Incidental Mutation 'R7835:Olfm5'
ID 605918
Institutional Source Beutler Lab
Gene Symbol Olfm5
Ensembl Gene ENSMUSG00000044265
Gene Name olfactomedin 5
Synonyms E030002O03Rik
MMRRC Submission 045889-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R7835 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 104153013-104164831 bp(-) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 104154445 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 195 (Y195*)
Ref Sequence ENSEMBL: ENSMUSP00000117893 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051137] [ENSMUST00000059121] [ENSMUST00000154555]
AlphaFold Q8BU90
Predicted Effect probably null
Transcript: ENSMUST00000051137
AA Change: Y270*
SMART Domains Protein: ENSMUSP00000052174
Gene: ENSMUSG00000044265
AA Change: Y270*

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
coiled coil region 47 85 N/A INTRINSIC
coiled coil region 157 198 N/A INTRINSIC
OLF 211 468 3.13e-70 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000059121
SMART Domains Protein: ENSMUSP00000056365
Gene: ENSMUSG00000051437

DomainStartEndE-ValueType
UBQ 31 101 5.13e-16 SMART
Blast:STI1 199 237 8e-11 BLAST
low complexity region 339 350 N/A INTRINSIC
low complexity region 402 419 N/A INTRINSIC
PDB:2DNA|A 561 610 3e-26 PDB
Blast:UBA 568 604 1e-10 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000154555
AA Change: Y195*
SMART Domains Protein: ENSMUSP00000117893
Gene: ENSMUSG00000044265
AA Change: Y195*

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
coiled coil region 47 123 N/A INTRINSIC
OLF 136 304 3.65e-10 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 98% (48/49)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acan T A 7: 79,099,875 (GRCm38) S1465T probably benign Het
Accsl T A 2: 93,865,984 (GRCm38) K90* probably null Het
Adamts3 A T 5: 89,700,440 (GRCm38) D674E possibly damaging Het
Adap2 T A 11: 80,160,231 (GRCm38) V129D probably benign Het
Ank3 A G 10: 69,987,727 (GRCm38) D742G Het
C1ra G A 6: 124,517,725 (GRCm38) E316K probably benign Het
C330021F23Rik A G 8: 3,580,452 (GRCm38) probably benign Het
Cachd1 G T 4: 100,974,153 (GRCm38) probably null Het
Ccne1 G T 7: 38,102,845 (GRCm38) Q133K probably benign Het
Cers3 C T 7: 66,773,639 (GRCm38) H111Y possibly damaging Het
Chst5 A T 8: 111,890,602 (GRCm38) L129M probably damaging Het
Depdc7 A G 2: 104,728,185 (GRCm38) S164P probably benign Het
Dnah10 G A 5: 124,777,234 (GRCm38) A1966T probably damaging Het
Fam208a G T 14: 27,476,643 (GRCm38) G1311C probably damaging Het
Fcgbp T G 7: 28,117,207 (GRCm38) S2365A possibly damaging Het
Ihh A G 1: 74,946,366 (GRCm38) V320A probably damaging Het
Kdm5d T C Y: 900,558 (GRCm38) V201A possibly damaging Het
Kif13b T A 14: 64,767,452 (GRCm38) H1117Q probably benign Het
Lcn8 C A 2: 25,655,296 (GRCm38) probably null Het
Lrp4 T C 2: 91,495,042 (GRCm38) V1404A possibly damaging Het
Lrrc61 A T 6: 48,568,572 (GRCm38) T110S probably benign Het
Mrpl19 G A 6: 81,962,126 (GRCm38) R232C probably damaging Het
Muc5ac G C 7: 141,809,303 (GRCm38) G2117A unknown Het
Mzt1 T C 14: 99,046,003 (GRCm38) T21A probably benign Het
Naip6 G T 13: 100,316,004 (GRCm38) A183E probably benign Het
Neb T C 2: 52,150,577 (GRCm38) D6624G probably benign Het
Nup85 A G 11: 115,570,071 (GRCm38) D183G probably benign Het
Olfr828 T A 9: 18,815,809 (GRCm38) M162L probably benign Het
Piezo2 A T 18: 63,082,945 (GRCm38) F1216I probably benign Het
Pkd1l3 GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA 8: 109,624,195 (GRCm38) probably benign Het
Polr1a T C 6: 71,915,142 (GRCm38) V135A probably benign Het
Ppcdc A G 9: 57,420,276 (GRCm38) S83P probably benign Het
Prss21 A T 17: 23,869,451 (GRCm38) Q130L possibly damaging Het
Rdx T A 9: 52,065,788 (GRCm38) N112K probably damaging Het
Rgs22 A G 15: 36,081,911 (GRCm38) probably null Het
Rps26 C T 10: 128,626,126 (GRCm38) V40I probably benign Het
Runx2 A T 17: 44,608,236 (GRCm38) M405K probably damaging Het
Serinc2 A C 4: 130,275,487 (GRCm38) C4G unknown Het
Sh3rf2 C A 18: 42,111,170 (GRCm38) R266S probably benign Het
Slc38a10 A G 11: 120,116,996 (GRCm38) I386T possibly damaging Het
Stab2 G A 10: 86,872,619 (GRCm38) P1694L probably benign Het
Taf4 G A 2: 179,932,029 (GRCm38) T682M probably damaging Het
Tmem102 A G 11: 69,804,345 (GRCm38) V267A probably damaging Het
Trim65 A G 11: 116,130,929 (GRCm38) L26P probably damaging Het
Vmn1r160 T A 7: 22,871,954 (GRCm38) M244K possibly damaging Het
Vmn1r57 A T 7: 5,221,139 (GRCm38) H221L probably benign Het
Wdr89 C A 12: 75,632,899 (GRCm38) V194F probably damaging Het
Wee1 C A 7: 110,130,878 (GRCm38) Y396* probably null Het
Zfp451 A T 1: 33,772,979 (GRCm38) V885D probably damaging Het
Zfp981 A T 4: 146,537,876 (GRCm38) Q419H probably benign Het
Znfx1 A G 2: 167,039,827 (GRCm38) Y1081H probably damaging Het
Other mutations in Olfm5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01843:Olfm5 APN 7 104,160,744 (GRCm38) missense possibly damaging 0.77
IGL02097:Olfm5 APN 7 104,154,231 (GRCm38) missense probably benign 0.20
IGL02322:Olfm5 APN 7 104,154,401 (GRCm38) missense probably damaging 1.00
IGL02324:Olfm5 APN 7 104,154,095 (GRCm38) splice site probably null
IGL02702:Olfm5 APN 7 104,154,357 (GRCm38) missense probably damaging 1.00
R0128:Olfm5 UTSW 7 104,160,926 (GRCm38) missense probably benign
R0400:Olfm5 UTSW 7 104,154,179 (GRCm38) missense probably damaging 1.00
R0600:Olfm5 UTSW 7 104,153,869 (GRCm38) nonsense probably null
R0610:Olfm5 UTSW 7 104,154,445 (GRCm38) nonsense probably null
R0699:Olfm5 UTSW 7 104,154,119 (GRCm38) missense probably damaging 1.00
R1960:Olfm5 UTSW 7 104,160,412 (GRCm38) missense possibly damaging 0.85
R1978:Olfm5 UTSW 7 104,164,741 (GRCm38) missense unknown
R2391:Olfm5 UTSW 7 104,160,834 (GRCm38) missense probably benign 0.00
R3774:Olfm5 UTSW 7 104,161,849 (GRCm38) missense possibly damaging 0.67
R4632:Olfm5 UTSW 7 104,160,893 (GRCm38) missense probably benign 0.00
R4770:Olfm5 UTSW 7 104,160,478 (GRCm38) missense probably benign 0.04
R4838:Olfm5 UTSW 7 104,154,365 (GRCm38) missense probably damaging 1.00
R5274:Olfm5 UTSW 7 104,159,983 (GRCm38) missense probably damaging 1.00
R5455:Olfm5 UTSW 7 104,154,462 (GRCm38) missense probably damaging 0.99
R5930:Olfm5 UTSW 7 104,154,155 (GRCm38) missense probably damaging 1.00
R6416:Olfm5 UTSW 7 104,154,053 (GRCm38) missense probably damaging 1.00
R7126:Olfm5 UTSW 7 104,159,980 (GRCm38) missense probably damaging 1.00
R7535:Olfm5 UTSW 7 104,154,237 (GRCm38) missense possibly damaging 0.92
R7682:Olfm5 UTSW 7 104,161,772 (GRCm38) missense probably null 0.49
R8308:Olfm5 UTSW 7 104,154,399 (GRCm38) missense probably damaging 1.00
R8531:Olfm5 UTSW 7 104,153,822 (GRCm38) missense probably benign 0.00
R9035:Olfm5 UTSW 7 104,153,892 (GRCm38) missense probably damaging 1.00
R9072:Olfm5 UTSW 7 104,153,777 (GRCm38) missense probably benign
R9185:Olfm5 UTSW 7 104,160,888 (GRCm38) nonsense probably null
X0011:Olfm5 UTSW 7 104,153,946 (GRCm38) missense possibly damaging 0.91
Z1088:Olfm5 UTSW 7 104,154,150 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTTGTTGTAGGTGGCACCAG -3'
(R):5'- ATGCCATATGAGACTTCCCAC -3'

Sequencing Primer
(F):5'- CCAGGCAATGGGCGTCG -3'
(R):5'- ATGTACACATCTTTAGGGCTGACCG -3'
Posted On 2019-12-20