|Institutional Source||Beutler Lab|
|Gene Name||opioid growth factor receptor|
|Is this an essential gene?||Possibly essential (E-score: 0.520)|
|Stock #||R7848 (G1)|
|Chromosomal Location||180589245-180595836 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 180592433 bp|
|Amino Acid Change||Leucine to Proline at position 99 (L99P)|
|Ref Sequence||ENSEMBL: ENSMUSP00000029087 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000029087]|
|Predicted Effect||probably damaging
AA Change: L99P
PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
AA Change: L99P
|Coding Region Coverage||
|Validation Efficiency||100% (62/62)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ogfr||
(F):5'- CCAGAGAGGAATTATTGCACCC -3'
(R):5'- TCCCAGGACATAAAAGCCTG -3'
(F):5'- GAGAGGAATTATTGCACCCCTTAC -3'
(R):5'- TGCCCACAGACCTGAGC -3'