Incidental Mutation 'R7835:Rps26'
ID 605929
Institutional Source Beutler Lab
Gene Symbol Rps26
Ensembl Gene ENSMUSG00000025362
Gene Name ribosomal protein S26
Synonyms
MMRRC Submission 045889-MU
Accession Numbers
Essential gene? Not available question?
Stock # R7835 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 128624534-128626747 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 128626126 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 40 (V40I)
Ref Sequence ENSEMBL: ENSMUSP00000026420 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026420] [ENSMUST00000133342]
AlphaFold P62855
Predicted Effect probably benign
Transcript: ENSMUST00000026420
AA Change: V40I

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000026420
Gene: ENSMUSG00000025362
AA Change: V40I

DomainStartEndE-ValueType
Pfam:Ribosomal_S26e 1 114 7.9e-57 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000133342
SMART Domains Protein: ENSMUSP00000114404
Gene: ENSMUSG00000002578

DomainStartEndE-ValueType
ZnF_C2H2 159 181 7.67e-2 SMART
ZnF_C2H2 187 209 1.72e-4 SMART
ZnF_C2H2 215 237 1.72e-4 SMART
ZnF_C2H2 248 271 1.18e-2 SMART
low complexity region 423 436 N/A INTRINSIC
low complexity region 475 484 N/A INTRINSIC
ZnF_C2H2 531 553 7.49e0 SMART
ZnF_C2H2 559 583 3.52e-1 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 98% (48/49)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acan T A 7: 79,099,875 (GRCm38) S1465T probably benign Het
Accsl T A 2: 93,865,984 (GRCm38) K90* probably null Het
Adamts3 A T 5: 89,700,440 (GRCm38) D674E possibly damaging Het
Adap2 T A 11: 80,160,231 (GRCm38) V129D probably benign Het
Ank3 A G 10: 69,987,727 (GRCm38) D742G Het
C1ra G A 6: 124,517,725 (GRCm38) E316K probably benign Het
C330021F23Rik A G 8: 3,580,452 (GRCm38) probably benign Het
Cachd1 G T 4: 100,974,153 (GRCm38) probably null Het
Ccne1 G T 7: 38,102,845 (GRCm38) Q133K probably benign Het
Cers3 C T 7: 66,773,639 (GRCm38) H111Y possibly damaging Het
Chst5 A T 8: 111,890,602 (GRCm38) L129M probably damaging Het
Depdc7 A G 2: 104,728,185 (GRCm38) S164P probably benign Het
Dnah10 G A 5: 124,777,234 (GRCm38) A1966T probably damaging Het
Fam208a G T 14: 27,476,643 (GRCm38) G1311C probably damaging Het
Fcgbp T G 7: 28,117,207 (GRCm38) S2365A possibly damaging Het
Ihh A G 1: 74,946,366 (GRCm38) V320A probably damaging Het
Kdm5d T C Y: 900,558 (GRCm38) V201A possibly damaging Het
Kif13b T A 14: 64,767,452 (GRCm38) H1117Q probably benign Het
Lcn8 C A 2: 25,655,296 (GRCm38) probably null Het
Lrp4 T C 2: 91,495,042 (GRCm38) V1404A possibly damaging Het
Lrrc61 A T 6: 48,568,572 (GRCm38) T110S probably benign Het
Mrpl19 G A 6: 81,962,126 (GRCm38) R232C probably damaging Het
Muc5ac G C 7: 141,809,303 (GRCm38) G2117A unknown Het
Mzt1 T C 14: 99,046,003 (GRCm38) T21A probably benign Het
Naip6 G T 13: 100,316,004 (GRCm38) A183E probably benign Het
Neb T C 2: 52,150,577 (GRCm38) D6624G probably benign Het
Nup85 A G 11: 115,570,071 (GRCm38) D183G probably benign Het
Olfm5 A T 7: 104,154,445 (GRCm38) Y195* probably null Het
Olfr828 T A 9: 18,815,809 (GRCm38) M162L probably benign Het
Piezo2 A T 18: 63,082,945 (GRCm38) F1216I probably benign Het
Pkd1l3 GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA 8: 109,624,195 (GRCm38) probably benign Het
Polr1a T C 6: 71,915,142 (GRCm38) V135A probably benign Het
Ppcdc A G 9: 57,420,276 (GRCm38) S83P probably benign Het
Prss21 A T 17: 23,869,451 (GRCm38) Q130L possibly damaging Het
Rdx T A 9: 52,065,788 (GRCm38) N112K probably damaging Het
Rgs22 A G 15: 36,081,911 (GRCm38) probably null Het
Runx2 A T 17: 44,608,236 (GRCm38) M405K probably damaging Het
Serinc2 A C 4: 130,275,487 (GRCm38) C4G unknown Het
Sh3rf2 C A 18: 42,111,170 (GRCm38) R266S probably benign Het
Slc38a10 A G 11: 120,116,996 (GRCm38) I386T possibly damaging Het
Stab2 G A 10: 86,872,619 (GRCm38) P1694L probably benign Het
Taf4 G A 2: 179,932,029 (GRCm38) T682M probably damaging Het
Tmem102 A G 11: 69,804,345 (GRCm38) V267A probably damaging Het
Trim65 A G 11: 116,130,929 (GRCm38) L26P probably damaging Het
Vmn1r160 T A 7: 22,871,954 (GRCm38) M244K possibly damaging Het
Vmn1r57 A T 7: 5,221,139 (GRCm38) H221L probably benign Het
Wdr89 C A 12: 75,632,899 (GRCm38) V194F probably damaging Het
Wee1 C A 7: 110,130,878 (GRCm38) Y396* probably null Het
Zfp451 A T 1: 33,772,979 (GRCm38) V885D probably damaging Het
Zfp981 A T 4: 146,537,876 (GRCm38) Q419H probably benign Het
Znfx1 A G 2: 167,039,827 (GRCm38) Y1081H probably damaging Het
Other mutations in Rps26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02656:Rps26 APN 10 128,625,257 (GRCm38) missense possibly damaging 0.81
R7226:Rps26 UTSW 10 128,625,218 (GRCm38) missense unknown
Predicted Primers PCR Primer
(F):5'- ACCATGCATGAGCCTCAATCTC -3'
(R):5'- AGGAAGGGCTGAATTCTCGC -3'

Sequencing Primer
(F):5'- GTTAAAACCCCATCATTAGGCCTG -3'
(R):5'- GCCCCCTTTCCAATAGCG -3'
Posted On 2019-12-20