|Institutional Source||Beutler Lab|
|Gene Name||F11 receptor|
|Synonyms||Jcam1, JAM-A, Ly106, ESTM33, BV11 antigen, JAM-1|
|Is this an essential gene?||Probably non essential (E-score: 0.171)|
|Stock #||RF063 (G1)|
|Chromosomal Location||171437535-171464603 bp(+) (GRCm38)|
|Type of Mutation||critical splice acceptor site|
|DNA Base Change (assembly)||CCCCCCCCC to CCCCCCCCCCC at 171461190 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000041907 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000043839]|
|Predicted Effect||probably benign
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice display increased dendritic cell migratory ability and contact hypersensitivity. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in F11r||
(F):5'- ACCTCACTGTGCTTGGTACG -3'
(R):5'- TTCATGAAGGCCCGGGTTTTC -3'
(F):5'- CCACGTAGTCTCATGTAGGCTTAAAG -3'
(R):5'- TCTTGGCATCTGCTGTAAGC -3'