Incidental Mutation 'R7846:Mfsd10'
ID 606603
Institutional Source Beutler Lab
Gene Symbol Mfsd10
Ensembl Gene ENSMUSG00000001082
Gene Name major facilitator superfamily domain containing 10
Synonyms 0610009O03Rik, Tetran
MMRRC Submission 045900-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7846 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 34790988-34794558 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 34793456 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Stop codon at position 95 (S95*)
Ref Sequence ENSEMBL: ENSMUSP00000001109 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000001108] [ENSMUST00000001109] [ENSMUST00000041364] [ENSMUST00000114329] [ENSMUST00000114331] [ENSMUST00000114335] [ENSMUST00000114338] [ENSMUST00000114340] [ENSMUST00000124668] [ENSMUST00000126257] [ENSMUST00000134156] [ENSMUST00000137150] [ENSMUST00000137506] [ENSMUST00000149657] [ENSMUST00000155577] [ENSMUST00000201147] [ENSMUST00000202378]
AlphaFold Q9D2V8
Predicted Effect probably benign
Transcript: ENSMUST00000001108
SMART Domains Protein: ENSMUSP00000001108
Gene: ENSMUSG00000029106

DomainStartEndE-ValueType
low complexity region 5 19 N/A INTRINSIC
Aldolase_II 147 329 5.49e-58 SMART
coiled coil region 599 631 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000001109
AA Change: S95*
SMART Domains Protein: ENSMUSP00000001109
Gene: ENSMUSG00000001082
AA Change: S95*

DomainStartEndE-ValueType
Pfam:MFS_1 29 413 6.9e-41 PFAM
Pfam:Sugar_tr 62 235 7.9e-9 PFAM
transmembrane domain 422 444 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000041364
SMART Domains Protein: ENSMUSP00000038382
Gene: ENSMUSG00000036693

DomainStartEndE-ValueType
Pfam:Nop14 21 849 2.2e-273 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000114329
AA Change: S95*
SMART Domains Protein: ENSMUSP00000109968
Gene: ENSMUSG00000001082
AA Change: S95*

DomainStartEndE-ValueType
Pfam:MFS_1 29 413 6.8e-41 PFAM
Pfam:Sugar_tr 71 228 2.3e-9 PFAM
transmembrane domain 422 444 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000114331
AA Change: S95*
SMART Domains Protein: ENSMUSP00000109970
Gene: ENSMUSG00000001082
AA Change: S95*

DomainStartEndE-ValueType
Pfam:MFS_1 29 413 6.8e-41 PFAM
Pfam:Sugar_tr 71 228 2.3e-9 PFAM
transmembrane domain 422 444 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000114335
SMART Domains Protein: ENSMUSP00000109974
Gene: ENSMUSG00000029106

DomainStartEndE-ValueType
low complexity region 5 19 N/A INTRINSIC
Aldolase_II 147 329 5.49e-58 SMART
coiled coil region 597 629 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000114338
SMART Domains Protein: ENSMUSP00000109977
Gene: ENSMUSG00000029106

DomainStartEndE-ValueType
low complexity region 5 19 N/A INTRINSIC
Aldolase_II 147 329 5.49e-58 SMART
coiled coil region 568 600 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000114340
SMART Domains Protein: ENSMUSP00000109979
Gene: ENSMUSG00000029106

DomainStartEndE-ValueType
low complexity region 5 19 N/A INTRINSIC
Aldolase_II 147 329 5.49e-58 SMART
coiled coil region 568 600 N/A INTRINSIC
low complexity region 666 685 N/A INTRINSIC
low complexity region 698 719 N/A INTRINSIC
low complexity region 727 733 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000124668
SMART Domains Protein: ENSMUSP00000119140
Gene: ENSMUSG00000001082

DomainStartEndE-ValueType
transmembrane domain 25 47 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000126257
AA Change: S95*
SMART Domains Protein: ENSMUSP00000144630
Gene: ENSMUSG00000001082
AA Change: S95*

DomainStartEndE-ValueType
Pfam:MFS_1 29 139 5.8e-9 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000134156
AA Change: S2*
SMART Domains Protein: ENSMUSP00000143812
Gene: ENSMUSG00000001082
AA Change: S2*

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000137150
SMART Domains Protein: ENSMUSP00000120814
Gene: ENSMUSG00000001082

DomainStartEndE-ValueType
transmembrane domain 25 47 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000137506
SMART Domains Protein: ENSMUSP00000144121
Gene: ENSMUSG00000001082

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
transmembrane domain 31 50 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000149657
AA Change: S95*
SMART Domains Protein: ENSMUSP00000118786
Gene: ENSMUSG00000001082
AA Change: S95*

DomainStartEndE-ValueType
Pfam:MFS_1 29 261 1.3e-26 PFAM
Pfam:Sugar_tr 71 228 9.3e-10 PFAM
Pfam:TRI12 76 232 3.4e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000152805
SMART Domains Protein: ENSMUSP00000121402
Gene: ENSMUSG00000029106

DomainStartEndE-ValueType
coiled coil region 95 127 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000155577
AA Change: S95*
SMART Domains Protein: ENSMUSP00000115204
Gene: ENSMUSG00000001082
AA Change: S95*

DomainStartEndE-ValueType
Pfam:MFS_1 29 269 1.1e-27 PFAM
Pfam:Sugar_tr 71 228 9.6e-10 PFAM
Pfam:TRI12 76 232 3.8e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000201147
SMART Domains Protein: ENSMUSP00000144239
Gene: ENSMUSG00000001082

DomainStartEndE-ValueType
low complexity region 80 95 N/A INTRINSIC
low complexity region 104 130 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000202065
Predicted Effect probably benign
Transcript: ENSMUST00000202378
SMART Domains Protein: ENSMUSP00000144117
Gene: ENSMUSG00000001082

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
transmembrane domain 24 43 N/A INTRINSIC
transmembrane domain 96 118 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abraxas1 A G 5: 100,954,698 (GRCm39) V247A probably damaging Het
Acot13 G T 13: 25,002,133 (GRCm39) T103K probably damaging Het
Acsl6 A T 11: 54,251,901 (GRCm39) I683F probably damaging Het
Acss2 A T 2: 155,402,953 (GRCm39) H577L probably damaging Het
Ahctf1 A T 1: 179,614,638 (GRCm39) V382D probably damaging Het
Aldob T C 4: 49,538,858 (GRCm39) H220R probably damaging Het
Ankrd1 C T 19: 36,094,218 (GRCm39) V169M probably damaging Het
Atp5f1a G A 18: 77,869,015 (GRCm39) R413H possibly damaging Het
Cep76 A G 18: 67,762,975 (GRCm39) F283L probably damaging Het
Chrna5 A T 9: 54,912,391 (GRCm39) D397V probably benign Het
Coro7 T C 16: 4,488,400 (GRCm39) D90G probably damaging Het
Csnk1g3 A G 18: 54,081,177 (GRCm39) N383D probably benign Het
Cwf19l2 C A 9: 3,477,889 (GRCm39) Q865K probably damaging Het
Cyth2 C A 7: 45,460,378 (GRCm39) W149C probably damaging Het
Dgkh C A 14: 78,856,026 (GRCm39) R349L probably damaging Het
Dnajc1 G T 2: 18,224,704 (GRCm39) T383N possibly damaging Het
Efcab3 T A 11: 104,605,571 (GRCm39) probably null Het
Extl3 A T 14: 65,313,181 (GRCm39) M667K probably damaging Het
Fam149a G T 8: 45,811,678 (GRCm39) A75E Het
Fgd4 T G 16: 16,240,590 (GRCm39) Q713P probably damaging Het
Frat2 T A 19: 41,836,215 (GRCm39) I46F probably damaging Het
Gzmc A G 14: 56,469,017 (GRCm39) V234A probably damaging Het
H2-Q4 A G 17: 35,599,134 (GRCm39) N135D probably damaging Het
Ighv1-85 A T 12: 115,963,937 (GRCm39) V21D possibly damaging Het
Itprid1 A G 6: 55,955,320 (GRCm39) Q976R possibly damaging Het
Kcna6 A T 6: 126,715,983 (GRCm39) V302E probably damaging Het
Kdm3b G T 18: 34,942,293 (GRCm39) V795L possibly damaging Het
Kdm5b G A 1: 134,545,578 (GRCm39) R913H probably damaging Het
Lpp T A 16: 24,426,876 (GRCm39) M1K probably null Het
Med12l T C 3: 59,172,355 (GRCm39) S1704P probably damaging Het
Napepld C T 5: 21,880,721 (GRCm39) E225K probably benign Het
Ndfip2 T C 14: 105,535,448 (GRCm39) F245L probably damaging Het
Oaf G A 9: 43,134,077 (GRCm39) R215C probably damaging Het
Or10k2 A G 8: 84,268,526 (GRCm39) H251R probably damaging Het
Or13a20 C T 7: 140,232,374 (GRCm39) H161Y probably damaging Het
Or51i1 A G 7: 103,670,736 (GRCm39) I263T possibly damaging Het
Or52z15 A G 7: 103,332,407 (GRCm39) I161V probably benign Het
Or5p6 A G 7: 107,631,199 (GRCm39) I117T probably benign Het
Or8b47 A G 9: 38,435,675 (GRCm39) T216A probably benign Het
Pcdhgb2 A T 18: 37,825,273 (GRCm39) I755F possibly damaging Het
Pde4dip A G 3: 97,622,490 (GRCm39) L1573P probably damaging Het
Peg3 A T 7: 6,713,650 (GRCm39) V524E probably damaging Het
Phc1 G T 6: 122,310,329 (GRCm39) T126N probably damaging Het
Phf1 C A 17: 27,154,291 (GRCm39) Y169* probably null Het
Pramel25 A T 4: 143,520,563 (GRCm39) D269V probably benign Het
Prl3a1 G A 13: 27,456,442 (GRCm39) E99K probably damaging Het
Prss57 G A 10: 79,623,213 (GRCm39) A78V probably damaging Het
Ptprb A T 10: 116,119,453 (GRCm39) T196S probably benign Het
Rgsl1 A T 1: 153,701,783 (GRCm39) C224S possibly damaging Het
Rtn4 T C 11: 29,643,274 (GRCm39) V29A unknown Het
Selplg G A 5: 113,957,481 (GRCm39) T275M probably damaging Het
Skint11 C T 4: 114,102,076 (GRCm39) T363I possibly damaging Het
Slc22a29 T A 19: 8,170,851 (GRCm39) I289F probably benign Het
Slc26a2 A G 18: 61,331,776 (GRCm39) S552P probably benign Het
Sptb T A 12: 76,655,300 (GRCm39) K1480* probably null Het
Sptbn1 C A 11: 30,092,153 (GRCm39) M537I probably damaging Het
Sqor A T 2: 122,627,008 (GRCm39) H43L probably benign Het
Srcin1 C A 11: 97,416,926 (GRCm39) E913* probably null Het
Srgap1 A G 10: 121,621,397 (GRCm39) L1032P probably damaging Het
Stc2 T C 11: 31,315,413 (GRCm39) K142R probably benign Het
Stox1 A C 10: 62,495,305 (GRCm39) N989K probably damaging Het
Tert T A 13: 73,776,314 (GRCm39) L355H probably damaging Het
Tfb2m A G 1: 179,358,926 (GRCm39) F319S probably damaging Het
Trps1 A G 15: 50,695,273 (GRCm39) F341L probably damaging Het
Ttk T C 9: 83,725,732 (GRCm39) V218A probably benign Het
Vmn1r159 A G 7: 22,542,696 (GRCm39) I112T probably benign Het
Vps8 C A 16: 21,351,070 (GRCm39) Q916K probably benign Het
Wdr12 A T 1: 60,121,225 (GRCm39) D364E probably damaging Het
Ylpm1 A G 12: 85,104,042 (GRCm39) E2019G probably damaging Het
Zfp267 C A 3: 36,219,738 (GRCm39) T587N probably benign Het
Zfp507 A G 7: 35,493,963 (GRCm39) L360P probably damaging Het
Other mutations in Mfsd10
AlleleSourceChrCoordTypePredicted EffectPPH Score
E0374:Mfsd10 UTSW 5 34,793,981 (GRCm39) splice site probably null
R0226:Mfsd10 UTSW 5 34,791,790 (GRCm39) missense probably benign 0.03
R0265:Mfsd10 UTSW 5 34,792,507 (GRCm39) splice site probably benign
R1803:Mfsd10 UTSW 5 34,794,094 (GRCm39) missense possibly damaging 0.81
R4235:Mfsd10 UTSW 5 34,792,969 (GRCm39) missense probably damaging 0.99
R4782:Mfsd10 UTSW 5 34,792,293 (GRCm39) intron probably benign
R5861:Mfsd10 UTSW 5 34,791,588 (GRCm39) unclassified probably benign
R6781:Mfsd10 UTSW 5 34,791,853 (GRCm39) missense possibly damaging 0.71
R7381:Mfsd10 UTSW 5 34,793,770 (GRCm39) missense probably damaging 1.00
R9036:Mfsd10 UTSW 5 34,792,751 (GRCm39) missense probably benign 0.04
R9124:Mfsd10 UTSW 5 34,791,940 (GRCm39) missense probably benign 0.00
R9333:Mfsd10 UTSW 5 34,792,427 (GRCm39) missense probably damaging 0.99
R9356:Mfsd10 UTSW 5 34,794,048 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GGCCAGAAGATCCCTCTAGAAG -3'
(R):5'- GTTCCTGCCTCCTTTAACTGAAAG -3'

Sequencing Primer
(F):5'- CTCTAGAAGGGATGGGAGCCC -3'
(R):5'- AGGGCTAAGTGTGGTCAA -3'
Posted On 2019-12-20