Mutagenetix > Incidental Mutations

Incidental Mutation 'R7847:Gm17334'

606696

Institutional Source

Beutler Lab

Gene Symbol

Gm17334

Ensembl Gene

ENSMUSG00000091191

Gene Name

predicted gene, 17334

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.188) question?

Stock #

R7847 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

53772281-53773187 bp(-) (GRCm38)

Type of Mutation

intron

DNA Base Change (assembly)

T to A at 53772738 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000118795 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000019043] [ENSMUST00000108920] [ENSMUST00000108922] [ENSMUST00000123376] [ENSMUST00000133291] [ENSMUST00000138913] [ENSMUST00000140866] [ENSMUST00000142221] [ENSMUST00000170390]

Predicted Effect

probably benign
Transcript: ENSMUST00000019043

SMART Domains

Protein: ENSMUSP00000019043
Gene: ENSMUSG00000018899

Domain	Start	End	E-Value	Type
IRF	1	114	6.75e-62	SMART
low complexity region	120	138	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108920

SMART Domains

Protein: ENSMUSP00000104548
Gene: ENSMUSG00000018899

Domain	Start	End	E-Value	Type
IRF	1	114	6.75e-62	SMART
low complexity region	120	138	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108922

SMART Domains

Protein: ENSMUSP00000104550
Gene: ENSMUSG00000018899

Domain	Start	End	E-Value	Type
IRF	1	114	6.75e-62	SMART
low complexity region	120	138	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000123376

SMART Domains

Protein: ENSMUSP00000122101
Gene: ENSMUSG00000018899

Domain	Start	End	E-Value	Type
IRF	1	114	6.75e-62	SMART
low complexity region	120	138	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128336

Predicted Effect

probably benign
Transcript: ENSMUST00000133291

SMART Domains

Protein: ENSMUSP00000116656
Gene: ENSMUSG00000018899

Domain	Start	End	E-Value	Type
IRF	1	114	6.75e-62	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000138913

SMART Domains

Protein: ENSMUSP00000118314
Gene: ENSMUSG00000018899

Domain	Start	End	E-Value	Type
IRF	1	62	2.41e-8	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000140866

SMART Domains

Protein: ENSMUSP00000114315
Gene: ENSMUSG00000018899

Domain	Start	End	E-Value	Type
IRF	1	114	6.75e-62	SMART
low complexity region	120	138	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000142221

SMART Domains

Protein: ENSMUSP00000118795
Gene: ENSMUSG00000018899

Domain	Start	End	E-Value	Type
Pfam:IRF	5	48	4.8e-11	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153054

Predicted Effect

unknown
Transcript: ENSMUST00000170390
AA Change: H99L

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.2%

Validation Efficiency

100% (45/45)

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2300002M23Rik	T	A	17: 35,568,652	Y296N	probably benign	Het
Abcc4	T	C	14: 118,627,480	E378G	probably damaging	Het
Acp2	C	T	2: 91,210,732	H422Y	possibly damaging	Het
Aldoart1	C	T	4: 72,851,956	C205Y	probably damaging	Het
Alg9	T	C	9: 50,789,605	L225S	possibly damaging	Het
Anapc1	A	C	2: 128,669,908	V455G	possibly damaging	Het
Arhgef5	C	A	6: 43,275,135	S940*	probably null	Het
Asb15	C	A	6: 24,564,267	A240E	probably damaging	Het
BB014433	GCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTACACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGG	GCACACAGCTTTGGAGGTGTACACACCCGGGTTGGGGCCTCTGCACACAGCTTTGG	8: 15,042,160		probably benign	Het
Ccdc17	A	G	4: 116,599,906	E529G	probably benign	Het
Cyp2b10	T	C	7: 25,897,760	S26P	possibly damaging	Het
Dcp1b	T	C	6: 119,215,295	S391P	probably benign	Het
Dock6	A	T	9: 21,801,207	L2086Q	unknown	Het
Ephx1	A	G	1: 181,001,861	S41P	probably benign	Het
Erbb3	G	A	10: 128,571,189	T1034M	probably damaging	Het
Golgb1	A	G	16: 36,931,920	H3227R	probably damaging	Het
Grin2c	G	A	11: 115,260,978	P52L	possibly damaging	Het
Herc2	T	C	7: 56,157,560		probably null	Het
Il17rb	A	G	14: 29,996,806	Y440H	probably damaging	Het
Kcng4	A	G	8: 119,626,142	L343P	probably damaging	Het
Knl1	G	A	2: 119,070,976	E1053K	probably benign	Het
Lipo4	A	T	19: 33,514,199	V128E	possibly damaging	Het
Lmntd2	T	C	7: 141,210,150	N650D	probably benign	Het
Lrrfip2	T	C	9: 111,213,880	L460P	probably damaging	Het
Man2a2	G	C	7: 80,368,865	A82G	probably benign	Het
Mtcl1	T	C	17: 66,344,333	Q1379R	probably damaging	Het
Mtfr2	G	A	10: 20,357,452	A256T	probably benign	Het
Mup17	T	A	4: 61,593,219	H159L	probably benign	Het
Ndufaf1	A	T	2: 119,660,053	D175E	probably damaging	Het
Nup210l	A	G	3: 90,151,123	M610V	probably benign	Het
Olfr1338	G	T	4: 118,754,368	H59N	possibly damaging	Het
Olfr1354	T	A	10: 78,916,896	S19T	probably benign	Het
Olfr955	A	G	9: 39,470,505	S74P	probably benign	Het
Pard3b	A	G	1: 62,343,934	D729G	probably benign	Het
Phactr1	T	C	13: 43,057,188	L169P	possibly damaging	Het
Rad54b	T	A	4: 11,612,655	S762R	probably damaging	Het
Senp5	C	T	16: 31,990,173	V88I	probably benign	Het
Specc1l	T	C	10: 75,309,836	V1105A	probably damaging	Het
Trak2	A	C	1: 58,935,818	S72A	possibly damaging	Het
Ttyh2	T	C	11: 114,675,674		probably null	Het
Ush2a	G	A	1: 188,430,808	C1029Y	probably damaging	Het
Vmn2r17	A	G	5: 109,420,197	Y62C	probably damaging	Het
Vmn2r41	A	G	7: 8,161,548	F2L	probably benign	Het
Xirp1	G	T	9: 120,019,753	D21E	possibly damaging	Het
Zfp114	C	A	7: 24,181,035	Q270K	possibly damaging	Het
Zfp341	T	C	2: 154,634,194	S441P	probably damaging	Het
Zfp780b	A	C	7: 27,964,418	H237Q	probably benign	Het

Other mutations in Gm17334

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL02954:Gm17334	APN	11	53772828	intron	probably benign
R2074:Gm17334	UTSW	11	53772828	intron	probably benign
R6431:Gm17334	UTSW	11	53772738	intron	probably benign
R7930:Gm17334	UTSW	11	53772738	intron	probably benign

Predicted Primers

PCR Primer
(F):5'- AAGGTCCCATGTTCCAATGCTC -3'
(R):5'- GGCATCCTTGTTGATGTCCC -3'

Sequencing Primer
(F):5'- CCATGTTCCAATGCTCGGTAG -3'
(R):5'- TGATGTCCCAGCCGTGCTTAG -3'

Posted On

2019-12-20