Incidental Mutation 'R7840:Moxd2'
ID 606209
Institutional Source Beutler Lab
Gene Symbol Moxd2
Ensembl Gene ENSMUSG00000029885
Gene Name monooxygenase, DBH-like 2
Synonyms Dbhl1
MMRRC Submission 045894-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R7840 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 40855728-40864428 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 40862378 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 147 (D147V)
Ref Sequence ENSEMBL: ENSMUSP00000031937 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031937]
AlphaFold Q7TT41
Predicted Effect possibly damaging
Transcript: ENSMUST00000031937
AA Change: D147V

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000031937
Gene: ENSMUSG00000029885
AA Change: D147V

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
DoH 66 156 1.43e-12 SMART
Pfam:Cu2_monooxygen 192 316 8.3e-39 PFAM
Pfam:Cu2_monoox_C 336 493 1.8e-37 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 99% (73/74)
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 A G 7: 120,074,689 (GRCm39) N577S probably benign Het
Ang4 A G 14: 52,001,529 (GRCm39) S140P probably damaging Het
Ankdd1b T C 13: 96,556,306 (GRCm39) probably null Het
Anln G T 9: 22,274,019 (GRCm39) A606D probably benign Het
Ano5 T G 7: 51,237,480 (GRCm39) V768G possibly damaging Het
Ccdc180 A T 4: 45,900,461 (GRCm39) Y275F possibly damaging Het
Chpf T C 1: 75,453,271 (GRCm39) Y334C probably damaging Het
Chrdl2 T C 7: 99,682,863 (GRCm39) L381S probably damaging Het
Cibar2 T C 8: 120,893,372 (GRCm39) D273G probably benign Het
Cox20 A T 1: 178,150,126 (GRCm39) Y100F probably benign Het
Dbn1 T C 13: 55,623,322 (GRCm39) D433G possibly damaging Het
Dclre1a A T 19: 56,519,684 (GRCm39) I983N probably damaging Het
Dok6 A T 18: 89,578,182 (GRCm39) H78Q probably benign Het
Efcab3 G A 11: 104,624,539 (GRCm39) D878N probably benign Het
Fpr1 A T 17: 18,097,634 (GRCm39) F118L probably benign Het
Fscn3 A G 6: 28,430,175 (GRCm39) Y115C probably damaging Het
Gabra4 A C 5: 71,798,256 (GRCm39) probably null Het
Gm45861 T C 8: 28,072,751 (GRCm39) V1290A unknown Het
Hivep1 T C 13: 42,308,828 (GRCm39) V356A probably benign Het
Ikbip T C 10: 90,937,617 (GRCm39) Y97H possibly damaging Het
Il10 A G 1: 130,947,805 (GRCm39) T53A probably benign Het
Inpp5f T C 7: 128,296,526 (GRCm39) V959A probably benign Het
Insr T C 8: 3,308,415 (GRCm39) E207G probably benign Het
Kndc1 T A 7: 139,503,731 (GRCm39) S1012T probably damaging Het
Krtap5-1 ACAGGGCTTGCAGCAGCTGGACTGACAGCAGCAGGGCTTGCAGCAGCTGGACTGACAGCAGCAGGGCTTGCAGCAGCTGGACTGACAGCAG ACAGGGCTTGCAGCAGCTGGACTGACAGCAGCAGGGCTTGCAGCAGCTGGACTGACAGCAG 7: 141,850,333 (GRCm39) probably benign Het
Ksr2 T C 5: 117,693,329 (GRCm39) V259A probably benign Het
Lox A T 18: 52,658,194 (GRCm39) Y326* probably null Het
Lpin2 C A 17: 71,537,269 (GRCm39) T272N probably benign Het
Lrp2 C T 2: 69,295,128 (GRCm39) E3397K probably damaging Het
Megf11 G A 9: 64,602,709 (GRCm39) C850Y possibly damaging Het
Morc1 T C 16: 48,319,147 (GRCm39) F284L probably benign Het
Mrpl21 T C 19: 3,337,752 (GRCm39) L153P probably damaging Het
Naip2 T C 13: 100,280,917 (GRCm39) T1432A probably benign Het
Naip6 T A 13: 100,451,979 (GRCm39) D211V probably damaging Het
Ncoa5 T C 2: 164,854,816 (GRCm39) H102R possibly damaging Het
Ndel1 A T 11: 68,720,806 (GRCm39) C293* probably null Het
Ninl A T 2: 150,808,016 (GRCm39) M82K probably benign Het
Nrcam G A 12: 44,587,858 (GRCm39) probably null Het
Nup210l A T 3: 90,030,036 (GRCm39) I250L probably benign Het
Obscn T C 11: 58,968,776 (GRCm39) E2532G possibly damaging Het
Or1e1 C A 11: 73,244,585 (GRCm39) A2E probably benign Het
Or5v1 G T 17: 37,809,868 (GRCm39) G109C probably damaging Het
Or8j3c A G 2: 86,253,583 (GRCm39) F146L probably benign Het
Osgin1 G A 8: 120,171,773 (GRCm39) S189N possibly damaging Het
Otud7b A G 3: 96,062,690 (GRCm39) E643G probably damaging Het
Phldb2 T A 16: 45,571,727 (GRCm39) T1222S probably damaging Het
Pwp1 C T 10: 85,723,914 (GRCm39) R472W probably damaging Het
Rad21 T C 15: 51,836,538 (GRCm39) Y211C probably damaging Het
Rexo1 A G 10: 80,386,572 (GRCm39) V162A probably benign Het
Rtl1 C T 12: 109,560,589 (GRCm39) V417I probably benign Het
Setbp1 G A 18: 78,826,639 (GRCm39) P1325S probably benign Het
Shld1 A G 2: 132,592,510 (GRCm39) T186A probably damaging Het
Shld2 A G 14: 33,959,523 (GRCm39) Y820H probably damaging Het
Skint7 G T 4: 111,839,423 (GRCm39) C239F probably benign Het
Slc25a1 A G 16: 17,744,138 (GRCm39) L221P probably benign Het
Snrnp70 T A 7: 45,026,214 (GRCm39) D385V unknown Het
Sp7 A C 15: 102,267,533 (GRCm39) V109G probably benign Het
Syne1 A T 10: 5,082,078 (GRCm39) Y849N probably damaging Het
Tas2r108 T C 6: 40,470,790 (GRCm39) F89L possibly damaging Het
Tcf3 C T 10: 80,246,301 (GRCm39) A581T possibly damaging Het
Tcta A G 9: 108,182,986 (GRCm39) L53P probably damaging Het
Traf3ip2 C G 10: 39,502,451 (GRCm39) Q200E probably damaging Het
Trgc1 A T 13: 19,400,691 (GRCm39) Y140F Het
Tyk2 A T 9: 21,036,263 (GRCm39) C75S probably damaging Het
Ugt3a1 G A 15: 9,311,903 (GRCm39) G382R probably damaging Het
Upp2 G T 2: 58,664,127 (GRCm39) probably null Het
Vmn1r212 A T 13: 23,067,323 (GRCm39) F337I unknown Het
Vmn1r58 T C 7: 5,414,242 (GRCm39) probably benign Het
Vps13d A T 4: 144,830,246 (GRCm39) V2856D Het
Wdr37 A C 13: 8,886,911 (GRCm39) L292R probably damaging Het
Yipf3 T C 17: 46,561,790 (GRCm39) I199T probably benign Het
Zdhhc23 A G 16: 43,791,907 (GRCm39) S289P possibly damaging Het
Zfp229 A T 17: 21,965,131 (GRCm39) K454* probably null Het
Other mutations in Moxd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00885:Moxd2 APN 6 40,861,113 (GRCm39) splice site probably benign
IGL02113:Moxd2 APN 6 40,862,338 (GRCm39) missense probably benign 0.06
IGL02223:Moxd2 APN 6 40,861,967 (GRCm39) missense probably damaging 1.00
IGL03204:Moxd2 APN 6 40,864,239 (GRCm39) missense probably benign 0.04
IGL03385:Moxd2 APN 6 40,855,952 (GRCm39) missense probably damaging 1.00
R0084:Moxd2 UTSW 6 40,856,342 (GRCm39) missense probably null 0.01
R1213:Moxd2 UTSW 6 40,868,831 (GRCm39) unclassified probably benign
R1326:Moxd2 UTSW 6 40,857,288 (GRCm39) missense probably benign 0.00
R1652:Moxd2 UTSW 6 40,864,337 (GRCm39) missense probably damaging 1.00
R1940:Moxd2 UTSW 6 40,860,466 (GRCm39) missense probably damaging 1.00
R2040:Moxd2 UTSW 6 40,861,887 (GRCm39) splice site probably null
R2088:Moxd2 UTSW 6 40,861,901 (GRCm39) missense probably damaging 1.00
R3018:Moxd2 UTSW 6 40,855,820 (GRCm39) missense probably benign 0.01
R3962:Moxd2 UTSW 6 40,862,331 (GRCm39) missense probably benign
R4248:Moxd2 UTSW 6 40,855,933 (GRCm39) missense probably damaging 1.00
R4438:Moxd2 UTSW 6 40,860,996 (GRCm39) missense probably damaging 1.00
R4715:Moxd2 UTSW 6 40,864,181 (GRCm39) missense probably damaging 1.00
R4732:Moxd2 UTSW 6 40,855,793 (GRCm39) missense probably benign
R4733:Moxd2 UTSW 6 40,855,793 (GRCm39) missense probably benign
R4760:Moxd2 UTSW 6 40,868,537 (GRCm39) missense probably benign 0.06
R4851:Moxd2 UTSW 6 40,855,756 (GRCm39) missense probably damaging 1.00
R5087:Moxd2 UTSW 6 40,856,270 (GRCm39) missense probably damaging 1.00
R5187:Moxd2 UTSW 6 40,856,271 (GRCm39) missense probably benign 0.18
R5339:Moxd2 UTSW 6 40,862,354 (GRCm39) missense probably damaging 1.00
R5452:Moxd2 UTSW 6 40,859,048 (GRCm39) splice site probably null
R5860:Moxd2 UTSW 6 40,857,341 (GRCm39) missense probably damaging 1.00
R5973:Moxd2 UTSW 6 40,855,744 (GRCm39) missense probably damaging 0.96
R6015:Moxd2 UTSW 6 40,860,688 (GRCm39) missense probably damaging 1.00
R6316:Moxd2 UTSW 6 40,860,481 (GRCm39) missense probably damaging 1.00
R7500:Moxd2 UTSW 6 40,868,746 (GRCm39) missense probably benign
R7561:Moxd2 UTSW 6 40,864,337 (GRCm39) missense probably damaging 1.00
R8042:Moxd2 UTSW 6 40,862,301 (GRCm39) missense probably benign 0.40
R9147:Moxd2 UTSW 6 40,860,978 (GRCm39) missense probably damaging 1.00
R9148:Moxd2 UTSW 6 40,860,978 (GRCm39) missense probably damaging 1.00
R9169:Moxd2 UTSW 6 40,860,490 (GRCm39) missense possibly damaging 0.94
R9259:Moxd2 UTSW 6 40,860,969 (GRCm39) missense probably damaging 1.00
R9291:Moxd2 UTSW 6 40,857,362 (GRCm39) missense probably damaging 1.00
R9448:Moxd2 UTSW 6 40,864,160 (GRCm39) missense probably benign 0.01
R9522:Moxd2 UTSW 6 40,857,375 (GRCm39) missense probably benign 0.13
R9635:Moxd2 UTSW 6 40,863,000 (GRCm39) missense possibly damaging 0.93
X0052:Moxd2 UTSW 6 40,859,462 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- ATGGTGGGGTCTTACATTACTGATC -3'
(R):5'- TGAGTTCAAGTTTGGTTCAACC -3'

Sequencing Primer
(F):5'- GGGGTCTTACATTACTGATCTTCAAG -3'
(R):5'- CCTTCTTATTCTGCAGGTGTATAAAG -3'
Posted On 2019-12-20