC TTCCCAGAGATCCCCTTGGCTGCTGAGATGGGCACTGTCCCAGAGATCCCCTTGGC 18: 60,966,637 (GRCm39) probably benign Het
Tgoln1 CAGAAT CAGAATCACCTCCCGTGGGCTTGCGAGAAT 6: 72,593,052 (GRCm39) probably benign Het
Trappc9 TGCTGCTGCTGCTGCTGCTGCTGCTGCTGC TGCTGCTGCTGCTGCGGCTGCTGCTGCTGCTGCTGCTGCTGCTGC 15: 72,673,144 (GRCm39) probably benign Het
Ttn ACCTCCTCCTCCTCCTCCTC ACCTCCTCCTCCTCCTC 2: 76,673,734 (GRCm39) probably benign Het
Zfp384 C CCCAGGCCCAGGG 6: 125,013,459 (GRCm39) probably benign Het
Other mutations in Prp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01383:Prp2 APN 6 132,576,841 (GRCm39) missense unknown
IGL02951:Prp2 APN 6 132,576,788 (GRCm39) missense unknown
PIT4458001:Prp2 UTSW 6 132,577,510 (GRCm39) missense unknown
R2034:Prp2 UTSW 6 132,572,947 (GRCm39) splice site probably null
R2432:Prp2 UTSW 6 132,576,874 (GRCm39) missense unknown
R5283:Prp2 UTSW 6 132,577,606 (GRCm39) missense unknown
R7761:Prp2 UTSW 6 132,577,306 (GRCm39) nonsense probably null
R7877:Prp2 UTSW 6 132,572,928 (GRCm39) missense unknown
R8033:Prp2 UTSW 6 132,577,391 (GRCm39) missense unknown
R8062:Prp2 UTSW 6 132,577,651 (GRCm39) missense unknown
R8695:Prp2 UTSW 6 132,576,932 (GRCm39) missense unknown
R8696:Prp2 UTSW 6 132,577,322 (GRCm39) missense unknown
R8938:Prp2 UTSW 6 132,577,581 (GRCm39) missense unknown
RF005:Prp2 UTSW 6 132,577,464 (GRCm39) small deletion probably benign
RF016:Prp2 UTSW 6 132,577,475 (GRCm39) small deletion probably benign
RF039:Prp2 UTSW 6 132,577,464 (GRCm39) small deletion probably benign
RF052:Prp2 UTSW 6 132,577,475 (GRCm39) small deletion probably benign
RF054:Prp2 UTSW 6 132,577,484 (GRCm39) frame shift probably null
X0053:Prp2 UTSW 6 132,577,559 (GRCm39) missense unknown
Z1176:Prp2 UTSW 6 132,577,200 (GRCm39) missense unknown
Z1177:Prp2 UTSW 6 132,572,933 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- AGCAGCGATACCCTCAAAGC -3'
(R):5'- AAGGGGATAACAATGAGTCATACCT -3'

Sequencing Primer
(F):5'- GCCCACCACCACCAGGAG -3'
(R):5'- AATGAGTCATACCTGTCACGG -3'
Posted On 2019-12-04