|Institutional Source||Beutler Lab|
|Gene Name||killer cell lectin-like receptor, subfamily A, member 2|
|Is this an essential gene?||Probably non essential (E-score: 0.060)|
|Stock #||RF064 (G1)|
|Chromosomal Location||131219223-131247362 bp(-) (GRCm38)|
|Type of Mutation||frame shift|
|DNA Base Change (assembly)||AAAGAAATCCA to AAAGAAATCCAAAGAAATCCA at 131221839 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000086252 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000032306] [ENSMUST00000088867]|
|Predicted Effect||probably benign
|Predicted Effect||probably null
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: The gene is a member of the large lectin-like type 2 transmembrane receptor family of the natural killer gene complex. The gene is located distantly telomeric to its family's gene cluster on chromosome 6. The gene differs from the other genes in its cluster as its promoter region contains long and short interspersed repetitive elements suggesting a possible rearrangement or gene conversion. It is unknown whether this gene's encoded protein is involved with natural killer cell differentiation as are its other family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Klra2||
(F):5'- GCAGAACATGTCAGACAGCC -3'
(R):5'- GGTTAATGTGTATTCTCATTACCACTG -3'
(F):5'- CAGCCATTGTCTTAATAGCCAGG -3'
(R):5'- GTGTATTCTCATTACCACTGTATCC -3'