Incidental Mutation 'R7842:Dnajc10'
ID 606351
Institutional Source Beutler Lab
Gene Symbol Dnajc10
Ensembl Gene ENSMUSG00000027006
Gene Name DnaJ heat shock protein family (Hsp40) member C10
Synonyms 1200006L06Rik, JPDI, ERdj5, D2Ertd706e
MMRRC Submission 045896-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.185) question?
Stock # R7842 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 80145810-80184387 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 80175409 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 599 (K599E)
Ref Sequence ENSEMBL: ENSMUSP00000028392 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028392]
AlphaFold Q9DC23
PDB Structure Crystal structure of full-length ERdj5 [X-RAY DIFFRACTION]
Crystal structure of J-Trx1 fragment of ERdj5 [X-RAY DIFFRACTION]
Crystal structure of Trx4 domain of ERdj5 [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000028392
AA Change: K599E

PolyPhen 2 Score 0.043 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000028392
Gene: ENSMUSG00000027006
AA Change: K599E

DomainStartEndE-ValueType
DnaJ 34 92 9.73e-26 SMART
Pfam:Thioredoxin 130 232 5.6e-21 PFAM
low complexity region 384 392 N/A INTRINSIC
Pfam:Thioredoxin 454 553 2.3e-21 PFAM
Pfam:Thioredoxin 557 663 2e-21 PFAM
Pfam:Thioredoxin 672 776 5.8e-26 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 99% (77/78)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased endoplasmic reticulum stress in the salivary gland. Female homozygous mutant mice are smaller than controls. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700034J05Rik T C 6: 146,855,034 (GRCm39) T3A unknown Het
4933412E24Rik T C 15: 59,888,422 (GRCm39) E6G probably damaging Het
Abca6 A G 11: 110,087,523 (GRCm39) L1135P possibly damaging Het
Agps A G 2: 75,681,876 (GRCm39) D113G probably damaging Het
Ankhd1 G T 18: 36,780,881 (GRCm39) V1978L probably benign Het
Ankrd31 T A 13: 96,957,966 (GRCm39) probably null Het
Arhgap5 T A 12: 52,565,480 (GRCm39) M817K possibly damaging Het
Bdp1 C A 13: 100,235,637 (GRCm39) V105F probably damaging Het
Brdt A G 5: 107,496,454 (GRCm39) N189D possibly damaging Het
Ccdc180 A T 4: 45,909,428 (GRCm39) N532I probably benign Het
Ccnc A C 4: 21,730,480 (GRCm39) K39T probably damaging Het
Cfap251 T C 5: 123,392,487 (GRCm39) V207A unknown Het
Cfap57 C A 4: 118,411,952 (GRCm39) G1231* probably null Het
Chd7 A T 4: 8,854,115 (GRCm39) T1896S probably benign Het
Clk4 A T 11: 51,171,956 (GRCm39) H412L probably benign Het
Creld1 T C 6: 113,465,100 (GRCm39) L109P probably damaging Het
Cxxc4 A T 3: 133,946,093 (GRCm39) I225L possibly damaging Het
Cyp4f39 A T 17: 32,702,291 (GRCm39) R263W probably benign Het
Dennd10 G A 19: 60,819,317 (GRCm39) A263T not run Het
Dip2c T C 13: 9,656,569 (GRCm39) probably null Het
Dnah14 A G 1: 181,455,463 (GRCm39) T863A probably damaging Het
Dnah17 C A 11: 117,970,508 (GRCm39) probably null Het
Dnajc7 C A 11: 100,489,544 (GRCm39) R101L probably benign Het
Dnttip2 G A 3: 122,069,990 (GRCm39) E402K probably benign Het
Dusp22 T A 13: 30,852,774 (GRCm39) probably null Het
Egflam C A 15: 7,280,675 (GRCm39) R450M probably null Het
Eml5 C T 12: 98,760,394 (GRCm39) R1785Q probably damaging Het
Fam78b G T 1: 166,829,178 (GRCm39) R15L probably damaging Het
Fbxl5 A T 5: 43,915,945 (GRCm39) I489N probably damaging Het
Flt3 G A 5: 147,271,263 (GRCm39) P893S probably damaging Het
Gm17019 T C 5: 15,081,049 (GRCm39) M131V possibly damaging Het
Gm21560 T A 14: 6,216,262 (GRCm38) I194F probably benign Het
Gm28729 T C 9: 96,399,705 (GRCm39) D158G probably damaging Het
Gucy2c C T 6: 136,746,814 (GRCm39) probably null Het
Hectd1 C T 12: 51,819,343 (GRCm39) G1247S probably damaging Het
Ireb2 T A 9: 54,816,970 (GRCm39) I946K probably benign Het
Itgb4 A T 11: 115,873,531 (GRCm39) D249V probably benign Het
Klhdc7a A G 4: 139,694,549 (GRCm39) S133P probably damaging Het
Lsr A T 7: 30,665,437 (GRCm39) D172E possibly damaging Het
Macf1 T C 4: 123,420,702 (GRCm39) E184G probably benign Het
Map2 T A 1: 66,455,570 (GRCm39) D1421E probably benign Het
Map3k4 A T 17: 12,490,030 (GRCm39) L467H possibly damaging Het
Mogat1 T C 1: 78,499,502 (GRCm39) probably null Het
Mxra8 A G 4: 155,927,367 (GRCm39) D384G probably damaging Het
Myo15b A G 11: 115,762,321 (GRCm39) T1214A Het
Naip1 T C 13: 100,563,506 (GRCm39) Y553C probably damaging Het
Nln A T 13: 104,189,137 (GRCm39) I278K probably benign Het
Nsmaf T A 4: 6,435,109 (GRCm39) probably null Het
Nynrin A G 14: 56,102,553 (GRCm39) R741G probably damaging Het
Or4p8 A G 2: 88,727,305 (GRCm39) V212A possibly damaging Het
Or52e19b A G 7: 103,032,783 (GRCm39) V142A probably benign Het
Or5d38 C T 2: 87,955,330 (GRCm39) probably benign Het
Or8j3 G T 2: 86,028,516 (GRCm39) Y193* probably null Het
Orc1 A G 4: 108,462,744 (GRCm39) H607R probably benign Het
Pate2 A T 9: 35,581,829 (GRCm39) Y41F probably damaging Het
Pcdhb20 A T 18: 37,638,112 (GRCm39) T213S possibly damaging Het
Pcm1 G A 8: 41,780,621 (GRCm39) E1858K possibly damaging Het
Pla2g2d A G 4: 138,506,089 (GRCm39) T59A probably damaging Het
Ppl C T 16: 4,906,725 (GRCm39) R1190H probably damaging Het
Prl2c2 A G 13: 13,179,907 (GRCm39) L2P probably benign Het
Proz G A 8: 13,113,406 (GRCm39) V76I probably benign Het
Prr36 A G 8: 4,260,953 (GRCm39) S955P probably benign Het
Pter T C 2: 12,983,352 (GRCm39) V119A probably damaging Het
Qrich1 T A 9: 108,433,567 (GRCm39) probably null Het
Rbm15b T C 9: 106,763,088 (GRCm39) E360G probably damaging Het
Skint11 G A 4: 114,101,968 (GRCm39) C327Y possibly damaging Het
Spag17 T A 3: 99,961,174 (GRCm39) S987T probably benign Het
Spata31f3 TCATTCAACACTTTGGAGAGCTCTGAACTCTGGCCATTCAACACTTTGGAGAGCTCTGAACTCTGGCCATTCAACACTTTGGAGAGCTCTGAACTCTGGTCATTCAACACTTTGG TCATTCAACACTTTGGAGAGCTCTGAACTCTGGCCATTCAACACTTTGGAGAGCTCTGAACTCTGGTCATTCAACACTTTGG 4: 42,871,823 (GRCm39) probably benign Het
Tbx1 T C 16: 18,405,365 (GRCm39) S100G unknown Het
Tiam2 C T 17: 3,568,399 (GRCm39) S1515L possibly damaging Het
Togaram1 C A 12: 65,013,233 (GRCm39) D161E probably damaging Het
Trhde A T 10: 114,532,003 (GRCm39) S366T possibly damaging Het
Ttc12 A G 9: 49,349,724 (GRCm39) I691T possibly damaging Het
Ube4a A G 9: 44,861,025 (GRCm39) probably null Het
Uggt2 A T 14: 119,235,516 (GRCm39) I1453N probably damaging Het
Unc79 T C 12: 103,058,313 (GRCm39) S972P probably damaging Het
Wdr20 G A 12: 110,704,649 (GRCm39) D63N probably benign Het
Wls T A 3: 159,578,816 (GRCm39) I126N probably benign Het
Xirp2 A G 2: 67,355,289 (GRCm39) D3350G probably benign Het
Other mutations in Dnajc10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01367:Dnajc10 APN 2 80,155,096 (GRCm39) splice site probably benign
IGL01420:Dnajc10 APN 2 80,175,367 (GRCm39) missense possibly damaging 0.81
IGL01466:Dnajc10 APN 2 80,151,631 (GRCm39) missense probably benign 0.00
IGL01645:Dnajc10 APN 2 80,170,871 (GRCm39) missense possibly damaging 0.46
IGL01929:Dnajc10 APN 2 80,158,420 (GRCm39) missense probably damaging 0.99
IGL01958:Dnajc10 APN 2 80,151,648 (GRCm39) splice site probably benign
IGL02205:Dnajc10 APN 2 80,179,702 (GRCm39) missense possibly damaging 0.74
IGL02289:Dnajc10 APN 2 80,170,870 (GRCm39) missense probably damaging 0.98
IGL02661:Dnajc10 APN 2 80,157,084 (GRCm39) splice site probably benign
IGL02865:Dnajc10 APN 2 80,161,647 (GRCm39) missense probably benign
IGL03026:Dnajc10 APN 2 80,179,647 (GRCm39) missense probably damaging 0.96
IGL03407:Dnajc10 APN 2 80,176,985 (GRCm39) missense probably damaging 1.00
PIT4283001:Dnajc10 UTSW 2 80,161,739 (GRCm39) missense probably benign 0.19
R0092:Dnajc10 UTSW 2 80,156,026 (GRCm39) missense probably damaging 0.97
R0457:Dnajc10 UTSW 2 80,175,290 (GRCm39) missense possibly damaging 0.65
R1414:Dnajc10 UTSW 2 80,178,021 (GRCm39) missense probably damaging 0.99
R1739:Dnajc10 UTSW 2 80,178,006 (GRCm39) missense probably benign 0.03
R2126:Dnajc10 UTSW 2 80,181,078 (GRCm39) critical splice donor site probably null
R3717:Dnajc10 UTSW 2 80,155,089 (GRCm39) splice site probably benign
R3718:Dnajc10 UTSW 2 80,155,089 (GRCm39) splice site probably benign
R4020:Dnajc10 UTSW 2 80,175,296 (GRCm39) missense probably damaging 1.00
R4453:Dnajc10 UTSW 2 80,176,967 (GRCm39) missense probably damaging 0.98
R4585:Dnajc10 UTSW 2 80,178,122 (GRCm39) missense probably damaging 1.00
R4586:Dnajc10 UTSW 2 80,178,122 (GRCm39) missense probably damaging 1.00
R4772:Dnajc10 UTSW 2 80,170,870 (GRCm39) missense probably damaging 0.98
R5653:Dnajc10 UTSW 2 80,179,712 (GRCm39) missense probably damaging 1.00
R6157:Dnajc10 UTSW 2 80,147,735 (GRCm39) start gained probably benign
R6263:Dnajc10 UTSW 2 80,174,292 (GRCm39) missense probably damaging 1.00
R6303:Dnajc10 UTSW 2 80,181,008 (GRCm39) missense probably benign 0.07
R6932:Dnajc10 UTSW 2 80,161,680 (GRCm39) missense probably benign
R7104:Dnajc10 UTSW 2 80,171,159 (GRCm39) missense probably damaging 1.00
R7181:Dnajc10 UTSW 2 80,149,587 (GRCm39) nonsense probably null
R7458:Dnajc10 UTSW 2 80,155,094 (GRCm39) splice site probably null
R8123:Dnajc10 UTSW 2 80,179,704 (GRCm39) missense probably damaging 1.00
R8276:Dnajc10 UTSW 2 80,179,614 (GRCm39) missense probably benign
R8365:Dnajc10 UTSW 2 80,176,902 (GRCm39) missense probably damaging 1.00
R8915:Dnajc10 UTSW 2 80,147,801 (GRCm39) missense possibly damaging 0.62
R9025:Dnajc10 UTSW 2 80,179,637 (GRCm39) missense probably damaging 1.00
R9169:Dnajc10 UTSW 2 80,163,315 (GRCm39) missense probably benign
R9262:Dnajc10 UTSW 2 80,176,965 (GRCm39) missense probably benign 0.17
R9292:Dnajc10 UTSW 2 80,176,916 (GRCm39) missense probably benign
R9332:Dnajc10 UTSW 2 80,175,327 (GRCm39) missense probably benign 0.35
X0018:Dnajc10 UTSW 2 80,181,018 (GRCm39) missense probably damaging 0.97
X0024:Dnajc10 UTSW 2 80,175,306 (GRCm39) missense probably benign 0.19
Z1177:Dnajc10 UTSW 2 80,149,577 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCAGTAACTTGCCAGAAATACATG -3'
(R):5'- TAGCACTGGTAGCACTTTGGTC -3'

Sequencing Primer
(F):5'- GCCAGAAATACATGAAAATCTTGGTG -3'
(R):5'- TGGTCAAAAGGATCTTAGACAGCTC -3'
Posted On 2019-12-20