Incidental Mutation 'R7840:Or8j3c'
ID 606197
Institutional Source Beutler Lab
Gene Symbol Or8j3c
Ensembl Gene ENSMUSG00000090059
Gene Name olfactory receptor family 8 subfamily J member 3C
Synonyms GA_x6K02T2Q125-47892992-47892045, Olfr1062, MOR185-1
MMRRC Submission 045894-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R7840 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 86253063-86254018 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 86253583 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 146 (F146L)
Ref Sequence ENSEMBL: ENSMUSP00000149742 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105213] [ENSMUST00000217481]
AlphaFold Q7TR71
Predicted Effect probably benign
Transcript: ENSMUST00000105213
AA Change: F146L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000100848
Gene: ENSMUSG00000090059
AA Change: F146L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.8e-46 PFAM
Pfam:7tm_1 41 290 2.8e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217481
AA Change: F146L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 99% (73/74)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 A G 7: 120,074,689 (GRCm39) N577S probably benign Het
Ang4 A G 14: 52,001,529 (GRCm39) S140P probably damaging Het
Ankdd1b T C 13: 96,556,306 (GRCm39) probably null Het
Anln G T 9: 22,274,019 (GRCm39) A606D probably benign Het
Ano5 T G 7: 51,237,480 (GRCm39) V768G possibly damaging Het
Ccdc180 A T 4: 45,900,461 (GRCm39) Y275F possibly damaging Het
Chpf T C 1: 75,453,271 (GRCm39) Y334C probably damaging Het
Chrdl2 T C 7: 99,682,863 (GRCm39) L381S probably damaging Het
Cibar2 T C 8: 120,893,372 (GRCm39) D273G probably benign Het
Cox20 A T 1: 178,150,126 (GRCm39) Y100F probably benign Het
Dbn1 T C 13: 55,623,322 (GRCm39) D433G possibly damaging Het
Dclre1a A T 19: 56,519,684 (GRCm39) I983N probably damaging Het
Dok6 A T 18: 89,578,182 (GRCm39) H78Q probably benign Het
Efcab3 G A 11: 104,624,539 (GRCm39) D878N probably benign Het
Fpr1 A T 17: 18,097,634 (GRCm39) F118L probably benign Het
Fscn3 A G 6: 28,430,175 (GRCm39) Y115C probably damaging Het
Gabra4 A C 5: 71,798,256 (GRCm39) probably null Het
Gm45861 T C 8: 28,072,751 (GRCm39) V1290A unknown Het
Hivep1 T C 13: 42,308,828 (GRCm39) V356A probably benign Het
Ikbip T C 10: 90,937,617 (GRCm39) Y97H possibly damaging Het
Il10 A G 1: 130,947,805 (GRCm39) T53A probably benign Het
Inpp5f T C 7: 128,296,526 (GRCm39) V959A probably benign Het
Insr T C 8: 3,308,415 (GRCm39) E207G probably benign Het
Kndc1 T A 7: 139,503,731 (GRCm39) S1012T probably damaging Het
Krtap5-1 ACAGGGCTTGCAGCAGCTGGACTGACAGCAGCAGGGCTTGCAGCAGCTGGACTGACAGCAGCAGGGCTTGCAGCAGCTGGACTGACAGCAG ACAGGGCTTGCAGCAGCTGGACTGACAGCAGCAGGGCTTGCAGCAGCTGGACTGACAGCAG 7: 141,850,333 (GRCm39) probably benign Het
Ksr2 T C 5: 117,693,329 (GRCm39) V259A probably benign Het
Lox A T 18: 52,658,194 (GRCm39) Y326* probably null Het
Lpin2 C A 17: 71,537,269 (GRCm39) T272N probably benign Het
Lrp2 C T 2: 69,295,128 (GRCm39) E3397K probably damaging Het
Megf11 G A 9: 64,602,709 (GRCm39) C850Y possibly damaging Het
Morc1 T C 16: 48,319,147 (GRCm39) F284L probably benign Het
Moxd2 T A 6: 40,862,378 (GRCm39) D147V possibly damaging Het
Mrpl21 T C 19: 3,337,752 (GRCm39) L153P probably damaging Het
Naip2 T C 13: 100,280,917 (GRCm39) T1432A probably benign Het
Naip6 T A 13: 100,451,979 (GRCm39) D211V probably damaging Het
Ncoa5 T C 2: 164,854,816 (GRCm39) H102R possibly damaging Het
Ndel1 A T 11: 68,720,806 (GRCm39) C293* probably null Het
Ninl A T 2: 150,808,016 (GRCm39) M82K probably benign Het
Nrcam G A 12: 44,587,858 (GRCm39) probably null Het
Nup210l A T 3: 90,030,036 (GRCm39) I250L probably benign Het
Obscn T C 11: 58,968,776 (GRCm39) E2532G possibly damaging Het
Or1e1 C A 11: 73,244,585 (GRCm39) A2E probably benign Het
Or5v1 G T 17: 37,809,868 (GRCm39) G109C probably damaging Het
Osgin1 G A 8: 120,171,773 (GRCm39) S189N possibly damaging Het
Otud7b A G 3: 96,062,690 (GRCm39) E643G probably damaging Het
Phldb2 T A 16: 45,571,727 (GRCm39) T1222S probably damaging Het
Pwp1 C T 10: 85,723,914 (GRCm39) R472W probably damaging Het
Rad21 T C 15: 51,836,538 (GRCm39) Y211C probably damaging Het
Rexo1 A G 10: 80,386,572 (GRCm39) V162A probably benign Het
Rtl1 C T 12: 109,560,589 (GRCm39) V417I probably benign Het
Setbp1 G A 18: 78,826,639 (GRCm39) P1325S probably benign Het
Shld1 A G 2: 132,592,510 (GRCm39) T186A probably damaging Het
Shld2 A G 14: 33,959,523 (GRCm39) Y820H probably damaging Het
Skint7 G T 4: 111,839,423 (GRCm39) C239F probably benign Het
Slc25a1 A G 16: 17,744,138 (GRCm39) L221P probably benign Het
Snrnp70 T A 7: 45,026,214 (GRCm39) D385V unknown Het
Sp7 A C 15: 102,267,533 (GRCm39) V109G probably benign Het
Syne1 A T 10: 5,082,078 (GRCm39) Y849N probably damaging Het
Tas2r108 T C 6: 40,470,790 (GRCm39) F89L possibly damaging Het
Tcf3 C T 10: 80,246,301 (GRCm39) A581T possibly damaging Het
Tcta A G 9: 108,182,986 (GRCm39) L53P probably damaging Het
Traf3ip2 C G 10: 39,502,451 (GRCm39) Q200E probably damaging Het
Trgc1 A T 13: 19,400,691 (GRCm39) Y140F Het
Tyk2 A T 9: 21,036,263 (GRCm39) C75S probably damaging Het
Ugt3a1 G A 15: 9,311,903 (GRCm39) G382R probably damaging Het
Upp2 G T 2: 58,664,127 (GRCm39) probably null Het
Vmn1r212 A T 13: 23,067,323 (GRCm39) F337I unknown Het
Vmn1r58 T C 7: 5,414,242 (GRCm39) probably benign Het
Vps13d A T 4: 144,830,246 (GRCm39) V2856D Het
Wdr37 A C 13: 8,886,911 (GRCm39) L292R probably damaging Het
Yipf3 T C 17: 46,561,790 (GRCm39) I199T probably benign Het
Zdhhc23 A G 16: 43,791,907 (GRCm39) S289P possibly damaging Het
Zfp229 A T 17: 21,965,131 (GRCm39) K454* probably null Het
Other mutations in Or8j3c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02040:Or8j3c APN 2 86,253,336 (GRCm39) missense probably damaging 0.98
IGL02638:Or8j3c APN 2 86,254,021 (GRCm39) splice site probably null
IGL02863:Or8j3c APN 2 86,253,457 (GRCm39) missense probably benign 0.44
R0211:Or8j3c UTSW 2 86,253,451 (GRCm39) missense probably damaging 0.96
R0211:Or8j3c UTSW 2 86,253,451 (GRCm39) missense probably damaging 0.96
R1486:Or8j3c UTSW 2 86,253,825 (GRCm39) missense probably damaging 0.99
R2327:Or8j3c UTSW 2 86,253,165 (GRCm39) nonsense probably null
R3695:Or8j3c UTSW 2 86,253,987 (GRCm39) missense probably damaging 0.96
R3981:Or8j3c UTSW 2 86,253,186 (GRCm39) missense probably damaging 1.00
R4156:Or8j3c UTSW 2 86,253,544 (GRCm39) missense possibly damaging 0.67
R4860:Or8j3c UTSW 2 86,253,301 (GRCm39) missense probably damaging 1.00
R4860:Or8j3c UTSW 2 86,253,301 (GRCm39) missense probably damaging 1.00
R5024:Or8j3c UTSW 2 86,253,805 (GRCm39) missense possibly damaging 0.77
R5351:Or8j3c UTSW 2 86,253,610 (GRCm39) missense probably damaging 1.00
R5566:Or8j3c UTSW 2 86,253,721 (GRCm39) nonsense probably null
R5777:Or8j3c UTSW 2 86,253,669 (GRCm39) missense probably benign 0.00
R6628:Or8j3c UTSW 2 86,253,361 (GRCm39) missense probably benign 0.02
R7039:Or8j3c UTSW 2 86,253,177 (GRCm39) missense possibly damaging 0.48
R7159:Or8j3c UTSW 2 86,253,956 (GRCm39) splice site probably null
R7236:Or8j3c UTSW 2 86,253,533 (GRCm39) nonsense probably null
R7251:Or8j3c UTSW 2 86,253,940 (GRCm39) missense probably benign 0.45
R7575:Or8j3c UTSW 2 86,253,582 (GRCm39) missense probably benign
R8048:Or8j3c UTSW 2 86,253,651 (GRCm39) missense probably damaging 1.00
R8167:Or8j3c UTSW 2 86,253,484 (GRCm39) missense probably damaging 1.00
R8465:Or8j3c UTSW 2 86,253,975 (GRCm39) missense probably benign 0.03
R8672:Or8j3c UTSW 2 86,253,976 (GRCm39) missense probably benign
R8871:Or8j3c UTSW 2 86,253,697 (GRCm39) missense probably benign
R9244:Or8j3c UTSW 2 86,253,423 (GRCm39) missense probably damaging 0.97
R9513:Or8j3c UTSW 2 86,253,707 (GRCm39) missense probably damaging 1.00
X0065:Or8j3c UTSW 2 86,253,466 (GRCm39) missense probably benign 0.39
Z1176:Or8j3c UTSW 2 86,253,718 (GRCm39) missense probably benign 0.07
Z1177:Or8j3c UTSW 2 86,253,756 (GRCm39) missense probably benign 0.12
Z1177:Or8j3c UTSW 2 86,253,597 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACGGATCCTCAAAATTGCAAG -3'
(R):5'- TGCTCCTAAAATGCTGGTCAAC -3'

Sequencing Primer
(F):5'- GGATCCTCAAAATTGCAAGTACTATG -3'
(R):5'- ATGCTGGTCAACTTCTTAGTCAG -3'
Posted On 2019-12-20