Incidental Mutation 'R0165:Vmn1r28'
ID 60677
Institutional Source Beutler Lab
Gene Symbol Vmn1r28
Ensembl Gene ENSMUSG00000115705
Gene Name vomeronasal 1 receptor 28
Synonyms V1rc25
MMRRC Submission 038441-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.125) question?
Stock # R0165 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 58262037-58275639 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 58265717 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 182 (A182T)
Ref Sequence ENSEMBL: ENSMUSP00000153785 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000176874] [ENSMUST00000226813] [ENSMUST00000227805] [ENSMUST00000228678]
AlphaFold Q8R2C9
Predicted Effect probably benign
Transcript: ENSMUST00000176874
AA Change: A182T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000135311
Gene: ENSMUSG00000094291
AA Change: A182T

DomainStartEndE-ValueType
Pfam:V1R 28 293 8.4e-59 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226813
AA Change: A182T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000227805
AA Change: A182T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000228678
AA Change: A182T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.5%
  • 10x: 96.2%
  • 20x: 91.4%
Validation Efficiency 96% (81/84)
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik G A 15: 8,216,382 (GRCm38) V1413M probably damaging Het
2700049A03Rik T C 12: 71,167,150 (GRCm38) I717T possibly damaging Het
3632451O06Rik A G 14: 49,773,786 (GRCm38) S155P probably benign Het
6430571L13Rik A G 9: 107,346,184 (GRCm38) probably benign Het
Abca15 T A 7: 120,350,903 (GRCm38) probably benign Het
Abca6 A G 11: 110,219,604 (GRCm38) V573A possibly damaging Het
Adgrl2 A G 3: 148,852,863 (GRCm38) probably benign Het
Agap3 A G 5: 24,479,745 (GRCm38) T544A probably damaging Het
Ahrr G A 13: 74,283,024 (GRCm38) probably benign Het
Akr1c20 T C 13: 4,523,296 (GRCm38) T7A probably benign Het
Ankrd26 A G 6: 118,540,484 (GRCm38) S459P probably benign Het
Ascc3 T A 10: 50,842,127 (GRCm38) probably null Het
Brd1 T C 15: 88,729,777 (GRCm38) N305S probably damaging Het
Catip T A 1: 74,368,469 (GRCm38) L320Q possibly damaging Het
Cttnbp2 G A 6: 18,435,410 (GRCm38) Q150* probably null Het
Cyp2d22 T G 15: 82,373,280 (GRCm38) N228T probably benign Het
Dapk1 T C 13: 60,761,593 (GRCm38) V1340A probably benign Het
Dcaf4 G A 12: 83,535,988 (GRCm38) probably benign Het
Ddhd1 G A 14: 45,595,592 (GRCm38) T849M probably damaging Het
Dnah6 A G 6: 73,021,323 (GRCm38) S3987P probably benign Het
Dst C A 1: 34,154,646 (GRCm38) probably benign Het
Epha2 T C 4: 141,321,892 (GRCm38) probably null Het
Ern2 T C 7: 122,179,779 (GRCm38) T281A probably benign Het
Extl1 A G 4: 134,357,703 (GRCm38) F652S probably damaging Het
Gckr A G 5: 31,326,948 (GRCm38) S541G possibly damaging Het
Gdap1l1 A G 2: 163,451,499 (GRCm38) probably null Het
Gm7535 T C 17: 17,911,175 (GRCm38) probably benign Het
Gmps T A 3: 63,993,954 (GRCm38) I398N probably damaging Het
Igf2r A G 17: 12,698,527 (GRCm38) V1556A probably benign Het
Il3ra T A 14: 14,350,967 (GRCm38) N283K probably benign Het
Ist1 A G 8: 109,675,366 (GRCm38) probably benign Het
Lama3 A T 18: 12,524,810 (GRCm38) I1934F probably damaging Het
Lars A T 18: 42,202,697 (GRCm38) M1118K possibly damaging Het
Lpin2 C T 17: 71,246,519 (GRCm38) S846L probably damaging Het
Lrrc4b C A 7: 44,462,315 (GRCm38) T537K probably damaging Het
Ltn1 G A 16: 87,405,519 (GRCm38) probably benign Het
Meiob A G 17: 24,835,161 (GRCm38) T401A probably benign Het
Mettl21e G A 1: 44,211,123 (GRCm38) T41M probably damaging Het
Miga1 C T 3: 152,290,843 (GRCm38) E323K probably damaging Het
Ndufs1 A T 1: 63,159,748 (GRCm38) probably null Het
Olfr486 T C 7: 108,172,675 (GRCm38) D23G probably benign Het
Otog G A 7: 46,304,231 (GRCm38) V2638M probably damaging Het
Parp6 T C 9: 59,632,925 (GRCm38) Y274H probably damaging Het
Prom2 A T 2: 127,539,514 (GRCm38) probably benign Het
Prune2 T A 19: 17,122,610 (GRCm38) M1826K probably benign Het
Qk T A 17: 10,238,963 (GRCm38) D159V probably damaging Het
Rab12 A T 17: 66,500,317 (GRCm38) I139N probably damaging Het
Rab25 T A 3: 88,548,055 (GRCm38) E7D probably benign Het
Rala A T 13: 17,888,589 (GRCm38) V139E probably benign Het
Ralgapa2 A G 2: 146,388,487 (GRCm38) probably benign Het
Rbl2 T A 8: 91,074,176 (GRCm38) Y89N probably damaging Het
Rho A T 6: 115,932,227 (GRCm38) I75F probably damaging Het
Slc38a4 C A 15: 97,008,949 (GRCm38) A303S probably benign Het
Slc6a15 A G 10: 103,409,809 (GRCm38) D551G probably null Het
Smyd3 T C 1: 179,043,872 (GRCm38) N314S probably benign Het
Speer4f1 T A 5: 17,479,514 (GRCm38) L180* probably null Het
Stat6 T C 10: 127,657,227 (GRCm38) V576A probably damaging Het
Strn T C 17: 78,677,374 (GRCm38) D127G possibly damaging Het
Syne1 T C 10: 5,033,096 (GRCm38) R8610G probably benign Het
Tbc1d7 A C 13: 43,153,202 (GRCm38) probably null Het
Tcf3 C T 10: 80,412,997 (GRCm38) R548Q probably damaging Het
Tlr9 C A 9: 106,226,087 (GRCm38) A859D probably benign Het
Tmem106c T A 15: 97,968,139 (GRCm38) probably benign Het
Tmprss11c A T 5: 86,231,927 (GRCm38) probably benign Het
Tnfsf18 A G 1: 161,494,731 (GRCm38) R7G probably benign Het
Tnrc6b T A 15: 80,858,670 (GRCm38) probably null Het
Trpm7 A T 2: 126,797,513 (GRCm38) F1684I probably damaging Het
Ttbk1 C A 17: 46,478,938 (GRCm38) R133L possibly damaging Het
Ttn A G 2: 76,721,342 (GRCm38) S22962P probably damaging Het
Ube2q1 T A 3: 89,776,153 (GRCm38) L135Q probably damaging Het
Vwce T C 19: 10,659,973 (GRCm38) probably benign Het
Wdhd1 A G 14: 47,267,068 (GRCm38) S350P probably benign Het
Zbtb21 A G 16: 97,951,404 (GRCm38) S560P probably damaging Het
Other mutations in Vmn1r28
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01365:Vmn1r28 APN 6 58,265,191 (GRCm38) missense possibly damaging 0.76
IGL01712:Vmn1r28 APN 6 58,265,408 (GRCm38) missense probably benign 0.00
IGL01788:Vmn1r28 APN 6 58,265,537 (GRCm38) missense probably benign 0.00
IGL02629:Vmn1r28 APN 6 58,265,816 (GRCm38) missense probably benign 0.00
R0001:Vmn1r28 UTSW 6 58,265,717 (GRCm38) missense probably benign 0.00
R0009:Vmn1r28 UTSW 6 58,265,717 (GRCm38) missense probably benign 0.00
R0040:Vmn1r28 UTSW 6 58,265,894 (GRCm38) missense probably damaging 1.00
R0078:Vmn1r28 UTSW 6 58,265,717 (GRCm38) missense probably benign 0.00
R0079:Vmn1r28 UTSW 6 58,265,717 (GRCm38) missense probably benign 0.00
R0081:Vmn1r28 UTSW 6 58,265,717 (GRCm38) missense probably benign 0.00
R0164:Vmn1r28 UTSW 6 58,265,717 (GRCm38) missense probably benign 0.00
R0164:Vmn1r28 UTSW 6 58,265,717 (GRCm38) missense probably benign 0.00
R0166:Vmn1r28 UTSW 6 58,265,717 (GRCm38) missense probably benign 0.00
R0167:Vmn1r28 UTSW 6 58,265,717 (GRCm38) missense probably benign 0.00
R0172:Vmn1r28 UTSW 6 58,265,717 (GRCm38) missense probably benign 0.00
R0173:Vmn1r28 UTSW 6 58,265,717 (GRCm38) missense probably benign 0.00
R0284:Vmn1r28 UTSW 6 58,265,717 (GRCm38) missense probably benign 0.00
R0288:Vmn1r28 UTSW 6 58,265,717 (GRCm38) missense probably benign 0.00
R0704:Vmn1r28 UTSW 6 58,265,717 (GRCm38) missense probably benign 0.00
R1143:Vmn1r28 UTSW 6 58,265,742 (GRCm38) missense probably benign 0.00
R1225:Vmn1r28 UTSW 6 58,265,966 (GRCm38) nonsense probably null
R1464:Vmn1r28 UTSW 6 58,265,232 (GRCm38) missense probably benign 0.05
R1464:Vmn1r28 UTSW 6 58,265,232 (GRCm38) missense probably benign 0.05
R1836:Vmn1r28 UTSW 6 58,265,252 (GRCm38) missense probably damaging 0.98
R1882:Vmn1r28 UTSW 6 58,265,978 (GRCm38) missense probably benign
R1905:Vmn1r28 UTSW 6 58,265,927 (GRCm38) missense probably benign 0.01
R4912:Vmn1r28 UTSW 6 58,265,540 (GRCm38) missense possibly damaging 0.86
R5071:Vmn1r28 UTSW 6 58,265,909 (GRCm38) missense probably benign 0.25
R5113:Vmn1r28 UTSW 6 58,265,858 (GRCm38) missense probably benign 0.12
R5261:Vmn1r28 UTSW 6 58,265,539 (GRCm38) missense probably benign 0.02
R5265:Vmn1r28 UTSW 6 58,265,964 (GRCm38) missense probably damaging 0.98
R5839:Vmn1r28 UTSW 6 58,265,295 (GRCm38) missense possibly damaging 0.94
R6180:Vmn1r28 UTSW 6 58,265,491 (GRCm38) missense probably damaging 0.99
R6643:Vmn1r28 UTSW 6 58,265,960 (GRCm38) missense probably benign 0.17
R6884:Vmn1r28 UTSW 6 58,265,648 (GRCm38) missense probably benign 0.03
R7393:Vmn1r28 UTSW 6 58,265,589 (GRCm38) missense possibly damaging 0.81
R7471:Vmn1r28 UTSW 6 58,265,865 (GRCm38) nonsense probably null
R7738:Vmn1r28 UTSW 6 58,266,054 (GRCm38) missense probably benign 0.00
R7961:Vmn1r28 UTSW 6 58,265,193 (GRCm38) missense probably benign
R8009:Vmn1r28 UTSW 6 58,265,193 (GRCm38) missense probably benign
R8156:Vmn1r28 UTSW 6 58,265,198 (GRCm38) missense probably damaging 1.00
R8167:Vmn1r28 UTSW 6 58,266,067 (GRCm38) missense noncoding transcript
R8879:Vmn1r28 UTSW 6 58,265,684 (GRCm38) missense probably benign 0.05
R9639:Vmn1r28 UTSW 6 58,266,011 (GRCm38) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TGTCACAATCAGTCCCAGTACCTCC -3'
(R):5'- ACACTACCAACAGCAAGATGGTCTG -3'

Sequencing Primer
(F):5'- GGTTTTACCAATGTGAGTGAGACC -3'
(R):5'- CAGCAAGATGGTCTGGGTGG -3'
Posted On 2013-07-24