Incidental Mutation 'R0086:Ncapg'
ID 60579
Institutional Source Beutler Lab
Gene Symbol Ncapg
Ensembl Gene ENSMUSG00000015880
Gene Name non-SMC condensin I complex, subunit G
Synonyms MFT.M05.13, Hcapg, 5730507H05Rik
MMRRC Submission 038373-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.952) question?
Stock # R0086 (G1)
Quality Score 141
Status Validated
Chromosome 5
Chromosomal Location 45827261-45857888 bp(+) (GRCm39)
Type of Mutation splice site (3 bp from exon)
DNA Base Change (assembly) A to G at 45834086 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000112871 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000117396]
AlphaFold E9PWG6
Predicted Effect probably null
Transcript: ENSMUST00000117396
SMART Domains Protein: ENSMUSP00000112871
Gene: ENSMUSG00000015880

DomainStartEndE-ValueType
Pfam:Cnd3 557 863 7.4e-87 PFAM
low complexity region 864 874 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129562
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134309
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198274
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.0%
  • 10x: 94.6%
  • 20x: 86.6%
Validation Efficiency 96% (91/95)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik T A 15: 81,946,802 (GRCm39) V233D probably benign Het
Abcg8 T C 17: 85,000,199 (GRCm39) V252A probably damaging Het
Adam39 C T 8: 41,279,397 (GRCm39) T596I possibly damaging Het
Agap2 C A 10: 126,923,751 (GRCm39) probably null Het
Ap4b1 T G 3: 103,722,176 (GRCm39) V50G probably damaging Het
Atp13a1 T A 8: 70,250,424 (GRCm39) I381N possibly damaging Het
Bcl2 G A 1: 106,640,292 (GRCm39) R107C probably damaging Het
Birc6 T C 17: 74,900,161 (GRCm39) V1113A possibly damaging Het
C1galt1 T A 6: 7,867,051 (GRCm39) probably benign Het
Capza2 A G 6: 17,660,773 (GRCm39) K158E probably damaging Het
Cenpe C T 3: 134,970,185 (GRCm39) probably benign Het
Cercam T C 2: 29,761,076 (GRCm39) L42P probably damaging Het
Cfap54 T C 10: 92,864,456 (GRCm39) E807G possibly damaging Het
Cog6 A G 3: 52,900,991 (GRCm39) V157A probably damaging Het
Cts6 A T 13: 61,344,271 (GRCm39) probably benign Het
Cyp2c39 A T 19: 39,499,357 (GRCm39) I15F unknown Het
Dock7 A T 4: 98,833,381 (GRCm39) V1970D probably damaging Het
Exph5 A G 9: 53,249,230 (GRCm39) D73G possibly damaging Het
Gjc2 A T 11: 59,067,672 (GRCm39) M270K probably benign Het
Gns G A 10: 121,227,378 (GRCm39) D463N probably damaging Het
Hoxd8 G T 2: 74,536,276 (GRCm39) G129W probably damaging Het
Ina A G 19: 47,012,030 (GRCm39) T483A possibly damaging Het
Lmod3 T A 6: 97,224,306 (GRCm39) Q505L probably damaging Het
Map3k13 A G 16: 21,732,975 (GRCm39) N526D probably damaging Het
Map3k2 A T 18: 32,351,521 (GRCm39) I435F probably damaging Het
Mfsd6l A G 11: 68,447,391 (GRCm39) T81A probably benign Het
Micall1 T C 15: 79,009,689 (GRCm39) probably benign Het
Mkrn2 G T 6: 115,590,296 (GRCm39) M217I possibly damaging Het
Mtrex G T 13: 113,063,862 (GRCm39) F10L probably benign Het
Myh11 C A 16: 14,041,883 (GRCm39) Q720H probably damaging Het
Nlrp9a G A 7: 26,257,972 (GRCm39) C530Y probably damaging Het
Numb T C 12: 83,842,704 (GRCm39) T442A probably damaging Het
Oip5 C T 2: 119,448,410 (GRCm39) probably benign Het
Or1j14 A T 2: 36,417,462 (GRCm39) I13F possibly damaging Het
Or4c119 C T 2: 88,986,820 (GRCm39) R233H probably benign Het
Or51k1 A G 7: 103,661,261 (GRCm39) I216T probably benign Het
Or8g22 T C 9: 38,958,191 (GRCm39) T175A probably benign Het
Pcnx1 T C 12: 82,038,832 (GRCm39) probably benign Het
Pkhd1l1 T A 15: 44,419,404 (GRCm39) N2956K possibly damaging Het
Plcl1 T A 1: 55,754,742 (GRCm39) W1030R probably damaging Het
Polr2i G A 7: 29,932,511 (GRCm39) V73M probably damaging Het
Prr14l T A 5: 32,988,903 (GRCm39) probably benign Het
Pxdn G T 12: 30,052,418 (GRCm39) R865L possibly damaging Het
Scnn1a T C 6: 125,319,550 (GRCm39) probably benign Het
Shkbp1 G T 7: 27,051,451 (GRCm39) H203N probably benign Het
Slc22a14 C T 9: 119,051,804 (GRCm39) probably benign Het
Snap29 C A 16: 17,246,100 (GRCm39) T240K probably damaging Het
Sp2 C A 11: 96,848,253 (GRCm39) G457C probably damaging Het
Ssr2 C T 3: 88,484,187 (GRCm39) probably benign Het
Synpo2 A T 3: 122,910,753 (GRCm39) C297* probably null Het
Tpm3 T A 3: 89,997,399 (GRCm39) probably benign Het
Trmt6 CTG C 2: 132,650,937 (GRCm39) probably benign Het
Trp63 T C 16: 25,689,837 (GRCm39) Y431H probably damaging Het
Tuba3b T A 6: 145,566,886 (GRCm39) C376S probably damaging Het
Ubxn4 G A 1: 128,190,641 (GRCm39) E256K probably benign Het
Ulk1 G A 5: 110,935,573 (GRCm39) probably benign Het
Usp24 T C 4: 106,249,557 (GRCm39) S1425P probably damaging Het
Xdh T C 17: 74,191,433 (GRCm39) I1335V probably benign Het
Zmynd15 T C 11: 70,355,058 (GRCm39) Y352H probably damaging Het
Other mutations in Ncapg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00662:Ncapg APN 5 45,850,502 (GRCm39) missense possibly damaging 0.53
IGL00777:Ncapg APN 5 45,853,107 (GRCm39) missense possibly damaging 0.93
IGL00857:Ncapg APN 5 45,833,927 (GRCm39) splice site probably null
IGL00916:Ncapg APN 5 45,828,534 (GRCm39) missense probably benign 0.37
IGL01293:Ncapg APN 5 45,839,196 (GRCm39) missense probably benign 0.01
IGL01360:Ncapg APN 5 45,831,727 (GRCm39) nonsense probably null
IGL01462:Ncapg APN 5 45,828,477 (GRCm39) missense probably benign 0.02
IGL01527:Ncapg APN 5 45,829,726 (GRCm39) missense possibly damaging 0.71
IGL01732:Ncapg APN 5 45,851,195 (GRCm39) missense probably damaging 1.00
IGL01788:Ncapg APN 5 45,828,423 (GRCm39) missense probably damaging 0.97
IGL01871:Ncapg APN 5 45,845,923 (GRCm39) missense probably benign 0.09
IGL03106:Ncapg APN 5 45,853,010 (GRCm39) missense probably damaging 1.00
IGL03124:Ncapg APN 5 45,828,551 (GRCm39) missense probably benign
R0109:Ncapg UTSW 5 45,851,090 (GRCm39) splice site probably null
R0110:Ncapg UTSW 5 45,850,489 (GRCm39) unclassified probably benign
R0377:Ncapg UTSW 5 45,851,159 (GRCm39) missense probably benign
R0432:Ncapg UTSW 5 45,829,770 (GRCm39) missense probably damaging 0.99
R0637:Ncapg UTSW 5 45,844,666 (GRCm39) missense probably damaging 1.00
R0835:Ncapg UTSW 5 45,838,790 (GRCm39) missense probably damaging 0.96
R0894:Ncapg UTSW 5 45,837,236 (GRCm39) missense probably null 0.24
R1069:Ncapg UTSW 5 45,833,272 (GRCm39) intron probably benign
R1216:Ncapg UTSW 5 45,857,261 (GRCm39) missense possibly damaging 0.68
R1967:Ncapg UTSW 5 45,857,252 (GRCm39) missense probably damaging 0.99
R2396:Ncapg UTSW 5 45,835,715 (GRCm39) missense probably benign 0.00
R3157:Ncapg UTSW 5 45,833,400 (GRCm39) missense probably benign
R3735:Ncapg UTSW 5 45,853,469 (GRCm39) missense probably benign 0.00
R3736:Ncapg UTSW 5 45,853,469 (GRCm39) missense probably benign 0.00
R3887:Ncapg UTSW 5 45,831,705 (GRCm39) missense probably benign
R4371:Ncapg UTSW 5 45,835,797 (GRCm39) missense probably benign
R4545:Ncapg UTSW 5 45,828,554 (GRCm39) missense probably damaging 1.00
R4546:Ncapg UTSW 5 45,828,554 (GRCm39) missense probably damaging 1.00
R4558:Ncapg UTSW 5 45,833,986 (GRCm39) missense probably benign 0.00
R4615:Ncapg UTSW 5 45,844,741 (GRCm39) missense probably benign 0.00
R4938:Ncapg UTSW 5 45,828,551 (GRCm39) missense probably benign
R5839:Ncapg UTSW 5 45,829,620 (GRCm39) missense probably damaging 0.99
R5871:Ncapg UTSW 5 45,853,039 (GRCm39) missense probably damaging 1.00
R6086:Ncapg UTSW 5 45,850,578 (GRCm39) missense probably damaging 1.00
R6418:Ncapg UTSW 5 45,839,158 (GRCm39) missense probably damaging 1.00
R6617:Ncapg UTSW 5 45,827,474 (GRCm39) missense probably benign 0.03
R7145:Ncapg UTSW 5 45,827,372 (GRCm39) missense possibly damaging 0.82
R7408:Ncapg UTSW 5 45,853,135 (GRCm39) missense probably benign 0.00
R7443:Ncapg UTSW 5 45,829,652 (GRCm39) missense probably benign 0.31
R7463:Ncapg UTSW 5 45,851,434 (GRCm39) splice site probably null
R7509:Ncapg UTSW 5 45,853,450 (GRCm39) missense probably benign 0.01
R7687:Ncapg UTSW 5 45,857,227 (GRCm39) missense probably benign 0.03
R7919:Ncapg UTSW 5 45,853,390 (GRCm39) missense probably benign 0.00
R8022:Ncapg UTSW 5 45,839,136 (GRCm39) missense probably damaging 1.00
R8177:Ncapg UTSW 5 45,851,095 (GRCm39) missense probably benign 0.00
R8261:Ncapg UTSW 5 45,844,730 (GRCm39) missense possibly damaging 0.90
R8263:Ncapg UTSW 5 45,849,134 (GRCm39) missense probably benign 0.44
R8324:Ncapg UTSW 5 45,853,010 (GRCm39) missense probably damaging 1.00
R8333:Ncapg UTSW 5 45,831,805 (GRCm39) missense probably damaging 0.96
R8742:Ncapg UTSW 5 45,851,216 (GRCm39) missense probably damaging 1.00
R9026:Ncapg UTSW 5 45,853,115 (GRCm39) missense probably benign 0.00
R9051:Ncapg UTSW 5 45,853,140 (GRCm39) missense probably damaging 1.00
R9076:Ncapg UTSW 5 45,833,983 (GRCm39) missense probably benign
R9122:Ncapg UTSW 5 45,846,015 (GRCm39) missense possibly damaging 0.95
R9751:Ncapg UTSW 5 45,851,195 (GRCm39) missense probably damaging 1.00
R9776:Ncapg UTSW 5 45,829,834 (GRCm39) missense probably damaging 0.96
RF019:Ncapg UTSW 5 45,856,198 (GRCm39) missense probably benign 0.00
Z1088:Ncapg UTSW 5 45,837,222 (GRCm39) missense probably damaging 1.00
Z1177:Ncapg UTSW 5 45,829,844 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- AGGCATTACTTTAGTTGTGCCCTTTCA -3'
(R):5'- TGTGACAGGGATAGTAAGACCCTGAC -3'

Sequencing Primer
(F):5'- ACCATGTTGACTCATCTGAAGC -3'
(R):5'- GGATAGTAAGACCCTGACTGTACAC -3'
Posted On 2013-07-24