Incidental Mutation 'R7835:Olfr828'
ID 605924
Institutional Source Beutler Lab
Gene Symbol Olfr828
Ensembl Gene ENSMUSG00000078116
Gene Name olfactory receptor 828
Synonyms MOR149-1, GA_x6K02T2PVTD-12559294-12558356
MMRRC Submission 045889-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.142) question?
Stock # R7835 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 18814728-18819526 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 18815809 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 162 (M162L)
Ref Sequence ENSEMBL: ENSMUSP00000148853 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000104914] [ENSMUST00000215380]
AlphaFold Q8VFM8
Predicted Effect probably benign
Transcript: ENSMUST00000104914
AA Change: M162L

PolyPhen 2 Score 0.054 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000100514
Gene: ENSMUSG00000078116
AA Change: M162L

DomainStartEndE-ValueType
Pfam:7tm_4 31 310 1e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 1.4e-5 PFAM
Pfam:7tm_1 41 290 2.1e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215380
AA Change: M162L

PolyPhen 2 Score 0.054 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 98% (48/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acan T A 7: 79,099,875 (GRCm38) S1465T probably benign Het
Accsl T A 2: 93,865,984 (GRCm38) K90* probably null Het
Adamts3 A T 5: 89,700,440 (GRCm38) D674E possibly damaging Het
Adap2 T A 11: 80,160,231 (GRCm38) V129D probably benign Het
Ank3 A G 10: 69,987,727 (GRCm38) D742G Het
C1ra G A 6: 124,517,725 (GRCm38) E316K probably benign Het
C330021F23Rik A G 8: 3,580,452 (GRCm38) probably benign Het
Cachd1 G T 4: 100,974,153 (GRCm38) probably null Het
Ccne1 G T 7: 38,102,845 (GRCm38) Q133K probably benign Het
Cers3 C T 7: 66,773,639 (GRCm38) H111Y possibly damaging Het
Chst5 A T 8: 111,890,602 (GRCm38) L129M probably damaging Het
Depdc7 A G 2: 104,728,185 (GRCm38) S164P probably benign Het
Dnah10 G A 5: 124,777,234 (GRCm38) A1966T probably damaging Het
Fam208a G T 14: 27,476,643 (GRCm38) G1311C probably damaging Het
Fcgbp T G 7: 28,117,207 (GRCm38) S2365A possibly damaging Het
Ihh A G 1: 74,946,366 (GRCm38) V320A probably damaging Het
Kdm5d T C Y: 900,558 (GRCm38) V201A possibly damaging Het
Kif13b T A 14: 64,767,452 (GRCm38) H1117Q probably benign Het
Lcn8 C A 2: 25,655,296 (GRCm38) probably null Het
Lrp4 T C 2: 91,495,042 (GRCm38) V1404A possibly damaging Het
Lrrc61 A T 6: 48,568,572 (GRCm38) T110S probably benign Het
Mrpl19 G A 6: 81,962,126 (GRCm38) R232C probably damaging Het
Muc5ac G C 7: 141,809,303 (GRCm38) G2117A unknown Het
Mzt1 T C 14: 99,046,003 (GRCm38) T21A probably benign Het
Naip6 G T 13: 100,316,004 (GRCm38) A183E probably benign Het
Neb T C 2: 52,150,577 (GRCm38) D6624G probably benign Het
Nup85 A G 11: 115,570,071 (GRCm38) D183G probably benign Het
Olfm5 A T 7: 104,154,445 (GRCm38) Y195* probably null Het
Piezo2 A T 18: 63,082,945 (GRCm38) F1216I probably benign Het
Pkd1l3 GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA 8: 109,624,195 (GRCm38) probably benign Het
Polr1a T C 6: 71,915,142 (GRCm38) V135A probably benign Het
Ppcdc A G 9: 57,420,276 (GRCm38) S83P probably benign Het
Prss21 A T 17: 23,869,451 (GRCm38) Q130L possibly damaging Het
Rdx T A 9: 52,065,788 (GRCm38) N112K probably damaging Het
Rgs22 A G 15: 36,081,911 (GRCm38) probably null Het
Rps26 C T 10: 128,626,126 (GRCm38) V40I probably benign Het
Runx2 A T 17: 44,608,236 (GRCm38) M405K probably damaging Het
Serinc2 A C 4: 130,275,487 (GRCm38) C4G unknown Het
Sh3rf2 C A 18: 42,111,170 (GRCm38) R266S probably benign Het
Slc38a10 A G 11: 120,116,996 (GRCm38) I386T possibly damaging Het
Stab2 G A 10: 86,872,619 (GRCm38) P1694L probably benign Het
Taf4 G A 2: 179,932,029 (GRCm38) T682M probably damaging Het
Tmem102 A G 11: 69,804,345 (GRCm38) V267A probably damaging Het
Trim65 A G 11: 116,130,929 (GRCm38) L26P probably damaging Het
Vmn1r160 T A 7: 22,871,954 (GRCm38) M244K possibly damaging Het
Vmn1r57 A T 7: 5,221,139 (GRCm38) H221L probably benign Het
Wdr89 C A 12: 75,632,899 (GRCm38) V194F probably damaging Het
Wee1 C A 7: 110,130,878 (GRCm38) Y396* probably null Het
Zfp451 A T 1: 33,772,979 (GRCm38) V885D probably damaging Het
Zfp981 A T 4: 146,537,876 (GRCm38) Q419H probably benign Het
Znfx1 A G 2: 167,039,827 (GRCm38) Y1081H probably damaging Het
Other mutations in Olfr828
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02088:Olfr828 APN 9 18,815,923 (GRCm38) missense probably benign 0.03
IGL02103:Olfr828 APN 9 18,815,709 (GRCm38) missense probably damaging 1.00
IGL02792:Olfr828 APN 9 18,815,958 (GRCm38) missense probably benign 0.00
IGL02964:Olfr828 APN 9 18,815,728 (GRCm38) missense probably damaging 1.00
IGL03087:Olfr828 APN 9 18,816,084 (GRCm38) missense probably damaging 1.00
IGL03105:Olfr828 APN 9 18,815,389 (GRCm38) missense probably benign 0.03
R0330:Olfr828 UTSW 9 18,815,641 (GRCm38) missense probably damaging 1.00
R0335:Olfr828 UTSW 9 18,815,994 (GRCm38) missense probably damaging 1.00
R0862:Olfr828 UTSW 9 18,815,706 (GRCm38) missense probably damaging 0.98
R1226:Olfr828 UTSW 9 18,815,970 (GRCm38) missense probably benign 0.34
R2004:Olfr828 UTSW 9 18,815,505 (GRCm38) missense probably benign 0.05
R2005:Olfr828 UTSW 9 18,815,505 (GRCm38) missense probably benign 0.05
R2006:Olfr828 UTSW 9 18,815,505 (GRCm38) missense probably benign 0.05
R2199:Olfr828 UTSW 9 18,815,923 (GRCm38) missense probably damaging 0.97
R2230:Olfr828 UTSW 9 18,815,725 (GRCm38) missense probably damaging 1.00
R2399:Olfr828 UTSW 9 18,816,027 (GRCm38) missense probably benign 0.07
R5652:Olfr828 UTSW 9 18,815,626 (GRCm38) missense probably damaging 1.00
R5738:Olfr828 UTSW 9 18,815,829 (GRCm38) missense possibly damaging 0.81
R6416:Olfr828 UTSW 9 18,815,892 (GRCm38) missense probably benign 0.21
R6813:Olfr828 UTSW 9 18,815,892 (GRCm38) missense probably benign 0.21
R7092:Olfr828 UTSW 9 18,816,057 (GRCm38) missense probably damaging 1.00
R7109:Olfr828 UTSW 9 18,815,608 (GRCm38) missense probably benign 0.01
R7292:Olfr828 UTSW 9 18,816,190 (GRCm38) missense probably damaging 1.00
R7429:Olfr828 UTSW 9 18,815,354 (GRCm38) makesense probably null
R7430:Olfr828 UTSW 9 18,815,354 (GRCm38) makesense probably null
R7490:Olfr828 UTSW 9 18,815,933 (GRCm38) nonsense probably null
R8016:Olfr828 UTSW 9 18,816,292 (GRCm38) start codon destroyed probably null 0.56
R8809:Olfr828 UTSW 9 18,815,623 (GRCm38) missense probably damaging 0.99
R8859:Olfr828 UTSW 9 18,815,696 (GRCm38) missense possibly damaging 0.90
R9036:Olfr828 UTSW 9 18,816,273 (GRCm38) missense probably damaging 1.00
R9079:Olfr828 UTSW 9 18,815,435 (GRCm38) missense probably damaging 0.99
R9177:Olfr828 UTSW 9 18,815,446 (GRCm38) missense probably damaging 1.00
R9182:Olfr828 UTSW 9 18,815,446 (GRCm38) missense probably damaging 1.00
R9184:Olfr828 UTSW 9 18,815,842 (GRCm38) missense probably benign 0.10
RF003:Olfr828 UTSW 9 18,815,482 (GRCm38) missense probably benign 0.03
X0026:Olfr828 UTSW 9 18,815,763 (GRCm38) missense possibly damaging 0.95
Z1176:Olfr828 UTSW 9 18,815,980 (GRCm38) frame shift probably null
Z1177:Olfr828 UTSW 9 18,816,148 (GRCm38) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- AGACATTCTCAAAACAGATGAGGC -3'
(R):5'- CTAGCTGTCTTACACAAATCTGC -3'

Sequencing Primer
(F):5'- TCTCAAAACAGATGAGGCAATTTGAG -3'
(R):5'- AGCTGTCTTACACAAATCTGCTTTAC -3'
Posted On 2019-12-20