Incidental Mutation 'R7831:Slit2'
ID 605608
Institutional Source Beutler Lab
Gene Symbol Slit2
Ensembl Gene ENSMUSG00000031558
Gene Name slit guidance ligand 2
Synonyms E030015M03Rik, Drad-1, b2b1200.1Clo, Slil3, E130320P19Rik
MMRRC Submission 045885-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7831 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 48140480-48465075 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 48402025 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 805 (T805A)
Ref Sequence ENSEMBL: ENSMUSP00000134263 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033967] [ENSMUST00000170109] [ENSMUST00000172493] [ENSMUST00000173107] [ENSMUST00000174313] [ENSMUST00000174421]
AlphaFold Q9R1B9
Predicted Effect probably benign
Transcript: ENSMUST00000033967
AA Change: T793A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000033967
Gene: ENSMUSG00000031558
AA Change: T793A

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LRRNT 27 59 6.53e-9 SMART
LRR 53 77 1.41e2 SMART
LRR_TYP 78 101 1.79e-2 SMART
LRR 102 125 2.45e0 SMART
LRR 126 149 9.96e-1 SMART
LRR 154 173 1.29e2 SMART
LRR_TYP 174 197 2.05e-2 SMART
LRRCT 209 258 3.42e-9 SMART
LRRNT 272 304 4.55e-8 SMART
LRR 298 322 3e1 SMART
LRR_TYP 323 346 1.95e-3 SMART
LRR_TYP 347 370 2.24e-3 SMART
LRR 371 394 1.31e0 SMART
LRR 395 418 2.49e-1 SMART
LRRCT 430 479 1.88e-6 SMART
LRRNT 497 529 1.45e-6 SMART
LRR_TYP 549 572 1.38e-3 SMART
LRR 597 620 9.96e-1 SMART
LRR_TYP 621 644 2.71e-2 SMART
LRRCT 656 705 3.56e-7 SMART
LRRNT 718 750 3.69e-8 SMART
LRR 768 791 7.36e0 SMART
LRR_TYP 792 815 5.59e-4 SMART
LRR_TYP 816 839 7.9e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000170109
AA Change: T805A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000127615
Gene: ENSMUSG00000031558
AA Change: T805A

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LRRNT 27 59 6.53e-9 SMART
LRR 53 77 1.41e2 SMART
LRR_TYP 78 101 1.79e-2 SMART
LRR 102 125 2.45e0 SMART
LRR 126 149 9.96e-1 SMART
LRR 154 173 1.29e2 SMART
LRR_TYP 174 197 2.05e-2 SMART
LRRCT 209 258 3.42e-9 SMART
LRRNT 272 304 4.55e-8 SMART
LRR 298 322 3e1 SMART
LRR_TYP 323 346 1.95e-3 SMART
LRR_TYP 347 370 2.24e-3 SMART
LRR 371 394 1.31e0 SMART
LRR 395 418 2.49e-1 SMART
LRRCT 430 479 1.88e-6 SMART
LRRNT 497 529 1.45e-6 SMART
LRR_TYP 549 572 1.38e-3 SMART
LRR 597 620 9.96e-1 SMART
LRR_TYP 621 644 2.71e-2 SMART
LRRCT 656 705 3.56e-7 SMART
LRRNT 718 750 3.69e-8 SMART
LRR 768 791 7.36e0 SMART
LRR_TYP 792 815 5.59e-4 SMART
LRR_TYP 816 839 7.9e-4 SMART
LRRCT 851 900 3.9e-13 SMART
EGF 913 947 3.73e-5 SMART
EGF 952 988 4.35e-6 SMART
EGF_CA 990 1026 2.21e-7 SMART
FOLN 993 1015 5.84e1 SMART
EGF 1031 1066 1.07e-5 SMART
EGF_CA 1068 1104 3.97e-9 SMART
FOLN 1116 1138 2.22e0 SMART
EGF 1116 1149 1.62e-5 SMART
LamG 1172 1308 4.82e-39 SMART
EGF 1327 1360 3.68e-4 SMART
EGF 1366 1399 3.88e-3 SMART
FOLN 1407 1429 3.34e0 SMART
EGF 1407 1440 4.46e-3 SMART
CT 1451 1520 4.23e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000172493
AA Change: T45A

PolyPhen 2 Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000134655
Gene: ENSMUSG00000031558
AA Change: T45A

DomainStartEndE-ValueType
LRR 20 43 3.1e-2 SMART
LRR_TYP 44 67 2.4e-6 SMART
LRR_TYP 68 91 3.2e-6 SMART
LRRCT 103 152 1.8e-15 SMART
EGF 176 210 1.8e-7 SMART
EGF 215 251 2.1e-8 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000173107
AA Change: T793A

PolyPhen 2 Score 0.409 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000133840
Gene: ENSMUSG00000031558
AA Change: T793A

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LRRNT 27 59 6.53e-9 SMART
LRR 53 77 1.41e2 SMART
LRR_TYP 78 101 1.79e-2 SMART
LRR 102 125 2.45e0 SMART
LRR 126 149 9.96e-1 SMART
LRR 154 173 1.29e2 SMART
LRR_TYP 174 197 2.05e-2 SMART
LRRCT 209 258 3.42e-9 SMART
LRRNT 272 304 4.55e-8 SMART
LRR 298 322 3e1 SMART
LRR_TYP 323 346 1.95e-3 SMART
LRR_TYP 347 370 2.24e-3 SMART
LRR 371 394 1.31e0 SMART
LRR 395 418 2.49e-1 SMART
LRRCT 430 479 1.88e-6 SMART
LRRNT 505 537 1.45e-6 SMART
LRR_TYP 557 580 1.38e-3 SMART
LRR 605 628 9.96e-1 SMART
LRR_TYP 629 652 2.71e-2 SMART
LRRCT 664 713 3.56e-7 SMART
LRRNT 726 758 3.69e-8 SMART
LRR 776 799 7.36e0 SMART
LRR_TYP 800 823 5.59e-4 SMART
LRR_TYP 824 847 7.9e-4 SMART
LRRCT 859 908 3.9e-13 SMART
EGF 921 955 3.73e-5 SMART
EGF 960 996 4.35e-6 SMART
EGF_CA 998 1034 2.21e-7 SMART
FOLN 1001 1023 5.84e1 SMART
EGF 1039 1074 1.07e-5 SMART
EGF_CA 1076 1112 3.97e-9 SMART
FOLN 1124 1146 2.22e0 SMART
EGF 1124 1157 1.62e-5 SMART
LamG 1180 1316 4.82e-39 SMART
EGF 1335 1368 3.68e-4 SMART
EGF 1374 1407 3.88e-3 SMART
FOLN 1415 1437 3.34e0 SMART
EGF 1415 1448 4.46e-3 SMART
CT 1459 1528 4.23e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000174313
AA Change: T797A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000133912
Gene: ENSMUSG00000031558
AA Change: T797A

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LRRNT 27 59 6.53e-9 SMART
LRR 53 77 1.41e2 SMART
LRR_TYP 78 101 1.79e-2 SMART
LRR 102 125 2.45e0 SMART
LRR 126 149 9.96e-1 SMART
LRR 154 173 1.29e2 SMART
LRR_TYP 174 197 2.05e-2 SMART
LRRCT 209 258 3.42e-9 SMART
LRRNT 276 308 4.55e-8 SMART
LRR 302 326 3e1 SMART
LRR_TYP 327 350 1.95e-3 SMART
LRR_TYP 351 374 2.24e-3 SMART
LRR 375 398 1.31e0 SMART
LRR 399 422 2.49e-1 SMART
LRRCT 434 483 1.88e-6 SMART
LRRNT 501 533 1.45e-6 SMART
LRR_TYP 553 576 1.38e-3 SMART
LRR 601 624 9.96e-1 SMART
LRR_TYP 625 648 2.71e-2 SMART
LRRCT 660 709 3.56e-7 SMART
LRRNT 722 754 3.69e-8 SMART
LRR 772 795 7.36e0 SMART
LRR_TYP 796 819 5.59e-4 SMART
LRR_TYP 820 843 7.9e-4 SMART
LRRCT 855 904 3.9e-13 SMART
EGF 917 951 3.73e-5 SMART
EGF 956 992 4.35e-6 SMART
EGF_CA 994 1030 2.21e-7 SMART
FOLN 997 1019 5.84e1 SMART
EGF 1035 1070 1.07e-5 SMART
EGF_CA 1072 1108 3.97e-9 SMART
FOLN 1120 1142 2.22e0 SMART
EGF 1120 1153 1.62e-5 SMART
LamG 1176 1312 4.82e-39 SMART
EGF 1331 1364 3.68e-4 SMART
EGF 1370 1403 3.88e-3 SMART
FOLN 1411 1433 3.34e0 SMART
EGF 1411 1444 4.46e-3 SMART
CT 1455 1524 4.23e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000174421
AA Change: T805A

PolyPhen 2 Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000134263
Gene: ENSMUSG00000031558
AA Change: T805A

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LRRNT 27 59 6.53e-9 SMART
LRR 53 77 1.41e2 SMART
LRR_TYP 78 101 1.79e-2 SMART
LRR 102 125 2.45e0 SMART
LRR 126 149 9.96e-1 SMART
LRR 154 173 1.29e2 SMART
LRR_TYP 174 197 2.05e-2 SMART
LRRCT 209 258 3.42e-9 SMART
LRRNT 276 308 4.55e-8 SMART
LRR 302 326 3e1 SMART
LRR_TYP 327 350 1.95e-3 SMART
LRR_TYP 351 374 2.24e-3 SMART
LRR 375 398 1.31e0 SMART
LRR 399 422 2.49e-1 SMART
LRRCT 434 483 1.88e-6 SMART
LRRNT 509 541 1.45e-6 SMART
LRR_TYP 561 584 1.38e-3 SMART
LRR 609 632 9.96e-1 SMART
LRR_TYP 633 656 2.71e-2 SMART
LRRCT 668 717 3.56e-7 SMART
LRRNT 730 762 3.69e-8 SMART
LRR 780 803 7.36e0 SMART
LRR_TYP 804 827 5.59e-4 SMART
LRR_TYP 828 851 7.9e-4 SMART
LRRCT 863 912 3.9e-13 SMART
EGF 925 959 3.73e-5 SMART
EGF 964 1000 4.35e-6 SMART
EGF_CA 1002 1047 4.74e-7 SMART
FOLN 1005 1027 5.84e1 SMART
EGF 1052 1087 1.07e-5 SMART
EGF_CA 1089 1125 3.97e-9 SMART
FOLN 1137 1159 2.22e0 SMART
EGF 1137 1170 1.62e-5 SMART
LamG 1193 1329 4.82e-39 SMART
EGF 1348 1381 3.68e-4 SMART
EGF 1387 1420 3.88e-3 SMART
FOLN 1428 1450 3.34e0 SMART
EGF 1428 1461 4.46e-3 SMART
CT 1472 1541 4.23e-4 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (87/87)
MGI Phenotype FUNCTION: The protein encoded by this gene is a member of the Slit family of secreted glycoproteins, which function as ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. In mammals, members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Mice deficient for this gene exhibit abnormal axonal projections in the embryonic forebrain and develop supernumerary uretic buds that maintain improper connections to the nephric duct. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
PHENOTYPE: Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter. [provided by MGI curators]
Allele List at MGI

All alleles(4) : Targeted(4)

Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 G A 11: 9,247,404 (GRCm39) V2384I possibly damaging Het
Acsl1 A G 8: 46,972,043 (GRCm39) D297G probably benign Het
Ap2a1 C A 7: 44,550,436 (GRCm39) R944L probably damaging Het
Apbb1ip A G 2: 22,756,933 (GRCm39) Y398C probably damaging Het
Atp8a2 A T 14: 60,011,202 (GRCm39) V968D probably damaging Het
Becn1 T C 11: 101,181,279 (GRCm39) T341A probably benign Het
Card11 G T 5: 140,859,167 (GRCm39) S1126R possibly damaging Het
Ccdc51 T C 9: 108,921,058 (GRCm39) L315S probably damaging Het
Cdk12 T C 11: 98,140,653 (GRCm39) L1298P unknown Het
Cep170b A T 12: 112,711,234 (GRCm39) D1538V probably benign Het
Cfap52 A T 11: 67,826,782 (GRCm39) F348I possibly damaging Het
Clip1 A T 5: 123,751,342 (GRCm39) M813K Het
Col19a1 G A 1: 24,565,563 (GRCm39) T256I unknown Het
Col6a3 A T 1: 90,724,268 (GRCm39) C2027* probably null Het
Crisp4 A T 1: 18,199,013 (GRCm39) N140K probably benign Het
Crocc2 G T 1: 93,143,195 (GRCm39) A1266S probably benign Het
Cyfip2 G A 11: 46,087,273 (GRCm39) R1206C probably damaging Het
Cyp24a1 T A 2: 170,327,860 (GRCm39) M461L probably damaging Het
Cyp2a5 C T 7: 26,534,940 (GRCm39) T51I possibly damaging Het
Cyp2b19 C T 7: 26,466,565 (GRCm39) H398Y possibly damaging Het
Cyp4a29 G A 4: 115,107,367 (GRCm39) V234I probably benign Het
Dicer1 T G 12: 104,675,059 (GRCm39) K734N probably damaging Het
Dnai1 T C 4: 41,614,695 (GRCm39) probably null Het
Entpd3 G A 9: 120,373,025 (GRCm39) G14D probably damaging Het
Entrep3 G A 3: 89,091,520 (GRCm39) probably null Het
Ermp1 T C 19: 29,595,367 (GRCm39) T634A probably benign Het
Evc C T 5: 37,476,427 (GRCm39) G374D probably damaging Het
Fcgbp C A 7: 27,806,404 (GRCm39) T2124K probably damaging Het
Fgf8 G A 19: 45,730,876 (GRCm39) P50S probably benign Het
Fmnl1 C T 11: 103,088,999 (GRCm39) R1074W unknown Het
Galnt18 C T 7: 111,155,665 (GRCm39) V223M possibly damaging Het
Galnt2 A G 8: 125,058,817 (GRCm39) N295S probably benign Het
Grip1 T G 10: 119,854,011 (GRCm39) V600G probably damaging Het
Insm2 T A 12: 55,647,323 (GRCm39) C356S probably damaging Het
Itpr2 T A 6: 146,193,082 (GRCm39) I1672F probably benign Het
Kdm1b T G 13: 47,204,098 (GRCm39) N76K probably benign Het
Khnyn T A 14: 56,125,303 (GRCm39) probably null Het
Kidins220 C T 12: 25,111,230 (GRCm39) A1167V possibly damaging Het
Krt40 T C 11: 99,432,087 (GRCm39) D208G probably benign Het
Lars1 T A 18: 42,350,627 (GRCm39) D894V probably benign Het
Lmx1a A T 1: 167,668,521 (GRCm39) N266I probably benign Het
Mrgprb5 T A 7: 47,817,997 (GRCm39) K246M probably benign Het
Mrpl2 G A 17: 46,959,598 (GRCm39) G176R possibly damaging Het
Muc21 T A 17: 35,929,651 (GRCm39) T1512S unknown Het
Nell1 T A 7: 49,632,548 (GRCm39) F60L possibly damaging Het
Nnt G A 13: 119,506,630 (GRCm39) A453V possibly damaging Het
Opa1 A G 16: 29,467,755 (GRCm39) K940R probably benign Het
Opn5 A C 17: 42,891,510 (GRCm39) I309S probably null Het
Or1af1 C T 2: 37,109,723 (GRCm39) T74I probably damaging Het
Or1r1 A C 11: 73,875,257 (GRCm39) M59R probably damaging Het
Or2ag15 T A 7: 106,340,620 (GRCm39) I174F probably damaging Het
P3h3 T G 6: 124,832,118 (GRCm39) E256A possibly damaging Het
Pald1 G T 10: 61,191,593 (GRCm39) T65K probably damaging Het
Pcnx3 T C 19: 5,735,989 (GRCm39) Y279C probably damaging Het
Pik3c2b G A 1: 132,998,980 (GRCm39) S367N possibly damaging Het
Pik3cb T C 9: 98,970,666 (GRCm39) T342A probably benign Het
Pkd1l3 A T 8: 110,357,990 (GRCm39) E837D possibly damaging Het
Ppp2r2b T A 18: 42,834,597 (GRCm39) Y191F probably benign Het
Ppp4r4 G A 12: 103,557,080 (GRCm39) E439K possibly damaging Het
Ptprk A G 10: 28,444,404 (GRCm39) I946V possibly damaging Het
Ror1 A G 4: 100,298,295 (GRCm39) N556S probably benign Het
Ryr3 C T 2: 112,757,183 (GRCm39) A391T possibly damaging Het
Selp G A 1: 163,972,584 (GRCm39) probably null Het
Setx T A 2: 29,069,866 (GRCm39) V2557E possibly damaging Het
Setx T C 2: 29,047,120 (GRCm39) L1866S probably damaging Het
Slc66a3 T A 12: 17,047,632 (GRCm39) probably null Het
Sorbs3 T G 14: 70,440,481 (GRCm39) N89T possibly damaging Het
Sorl1 C A 9: 42,001,257 (GRCm39) V248L probably benign Het
Srebf2 T A 15: 82,066,288 (GRCm39) V612E probably damaging Het
Sv2c T A 13: 96,113,200 (GRCm39) Y583F probably damaging Het
Tada1 G T 1: 166,217,442 (GRCm39) R193I probably damaging Het
Tnrc6b C G 15: 80,764,580 (GRCm39) A694G possibly damaging Het
Ttll3 CAAAGTAA CAAAGTAAAGTAA 6: 113,376,118 (GRCm39) probably null Het
Ttn C T 2: 76,711,425 (GRCm39) G8372D unknown Het
Ube2g2 A G 10: 77,470,576 (GRCm39) T68A Het
Ubl7 T G 9: 57,821,918 (GRCm39) V89G possibly damaging Het
Ush2a T A 1: 188,492,038 (GRCm39) I3109N probably damaging Het
Utp20 T A 10: 88,598,632 (GRCm39) K115* probably null Het
Vmn2r26 T A 6: 124,016,758 (GRCm39) Y407* probably null Het
Yod1 G T 1: 130,646,986 (GRCm39) V288F probably damaging Het
Zbed5 A C 5: 129,930,798 (GRCm39) N249T possibly damaging Het
Zbtb5 T C 4: 44,995,244 (GRCm39) T47A probably damaging Het
Zcchc14 T C 8: 122,331,984 (GRCm39) T460A not run Het
Zfp712 A C 13: 67,200,483 (GRCm39) probably null Het
Zfyve16 A T 13: 92,658,836 (GRCm39) H358Q probably benign Het
Other mutations in Slit2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00791:Slit2 APN 5 48,461,374 (GRCm39) missense possibly damaging 0.86
IGL00809:Slit2 APN 5 48,146,493 (GRCm39) missense possibly damaging 0.88
IGL00811:Slit2 APN 5 48,146,493 (GRCm39) missense possibly damaging 0.88
IGL00813:Slit2 APN 5 48,146,493 (GRCm39) missense possibly damaging 0.88
IGL00815:Slit2 APN 5 48,146,493 (GRCm39) missense possibly damaging 0.88
IGL00816:Slit2 APN 5 48,146,493 (GRCm39) missense possibly damaging 0.88
IGL00817:Slit2 APN 5 48,146,493 (GRCm39) missense possibly damaging 0.88
IGL00819:Slit2 APN 5 48,146,493 (GRCm39) missense possibly damaging 0.88
IGL00820:Slit2 APN 5 48,146,493 (GRCm39) missense possibly damaging 0.88
IGL00822:Slit2 APN 5 48,146,493 (GRCm39) missense possibly damaging 0.88
IGL01077:Slit2 APN 5 48,374,785 (GRCm39) splice site probably null
IGL01375:Slit2 APN 5 48,439,056 (GRCm39) splice site probably benign
IGL01481:Slit2 APN 5 48,460,273 (GRCm39) missense probably benign 0.05
IGL01934:Slit2 APN 5 48,395,747 (GRCm39) missense possibly damaging 0.93
IGL01992:Slit2 APN 5 48,395,759 (GRCm39) missense probably benign 0.01
IGL02315:Slit2 APN 5 48,145,213 (GRCm39) missense probably damaging 0.98
IGL02328:Slit2 APN 5 48,387,646 (GRCm39) missense probably damaging 1.00
IGL02366:Slit2 APN 5 48,461,410 (GRCm39) missense possibly damaging 0.53
IGL02526:Slit2 APN 5 48,461,565 (GRCm39) nonsense probably null
IGL02852:Slit2 APN 5 48,402,014 (GRCm39) missense probably damaging 1.00
IGL02887:Slit2 APN 5 48,374,816 (GRCm39) missense probably benign 0.44
IGL03123:Slit2 APN 5 48,368,681 (GRCm39) missense probably damaging 1.00
IGL03182:Slit2 APN 5 48,377,395 (GRCm39) missense possibly damaging 0.77
P0025:Slit2 UTSW 5 48,461,377 (GRCm39) missense probably damaging 0.96
R0032:Slit2 UTSW 5 48,414,198 (GRCm39) missense probably damaging 0.99
R0032:Slit2 UTSW 5 48,414,198 (GRCm39) missense probably damaging 0.99
R0055:Slit2 UTSW 5 48,439,068 (GRCm39) nonsense probably null
R0055:Slit2 UTSW 5 48,439,068 (GRCm39) nonsense probably null
R0267:Slit2 UTSW 5 48,339,673 (GRCm39) splice site probably benign
R0552:Slit2 UTSW 5 48,395,721 (GRCm39) missense probably damaging 1.00
R0610:Slit2 UTSW 5 48,433,016 (GRCm39) missense possibly damaging 0.77
R0883:Slit2 UTSW 5 48,402,915 (GRCm39) splice site probably benign
R1390:Slit2 UTSW 5 48,374,832 (GRCm39) missense probably benign 0.06
R1442:Slit2 UTSW 5 48,395,725 (GRCm39) missense probably damaging 0.96
R1453:Slit2 UTSW 5 48,414,393 (GRCm39) missense possibly damaging 0.88
R1508:Slit2 UTSW 5 48,349,591 (GRCm39) missense probably damaging 0.98
R1639:Slit2 UTSW 5 48,416,996 (GRCm39) missense probably damaging 1.00
R1705:Slit2 UTSW 5 48,346,814 (GRCm39) missense probably damaging 0.99
R1828:Slit2 UTSW 5 48,461,372 (GRCm39) missense probably damaging 1.00
R1897:Slit2 UTSW 5 48,395,765 (GRCm39) missense probably damaging 1.00
R1908:Slit2 UTSW 5 48,439,330 (GRCm39) missense probably damaging 1.00
R1919:Slit2 UTSW 5 48,348,358 (GRCm39) unclassified probably benign
R1982:Slit2 UTSW 5 48,407,178 (GRCm39) missense probably damaging 1.00
R2013:Slit2 UTSW 5 48,459,832 (GRCm39) missense probably damaging 1.00
R2136:Slit2 UTSW 5 48,461,567 (GRCm39) missense probably benign 0.03
R2655:Slit2 UTSW 5 48,346,917 (GRCm39) missense possibly damaging 0.88
R3402:Slit2 UTSW 5 48,440,763 (GRCm39) missense probably damaging 0.98
R3724:Slit2 UTSW 5 48,414,225 (GRCm39) critical splice donor site probably null
R4176:Slit2 UTSW 5 48,394,586 (GRCm39) splice site probably null
R4306:Slit2 UTSW 5 48,460,125 (GRCm39) missense possibly damaging 0.83
R4397:Slit2 UTSW 5 48,377,423 (GRCm39) critical splice donor site probably null
R4525:Slit2 UTSW 5 48,407,215 (GRCm39) missense probably damaging 1.00
R4688:Slit2 UTSW 5 48,414,345 (GRCm39) splice site probably null
R5026:Slit2 UTSW 5 48,414,147 (GRCm39) missense probably damaging 0.99
R5138:Slit2 UTSW 5 48,439,309 (GRCm39) missense probably damaging 1.00
R5465:Slit2 UTSW 5 48,407,254 (GRCm39) missense probably damaging 1.00
R5471:Slit2 UTSW 5 48,346,897 (GRCm39) missense probably damaging 1.00
R5699:Slit2 UTSW 5 48,378,333 (GRCm39) critical splice donor site probably null
R5735:Slit2 UTSW 5 48,416,958 (GRCm39) missense probably damaging 1.00
R5834:Slit2 UTSW 5 48,416,989 (GRCm39) missense probably damaging 1.00
R5967:Slit2 UTSW 5 48,142,506 (GRCm39) missense probably damaging 0.99
R6150:Slit2 UTSW 5 48,461,516 (GRCm39) missense probably damaging 1.00
R6219:Slit2 UTSW 5 48,459,770 (GRCm39) missense possibly damaging 0.53
R6344:Slit2 UTSW 5 48,377,023 (GRCm39) missense probably benign 0.07
R6408:Slit2 UTSW 5 48,142,328 (GRCm39) unclassified probably benign
R6479:Slit2 UTSW 5 48,389,331 (GRCm39) missense probably damaging 1.00
R6526:Slit2 UTSW 5 48,461,509 (GRCm39) missense probably damaging 0.99
R6959:Slit2 UTSW 5 48,395,727 (GRCm39) missense possibly damaging 0.83
R7139:Slit2 UTSW 5 48,402,025 (GRCm39) missense probably benign 0.19
R7201:Slit2 UTSW 5 48,394,627 (GRCm39) missense probably null 0.85
R7472:Slit2 UTSW 5 48,414,180 (GRCm39) missense probably damaging 0.97
R7491:Slit2 UTSW 5 48,377,336 (GRCm39) missense probably benign 0.18
R7566:Slit2 UTSW 5 48,407,239 (GRCm39) missense probably damaging 0.99
R7622:Slit2 UTSW 5 48,142,547 (GRCm39) missense probably damaging 0.98
R7870:Slit2 UTSW 5 48,459,649 (GRCm39) missense probably damaging 0.99
R7899:Slit2 UTSW 5 48,404,527 (GRCm39) missense possibly damaging 0.89
R7969:Slit2 UTSW 5 48,461,378 (GRCm39) missense possibly damaging 0.47
R7984:Slit2 UTSW 5 48,333,465 (GRCm39) intron probably benign
R8021:Slit2 UTSW 5 48,459,834 (GRCm39) nonsense probably null
R8253:Slit2 UTSW 5 48,433,013 (GRCm39) missense probably benign 0.00
R8321:Slit2 UTSW 5 48,387,609 (GRCm39) missense probably damaging 1.00
R8426:Slit2 UTSW 5 48,382,105 (GRCm39) missense probably benign 0.00
R8513:Slit2 UTSW 5 48,382,050 (GRCm39) nonsense probably null
R8756:Slit2 UTSW 5 48,459,829 (GRCm39) nonsense probably null
R8796:Slit2 UTSW 5 48,460,190 (GRCm39) missense probably benign 0.01
R8799:Slit2 UTSW 5 48,461,524 (GRCm39) missense possibly damaging 0.73
R8947:Slit2 UTSW 5 48,407,140 (GRCm39) missense probably damaging 1.00
R9005:Slit2 UTSW 5 48,459,860 (GRCm39) missense possibly damaging 0.73
R9173:Slit2 UTSW 5 48,377,285 (GRCm39) missense probably damaging 0.98
R9310:Slit2 UTSW 5 48,349,568 (GRCm39) missense possibly damaging 0.59
R9365:Slit2 UTSW 5 48,461,534 (GRCm39) missense probably benign 0.04
Z1088:Slit2 UTSW 5 48,459,695 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGATCATAAGGCTCCTATAATGTTCC -3'
(R):5'- GTGTGTTTCTTAAGCTACACCTAAC -3'

Sequencing Primer
(F):5'- GTGGTTTGTTCCAAACCC -3'
(R):5'- GCTACACCTAACACTTTGAGTATC -3'
Posted On 2019-12-20