Incidental Mutation 'R7845:Adat2'
ID 606566
Institutional Source Beutler Lab
Gene Symbol Adat2
Ensembl Gene ENSMUSG00000019808
Gene Name adenosine deaminase, tRNA-specific 2
Synonyms Deadc1, 4933426M09Rik
MMRRC Submission 045899-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.937) question?
Stock # R7845 (G1)
Quality Score 213.009
Status Validated
Chromosome 10
Chromosomal Location 13428651-13439120 bp(+) (GRCm39)
Type of Mutation utr 5 prime
DNA Base Change (assembly) G to T at 13428741 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000128512 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019944] [ENSMUST00000019945] [ENSMUST00000105539] [ENSMUST00000105541] [ENSMUST00000170376]
AlphaFold Q6P6J0
Predicted Effect probably benign
Transcript: ENSMUST00000019944
SMART Domains Protein: ENSMUSP00000019944
Gene: ENSMUSG00000019808

DomainStartEndE-ValueType
Pfam:dCMP_cyt_deam_1 19 126 5.3e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000019945
SMART Domains Protein: ENSMUSP00000019945
Gene: ENSMUSG00000019809

DomainStartEndE-ValueType
Pfam:Peroxin-3 4 99 9.9e-23 PFAM
Pfam:Peroxin-3 94 363 5.7e-53 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105539
SMART Domains Protein: ENSMUSP00000101178
Gene: ENSMUSG00000019809

DomainStartEndE-ValueType
Pfam:Peroxin-3 28 298 6.1e-83 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105541
SMART Domains Protein: ENSMUSP00000101180
Gene: ENSMUSG00000019809

DomainStartEndE-ValueType
Pfam:Peroxin-3 28 286 2e-74 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000170376
SMART Domains Protein: ENSMUSP00000128512
Gene: ENSMUSG00000019809

DomainStartEndE-ValueType
Pfam:Peroxin-3 2 97 2.4e-35 PFAM
Pfam:Peroxin-3 94 352 7.3e-75 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 96% (43/45)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik T C 2: 151,314,229 (GRCm39) H483R probably damaging Het
Acot2 G T 12: 84,039,762 (GRCm39) G424* probably null Het
Arhgef18 T C 8: 3,436,959 (GRCm39) Y250H probably damaging Het
Bcl2l2 A G 14: 55,122,308 (GRCm39) Y157C unknown Het
Bglap2 T A 3: 88,286,001 (GRCm39) probably benign Het
Ccdc14 T C 16: 34,535,734 (GRCm39) L495P probably damaging Het
Cobl T C 11: 12,315,139 (GRCm39) D275G probably benign Het
Cpne2 A G 8: 95,277,832 (GRCm39) N72S probably benign Het
D7Ertd443e A G 7: 133,871,977 (GRCm39) F628S probably damaging Het
Dars2 A T 1: 160,869,318 (GRCm39) S644T probably benign Het
Depdc5 A G 5: 33,061,259 (GRCm39) probably null Het
Dip2c A G 13: 9,659,080 (GRCm39) S860G probably damaging Het
Dnajc21 T G 15: 10,447,227 (GRCm39) H507P probably damaging Het
Eif2ak2 G T 17: 79,171,327 (GRCm39) Q359K probably damaging Het
Epha8 T C 4: 136,663,712 (GRCm39) E448G probably benign Het
Exoc3l G C 8: 106,016,782 (GRCm39) S677R probably damaging Het
Fads1 T A 19: 10,171,405 (GRCm39) H345Q probably damaging Het
Fam118a T A 15: 84,930,052 (GRCm39) D93E possibly damaging Het
Fam135a T C 1: 24,068,738 (GRCm39) I710M probably benign Het
Fbxw14 T A 9: 109,116,671 (GRCm39) I13F probably damaging Het
Gemin6 A G 17: 80,533,090 (GRCm39) S8G probably benign Het
Ints2 A T 11: 86,129,089 (GRCm39) M498K possibly damaging Het
Man2a2 G C 7: 80,018,613 (GRCm39) A82G probably benign Het
Mast1 C A 8: 85,651,954 (GRCm39) E343* probably null Het
Micu1 T C 10: 59,675,607 (GRCm39) probably null Het
Mis18bp1 A G 12: 65,196,102 (GRCm39) I554T probably benign Het
Mrps28 T A 3: 8,988,775 (GRCm39) N28Y possibly damaging Het
Mtpap T A 18: 4,387,134 (GRCm39) S395T possibly damaging Het
Muc16 A T 9: 18,552,069 (GRCm39) H4741Q probably benign Het
Ogfr GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG 2: 180,237,059 (GRCm39) probably benign Het
Or13p8 T C 4: 118,584,158 (GRCm39) M238T probably benign Het
Or4k44 C A 2: 111,368,512 (GRCm39) G41* probably null Het
Or51f23 G A 7: 102,453,492 (GRCm39) R269Q not run Het
Ptx4 T C 17: 25,343,928 (GRCm39) Y393H possibly damaging Het
Ranbp2 G A 10: 58,282,844 (GRCm39) V15M probably damaging Het
Rbp3 G T 14: 33,678,421 (GRCm39) A790S probably benign Het
Rfx6 T A 10: 51,554,122 (GRCm39) S73T probably benign Het
Sec14l3 T A 11: 4,017,972 (GRCm39) M84K probably benign Het
Sec23b T A 2: 144,401,316 (GRCm39) V59E possibly damaging Het
Slc2a1 T C 4: 118,993,125 (GRCm39) V425A possibly damaging Het
Stab2 A T 10: 86,832,758 (GRCm39) V89D probably benign Het
Stra8 A G 6: 34,907,899 (GRCm39) D117G probably benign Het
Syt17 A T 7: 118,009,194 (GRCm39) I338N possibly damaging Het
Tas2r136 T A 6: 132,754,833 (GRCm39) Y98F probably benign Het
Tsks C A 7: 44,603,168 (GRCm39) probably null Het
Wdr62 A G 7: 29,964,667 (GRCm39) V359A possibly damaging Het
Xrcc6 T C 15: 81,900,678 (GRCm39) probably null Het
Other mutations in Adat2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01511:Adat2 APN 10 13,435,982 (GRCm39) missense probably null 1.00
IGL03031:Adat2 APN 10 13,432,590 (GRCm39) unclassified probably benign
R0243:Adat2 UTSW 10 13,429,037 (GRCm39) missense probably benign
R2082:Adat2 UTSW 10 13,435,907 (GRCm39) missense probably damaging 1.00
R4976:Adat2 UTSW 10 13,432,650 (GRCm39) missense probably damaging 1.00
R5119:Adat2 UTSW 10 13,432,650 (GRCm39) missense probably damaging 1.00
R5298:Adat2 UTSW 10 13,432,650 (GRCm39) missense probably benign 0.04
R7615:Adat2 UTSW 10 13,429,020 (GRCm39) missense probably benign 0.02
R8752:Adat2 UTSW 10 13,432,604 (GRCm39) missense probably benign
R9671:Adat2 UTSW 10 13,438,452 (GRCm39) missense probably damaging 1.00
X0061:Adat2 UTSW 10 13,437,454 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGTTGTCACTCACCTCCGAG -3'
(R):5'- AAGTTTGCGCTCTCAGCATC -3'

Sequencing Primer
(F):5'- ACTCACCTCCGAGGACTGTG -3'
(R):5'- ACCTTGCTTCCAGGAGGAC -3'
Posted On 2019-12-20