|Institutional Source||Beutler Lab|
|Gene Name||adenylate cyclase 1|
|Synonyms||I-AC, D11Bwg1392e, AC1|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R0082 (G1)|
|Chromosomal Location||7063489-7178506 bp(+) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to C at 7149497 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000020706 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000020706]|
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||94% (136/144)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
PHENOTYPE: Mice homozygous for an insertional or null mutation fail to develop normal patterned distribution of neurons in the brain and display behavioral and learning abnormalities. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Adcy1||
(F):5'- TTGGGTGTCTTGCTGAGAACACAG -3'
(R):5'- GGCTTCAAATGCCTTTGCTGCTG -3'
(F):5'- CAGTGtgtgttactggggttac -3'
(R):5'- TGGTCTCCAAGGCAGACAAC -3'