|Institutional Source||Beutler Lab|
|Gene Name||triggering receptor expressed on myeloid cells-like 1|
|Essential gene?||Non essential (E-score: 0.000)|
|Stock #||RF058 (G1)|
|Chromosomal Location||48359916-48367176 bp(+) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||ACCT to A at 48359947 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000153104 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000024792] [ENSMUST00000223956] [ENSMUST00000224001] [ENSMUST00000225849]|
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]
PHENOTYPE: Mice homozygous for a knock-out allele show a reduced platelet count, defective platelet aggregation, prolonged bleeding times, enhanced inflammatory hemorrhage, and increased susceptibility to death from endotoxin (LPS) challenge. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Treml1||
(F):5'- CCTTCTGAACCTTGAGCCAAG -3'
(R):5'- CTAGAATGGATGACCCCACC -3'
(F):5'- ACCTTGAGCCAAGAAATCTATGG -3'
(R):5'- ATGACTGTCAGCTGAGCCTTG -3'