Incidental Mutation 'RF057:Morn4'
| ID |
605319 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Morn4
|
| Ensembl Gene |
ENSMUSG00000049670 |
| Gene Name |
MORN repeat containing 4 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.196)
|
| Stock # |
RF057 (G1)
|
| Quality Score |
214.458 |
|
Status
|
Not validated
|
| Chromosome |
19 |
| Chromosomal Location |
42063378-42074796 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
GTCAGGCAGTGA to GTCAGGCAGTGACTCAGGCAGTGA
at 42064545 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000062887
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000051772]
|
| AlphaFold |
Q6PGF2 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000051772
|
| SMART Domains |
Protein: ENSMUSP00000062887
Gene: ENSMUSG00000049670
| Domain | Start | End | E-Value | Type |
|---|
|
MORN
|
14 |
35 |
1.64e-5 |
SMART |
|
MORN
|
37 |
58 |
4.15e-2 |
SMART |
|
MORN
|
60 |
81 |
1.86e-4 |
SMART |
|
MORN
|
83 |
104 |
1.84e0 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.8%
- 3x: 99.6%
- 10x: 99.3%
- 20x: 98.6%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 26 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 6030445D17Rik |
GCACATGCACACACA |
GCACA |
4: 136,189,617 (GRCm39) |
|
probably null |
Het |
| Alpk3 |
AAGGCACCGAC |
A |
7: 80,742,165 (GRCm39) |
|
probably null |
Het |
| Ankhd1 |
CGGC |
CGGCGGTGGC |
18: 36,693,982 (GRCm39) |
|
probably benign |
Het |
| Calhm1 |
GCTGTGGC |
GCTGTGGCTGTGTCTGTGGC |
19: 47,129,709 (GRCm39) |
|
probably benign |
Het |
| Crtam |
TTCTTGATCTGAA |
T |
9: 40,895,650 (GRCm39) |
|
probably null |
Het |
| Cul9 |
CCT |
CCTACT |
17: 46,811,789 (GRCm39) |
|
probably null |
Het |
| Dmkn |
GAAGTGGTGGAAGTGGTGG |
GAAGTGGTGGAAGTGGTGGAAGTGGTGTAAGTGGTGGAAGTGGTGG |
7: 30,466,613 (GRCm39) |
|
probably benign |
Het |
| Efhd2 |
CGCCG |
CGCCGAAGCCG |
4: 141,602,080 (GRCm39) |
|
probably benign |
Het |
| Eps8 |
CGCTC |
CGCTCGCTC |
6: 137,494,062 (GRCm39) |
|
probably benign |
Het |
| Garin5a |
GGAGGA |
GGAGGAAGGCTGGATCCTGGATACCTGGGTCTGAGTGAGGA |
7: 44,149,956 (GRCm39) |
|
probably null |
Het |
| Gm16519 |
AAGCAG |
AAGCAGCAG |
17: 71,236,326 (GRCm39) |
|
probably benign |
Het |
| Krt10 |
CGCC |
CGCCGCC |
11: 99,277,025 (GRCm39) |
|
probably benign |
Het |
| Lypd8 |
CCAACA |
CCAACAGTTCCCTCGCCTCTGTTACCCCACAAATCAACAACA |
11: 58,281,065 (GRCm39) |
|
probably benign |
Het |
| Mapk6 |
CCCCA |
CCCCATCCCA |
9: 75,295,540 (GRCm39) |
|
probably null |
Het |
| Med12l |
GCA |
GCATCA |
3: 59,183,401 (GRCm39) |
|
probably benign |
Het |
| Pdik1l |
TTTTTGTTTT |
TTTTTGTTTTGGTTTTGTTTT |
4: 134,006,679 (GRCm39) |
|
probably null |
Het |
| Prp2 |
CACCACCACCAGGTGGCCCACAGCCGAGACCCCCTCAAGGCCCA |
C |
6: 132,577,493 (GRCm39) |
|
probably null |
Het |
| Rtbdn |
GCAGCG |
GCAGCGACAGCG |
8: 85,682,795 (GRCm39) |
|
probably benign |
Het |
| Tcof1 |
TTTCCCAGAGATCCCCTTGGC |
TTTCCCAGAGATCCCCTTGGCTGCTGAGATGGGCACCTTCCCAGAGATCCCCTTGGC |
18: 60,966,636 (GRCm39) |
|
probably benign |
Het |
| Tcof1 |
GAGATCCCCTTGGC |
GAGATCCCCTTGGCTGCTGAGATGGGCACTTTCCCATAGATCCCCTTGGC |
18: 60,966,643 (GRCm39) |
|
probably benign |
Het |
| Tcof1 |
TCCCAGAGATCCCCTTGGC |
TCCCAGAGATCCCCTTGGCTGCTGAGATGGGCACTTGCCCAGAGATCCCCTTGGC |
18: 60,966,638 (GRCm39) |
|
probably benign |
Het |
| Tcof1 |
TTCCCAGAGATCCCCTTGGC |
TTCCCAGAGATCCCCTTGGCTGCTGAGATGGGCACTGTCCCAGAGATCCCCTTGGC |
18: 60,966,637 (GRCm39) |
|
probably benign |
Het |
| Tgoln1 |
CAGAAT |
CAGAATCACCTCCCGTGGGCTTGCGAGAAT |
6: 72,593,052 (GRCm39) |
|
probably benign |
Het |
| Trappc9 |
TGCTGCTGCTGCTGCTGCTGCTGCTGCTGC |
TGCTGCTGCTGCTGCGGCTGCTGCTGCTGCTGCTGCTGCTGCTGC |
15: 72,673,144 (GRCm39) |
|
probably benign |
Het |
| Ttn |
ACCTCCTCCTCCTCCTCCTC |
ACCTCCTCCTCCTCCTC |
2: 76,673,734 (GRCm39) |
|
probably benign |
Het |
| Zfp384 |
C |
CCCAGGCCCAGGG |
6: 125,013,459 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Morn4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00971:Morn4
|
APN |
19 |
42,064,559 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL02572:Morn4
|
APN |
19 |
42,064,886 (GRCm39) |
splice site |
probably benign |
|
|
IGL02933:Morn4
|
APN |
19 |
42,064,661 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4449:Morn4
|
UTSW |
19 |
42,064,548 (GRCm39) |
small insertion |
probably benign |
|
|
FR4548:Morn4
|
UTSW |
19 |
42,064,548 (GRCm39) |
small insertion |
probably benign |
|
|
R1997:Morn4
|
UTSW |
19 |
42,064,977 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R2239:Morn4
|
UTSW |
19 |
42,066,471 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4409:Morn4
|
UTSW |
19 |
42,066,986 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5544:Morn4
|
UTSW |
19 |
42,064,686 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5695:Morn4
|
UTSW |
19 |
42,064,556 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6986:Morn4
|
UTSW |
19 |
42,066,453 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7024:Morn4
|
UTSW |
19 |
42,066,483 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8721:Morn4
|
UTSW |
19 |
42,066,439 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
RF025:Morn4
|
UTSW |
19 |
42,064,550 (GRCm39) |
nonsense |
probably null |
|
|
RF030:Morn4
|
UTSW |
19 |
42,064,550 (GRCm39) |
nonsense |
probably null |
|
|
RF036:Morn4
|
UTSW |
19 |
42,064,553 (GRCm39) |
nonsense |
probably null |
|
|
RF040:Morn4
|
UTSW |
19 |
42,064,550 (GRCm39) |
nonsense |
probably null |
|
|
RF042:Morn4
|
UTSW |
19 |
42,064,550 (GRCm39) |
nonsense |
probably null |
|
|
RF044:Morn4
|
UTSW |
19 |
42,064,553 (GRCm39) |
nonsense |
probably null |
|
|
X0063:Morn4
|
UTSW |
19 |
42,066,407 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAAGGACATAACTGCCGCAG -3'
(R):5'- CTGAGCGGAAACATTAATGCC -3'
Sequencing Primer
(F):5'- CTGTGGCATCAAGGTCAT -3'
(R):5'- GAGCGGAAACATTAATGCCCTCTC -3'
|
| Posted On |
2019-12-04 |
Incidental Mutation