Mutagenetix > Incidental Mutation

Incidental Mutation 'R7847:Zfp341'

606668

Institutional Source

Beutler Lab

Gene Symbol

Zfp341

Ensembl Gene

ENSMUSG00000059842

Gene Name

zinc finger protein 341

Synonyms

MMRRC Submission

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7847 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

154613297-154646821 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 154634194 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 441 (S441P)

Ref Sequence

ENSEMBL: ENSMUSP00000080596 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081926] [ENSMUST00000109702] [ENSMUST00000126421]

AlphaFold

Q6PGC9

Predicted Effect

probably damaging
Transcript: ENSMUST00000081926
AA Change: S441P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000080596
Gene: ENSMUSG00000059842
AA Change: S441P

Domain	Start	End	E-Value	Type
ZnF_C2H2	53	73	4.16e1	SMART
low complexity region	96	110	N/A	INTRINSIC
low complexity region	154	161	N/A	INTRINSIC
low complexity region	177	200	N/A	INTRINSIC
ZnF_C2H2	320	342	3.69e-4	SMART
ZnF_C2H2	348	370	1.04e-3	SMART
ZnF_C2H2	442	464	1.45e-2	SMART
ZnF_C2H2	470	494	2.17e-1	SMART
ZnF_C2H2	500	522	2.91e-2	SMART
ZnF_C2H2	537	561	1.23e0	SMART
ZnF_C2H2	563	585	3.58e-2	SMART
ZnF_C2H2	591	613	1.62e0	SMART
ZnF_C2H2	619	641	2.27e-4	SMART
ZnF_C2H2	647	674	7.29e0	SMART
ZnF_C2H2	680	702	5.14e-3	SMART
low complexity region	740	759	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000109702
AA Change: S434P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000105324
Gene: ENSMUSG00000059842
AA Change: S434P

Domain	Start	End	E-Value	Type
ZnF_C2H2	53	73	4.16e1	SMART
low complexity region	96	110	N/A	INTRINSIC
low complexity region	154	161	N/A	INTRINSIC
low complexity region	177	200	N/A	INTRINSIC
ZnF_C2H2	313	335	3.69e-4	SMART
ZnF_C2H2	341	363	1.04e-3	SMART
ZnF_C2H2	435	457	1.45e-2	SMART
ZnF_C2H2	463	487	2.17e-1	SMART
ZnF_C2H2	493	515	2.91e-2	SMART
ZnF_C2H2	530	554	1.23e0	SMART
ZnF_C2H2	556	578	3.58e-2	SMART
ZnF_C2H2	584	606	1.62e0	SMART
ZnF_C2H2	612	634	2.27e-4	SMART
ZnF_C2H2	640	667	7.29e0	SMART
ZnF_C2H2	673	695	5.14e-3	SMART
low complexity region	733	752	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000126421

Meta Mutation Damage Score

0.3188

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.2%

Validation Efficiency

100% (45/45)

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2300002M23Rik	T	A	17: 35,568,652	Y296N	probably benign	Het
Abcc4	T	C	14: 118,627,480	E378G	probably damaging	Het
Acp2	C	T	2: 91,210,732	H422Y	possibly damaging	Het
Aldoart1	C	T	4: 72,851,956	C205Y	probably damaging	Het
Alg9	T	C	9: 50,789,605	L225S	possibly damaging	Het
Anapc1	A	C	2: 128,669,908	V455G	possibly damaging	Het
Arhgef5	C	A	6: 43,275,135	S940*	probably null	Het
Asb15	C	A	6: 24,564,267	A240E	probably damaging	Het
BB014433	GCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTACACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGG	GCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGG	8: 15,042,160		probably benign	Het
Ccdc17	A	G	4: 116,599,906	E529G	probably benign	Het
Cyp2b10	T	C	7: 25,897,760	S26P	possibly damaging	Het
Dcp1b	T	C	6: 119,215,295	S391P	probably benign	Het
Dock6	A	T	9: 21,801,207	L2086Q	unknown	Het
Ephx1	A	G	1: 181,001,861	S41P	probably benign	Het
Erbb3	G	A	10: 128,571,189	T1034M	probably damaging	Het
Gm17334	T	A	11: 53,772,738		probably benign	Het
Golgb1	A	G	16: 36,931,920	H3227R	probably damaging	Het
Grin2c	G	A	11: 115,260,978	P52L	possibly damaging	Het
Herc2	T	C	7: 56,157,560		probably null	Het
Il17rb	A	G	14: 29,996,806	Y440H	probably damaging	Het
Kcng4	A	G	8: 119,626,142	L343P	probably damaging	Het
Knl1	G	A	2: 119,070,976	E1053K	probably benign	Het
Lipo4	A	T	19: 33,514,199	V128E	possibly damaging	Het
Lmntd2	T	C	7: 141,210,150	N650D	probably benign	Het
Lrrfip2	T	C	9: 111,213,880	L460P	probably damaging	Het
Man2a2	G	C	7: 80,368,865	A82G	probably benign	Het
Mtcl1	T	C	17: 66,344,333	Q1379R	probably damaging	Het
Mtfr2	G	A	10: 20,357,452	A256T	probably benign	Het
Mup17	T	A	4: 61,593,219	H159L	probably benign	Het
Ndufaf1	A	T	2: 119,660,053	D175E	probably damaging	Het
Nup210l	A	G	3: 90,151,123	M610V	probably benign	Het
Olfr1338	G	T	4: 118,754,368	H59N	possibly damaging	Het
Olfr1354	T	A	10: 78,916,896	S19T	probably benign	Het
Olfr955	A	G	9: 39,470,505	S74P	probably benign	Het
Pard3b	A	G	1: 62,343,934	D729G	probably benign	Het
Phactr1	T	C	13: 43,057,188	L169P	possibly damaging	Het
Rad54b	T	A	4: 11,612,655	S762R	probably damaging	Het
Senp5	C	T	16: 31,990,173	V88I	probably benign	Het
Specc1l	T	C	10: 75,309,836	V1105A	probably damaging	Het
Trak2	A	C	1: 58,935,818	S72A	possibly damaging	Het
Ttyh2	T	C	11: 114,675,674		probably null	Het
Ush2a	G	A	1: 188,430,808	C1029Y	probably damaging	Het
Vmn2r17	A	G	5: 109,420,197	Y62C	probably damaging	Het
Vmn2r41	A	G	7: 8,161,548	F2L	probably benign	Het
Xirp1	G	T	9: 120,019,753	D21E	possibly damaging	Het
Zfp114	C	A	7: 24,181,035	Q270K	possibly damaging	Het
Zfp780b	A	C	7: 27,964,418	H237Q	probably benign	Het

Other mutations in Zfp341

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00499:Zfp341	APN	2	154634231	missense	probably damaging	1.00
IGL01352:Zfp341	APN	2	154628896	missense	probably benign	0.00
IGL01748:Zfp341	APN	2	154628927	missense	probably damaging	0.99
IGL02260:Zfp341	APN	2	154642049	missense	possibly damaging	0.89
IGL02329:Zfp341	APN	2	154632304	missense	possibly damaging	0.90
casanova_grimbacher	UTSW	2	154624881	missense	probably damaging	1.00
Specious	UTSW	2	154646134	missense	possibly damaging	0.63
R0079:Zfp341	UTSW	2	154624994	nonsense	probably null
R0570:Zfp341	UTSW	2	154646068	missense	probably benign	0.02
R0620:Zfp341	UTSW	2	154634273	missense	possibly damaging	0.94
R1018:Zfp341	UTSW	2	154646052	missense	probably damaging	1.00
R1611:Zfp341	UTSW	2	154645703	missense	probably damaging	1.00
R1733:Zfp341	UTSW	2	154641378	missense	probably benign	0.19
R1822:Zfp341	UTSW	2	154646134	missense	possibly damaging	0.63
R1956:Zfp341	UTSW	2	154638212	missense	probably benign	0.09
R2437:Zfp341	UTSW	2	154628801	missense	probably damaging	0.97
R3623:Zfp341	UTSW	2	154624881	missense	probably damaging	1.00
R4417:Zfp341	UTSW	2	154628987	missense	possibly damaging	0.94
R4806:Zfp341	UTSW	2	154645866	utr 3 prime	probably benign
R4807:Zfp341	UTSW	2	154645866	utr 3 prime	probably benign
R4863:Zfp341	UTSW	2	154645866	utr 3 prime	probably benign
R4955:Zfp341	UTSW	2	154638030	missense	probably damaging	0.98
R4962:Zfp341	UTSW	2	154626814	missense	possibly damaging	0.80
R5484:Zfp341	UTSW	2	154625001	missense	probably benign	0.00
R5864:Zfp341	UTSW	2	154643554	missense	possibly damaging	0.95
R5877:Zfp341	UTSW	2	154632289	missense	probably damaging	1.00
R5975:Zfp341	UTSW	2	154630441	missense	probably damaging	1.00
R5990:Zfp341	UTSW	2	154645659	missense	probably damaging	0.98
R6057:Zfp341	UTSW	2	154625034	missense	probably benign	0.01
R6882:Zfp341	UTSW	2	154638023	missense	probably damaging	1.00
R7686:Zfp341	UTSW	2	154624861	missense	probably damaging	0.96
R7701:Zfp341	UTSW	2	154634080	splice site	probably null
R8109:Zfp341	UTSW	2	154627900	missense	probably benign	0.04
R9313:Zfp341	UTSW	2	154627987	missense	probably damaging	1.00
R9484:Zfp341	UTSW	2	154643843	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGCCTTGAACACAGCGTGTG -3'
(R):5'- TATCATTTCTCCAGGCAGCAGG -3'

Sequencing Primer
(F):5'- AAGTCTGCAGTAGGTGTCCCAG -3'
(R):5'- GCAGCAGGGGTGTGACC -3'

Posted On

2019-12-20