Incidental Mutation 'R7846:Kdm5b'
| ID |
606589 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kdm5b
|
| Ensembl Gene |
ENSMUSG00000042207 |
| Gene Name |
lysine (K)-specific demethylase 5B |
| Synonyms |
Jarid1b, Plu1, Rb-Bp2, 2210016I17Rik, 2010009J12Rik, PLU-1, D1Ertd202e |
| MMRRC Submission |
045900-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.268)
|
| Stock # |
R7846 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
134560171-134635285 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 134617840 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Histidine
at position 913
(R913H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000038138
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047714]
[ENSMUST00000112198]
|
| AlphaFold |
Q80Y84 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000047714
AA Change: R913H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000038138
Gene: ENSMUSG00000042207
AA Change: R913H
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
PHD
|
311 |
357 |
6.15e-14 |
SMART |
|
JmjC
|
453 |
619 |
2.33e-67 |
SMART |
|
Pfam:zf-C5HC2
|
692 |
744 |
2.2e-17 |
PFAM |
|
Pfam:PLU-1
|
757 |
1088 |
5.6e-92 |
PFAM |
|
low complexity region
|
1097 |
1109 |
N/A |
INTRINSIC |
|
PHD
|
1178 |
1222 |
6.2e-10 |
SMART |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1406 |
1417 |
N/A |
INTRINSIC |
|
low complexity region
|
1470 |
1484 |
N/A |
INTRINSIC |
|
PHD
|
1486 |
1536 |
1.18e-6 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112198
AA Change: R913H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000107817
Gene: ENSMUSG00000042207
AA Change: R913H
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
PHD
|
311 |
357 |
6.15e-14 |
SMART |
|
JmjC
|
453 |
619 |
2.33e-67 |
SMART |
|
Pfam:zf-C5HC2
|
692 |
745 |
6.7e-21 |
PFAM |
|
Pfam:PLU-1
|
756 |
1088 |
6e-94 |
PFAM |
|
low complexity region
|
1097 |
1109 |
N/A |
INTRINSIC |
|
PHD
|
1178 |
1222 |
6.2e-10 |
SMART |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1406 |
1417 |
N/A |
INTRINSIC |
|
low complexity region
|
1470 |
1484 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Homozygous mutant mice display decreased body weight, decreased female fertility, lower uterine weight, and a delay in mammary development. Knockout of this gene has also been associated with embryonic lethality. [provided by RefSeq, Dec 2016]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit decreased body weight, background-sensitive premature mortality, decreased female fertility, delayed mammary gland development, decreased serum estradiol levels, and reduced mammary epithelial cell proliferation in early puberty. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abraxas1 |
A |
G |
5: 100,806,832 (GRCm38) |
V247A |
probably damaging |
Het |
| Acot13 |
G |
T |
13: 24,818,150 (GRCm38) |
T103K |
probably damaging |
Het |
| Acsl6 |
A |
T |
11: 54,361,075 (GRCm38) |
I683F |
probably damaging |
Het |
| Acss2 |
A |
T |
2: 155,561,033 (GRCm38) |
H577L |
probably damaging |
Het |
| Ahctf1 |
A |
T |
1: 179,787,073 (GRCm38) |
V382D |
probably damaging |
Het |
| Aldob |
T |
C |
4: 49,538,858 (GRCm38) |
H220R |
probably damaging |
Het |
| Ankrd1 |
C |
T |
19: 36,116,818 (GRCm38) |
V169M |
probably damaging |
Het |
| Atp5f1a |
G |
A |
18: 77,781,315 (GRCm38) |
R413H |
possibly damaging |
Het |
| Cep76 |
A |
G |
18: 67,629,905 (GRCm38) |
F283L |
probably damaging |
Het |
| Chrna5 |
A |
T |
9: 55,005,107 (GRCm38) |
D397V |
probably benign |
Het |
| Coro7 |
T |
C |
16: 4,670,536 (GRCm38) |
D90G |
probably damaging |
Het |
| Csnk1g3 |
A |
G |
18: 53,948,105 (GRCm38) |
N383D |
probably benign |
Het |
| Cwf19l2 |
C |
A |
9: 3,477,889 (GRCm38) |
Q865K |
probably damaging |
Het |
| Cyth2 |
C |
A |
7: 45,810,954 (GRCm38) |
W149C |
probably damaging |
Het |
| Dgkh |
C |
A |
14: 78,618,586 (GRCm38) |
R349L |
probably damaging |
Het |
| Dnajc1 |
G |
T |
2: 18,219,893 (GRCm38) |
T383N |
possibly damaging |
Het |
| Extl3 |
A |
T |
14: 65,075,732 (GRCm38) |
M667K |
probably damaging |
Het |
| Fam149a |
G |
T |
8: 45,358,641 (GRCm38) |
A75E |
|
Het |
| Fgd4 |
T |
G |
16: 16,422,726 (GRCm38) |
Q713P |
probably damaging |
Het |
| Frat2 |
T |
A |
19: 41,847,776 (GRCm38) |
I46F |
probably damaging |
Het |
| Gm11639 |
T |
A |
11: 104,714,745 (GRCm38) |
|
probably null |
Het |
| Gzmc |
A |
G |
14: 56,231,560 (GRCm38) |
V234A |
probably damaging |
Het |
| H2-Q4 |
A |
G |
17: 35,380,158 (GRCm38) |
N135D |
probably damaging |
Het |
| Ighv1-85 |
A |
T |
12: 116,000,317 (GRCm38) |
V21D |
possibly damaging |
Het |
| Itprid1 |
A |
G |
6: 55,978,335 (GRCm38) |
Q976R |
possibly damaging |
Het |
| Kcna6 |
A |
T |
6: 126,739,020 (GRCm38) |
V302E |
probably damaging |
Het |
| Kdm3b |
G |
T |
18: 34,809,240 (GRCm38) |
V795L |
possibly damaging |
Het |
| Lpp |
T |
A |
16: 24,608,126 (GRCm38) |
M1K |
probably null |
Het |
| Med12l |
T |
C |
3: 59,264,934 (GRCm38) |
S1704P |
probably damaging |
Het |
| Mfsd10 |
G |
T |
5: 34,636,112 (GRCm38) |
S95* |
probably null |
Het |
| Napepld |
C |
T |
5: 21,675,723 (GRCm38) |
E225K |
probably benign |
Het |
| Ndfip2 |
T |
C |
14: 105,298,014 (GRCm38) |
F245L |
probably damaging |
Het |
| Oaf |
G |
A |
9: 43,222,780 (GRCm38) |
R215C |
probably damaging |
Het |
| Olfr625-ps1 |
A |
G |
7: 103,683,200 (GRCm38) |
I161V |
probably benign |
Het |
| Olfr911-ps1 |
A |
G |
9: 38,524,379 (GRCm38) |
T216A |
probably benign |
Het |
| Or10k2 |
A |
G |
8: 83,541,897 (GRCm38) |
H251R |
probably damaging |
Het |
| Or13a20 |
C |
T |
7: 140,652,461 (GRCm38) |
H161Y |
probably damaging |
Het |
| Or51i1 |
A |
G |
7: 104,021,529 (GRCm38) |
I263T |
possibly damaging |
Het |
| Or5p6 |
A |
G |
7: 108,031,992 (GRCm38) |
I117T |
probably benign |
Het |
| Pcdhgb2 |
A |
T |
18: 37,692,220 (GRCm38) |
I755F |
possibly damaging |
Het |
| Pde4dip |
A |
G |
3: 97,715,174 (GRCm38) |
L1573P |
probably damaging |
Het |
| Peg3 |
A |
T |
7: 6,710,651 (GRCm38) |
V524E |
probably damaging |
Het |
| Phc1 |
G |
T |
6: 122,333,370 (GRCm38) |
T126N |
probably damaging |
Het |
| Phf1 |
C |
A |
17: 26,935,317 (GRCm38) |
Y169* |
probably null |
Het |
| Pramel25 |
A |
T |
4: 143,793,993 (GRCm38) |
D269V |
probably benign |
Het |
| Prl3a1 |
G |
A |
13: 27,272,459 (GRCm38) |
E99K |
probably damaging |
Het |
| Prss57 |
G |
A |
10: 79,787,379 (GRCm38) |
A78V |
probably damaging |
Het |
| Ptprb |
A |
T |
10: 116,283,548 (GRCm38) |
T196S |
probably benign |
Het |
| Rgsl1 |
A |
T |
1: 153,826,037 (GRCm38) |
C224S |
possibly damaging |
Het |
| Rtn4 |
T |
C |
11: 29,693,274 (GRCm38) |
V29A |
unknown |
Het |
| Selplg |
G |
A |
5: 113,819,420 (GRCm38) |
T275M |
probably damaging |
Het |
| Skint11 |
C |
T |
4: 114,244,879 (GRCm38) |
T363I |
possibly damaging |
Het |
| Slc22a29 |
T |
A |
19: 8,193,487 (GRCm38) |
I289F |
probably benign |
Het |
| Slc26a2 |
A |
G |
18: 61,198,704 (GRCm38) |
S552P |
probably benign |
Het |
| Sptb |
T |
A |
12: 76,608,526 (GRCm38) |
K1480* |
probably null |
Het |
| Sptbn1 |
C |
A |
11: 30,142,153 (GRCm38) |
M537I |
probably damaging |
Het |
| Sqor |
A |
T |
2: 122,785,088 (GRCm38) |
H43L |
probably benign |
Het |
| Srcin1 |
C |
A |
11: 97,526,100 (GRCm38) |
E913* |
probably null |
Het |
| Srgap1 |
A |
G |
10: 121,785,492 (GRCm38) |
L1032P |
probably damaging |
Het |
| Stc2 |
T |
C |
11: 31,365,413 (GRCm38) |
K142R |
probably benign |
Het |
| Stox1 |
A |
C |
10: 62,659,526 (GRCm38) |
N989K |
probably damaging |
Het |
| Tert |
T |
A |
13: 73,628,195 (GRCm38) |
L355H |
probably damaging |
Het |
| Tfb2m |
A |
G |
1: 179,531,361 (GRCm38) |
F319S |
probably damaging |
Het |
| Trps1 |
A |
G |
15: 50,831,877 (GRCm38) |
F341L |
probably damaging |
Het |
| Ttk |
T |
C |
9: 83,843,679 (GRCm38) |
V218A |
probably benign |
Het |
| Vmn1r159 |
A |
G |
7: 22,843,271 (GRCm38) |
I112T |
probably benign |
Het |
| Vps8 |
C |
A |
16: 21,532,320 (GRCm38) |
Q916K |
probably benign |
Het |
| Wdr12 |
A |
T |
1: 60,082,066 (GRCm38) |
D364E |
probably damaging |
Het |
| Ylpm1 |
A |
G |
12: 85,057,268 (GRCm38) |
E2019G |
probably damaging |
Het |
| Zfp267 |
C |
A |
3: 36,165,589 (GRCm38) |
T587N |
probably benign |
Het |
| Zfp507 |
A |
G |
7: 35,794,538 (GRCm38) |
L360P |
probably damaging |
Het |
|
| Other mutations in Kdm5b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00230:Kdm5b
|
APN |
1 |
134,620,955 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01458:Kdm5b
|
APN |
1 |
134,621,986 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
IGL01567:Kdm5b
|
APN |
1 |
134,602,540 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01625:Kdm5b
|
APN |
1 |
134,617,968 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
IGL01970:Kdm5b
|
APN |
1 |
134,600,727 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02183:Kdm5b
|
APN |
1 |
134,624,931 (GRCm38) |
missense |
probably benign |
0.09 |
|
IGL02592:Kdm5b
|
APN |
1 |
134,624,853 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02695:Kdm5b
|
APN |
1 |
134,604,485 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL02697:Kdm5b
|
APN |
1 |
134,588,773 (GRCm38) |
splice site |
probably benign |
|
|
IGL03036:Kdm5b
|
APN |
1 |
134,608,937 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03056:Kdm5b
|
APN |
1 |
134,587,979 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03206:Kdm5b
|
APN |
1 |
134,627,317 (GRCm38) |
missense |
probably benign |
|
|
IGL03342:Kdm5b
|
APN |
1 |
134,602,576 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03388:Kdm5b
|
APN |
1 |
134,627,322 (GRCm38) |
missense |
probably benign |
|
|
amaryllis
|
UTSW |
1 |
134,609,061 (GRCm38) |
critical splice donor site |
probably null |
|
|
PIT4486001:Kdm5b
|
UTSW |
1 |
134,628,685 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0233:Kdm5b
|
UTSW |
1 |
134,604,634 (GRCm38) |
splice site |
probably benign |
|
|
R0334:Kdm5b
|
UTSW |
1 |
134,604,522 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0504:Kdm5b
|
UTSW |
1 |
134,621,023 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0505:Kdm5b
|
UTSW |
1 |
134,602,571 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0521:Kdm5b
|
UTSW |
1 |
134,618,033 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R1004:Kdm5b
|
UTSW |
1 |
134,588,904 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R1087:Kdm5b
|
UTSW |
1 |
134,600,637 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1126:Kdm5b
|
UTSW |
1 |
134,613,991 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R1221:Kdm5b
|
UTSW |
1 |
134,599,091 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1230:Kdm5b
|
UTSW |
1 |
134,613,254 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1345:Kdm5b
|
UTSW |
1 |
134,630,550 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R1482:Kdm5b
|
UTSW |
1 |
134,624,897 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1582:Kdm5b
|
UTSW |
1 |
134,624,853 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1653:Kdm5b
|
UTSW |
1 |
134,602,481 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1693:Kdm5b
|
UTSW |
1 |
134,597,576 (GRCm38) |
splice site |
probably benign |
|
|
R1721:Kdm5b
|
UTSW |
1 |
134,613,181 (GRCm38) |
splice site |
probably benign |
|
|
R1741:Kdm5b
|
UTSW |
1 |
134,618,017 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R1762:Kdm5b
|
UTSW |
1 |
134,604,467 (GRCm38) |
nonsense |
probably null |
|
|
R1820:Kdm5b
|
UTSW |
1 |
134,597,670 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R1872:Kdm5b
|
UTSW |
1 |
134,624,994 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1966:Kdm5b
|
UTSW |
1 |
134,613,873 (GRCm38) |
splice site |
probably null |
|
|
R2056:Kdm5b
|
UTSW |
1 |
134,613,214 (GRCm38) |
missense |
probably benign |
0.05 |
|
R2059:Kdm5b
|
UTSW |
1 |
134,613,214 (GRCm38) |
missense |
probably benign |
0.05 |
|
R2405:Kdm5b
|
UTSW |
1 |
134,609,016 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3417:Kdm5b
|
UTSW |
1 |
134,587,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3771:Kdm5b
|
UTSW |
1 |
134,613,345 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3783:Kdm5b
|
UTSW |
1 |
134,630,542 (GRCm38) |
missense |
probably benign |
|
|
R3803:Kdm5b
|
UTSW |
1 |
134,615,941 (GRCm38) |
missense |
probably benign |
0.07 |
|
R3980:Kdm5b
|
UTSW |
1 |
134,619,670 (GRCm38) |
missense |
probably benign |
0.11 |
|
R3983:Kdm5b
|
UTSW |
1 |
134,631,304 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4013:Kdm5b
|
UTSW |
1 |
134,627,329 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R4162:Kdm5b
|
UTSW |
1 |
134,625,161 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4701:Kdm5b
|
UTSW |
1 |
134,606,012 (GRCm38) |
intron |
probably benign |
|
|
R4791:Kdm5b
|
UTSW |
1 |
134,630,800 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R4836:Kdm5b
|
UTSW |
1 |
134,593,315 (GRCm38) |
splice site |
probably null |
|
|
R4924:Kdm5b
|
UTSW |
1 |
134,631,351 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5135:Kdm5b
|
UTSW |
1 |
134,588,746 (GRCm38) |
intron |
probably benign |
|
|
R5248:Kdm5b
|
UTSW |
1 |
134,620,997 (GRCm38) |
missense |
probably benign |
0.11 |
|
R5290:Kdm5b
|
UTSW |
1 |
134,622,099 (GRCm38) |
splice site |
probably null |
|
|
R5358:Kdm5b
|
UTSW |
1 |
134,607,694 (GRCm38) |
nonsense |
probably null |
|
|
R5388:Kdm5b
|
UTSW |
1 |
134,608,897 (GRCm38) |
nonsense |
probably null |
|
|
R5396:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5397:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5398:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5399:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5529:Kdm5b
|
UTSW |
1 |
134,588,003 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5540:Kdm5b
|
UTSW |
1 |
134,631,241 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5661:Kdm5b
|
UTSW |
1 |
134,599,073 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5663:Kdm5b
|
UTSW |
1 |
134,630,635 (GRCm38) |
missense |
probably benign |
|
|
R5822:Kdm5b
|
UTSW |
1 |
134,588,773 (GRCm38) |
splice site |
probably benign |
|
|
R6226:Kdm5b
|
UTSW |
1 |
134,608,878 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6368:Kdm5b
|
UTSW |
1 |
134,599,207 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6681:Kdm5b
|
UTSW |
1 |
134,613,269 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R6715:Kdm5b
|
UTSW |
1 |
134,609,061 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7132:Kdm5b
|
UTSW |
1 |
134,599,106 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7202:Kdm5b
|
UTSW |
1 |
134,624,759 (GRCm38) |
missense |
probably benign |
|
|
R7258:Kdm5b
|
UTSW |
1 |
134,621,021 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7335:Kdm5b
|
UTSW |
1 |
134,560,439 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7420:Kdm5b
|
UTSW |
1 |
134,604,497 (GRCm38) |
missense |
probably benign |
0.14 |
|
R7426:Kdm5b
|
UTSW |
1 |
134,595,833 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7452:Kdm5b
|
UTSW |
1 |
134,624,948 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7595:Kdm5b
|
UTSW |
1 |
134,608,966 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7612:Kdm5b
|
UTSW |
1 |
134,624,918 (GRCm38) |
nonsense |
probably null |
|
|
R7704:Kdm5b
|
UTSW |
1 |
134,587,931 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8115:Kdm5b
|
UTSW |
1 |
134,619,673 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R8146:Kdm5b
|
UTSW |
1 |
134,625,126 (GRCm38) |
missense |
probably benign |
0.05 |
|
R8160:Kdm5b
|
UTSW |
1 |
134,613,919 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8527:Kdm5b
|
UTSW |
1 |
134,605,774 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R8542:Kdm5b
|
UTSW |
1 |
134,605,774 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R8930:Kdm5b
|
UTSW |
1 |
134,616,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8932:Kdm5b
|
UTSW |
1 |
134,616,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8950:Kdm5b
|
UTSW |
1 |
134,613,926 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R9089:Kdm5b
|
UTSW |
1 |
134,607,768 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9109:Kdm5b
|
UTSW |
1 |
134,600,755 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9133:Kdm5b
|
UTSW |
1 |
134,602,585 (GRCm38) |
missense |
probably benign |
|
|
R9298:Kdm5b
|
UTSW |
1 |
134,600,755 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9423:Kdm5b
|
UTSW |
1 |
134,587,967 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R9630:Kdm5b
|
UTSW |
1 |
134,585,233 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9670:Kdm5b
|
UTSW |
1 |
134,630,502 (GRCm38) |
nonsense |
probably null |
|
|
X0063:Kdm5b
|
UTSW |
1 |
134,588,876 (GRCm38) |
missense |
probably benign |
0.07 |
|
Z1176:Kdm5b
|
UTSW |
1 |
134,625,035 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Kdm5b
|
UTSW |
1 |
134,595,798 (GRCm38) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GGCTCTCAGGTGTCATTTACG -3'
(R):5'- TTCTGACACTGTTAGCAGCTCC -3'
Sequencing Primer
(F):5'- TGGGATTAAAGTTGCCCACC -3'
(R):5'- CTGCAGGCGGGCCATAG -3'
|
| Posted On |
2019-12-20 |
Incidental Mutation