Mutagenetix > Incidental Mutations

Incidental Mutation 'R7843:Vmn2r72'

606443

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r72

Ensembl Gene

ENSMUSG00000051877

Gene Name

vomeronasal 2, receptor 72

Synonyms

Vmn2r72-ps, EG244114

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.106) question?

Stock #

R7843 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

85737784-85754981 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 85749630 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 505 (T505I)

Ref Sequence

ENSEMBL: ENSMUSP00000133014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063425]

Predicted Effect

probably benign
Transcript: ENSMUST00000063425
AA Change: T505I

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: T505I

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	2.3e-28	PFAM
Pfam:NCD3G	512	564	1.2e-18	PFAM
Pfam:7tm_3	594	832	4e-53	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcf1	T	C	17: 35,959,243	D641G	possibly damaging	Het
Adam1b	A	T	5: 121,501,437	I515N	probably damaging	Het
Adamtsl5	A	G	10: 80,342,923	V207A	probably damaging	Het
Ampd3	A	G	7: 110,791,188	I143V	probably benign	Het
Ank3	A	T	10: 69,986,958	T486S	probably benign	Het
BC051142	C	T	17: 34,449,824	T176I	possibly damaging	Het
Bcl11a	A	G	11: 24,164,831	I725V	probably benign	Het
Blmh	A	G	11: 76,946,313	N29D	probably damaging	Het
C6	T	A	15: 4,808,404	V832D		Het
Ccdc191	T	A	16: 43,959,336	L777M	probably damaging	Het
Ccdc74a	C	G	16: 17,646,749	H45Q		Het
Cenpe	T	A	3: 135,232,959	Y517*	probably null	Het
Cep290	G	T	10: 100,516,188	R752L	possibly damaging	Het
Cers5	A	T	15: 99,772,331	W17R	unknown	Het
Chpf	T	C	1: 75,478,287		probably benign	Het
Chst5	C	A	8: 111,890,572	A139S	probably benign	Het
Cpn1	T	A	19: 43,986,158	D44V	probably benign	Het
Cstf1	T	C	2: 172,378,000	Y344H	probably damaging	Het
D7Ertd443e	A	C	7: 134,349,095	M283R	possibly damaging	Het
Dclk1	T	A	3: 55,255,877	V130D	probably damaging	Het
Dscam	C	T	16: 96,825,630	V360M	probably damaging	Het
Dvl2	A	G	11: 70,008,786	N518S	probably benign	Het
Eif2ak2	T	A	17: 78,868,774	K231N	probably benign	Het
Elovl4	T	C	9: 83,788,271	R123G	probably damaging	Het
Ern2	A	G	7: 122,173,708	V562A	probably damaging	Het
F13a1	A	T	13: 37,025,771	N73K	probably benign	Het
Gcc2	C	A	10: 58,268,021	Q90K	possibly damaging	Het
Gnpda1	A	T	18: 38,328,899	S282T	probably benign	Het
Gpatch1	G	T	7: 35,281,454	H880Q	unknown	Het
Haus6	T	C	4: 86,586,341	D471G	possibly damaging	Het
Hcfc1r1	G	T	17: 23,674,656	E70*	probably null	Het
Ighv1-54	A	G	12: 115,193,863	W55R	probably damaging	Het
Jam3	T	C	9: 27,106,416		probably null	Het
Klhdc7a	A	T	4: 139,966,844	V264E	possibly damaging	Het
Lrrc4c	A	T	2: 97,630,213	T395S	probably benign	Het
Man2a2	G	C	7: 80,368,865	A82G	probably benign	Het
Mast2	G	T	4: 116,353,011	T186K	probably damaging	Het
Meig1	T	A	2: 3,409,211	K84M	probably damaging	Het
Mep1b	G	T	18: 21,095,053	S571I	probably damaging	Het
Muc2	T	G	7: 141,695,419	V507G	probably benign	Het
Nkx2-3	C	A	19: 43,614,882	T309N	probably benign	Het
Oaf	G	A	9: 43,222,780	R215C	probably damaging	Het
Olfr1377	A	T	11: 50,985,018	T106S	probably benign	Het
Olfr1463	A	T	19: 13,234,537	N96Y	possibly damaging	Het
Olfr905	T	C	9: 38,472,947	S67P	probably damaging	Het
Pla2r1	T	G	2: 60,447,475	T835P	possibly damaging	Het
Ppil6	C	T	10: 41,501,866	T191I	probably benign	Het
Rps6ka5	T	C	12: 100,553,149	D735G	possibly damaging	Het
Setx	T	A	2: 29,173,569	N2292K	probably damaging	Het
Slc1a6	A	T	10: 78,796,260	I307F	probably damaging	Het
Slc5a3	T	A	16: 92,079,019	W655R	probably benign	Het
Slc9a1	T	C	4: 133,370,442		probably benign	Het
Sptbn1	A	G	11: 30,154,320	V128A	probably damaging	Het
Tenm3	T	A	8: 48,229,111	K2495*	probably null	Het
Tnni3k	T	A	3: 155,038,524	T64S	probably damaging	Het
Top1	T	C	2: 160,714,256	V545A	possibly damaging	Het
Trabd	A	G	15: 89,081,954	D38G	possibly damaging	Het
Umad1	G	A	6: 8,401,140	D70N	unknown	Het
Usp36	T	C	11: 118,285,965	E9G	probably damaging	Het
Vmn2r53	A	G	7: 12,582,099	S598P	probably damaging	Het
Vmn2r60	A	T	7: 42,195,087	T625S	probably benign	Het
Vwce	T	A	19: 10,664,283	I791K	probably benign	Het
Wdr64	C	A	1: 175,812,102	H1046N	probably benign	Het
Zdhhc4	A	T	5: 143,320,276	D232E	probably damaging	Het
Zfp984	A	T	4: 147,757,708	F51I	probably damaging	Het

Other mutations in Vmn2r72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00931:Vmn2r72	APN	7	85749646	missense	probably benign	0.01
IGL01019:Vmn2r72	APN	7	85738334	missense	probably benign	0.26
IGL01445:Vmn2r72	APN	7	85749646	missense	probably benign	0.06
IGL02076:Vmn2r72	APN	7	85738367	missense	probably damaging	1.00
IGL02082:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02086:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02089:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02125:Vmn2r72	APN	7	85750711	missense	probably benign	0.00
IGL02146:Vmn2r72	APN	7	85737962	missense	probably damaging	1.00
IGL02272:Vmn2r72	APN	7	85750693	missense	probably benign
IGL02514:Vmn2r72	APN	7	85738699	missense	possibly damaging	0.90
IGL02662:Vmn2r72	APN	7	85738183	missense	probably benign	0.26
IGL02697:Vmn2r72	APN	7	85738671	missense	probably benign	0.36
IGL02733:Vmn2r72	APN	7	85751813	missense	probably benign	0.05
IGL03070:Vmn2r72	APN	7	85752041	splice site	probably benign
IGL03150:Vmn2r72	APN	7	85751176	missense	probably damaging	1.00
IGL03159:Vmn2r72	APN	7	85754954	missense	probably benign	0.05
IGL03333:Vmn2r72	APN	7	85750867	missense	probably benign	0.10
R0081:Vmn2r72	UTSW	7	85751836	missense	probably benign	0.01
R0090:Vmn2r72	UTSW	7	85754876	missense	probably benign
R0655:Vmn2r72	UTSW	7	85738111	nonsense	probably null
R0778:Vmn2r72	UTSW	7	85749739	missense	probably benign	0.00
R1169:Vmn2r72	UTSW	7	85751309	missense	probably benign	0.01
R1172:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1173:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1175:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1248:Vmn2r72	UTSW	7	85749188	missense	probably benign	0.02
R1302:Vmn2r72	UTSW	7	85738257	missense	probably damaging	1.00
R1506:Vmn2r72	UTSW	7	85749211	missense	probably benign
R1632:Vmn2r72	UTSW	7	85751792	missense	probably benign	0.13
R1775:Vmn2r72	UTSW	7	85738170	missense	probably benign	0.01
R1962:Vmn2r72	UTSW	7	85749161	missense	probably benign	0.00
R2201:Vmn2r72	UTSW	7	85738236	missense	probably benign	0.12
R2290:Vmn2r72	UTSW	7	85738341	missense	probably damaging	1.00
R2327:Vmn2r72	UTSW	7	85738256	missense	probably damaging	1.00
R2424:Vmn2r72	UTSW	7	85750953	missense	probably damaging	1.00
R2655:Vmn2r72	UTSW	7	85751269	missense	possibly damaging	0.95
R2860:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2861:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2862:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R3009:Vmn2r72	UTSW	7	85749642	missense	probably benign	0.00
R3797:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3798:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3902:Vmn2r72	UTSW	7	85749735	missense	possibly damaging	0.52
R3959:Vmn2r72	UTSW	7	85751131	missense	probably benign	0.36
R3974:Vmn2r72	UTSW	7	85749809	missense	probably damaging	1.00
R4399:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4421:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4426:Vmn2r72	UTSW	7	85737828	nonsense	probably null
R4522:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4523:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4533:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4691:Vmn2r72	UTSW	7	85737911	nonsense	probably null
R4781:Vmn2r72	UTSW	7	85737861	missense	probably benign	0.14
R4863:Vmn2r72	UTSW	7	85750598	missense	possibly damaging	0.91
R4952:Vmn2r72	UTSW	7	85751109	missense	probably benign
R4991:Vmn2r72	UTSW	7	85751130	missense	probably damaging	0.99
R4995:Vmn2r72	UTSW	7	85738485	missense	probably damaging	1.00
R5095:Vmn2r72	UTSW	7	85737853	missense	probably damaging	0.98
R5174:Vmn2r72	UTSW	7	85737840	missense	probably benign	0.00
R5276:Vmn2r72	UTSW	7	85738254	missense	possibly damaging	0.90
R5395:Vmn2r72	UTSW	7	85750897	missense	possibly damaging	0.71
R5560:Vmn2r72	UTSW	7	85751942	missense	probably damaging	0.96
R5933:Vmn2r72	UTSW	7	85737850	missense	probably benign	0.05
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6354:Vmn2r72	UTSW	7	85750539	critical splice donor site	probably null
R6362:Vmn2r72	UTSW	7	85751174	missense	probably damaging	1.00
R6594:Vmn2r72	UTSW	7	85749684	missense	probably benign	0.32
R6794:Vmn2r72	UTSW	7	85737996	missense	probably damaging	1.00
R7113:Vmn2r72	UTSW	7	85749803	splice site	probably null
R7189:Vmn2r72	UTSW	7	85754917	missense	probably benign	0.36
R7266:Vmn2r72	UTSW	7	85738274	nonsense	probably null
R7323:Vmn2r72	UTSW	7	85750563	missense	probably benign
R7426:Vmn2r72	UTSW	7	85751140	missense	probably benign
R7606:Vmn2r72	UTSW	7	85751154	missense	possibly damaging	0.91
R7651:Vmn2r72	UTSW	7	85751938	missense	probably damaging	1.00
R7688:Vmn2r72	UTSW	7	85754890	missense	probably benign	0.32
R7753:Vmn2r72	UTSW	7	85750626	missense	probably damaging	1.00
R8157:Vmn2r72	UTSW	7	85751233	missense	probably benign	0.09
R8254:Vmn2r72	UTSW	7	85751019	missense	probably damaging	1.00
R8389:Vmn2r72	UTSW	7	85751960	missense	probably damaging	0.99
R8444:Vmn2r72	UTSW	7	85738175	missense	probably benign
Z1176:Vmn2r72	UTSW	7	85749191	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- CAATGAAAGACCTGGTTTAACACAC -3'
(R):5'- TGGAGACCTAGTCAACATGAAC -3'

Sequencing Primer
(F):5'- GGTGGCGTACTCCTTTATACCCAG -3'
(R):5'- CCTAGTCAACATGAACCAGAATTTG -3'

Posted On

2019-12-20